leucyl-tRNA synthetase 2, mitochondrial (LARS2) - coding DNA reference sequence

(used for variant description)

(last modified December 18, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_015340.3 in the LARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering LARS2 transcript NM_015340.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        tgaca       c.-181

 .         .         .         .         .         .                g.5065
 acatggcggcgcccatggtccgtggcccggcagtgctcgcctaaaggtggagaacgagga       c.-121

 .         .         .         .   | 02     .         .             g.8027
 gtagaggagccgcaggccagagcctgtgagcag | atccagacctacagataaaaaacatta    c.-61

 .         .         .         .         | 03         .             g.10871
 tttaatctatctgggatttactccggcttatgatttgag | ggccttctcaccttctgaaga    c.-1

          .         .         .         .         .         .       g.10931
 ATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAAT       c.60
 M  A  S  V  W  Q  R  L  G  F  Y  A  S  L  L  K  R  Q  L  N         p.20

          .         .         .         .         .         .       g.10991
 GGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATC       c.120
 G  G  P  D  V  I  K  W  E  R  R  V  I  P  G  C  T  R  S  I         p.40

          .         .         .         .         .         .       g.11051
 TACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAG       c.180
 Y  S  A  T  G  K  W  T  K  E  Y  T  L  Q  T  R  K  D  V  E         p.60

          .         .         .         .         .     | 04   .    g.16668
 AAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGAT | AAATCG    c.240
 K  W  W  H  Q  R  I  K  E  Q  A  S  K  I  S  E  A  D   | K  S      p.80

          .         .         .         .         .         .       g.16728
 AAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATGGGC       c.300
 K  P  K  F  Y  V  L  S  M  F  P  Y  P  S  G  K  L  H  M  G         p.100

          .         .         .         .         .         .       g.16788
 CATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATG       c.360
 H  V  R  V  Y  T  I  S  D  T  I  A  R  F  Q  K  M  R  G  M         p.120

     | 05    .         .         .         .         .         .    g.33956
 CAG | GTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTC    c.420
 Q   | V  I  N  P  M  G  W  D  A  F  G  L  P  A  E  N  A  A  V      p.140

          .         .         .      | 06  .         .         .    g.36111
 GAGAGGAATCTACATCCACAAAGTTGGACACAAAG | TAATATTAAACACATGAGGAAACAG    c.480
 E  R  N  L  H  P  Q  S  W  T  Q  S  |  N  I  K  H  M  R  K  Q      p.160

          .         .         .       | 07 .         .         .    g.63332
 CTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGG | GAAATAACTACGTGTTTGCCAGAT    c.540
 L  D  R  L  G  L  C  F  S  W  D  R   | E  I  T  T  C  L  P  D      p.180

          .         .         .         .         .         .       g.63392
 TACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTATCAA       c.600
 Y  Y  K  W  T  Q  Y  L  F  I  K  L  Y  E  A  G  L  A  Y  Q         p.200

        | 08 .         .         .         .         .         .    g.75214
 AAGGAG | GCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAGGTG    c.660
 K  E   | A  L  V  N  W  D  P  V  D  Q  T  V  L  A  N  E  Q  V      p.220

          .         .         .         .         .         .       g.75274
 GATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGACAA       c.720
 D  E  H  G  C  S  W  R  S  G  A  K  V  E  Q  K  Y  L  R  Q         p.240

          .         .         . | 09       .         .         .    g.90690
 TGGTTTATTAAGACAACCGCTTATGCAAAG | GCCATGCAGGACGCGTTGGCAGACCTTCCA    c.780
 W  F  I  K  T  T  A  Y  A  K   | A  M  Q  D  A  L  A  D  L  P      p.260

          .         .         .         .         .         .       g.90750
 GAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGCCAC       c.840
 E  W  Y  G  I  K  G  M  Q  A  H  W  I  G  D  C  V  G  C  H         p.280

          .         | 10         .         .         .         .    g.92927
 CTGGACTTCACATTAAAG | GTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTATACG    c.900
 L  D  F  T  L  K   | V  H  G  Q  A  T  G  E  K  L  T  A  Y  T      p.300

          .         .         .         .         .         .       g.92987
 GCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGACTC       c.960
 A  T  P  E  A  I  Y  G  T  S  H  V  A  I  S  P  S  H  R  L         p.320

          .         .         .         .         .         | 11    g.102111
 CTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAAG | AT    c.1020
 L  H  G  H  S  S  L  K  E  A  L  R  M  A  L  V  P  G  K  D |       p.340

          .         .         .         .         .         .       g.102171
 TGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTTATT       c.1080
 C  L  T  P  V  M  A  V  N  M  L  T  Q  Q  E  V  P  V  V  I         p.360

          .         .         .         .    | 12    .         .    g.105131
 TTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAG | GAATTCCCAGTACTAGC    c.1140
 L  A  K  A  D  L  E  G  S  L  D  S  K  I  G |   I  P  S  T  S      p.380

          .         .         .         .         .         .       g.105191
 TCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAAACT       c.1200
 S  E  D  T  I  L  A  Q  T  L  G  L  A  Y  S  E  V  I  E  T         p.400

          .         .         .          | 13        .         .    g.107955
 TTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAG | TTCACAGGTATGACCCGGCAG    c.1260
 L  P  D  G  T  E  R  L  S  S  S  A  E   | F  T  G  M  T  R  Q      p.420

          .         .         .         .         .         .       g.108015
 GATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTGACA       c.1320
 D  A  F  L  A  L  T  Q  K  A  R  G  K  R  V  G  G  D  V  T         p.440

          .         .         .         .         .         .       g.108075
 AGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATCCCC       c.1380
 S  D  K  L  K  D  W  L  I  S  R  Q  R  Y  W  G  T  P  I  P         p.460

          .         .         .         .         .         .       g.108135
 ATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTGACC       c.1440
 I  V  H  C  P  V  C  G  P  T  P  V  P  L  E  D  L  P  V  T         p.480

          .         .         .         .         .         .       g.108195
 CTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCAGAG       c.1500
 L  P  N  I  A  S  F  T  G  K  G  G  P  P  L  A  M  A  S  E         p.500

          .         .    | 14    .         .         .         .    g.112729
 TGGGTGAACTGCTCCTGCCCAAG | GTGCAAGGGAGCAGCCAAGAGAGAGACAGACACGATG    c.1560
 W  V  N  C  S  C  P  R  |  C  K  G  A  A  K  R  E  T  D  T  M      p.520

          .         .         .         .         .         .       g.112789
 GATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCACAC       c.1620
 D  T  F  V  D  S  A  W  Y  Y  F  R  Y  T  D  P  H  N  P  H         p.540

    | 15     .         .         .         .         .         .    g.116917
 AG | CCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGAGGG    c.1680
 S  |  P  F  N  T  A  V  A  D  Y  W  M  P  V  D  L  Y  I  G  G      p.560

          .         .         .         .         .         .       g.116977
 AAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCATGAT       c.1740
 K  E  H  A  V  M  H  L  F  Y  A  R  F  F  S  H  F  C  H  D         p.580

          .         . | 16       .         .         .         .    g.129592
 CAAAAAATGGTTAAACATAG | GGAGCCTTTTCATAAGCTGCTGGCCCAAGGCCTTATCAAG    c.1800
 Q  K  M  V  K  H  R  |  E  P  F  H  K  L  L  A  Q  G  L  I  K      p.600

          .         .         .         .         .         .       g.129652
 GGGCAGACATTCCGCCTACCATCTGGACAGTATCTACAGAGAGAGGAAGTGGATCTCACA       c.1860
 G  Q  T  F  R  L  P  S  G  Q  Y  L  Q  R  E  E  V  D  L  T         p.620

   | 17      .         .         .         .         .         .    g.132570
 G | GTTCCGTTCCTGTTCATGCAAAAACGAAAGAGAAGTTAGAGGTGACGTGGGAGAAGATG    c.1920
 G |   S  V  P  V  H  A  K  T  K  E  K  L  E  V  T  W  E  K  M      p.640

          .         .         .         .         .         .       g.132630
 AGTAAGTCCAAACACAACGGGGTGGACCCAGAGGAAGTTGTGGAGCAGTATGGGATCGAC       c.1980
 S  K  S  K  H  N  G  V  D  P  E  E  V  V  E  Q  Y  G  I  D         p.660

          .         .         .         .         .         .       g.132690
 ACGATTCGGCTCTACATCCTTTTTGCTGCCCCTCCTGAGAAGGATATCTTGTGGGATGTG       c.2040
 T  I  R  L  Y  I  L  F  A  A  P  P  E  K  D  I  L  W  D  V         p.680

      | 18   .         .         .         .         .         .    g.134376
 AAAA | CTGATGCTCTCCCTGGGGTGCTGAGATGGCAACAACGACTGTGGACCTTGACAACT    c.2100
 K  T |   D  A  L  P  G  V  L  R  W  Q  Q  R  L  W  T  L  T  T      p.700

          .         .         .         .         .         .       g.134436
 CGGTTTATTGAGGCCAGGGCTTCTGGGAAGTCTCCCCAGCCTCAGCTGCTGAGTAACAAG       c.2160
 R  F  I  E  A  R  A  S  G  K  S  P  Q  P  Q  L  L  S  N  K         p.720

          .         .         .         .         .     | 19   .    g.136642
 GAGAAAGCTGAGGCCAGGAAGCTCTGGGAGTACAAGAACTCCGTCATCTCTCAG | GTGACC    c.2220
 E  K  A  E  A  R  K  L  W  E  Y  K  N  S  V  I  S  Q   | V  T      p.740

          .         .         .         .         .         .       g.136702
 ACCCATTTCACAGAGGACTTCTCACTGAATTCTGCAATTTCTCAGCTGATGGGACTCAGC       c.2280
 T  H  F  T  E  D  F  S  L  N  S  A  I  S  Q  L  M  G  L  S         p.760

          .   | 20     .         .         .         .         .    g.140462
 AATGCCCTCTCG | CAAGCCTCTCAGAGCGTCATTCTCCACAGCCCCGAGTTTGAGGATGCT    c.2340
 N  A  L  S   | Q  A  S  Q  S  V  I  L  H  S  P  E  F  E  D  A      p.780

          .         .         .         .         .         .       g.140522
 TTGTGTGCCCTGATGGTAATGGCTGCTCCACTGGCCCCTCATGTAACCTCAGAGATCTGG       c.2400
 L  C  A  L  M  V  M  A  A  P  L  A  P  H  V  T  S  E  I  W         p.800

      | 21   .         .         .         .         .         .    g.158302
 GCAG | GCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTG    c.2460
 A  G |   L  A  L  V  P  R  K  L  C  A  H  Y  T  W  D  A  S  V      p.820

          .         .         .         .         .         .       g.158362
 CTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAG       c.2520
 L  L  Q  A  W  P  A  V  D  P  E  F  L  Q  Q  P  E  V  V  Q         p.840

          .   | 22     .         .         .         .         .    g.163816
 ATGGCAGTTCTG | ATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCC    c.2580
 M  A  V  L   | I  N  N  K  A  C  G  K  I  P  V  P  Q  Q  V  A      p.860

          .         .         .         .         .         .       g.163876
 CGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTG       c.2640
 R  D  Q  D  K  V  H  E  F  V  L  Q  S  E  L  G  V  R  L  L         p.880

          .         .         .         .         .         .       g.163936
 CAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTG       c.2700
 Q  G  R  S  I  K  K  S  F  L  S  P  R  T  A  L  I  N  F  L         p.900

          .                                                         g.163948
 GTGCAAGATTGA                                                       c.2712
 V  Q  D  X                                                         p.903

          .         .         .         .         .         .       g.164008
 cagccaggaggctgcagctaccacgagggcctctgaggaacctccttccaggcctgggat       c.*60

          .         .         .         .         .         .       g.164068
 gagggggcgatgtctgctggcccaggggaagggaaaagacaaatgtcttgactgttgacc       c.*120

          .         .         .         .         .         .       g.164128
 tcggtcctgtggcagactgcagtcaacagtgtgcctctgtagtgtggcctggtgctgggg       c.*180

          .         .         .         .         .         .       g.164188
 tgaaggtgagctgggcaaaggagaaatatgagctactgaggagggggttggacatcctgc       c.*240

          .         .         .         .         .         .       g.164248
 ccctcaccccccacccacactgcaggtagaggaggccatctgatcccatgggaagccatc       c.*300

          .         .         .         .         .         .       g.164308
 agagacactgctggtgggagcaggaaggagcagtgcccctcgagcagccaggaagcctgc       c.*360

          .         .         .         .         .         .       g.164368
 ggatctgggaaatggctctgccttaggcacttctcgggaatttgaggccagcctgaggaa       c.*420

          .         .         .         .         .         .       g.164428
 ctgcaggactcaggtgcaatgtgccagccacttggaactgctaactgagcctccagatgg       c.*480

          .         .         .         .         .         .       g.164488
 tagtgaatggtctctttgccttcaggctggatgaggaagtcatttaggaaatgttcaaat       c.*540

          .         .         .         .         .         .       g.164548
 aaccaatatgtggaaatggacacagggatcttctgaagttgctttgaatcaaaaggcagg       c.*600

          .         .         .         .         .         .       g.164608
 cagtgctggttcctctgcctgtgtccccaccactccccagctctgtcatgcaggcctgtc       c.*660

          .         .         .         .         .         .       g.164668
 ctccccaaccccagctggatgtgcctcccaggcctgctgtggttctgacacacaggatcc       c.*720

          .         .         .         .         .         .       g.164728
 caggcaaggcaccacttcctcacatgaatgaggagcagcaagtcataaccactcccttgg       c.*780

          .         .         .         .         .         .       g.164788
 gtatacaatttgctgtgtagtgaagtggaaccaggctcaggctgctggtcccaacctcag       c.*840

          .         .         .         .         .         .       g.164848
 agccccaccgcagcccagtagggatgcagcacgccccagagggctcatgtgggccccaga       c.*900

          .         .         .         .         .         .       g.164908
 tggcaatgccaccattgttgatgtgactccagagccagttattaggaagagcaagctcac       c.*960

          .         .         .         .         .         .       g.164968
 cacagaggagtggaactgaggccccccagatgttgcctccggtgtccaagccacagcggt       c.*1020

          .         .         .         .         .         .       g.165028
 ctggctgttgggaagatggccaggaatggactcataccattggcacattaggctaatcct       c.*1080

          .         .         .         .         .         .       g.165088
 ggttttatgtgaagtcagcaattaagtgttcccactagaactgacctaagccactgatta       c.*1140

          .         .         .         .         .         .       g.165148
 atatttaatgagggaaggtaggggagaatctagccattttataatgccagaaatctatat       c.*1200

          .         .         .         .         .         .       g.165208
 atgttatctgatgccatttttctgaagtagcctcacatgtggtccccctgcagttcagca       c.*1260

          .         .         .         .                           g.165254
 gttaacagatgacttttttagtgtaataaaatgtttatcatctatg                     c.*1306

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Leucyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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