low density lipoprotein receptor adaptor protein 1 (LDLRAP1) - coding DNA reference sequence

(used for variant description)

(last modified July 1, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_015627.2 in the LDLRAP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008932.1, covering LDLRAP1 transcript NM_015627.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       ggagctggcgctgggaggggaggagcgcgcagcccgcgcgccgcagggccgggc       c.-61

 .         .         .         .         .         .                g.5114
 ggaaagtttttcctgacggagttttggctgcggcagcggcggcggcggccggagcgggcc       c.-1

          .         .         .         .         .         .       g.5174
 ATGGACGCGCTCAAGTCGGCGGGGCGGGCGCTGATCCGGAGCCCCAGCTTGGCCAAGCAG       c.60
 M  D  A  L  K  S  A  G  R  A  L  I  R  S  P  S  L  A  K  Q         p.20

          .         .         | 02         .         .         .    g.15369
 AGCTGGGGGGGCGGTGGCCGGCACCGCA | AGCTGCCTGAGAACTGGACAGACACGCGGGAG    c.120
 S  W  G  G  G  G  R  H  R  K |   L  P  E  N  W  T  D  T  R  E      p.40

          .         .         .         .         .         .       g.15429
 ACGCTGCTGGAGGGGATGCTGTTCAGCCTCAAGTACCTGGGCATGACGCTAGTGGAGCAG       c.180
 T  L  L  E  G  M  L  F  S  L  K  Y  L  G  M  T  L  V  E  Q         p.60

          .         .         .         .         .  | 03      .    g.16284
 CCCAAGGGTGAGGAGCTGTCGGCCGCCGCCATCAAGAGGATCGTGGCTACA | GCTAAGGCC    c.240
 P  K  G  E  E  L  S  A  A  A  I  K  R  I  V  A  T   | A  K  A      p.80

          .         .         .         .         .         .       g.16344
 AGTGGGAAGAAGCTGCAGAAGGTGACTCTGAAGGTGTCGCCACGGGGAATTATCCTGACA       c.300
 S  G  K  K  L  Q  K  V  T  L  K  V  S  P  R  G  I  I  L  T         p.100

          .         .         .         .     | 04   .         .    g.18584
 GACAACCTCACCAACCAGCTCATTGAGAACGTGTCCATATACAG | GATCTCCTATTGCACA    c.360
 D  N  L  T  N  Q  L  I  E  N  V  S  I  Y  R  |  I  S  Y  C  T      p.120

          .         .         .         .         .         .       g.18644
 GCAGACAAGATGCACGACAAGGTGTTTGCATACATCGCCCAGAGCCAGCACAACCAGAGC       c.420
 A  D  K  M  H  D  K  V  F  A  Y  I  A  Q  S  Q  H  N  Q  S         p.140

          .         .         .          | 05        .         .    g.24080
 CTCGAGTGCCACGCCTTCCTCTGCACCAAGCGGAAGATG | GCACAGGCTGTTACCCTCACC    c.480
 L  E  C  H  A  F  L  C  T  K  R  K  M   | A  Q  A  V  T  L  T      p.160

          .         .         .         .         .   | 06     .    g.24493
 GTAGCCCAGGCCTTCAAAGTCGCCTTTGAGTTTTGGCAGGTGTCCAAGGAAG | AGAAAGAG    c.540
 V  A  Q  A  F  K  V  A  F  E  F  W  Q  V  S  K  E  E |   K  E      p.180

          .         .         .         .         .         .       g.24553
 AAGAGGGACAAAGCCAGCCAAGAGGGAGGGGACGTCCTGGGGGCCCGCCAAGACTGCACC       c.600
 K  R  D  K  A  S  Q  E  G  G  D  V  L  G  A  R  Q  D  C  T         p.200

          .       | 07 .         .         .         .         .    g.25120
 CCCTCCTTGAAGAGCT | TGGTCGCCACTGGGAACCTGCTGGACTTAGAGGAGACAGCTAAG    c.660
 P  S  L  K  S  L |   V  A  T  G  N  L  L  D  L  E  E  T  A  K      p.220

          .         .         .         .         .         .       g.25180
 GCCCCGCTGTCCACGGTCAGCGCCAACACCACCAACATGGACGAGGTGCCGCGGCCACAA       c.720
 A  P  L  S  T  V  S  A  N  T  T  N  M  D  E  V  P  R  P  Q         p.240

          .         .        | 08.         .         .         .    g.26621
 GCCTTGAGTGGCAGCAGTGTTGTCTGG | GAGCTGGATGATGGCCTGGATGAAGCGTTTTCG    c.780
 A  L  S  G  S  S  V  V  W   | E  L  D  D  G  L  D  E  A  F  S      p.260

    | 09     .         .         .         .         .         .    g.28321
 AG | GCTTGCCCAGTCTCGGACAAACCCTCAGGTCCTGGACACTGGCCTGACAGCCCAGGAC    c.840
 R  |  L  A  Q  S  R  T  N  P  Q  V  L  D  T  G  L  T  A  Q  D      p.280

          .         .         .         .         .         .       g.28381
 ATGCATTACGCCCAGTGCCTCTCGCCTGTCGACTGGGACAAGCCTGACAGCAGCGGCACA       c.900
 M  H  Y  A  Q  C  L  S  P  V  D  W  D  K  P  D  S  S  G  T         p.300

          .         .                                               g.28408
 GAGCAGGATGACCTCTTCAGCTTCTGA                                        c.927
 E  Q  D  D  L  F  S  F  X                                          p.308

          .         .         .         .         .         .       g.28468
 gggcccggggccagccggacacaagcggccctgacacgtgatggaccaaagccacctgct       c.*60

          .         .         .         .         .         .       g.28528
 gcgggggagccagttctggggcccgcctgccacctctcccagccctcagcattgtcagcc       c.*120

          .         .         .         .         .         .       g.28588
 tgaagatcagagctgcagccagtcaggcaggggagagatttttcttttaagccctgctct       c.*180

          .         .         .         .         .         .       g.28648
 ttctctgagaaccaaaagatgccttgaatatttattcagtgacttctggcttatgctcag       c.*240

          .         .         .         .         .         .       g.28708
 aagccagtctgcgtcaggcacgtctcctgctgcgtgacatgtgcagtgctgtaatcggct       c.*300

          .         .         .         .         .         .       g.28768
 cccgcttgctctcctggagcaagctctgccctggctgtgggtatcaggactgtgaccaaa       c.*360

          .         .         .         .         .         .       g.28828
 gcatttctagtcccttctctctttctaaggacccaaatttccctgggggcatcctgcttc       c.*420

          .         .         .         .         .         .       g.28888
 ctgaaagctgttggatttcagtgatttttccccccaccccccagcacaggagagcaccca       c.*480

          .         .         .         .         .         .       g.28948
 cagccgcagaaggggaatgtgtcctcctgctctgcttcctcagggcccagcaggcggggg       c.*540

          .         .         .         .         .         .       g.29008
 tttgagccctggaccccaggctcttagagactaaggggcagctcctgaccaaagacgata       c.*600

          .         .         .         .         .         .       g.29068
 cagcttggcactttaaagcattaacagcaggtgtgaccctgagggctcctccatggtgct       c.*660

          .         .         .         .         .         .       g.29128
 gcattgagtccagctttccttctgcccttcctccaggagaaggggcccaaggtccccgtg       c.*720

          .         .         .         .         .         .       g.29188
 gatggtctccacctgtgcttggaaccagtgtaactggctgctccctgctcccagggactg       c.*780

          .         .         .         .         .         .       g.29248
 acacggggatcatctctgtgaccgccctccgtcgggcccctgcctgccttctcccctcca       c.*840

          .         .         .         .         .         .       g.29308
 cgcaaggctgtgctcttcctctggtttctgtgtgtccgtttgagtgtctgcgccccgcct       c.*900

          .         .         .         .         .         .       g.29368
 ccccatacttcctgggatgatgtgtgaaacctgacacctagatttatttggaaatattct       c.*960

          .         .         .         .         .         .       g.29428
 atgaccactttacagatgaggaaacaggcctcaagcgtggaggggtagagtgaagagtag       c.*1020

          .         .         .         .         .         .       g.29488
 aacccaggtctgatgccaaagctgctttcttctctgcctcctcctcacgcaactcacacc       c.*1080

          .         .         .         .         .         .       g.29548
 tccttttcttctagctttgttgtcctcccaggaaccaaaaaaccccagctattttctgac       c.*1140

          .         .         .         .         .         .       g.29608
 caaaatgtgtttcataacaaaccatctggtgcctttccacacagaactggcaggagcctc       c.*1200

          .         .         .         .         .         .       g.29668
 gtgtcctgctagctgtctctcttgttgatttccgtgaaaatgcaagtgtttgaagtctgc       c.*1260

          .         .         .         .         .         .       g.29728
 tcattccgagggtgaaacaaaatccaaccctgtcagaatcatgctgttctctttgctgac       c.*1320

          .         .         .         .         .         .       g.29788
 actgtgaccctgggtcgggacagaccagcagcaatctgtctttagaatcgctttccttcc       c.*1380

          .         .         .         .         .         .       g.29848
 tccccttttgcccccgtggggctcccggcatcctgaaagccagcaaagcctccagcatct       c.*1440

          .         .         .         .         .         .       g.29908
 tttccatcctgaggtgcctcccagtggcctggcttgtcggagcaagtttcatcagcccta       c.*1500

          .         .         .         .         .         .       g.29968
 gggaaaacacggccctcctgggaacctccttacctggagtaaccggacaccttagacgga       c.*1560

          .         .         .         .         .         .       g.30028
 ggtgcctgagggtggggtgggatttgcagggtcattatcagaacatgaggataacttcct       c.*1620

          .         .         .         .         .         .       g.30088
 tgcccctgctctgtagccacctccttggcaccggcctctatttgtcataaggcggcgtgg       c.*1680

          .         .         .         .         .         .       g.30148
 gcgaggcctgacacaggccagccttggcacgaggggggccaggggttctgagaagcgctg       c.*1740

          .         .         .         .         .         .       g.30208
 ccctgtgagagccacgctggccttcgtctccatctctggttgacgggctgtccgtgtgcc       c.*1800

          .         .         .         .         .         .       g.30268
 tcctgtgtgtctgcagacaagtcttgctgtgctttatttgtgaaactttaatgaggaaaa       c.*1860

          .         .         .                                     g.30302
 aacaaataataaatgttctcgttttgaaactcaa                                 c.*1894

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Low density lipoprotein receptor adaptor protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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