keratin 16 (KRT16) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_005557.3 in the KRT16 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008301.1, covering KRT16 transcript NM_005557.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5019
                                          agttaggagggccccgcct       c.-121

 .         .         .         .         .         .                g.5079
 tccccagctgcatataaaggtctctggggttggaggcagccacagcacgctctcagcctt       c.-61

 .         .         .         .         .         .                g.5139
 cctgagcacctttccttctttcagccaactgctcactcgctcacctccctccttggcacc       c.-1

          .         .         .         .         .         .       g.5199
 ATGACCACCTGCAGCCGCCAGTTCACCTCCTCCAGCTCCATGAAGGGCTCCTGCGGCATC       c.60
 M  T  T  C  S  R  Q  F  T  S  S  S  S  M  K  G  S  C  G  I         p.20

          .         .         .         .         .         .       g.5259
 GGAGGCGGCATCGGGGGCGGCTCCAGCCGCATCTCCTCCGTCCTGGCCGGAGGGTCCTGC       c.120
 G  G  G  I  G  G  G  S  S  R  I  S  S  V  L  A  G  G  S  C         p.40

          .         .         .         .         .         .       g.5319
 CGTGCCCCCAGCACCTACGGGGGCGGCCTGTCTGTCTCCTCTCGCTTCTCCTCTGGGGGA       c.180
 R  A  P  S  T  Y  G  G  G  L  S  V  S  S  R  F  S  S  G  G         p.60

          .         .         .         .         .         .       g.5379
 GCCTGCGGGCTGGGGGGCGGCTATGGCGGTGGCTTCAGCAGCAGCAGCAGCTTTGGTAGT       c.240
 A  C  G  L  G  G  G  Y  G  G  G  F  S  S  S  S  S  F  G  S         p.80

          .         .         .         .         .         .       g.5439
 GGCTTCGGGGGAGGATATGGTGGTGGCCTTGGTGCTGGCTTCGGTGGTGGCTTGGGTGCT       c.300
 G  F  G  G  G  Y  G  G  G  L  G  A  G  F  G  G  G  L  G  A         p.100

          .         .         .         .         .         .       g.5499
 GGCTTTGGTGGTGGTTTTGCTGGTGGTGATGGGCTTCTGGTGGGCAGTGAGAAGGTGACC       c.360
 G  F  G  G  G  F  A  G  G  D  G  L  L  V  G  S  E  K  V  T         p.120

          .         .         .         .         .         .       g.5559
 ATGCAGAACCTCAATGACCGCCTGGCCTCCTACCTGGACAAGGTGCGTGCTCTGGAGGAG       c.420
 M  Q  N  L  N  D  R  L  A  S  Y  L  D  K  V  R  A  L  E  E         p.140

          .         .         .         .         .         .       g.5619
 GCCAACGCCGACCTGGAAGTGAAGATCCGTGACTGGTACCAGAGGCAGCGGCCCAGTGAG       c.480
 A  N  A  D  L  E  V  K  I  R  D  W  Y  Q  R  Q  R  P  S  E         p.160

          .         .         .         .         .  | 02      .    g.6115
 ATCAAAGACTACAGTCCCTACTTCAAGACCATCGAGGACCTGAGGAACAAG | ATCATTGCG    c.540
 I  K  D  Y  S  P  Y  F  K  T  I  E  D  L  R  N  K   | I  I  A      p.180

          .         .         .         .         .         .       g.6175
 GCCACCATTGAGAATGCGCAGCCCATTTTGCAGATTGACAATGCCAGGCTGGCAGCCGAT       c.600
 A  T  I  E  N  A  Q  P  I  L  Q  I  D  N  A  R  L  A  A  D         p.200

          .     | 03   .         .         .         .         .    g.6372
 GACTTCAGGACCAA | GTATGAGCATGAACTGGCCCTGCGGCAGACTGTGGAGGCCGACGTC    c.660
 D  F  R  T  K  |  Y  E  H  E  L  A  L  R  Q  T  V  E  A  D  V      p.220

          .         .         .         .         .         .       g.6432
 AATGGCCTGCGCCGGGTGTTGGATGAGCTGACCCTGGCCAGGACTGACCTGGAGATGCAG       c.720
 N  G  L  R  R  V  L  D  E  L  T  L  A  R  T  D  L  E  M  Q         p.240

          .         .         .         .         .  | 04      .    g.6606
 ATCGAAGGCCTGAAGGAGGAGCTGGCCTACCTGAGGAAGAACCACGAGGAG | GAGATGCTT    c.780
 I  E  G  L  K  E  E  L  A  Y  L  R  K  N  H  E  E   | E  M  L      p.260

          .         .         .         .         .         .       g.6666
 GCTCTGAGAGGTCAGACCGGCGGAGATGTGAACGTGGAGATGGATGCTGCACCTGGCGTG       c.840
 A  L  R  G  Q  T  G  G  D  V  N  V  E  M  D  A  A  P  G  V         p.280

          .         .         .         .         .         .       g.6726
 GACCTGAGCCGCATCCTGAATGAGATGCGTGACCAGTACGAGCAGATGGCAGAGAAAAAC       c.900
 D  L  S  R  I  L  N  E  M  R  D  Q  Y  E  Q  M  A  E  K  N         p.300

          .         .         .    | 05    .         .         .    g.6875
 CGCAGAGACGCTGAGACCTGGTTCCTGAGCAAG | ACCGAGGAGCTGAACAAAGAAGTGGCC    c.960
 R  R  D  A  E  T  W  F  L  S  K   | T  E  E  L  N  K  E  V  A      p.320

          .         .         .         .         .         .       g.6935
 TCCAACAGCGAACTGGTACAGAGCAGCCGCAGTGAGGTGACGGAGCTCCGGAGGGTGCTC       c.1020
 S  N  S  E  L  V  Q  S  S  R  S  E  V  T  E  L  R  R  V  L         p.340

          .         .         .          | 06        .         .    g.7297
 CAGGGCCTGGAGATTGAGCTGCAGTCCCAGCTCAGCATG | AAAGCATCCCTGGAGAACAGC    c.1080
 Q  G  L  E  I  E  L  Q  S  Q  L  S  M   | K  A  S  L  E  N  S      p.360

          .         .         .         .         .         .       g.7357
 CTGGAGGAGACCAAAGGCCGCTACTGCATGCAGCTGTCCCAGATCCAGGGACTGATTGGC       c.1140
 L  E  E  T  K  G  R  Y  C  M  Q  L  S  Q  I  Q  G  L  I  G         p.380

          .         .         .         .         .         .       g.7417
 AGTGTGGAGGAGCAGCTGGCCCAGCTACGCTGTGAGATGGAGCAGCAGAGCCAGGAGTAC       c.1200
 S  V  E  E  Q  L  A  Q  L  R  C  E  M  E  Q  Q  S  Q  E  Y         p.400

          .         .         .         .         .         .       g.7477
 CAGATCTTGCTGGATGTGAAGACGCGGCTGGAGCAGGAGATTGCCACCTACCGCCGCCTG       c.1260
 Q  I  L  L  D  V  K  T  R  L  E  Q  E  I  A  T  Y  R  R  L         p.420

          .         . | 07       .         .         .         .    g.7631
 CTGGAGGGCGAGGATGCCCA | CCTTTCCTCCCAGCAAGCATCTGGCCAATCCTATTCTTCC    c.1320
 L  E  G  E  D  A  H  |  L  S  S  Q  Q  A  S  G  Q  S  Y  S  S      p.440

         | 08.         .         .         .         .         .    g.7851
 CGCGAGG | TCTTCACCTCCTCCTCGTCCTCTTCGAGCCGTCAGACCCGGCCCATCCTCAAG    c.1380
 R  E  V |   F  T  S  S  S  S  S  S  S  R  Q  T  R  P  I  L  K      p.460

          .         .         .         .                           g.7893
 GAGCAGAGCTCATCCAGCTTCAGCCAGGGCCAGAGCTCCTAG                         c.1422
 E  Q  S  S  S  S  F  S  Q  G  Q  S  S  X                           p.473

          .         .         .         .         .         .       g.7953
 aactgagctgcctctaccacagcctcctgcccaccagctggcctcacctcctgaaggccc       c.*60

          .         .         .         .         .         .       g.8013
 gggtcaggaccctgctctcctggcgcagttcccagctatctcccctgctcctctgctggt       c.*120

          .         .         .                                     g.8050
 ggtgggctaataaagctgactttctggttgatgcaaa                              c.*157

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Keratin 16 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.