keratin 86 (KRT86) - coding DNA reference sequence

(used for variant description)

(last modified December 7, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_002284.3 in the KRT86 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering KRT86 transcript NM_002284.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         tccattcggacgtctccatcctcagaacctcctctcttccccaaaaagcacc       c.-1

          .         .         .         .         .         .       g.5112
 ATGACTTGTGGATCTTACTGTGGTGGCCGCGCCTTCAGCTGCATCTCGGCCTGCGGGCCC       c.60
 M  T  C  G  S  Y  C  G  G  R  A  F  S  C  I  S  A  C  G  P         p.20

          .         .         .         .         .         .       g.5172
 CGGCCCGGCCGCTGCTGCATCACCGCCGCCCCCTACCGTGGCATCTCCTGCTACCGCGGC       c.120
 R  P  G  R  C  C  I  T  A  A  P  Y  R  G  I  S  C  Y  R  G         p.40

          .         .         .         .         .         .       g.5232
 CTCACCGGGGGCTTCGGCAGCCACAGCGTGTGCGGAGGCTTTCGGGCCGGCTCCTGCGGA       c.180
 L  T  G  G  F  G  S  H  S  V  C  G  G  F  R  A  G  S  C  G         p.60

          .         .         .         .         .         .       g.5292
 CGCAGCTTCGGCTACCGCTCCGGGGGCGTGTGCGGGCCCAGTCCCCCATGCATCACCACC       c.240
 R  S  F  G  Y  R  S  G  G  V  C  G  P  S  P  P  C  I  T  T         p.80

          .         .         .         .         .         .       g.5352
 GTGTCGGTCAACGAGAGCCTCCTCACGCCCCTCAACCTGGAGATCGACCCCAACGCGCAG       c.300
 V  S  V  N  E  S  L  L  T  P  L  N  L  E  I  D  P  N  A  Q         p.100

          .         .         .         .         .         .       g.5412
 TGCGTGAAGCAGGAGGAGAAGGAGCAGATCAAGTCCCTCAACAGCAGGTTCGCGGCCTTC       c.360
 C  V  K  Q  E  E  K  E  Q  I  K  S  L  N  S  R  F  A  A  F         p.120

           | 02        .         .         .         .         .    g.6286
 ATCGACAAG | GTGCGCTTCCTGGAGCAGCAGAACAAACTGCTGGAGACAAAGCTGCAGTTC    c.420
 I  D  K   | V  R  F  L  E  Q  Q  N  K  L  L  E  T  K  L  Q  F      p.140

          .         .         .         .         .         .       g.6346
 TACCAGAACCGCGAGTGTTGCCAGAGCAACCTGGAGCCCCTGTTTGAGGGCTACATCGAG       c.480
 Y  Q  N  R  E  C  C  Q  S  N  L  E  P  L  F  E  G  Y  I  E         p.160

          .         .         .         .         .         .       g.6406
 ACTCTGCGGCGGGAGGCCGAGTGCGTGGAGGCCGACAGCGGGAGGCTGGCCTCAGAGCTT       c.540
 T  L  R  R  E  A  E  C  V  E  A  D  S  G  R  L  A  S  E  L         p.180

          .         .         .         | 03         .         .    g.7268
 AACCACGTGCAGGAGGTGCTGGAGGGCTACAAGAAGAA | GTATGAGGAGGAGGTTTCTCTG    c.600
 N  H  V  Q  E  V  L  E  G  Y  K  K  K  |  Y  E  E  E  V  S  L      p.200

          .         .         .          | 04        .         .    g.8088
 AGAGCAACAGCTGAGAACGAGTTTGTGGCTCTGAAGAAG | GATGTGGACTGCGCCTACCTC    c.660
 R  A  T  A  E  N  E  F  V  A  L  K  K   | D  V  D  C  A  Y  L      p.220

          .         .         .         .         .         .       g.8148
 CGCAAATCAGACCTGGAGGCCAATGTGGAGGCCCTGATCCAGGAGATCGACTTCCTGAGG       c.720
 R  K  S  D  L  E  A  N  V  E  A  L  I  Q  E  I  D  F  L  R         p.240

          .      | 05  .         .         .         .         .    g.8420
 CGGCTGTATGAGGAG | GAGATCCGCGTTCTCCAGTCCCACATCTCAGACACCTCCGTGGTT    c.780
 R  L  Y  E  E   | E  I  R  V  L  Q  S  H  I  S  D  T  S  V  V      p.260

          .         .         .         .         .         .       g.8480
 GTCAAGCTGGACAACAGCCGGGACCTGAACATGGACTGCATCATTGCCGAGATCAAGGCA       c.840
 V  K  L  D  N  S  R  D  L  N  M  D  C  I  I  A  E  I  K  A         p.280

          .         .         .         .         .         .       g.8540
 CAGTACGATGACATTGTCACCCGTAGCCGGGCTGAGGCCGAGTCCTGGTACCGCAGCAAG       c.900
 Q  Y  D  D  I  V  T  R  S  R  A  E  A  E  S  W  Y  R  S  K         p.300

  | 06       .         .         .         .         .         .    g.8858
  | TGTGAGGAGATGAAGGCCACGGTGATCAGGCACGGGGAGACCCTGCGCCGCACCAAGGAG    c.960
  | C  E  E  M  K  A  T  V  I  R  H  G  E  T  L  R  R  T  K  E      p.320

          .         .         .         .         .         .       g.8918
 GAGATCAACGAGCTGAACCGCATGATCCAGAGGCTGACGGCTGAGGTGGAGAATGCCAAG       c.1020
 E  I  N  E  L  N  R  M  I  Q  R  L  T  A  E  V  E  N  A  K         p.340

        | 07 .         .         .         .         .         .    g.9249
 TGCCAG | AATTCCAAGCTGGAGGCTGCGGTGGCTCAGTCTGAGCAGCAGGGTGAGGCGGCC    c.1080
 C  Q   | N  S  K  L  E  A  A  V  A  Q  S  E  Q  Q  G  E  A  A      p.360

          .         .         .         .         .         .       g.9309
 CTCAGCGATGCCCGCTGCAAGTTGGCCGAGCTGGAGGGTGCCCTGCAGAAGGCCAAGCAG       c.1140
 L  S  D  A  R  C  K  L  A  E  L  E  G  A  L  Q  K  A  K  Q         p.380

          .         .         .         .         .         .       g.9369
 GACATGGCCTGCCTGATCAGGGAGTACCAGGAGGTGATGAACTCCAAGCTGGGCCTGGAC       c.1200
 D  M  A  C  L  I  R  E  Y  Q  E  V  M  N  S  K  L  G  L  D         p.400

          .         .         .         .        | 08.         .    g.11381
 ATCGAGATCGCCACCTACAGGCGCCTGCTGGAGGGCGAGGAGCAGAG | GCTGTGCGAGGGC    c.1260
 I  E  I  A  T  Y  R  R  L  L  E  G  E  E  Q  R  |  L  C  E  G      p.420

          .          | 09        .         .         .         .    g.11580
 GTCGGCTCGGTGAATGTCT | GCGTCAGCAGCTCCCGCGGTGGCGTTGTCTGTGGCGATCTC    c.1320
 V  G  S  V  N  V  C |   V  S  S  S  R  G  G  V  V  C  G  D  L      p.440

          .         .         .         .         .         .       g.11640
 TGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGC       c.1380
 C  A  S  T  T  A  P  V  V  S  T  R  V  S  S  V  P  S  N  S         p.460

          .         .         .         .         .         .       g.11700
 AACGTGGTGGTGGGCACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGC       c.1440
 N  V  V  V  G  T  T  N  A  C  A  P  S  A  R  V  G  V  C  G         p.480

          .         .                                               g.11721
 GGCAGCTGTAAGAGGTGCTAG                                              c.1461
 G  S  C  K  R  C  X                                                p.486

          .         .         .         .         .         .       g.11781
 gaggctgccgcctccgccagcgcctgtcgccgtcactctccacccagccagtacctcgcg       c.*60

          .         .         .         .         .         .       g.11841
 ccaccagaacgcgccgcccgcgccggcctcccaatagccgccgcccgctgcctgcactct       c.*120

          .         .         .         .         .         .       g.11901
 aagcgccctccccaccgctccgctccgggagccatccccggtcgcaggagtccggggagg       c.*180

          .         .         .         .         .         .       g.11961
 gccgggaggcgccatggtctctctctgtagcctttcctggtagtcaatttgttgtcccga       c.*240

          .         .         .         .         .         .       g.12021
 ggattcatctttttcttccgcctgccttctgttttttttgctgtatacattggtcttgcc       c.*300

          .         .         .         .         .         .       g.12081
 tgagctcttccccaaagcttggaggaacgggggaggcccgggaatgtccctgtctgcacg       c.*360

          .         .         .         .         .         .       g.12141
 acctgggactctgcccatgtgcttttgcctgtggaatggagacgcggaccctggatagtg       c.*420

          .         .         .         .         .         .       g.12201
 gttctatgactctgcgagggacaggcccacgcgtgtggggagaacatctcccttccgggg       c.*480

          .         .         .         .         .         .       g.12261
 ctgccctcaagagcttctgaaaaactaatgactctgctgccttctcctttgtctttgttt       c.*540

          .         .         .                                     g.12299
 cactctgtgtttccaataaactcattgtagcgaatcaa                             c.*578

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Keratin 86 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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