keratin 1 (KRT1) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_006121.3 in the KRT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008364.1, covering KRT1 transcript NM_006121.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  agaggagtgtttagctccttcccttactctaccttgctcctacttttctctaagtcaac       c.-1

          .         .         .         .         .         .       g.5119
 ATGAGTCGACAGTTTAGTTCCAGGTCTGGGTACCGAAGTGGAGGGGGCTTCAGCTCTGGC       c.60
 M  S  R  Q  F  S  S  R  S  G  Y  R  S  G  G  G  F  S  S  G         p.20

          .         .         .         .         .         .       g.5179
 TCTGCTGGGATCATCAACTACCAGCGCAGGACCACCAGCAGCTCCACACGCCGCAGTGGA       c.120
 S  A  G  I  I  N  Y  Q  R  R  T  T  S  S  S  T  R  R  S  G         p.40

          .         .         .         .         .         .       g.5239
 GGAGGTGGTGGGAGATTTTCAAGCTGTGGTGGTGGTGGTGGTAGCTTTGGTGCTGGTGGT       c.180
 G  G  G  G  R  F  S  S  C  G  G  G  G  G  S  F  G  A  G  G         p.60

          .         .         .         .         .         .       g.5299
 GGATTTGGAAGTCGGAGTCTTGTTAACCTTGGTGGCAGTAAAAGCATCTCCATAAGTGTG       c.240
 G  F  G  S  R  S  L  V  N  L  G  G  S  K  S  I  S  I  S  V         p.80

          .         .         .         .         .         .       g.5359
 GCTAGAGGAGGTGGACGTGGTAGTGGCTTTGGTGGTGGTTATGGTGGTGGTGGCTTTGGT       c.300
 A  R  G  G  G  R  G  S  G  F  G  G  G  Y  G  G  G  G  F  G         p.100

          .         .         .         .         .         .       g.5419
 GGTGGTGGCTTTGGTGGTGGTGGCTTTGGTGGAGGTGGCATTGGGGGTGGTGGCTTTGGT       c.360
 G  G  G  F  G  G  G  G  F  G  G  G  G  I  G  G  G  G  F  G         p.120

          .         .         .         .         .         .       g.5479
 GGTTTTGGCAGTGGTGGTGGTGGTTTTGGTGGAGGTGGCTTTGGGGGTGGTGGATATGGG       c.420
 G  F  G  S  G  G  G  G  F  G  G  G  G  F  G  G  G  G  Y  G         p.140

          .         .         .         .         .         .       g.5539
 GGTGGTTATGGTCCTGTCTGCCCTCCTGGTGGCATACAAGAAGTCACTATCAACCAGAGC       c.480
 G  G  Y  G  P  V  C  P  P  G  G  I  Q  E  V  T  I  N  Q  S         p.160

          .         .         .         .         .         .       g.5599
 CTTCTTCAGCCCCTCAATGTGGAGATTGACCCTGAGATCCAAAAGGTGAAGTCTCGAGAA       c.540
 L  L  Q  P  L  N  V  E  I  D  P  E  I  Q  K  V  K  S  R  E         p.180

          .         .         .         .         .  | 02      .    g.6660
 AGGGAGCAAATCAAGTCACTCAACAACCAATTTGCCTCCTTCATTGACAAG | GTGAGGTTC    c.600
 R  E  Q  I  K  S  L  N  N  Q  F  A  S  F  I  D  K   | V  R  F      p.200

          .         .         .         .         .         .       g.6720
 CTGGAGCAGCAGAACCAGGTACTGCAAACAAAATGGGAGCTGCTGCAGCAGGTAGATACC       c.660
 L  E  Q  Q  N  Q  V  L  Q  T  K  W  E  L  L  Q  Q  V  D  T         p.220

          .         .         .         .         .         .       g.6780
 TCCACTAGAACCCATAATTTAGAGCCCTACTTTGAGTCATTCATCAACAATCTCCGAAGG       c.720
 S  T  R  T  H  N  L  E  P  Y  F  E  S  F  I  N  N  L  R  R         p.240

          .         .         .         .         .         .       g.6840
 AGAGTGGACCAACTGAAGAGTGATCAATCTCGGTTGGATTCGGAACTGAAGAACATGCAG       c.780
 R  V  D  Q  L  K  S  D  Q  S  R  L  D  S  E  L  K  N  M  Q         p.260

          .         .       | 03 .         .         .         .    g.7218
 GACATGGTGGAGGATTACCGGAACAA | GTATGAGGATGAAATCAACAAGCGGACAAATGCA    c.840
 D  M  V  E  D  Y  R  N  K  |  Y  E  D  E  I  N  K  R  T  N  A      p.280

          .         .        | 04.         .         .         .    g.7695
 GAGAATGAATTTGTGACCATCAAGAAG | GATGTGGATGGTGCTTATATGACCAAGGTGGAC    c.900
 E  N  E  F  V  T  I  K  K   | D  V  D  G  A  Y  M  T  K  V  D      p.300

          .         .         .         .         .         .       g.7755
 CTTCAGGCCAAACTTGACAACTTGCAGCAGGAAATTGATTTCCTTACAGCACTCTACCAA       c.960
 L  Q  A  K  L  D  N  L  Q  Q  E  I  D  F  L  T  A  L  Y  Q         p.320

     | 05    .         .         .         .         .         .    g.7984
 GCA | GAGTTGTCTCAGATGCAGACTCAAATCAGTGAAACTAATGTCATCCTCTCTATGGAC    c.1020
 A   | E  L  S  Q  M  Q  T  Q  I  S  E  T  N  V  I  L  S  M  D      p.340

          .         .         .         .         .         .       g.8044
 AACAACCGCAGTCTCGACCTGGACAGCATCATTGCTGAGGTCAAGGCCCAGTACGAGGAT       c.1080
 N  N  R  S  L  D  L  D  S  I  I  A  E  V  K  A  Q  Y  E  D         p.360

          .         .         .         .         | 06         .    g.8235
 ATAGCCCAGAAGAGCAAAGCTGAGGCCGAGTCCTTGTACCAGAGCAAG | TATGAAGAGCTG    c.1140
 I  A  Q  K  S  K  A  E  A  E  S  L  Y  Q  S  K   | Y  E  E  L      p.380

          .         .         .         .         .         .       g.8295
 CAGATCACTGCTGGCAGACATGGGGATAGTGTGAGAAATTCAAAGATAGAAATTTCTGAG       c.1200
 Q  I  T  A  G  R  H  G  D  S  V  R  N  S  K  I  E  I  S  E         p.400

          .         .         .         .         .     | 07   .    g.8918
 CTGAATCGTGTGATCCAGAGACTTAGATCTGAAATCGACAATGTCAAGAAGCAG | ATCTCC    c.1260
 L  N  R  V  I  Q  R  L  R  S  E  I  D  N  V  K  K  Q   | I  S      p.420

          .         .         .         .         .         .       g.8978
 AACTTGCAGCAGTCCATCAGTGATGCAGAGCAGCGTGGCGAGAATGCCCTCAAGGATGCC       c.1320
 N  L  Q  Q  S  I  S  D  A  E  Q  R  G  E  N  A  L  K  D  A         p.440

          .         .         .         .         .         .       g.9038
 AAGAACAAGCTGAATGACCTGGAGGATGCCCTGCAGCAGGCCAAGGAAGACCTGGCCCGC       c.1380
 K  N  K  L  N  D  L  E  D  A  L  Q  Q  A  K  E  D  L  A  R         p.460

          .         .         .         .         .         .       g.9098
 CTGCTGCGCGACTACCAGGAGCTGATGAACACCAAGCTGGCCCTGGATCTGGAGATTGCC       c.1440
 L  L  R  D  Y  Q  E  L  M  N  T  K  L  A  L  D  L  E  I  A         p.480

          .         .         .      | 08  .         .         .    g.9688
 ACCTACAGGACCCTCCTGGAGGGAGAAGAAAGCAG | GATGTCTGGAGAATGTGCCCCGAAC    c.1500
 T  Y  R  T  L  L  E  G  E  E  S  R  |  M  S  G  E  C  A  P  N      p.500

          . | 09       .         .         .         .         .    g.9840
 GTGAGTGTGT | CTGTGAGCACAAGCCACACCACCATCAGTGGAGGTGGCAGCCGAGGAGGT    c.1560
 V  S  V  S |   V  S  T  S  H  T  T  I  S  G  G  G  S  R  G  G      p.520

          .         .         .         .         .         .       g.9900
 GGCGGCGGTGGCTACGGCTCTGGAGGTAGCAGCTATGGCTCCGGAGGTGGTAGCTATGGT       c.1620
 G  G  G  G  Y  G  S  G  G  S  S  Y  G  S  G  G  G  S  Y  G         p.540

          .         .         .         .         .         .       g.9960
 TCTGGAGGTGGCGGCGGCGGCGGCCGTGGCAGCTATGGCTCCGGAGGTAGCAGCTACGGC       c.1680
 S  G  G  G  G  G  G  G  R  G  S  Y  G  S  G  G  S  S  Y  G         p.560

          .         .         .         .         .         .       g.10020
 TCCGGAGGTGGCAGCTATGGCTCTGGAGGTGGCGGCGGCGGCCATGGCAGCTACGGCTCC       c.1740
 S  G  G  G  S  Y  G  S  G  G  G  G  G  G  H  G  S  Y  G  S         p.580

          .         .         .         .         .         .       g.10080
 GGAAGCAGCAGTGGGGGCTACAGAGGTGGCTCTGGAGGCGGCGGCGGCGGCAGCTCTGGC       c.1800
 G  S  S  S  G  G  Y  R  G  G  S  G  G  G  G  G  G  S  S  G         p.600

          .         .         .         .         .         .       g.10140
 GGCCGGGGCTCTGGCGGCGGGAGCTCTGGAGGCTCCATAGGAGGCCGGGGATCCAGCTCT       c.1860
 G  R  G  S  G  G  G  S  S  G  G  S  I  G  G  R  G  S  S  S         p.620

          .         .         .         .         .         .       g.10200
 GGGGGTGTCAAGTCCTCTGGTGGCAGTTCCAGCGTGAAGTTTGTTTCTACCACTTATTCC       c.1920
 G  G  V  K  S  S  G  G  S  S  S  V  K  F  V  S  T  T  Y  S         p.640

          .                                                         g.10215
 GGAGTAACCAGATAA                                                    c.1935
 G  V  T  R  X                                                      p.644

          .         .         .         .         .         .       g.10275
 agagatgccctctgtttcattagctctagttctcccccagcatcactaacaaatatgctt       c.*60

          .         .         .         .         .         .       g.10335
 ggcaagaccgaggtcgatttgtcccagccttaccggagaaaagagctatggttagttaca       c.*120

          .         .         .         .         .         .       g.10395
 ctagctcatcctattcccccagctctttcttttctgctgtttcccaatgaagttttcaga       c.*180

          .         .         .         .         .         .       g.10455
 tcagtggcaatctcagtcccctggctatgaccctgctttgttctttccctgagaaacagt       c.*240

          .         .         .         .         .         .       g.10515
 tcagcagtgaccaccacccacatgacatttcaaagcacctccttaagccagccagagtag       c.*300

          .         .         .         .         .         .       g.10575
 gaccagttagacccagggtgtggacagctccttagcatcttatctctgtgctgttttggt       c.*360

          .         .         .         .         .         .       g.10635
 tttgtacataaggtgtaagcaagttgtttttcttttgtggagaggtcttaaactccccat       c.*420

          .         .         .                                     g.10672
 ttccttgttttgctgcaataaactgcatttgaaattc                              c.*457

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Keratin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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