LEM domain containing 2 (LEMD2) - coding DNA reference sequence

(used for variant description)

(last modified February 12, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_181336.3 in the LEMD2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_053042.1, covering LEMD2 transcript NM_181336.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.10158
                                                cggcgtcctggcc       c.-1

          .         .         .         .         .         .       g.10218
 ATGGCCGGCCTGTCGGACCTGGAACTGCGGCGGGAGCTGCAGGCCCTGGGCTTCCAGCCA       c.60
 M  A  G  L  S  D  L  E  L  R  R  E  L  Q  A  L  G  F  Q  P         p.20

          .         .         .         .         .         .       g.10278
 GGACCCATCACCGACACCACCCGGGATGTCTACCGCAACAAGCTGCGCCGCCTGCGGGGC       c.120
 G  P  I  T  D  T  T  R  D  V  Y  R  N  K  L  R  R  L  R  G         p.40

          .         .         .         .         .         .       g.10338
 GAGGCCCGGCTGCGCGACGAGGAGCGGCTGCGGGAGGAGGCCCGGCCGCGGGGCGAGGAG       c.180
 E  A  R  L  R  D  E  E  R  L  R  E  E  A  R  P  R  G  E  E         p.60

          .         .         .         .         .         .       g.10398
 CGGTTACGGGAAGAGGCCCGGTTACGCGAGGATGCGCCGCTGCGCGCCCGGCCCGCCGCG       c.240
 R  L  R  E  E  A  R  L  R  E  D  A  P  L  R  A  R  P  A  A         p.80

          .         .         .         .         .         .       g.10458
 GCCTCTCCGCGGGCGGAGCCCTGGCTCTCCCAGCCGGCCTCGGGCTCGGCCTACGCGACC       c.300
 A  S  P  R  A  E  P  W  L  S  Q  P  A  S  G  S  A  Y  A  T         p.100

          .         .         .         .         .         .       g.10518
 CCTGGGGCCTACGGTGATATCCGGCCCTCCGCGGCTTCCTGGGTAGGGAGCCGCGGCCTC       c.360
 P  G  A  Y  G  D  I  R  P  S  A  A  S  W  V  G  S  R  G  L         p.120

          .         .         .         .         .         .       g.10578
 GCCTATCCTGCCCGCCCGGCGCAACTCAGGCGCCGCGCCTCGGTCCGGGGCAGCTCCGAG       c.420
 A  Y  P  A  R  P  A  Q  L  R  R  R  A  S  V  R  G  S  S  E         p.140

          .         .         .         .         .         .       g.10638
 GAGGACGAGGACGCCCGGACGCCCGACAGGGCCACGCAGGGCCCGGGTCTCGCGGCCCGC       c.480
 E  D  E  D  A  R  T  P  D  R  A  T  Q  G  P  G  L  A  A  R         p.160

          .         .         .         .         .         .       g.10698
 CGCTGGTGGGCAGCGTCTCCCGCCCCGGCGCGGCTGCCTTCCTCCCTCCTCGGTCCCGAC       c.540
 R  W  W  A  A  S  P  A  P  A  R  L  P  S  S  L  L  G  P  D         p.180

          .         .         .         .         .         .       g.10758
 CCGCGCCCGGGCCTGCGGGCGACTCGAGCGGGCCCTGCTGGCGCGGCGAGGGCCCGGCCT       c.600
 P  R  P  G  L  R  A  T  R  A  G  P  A  G  A  A  R  A  R  P         p.200

          .         .         .         .         .         .       g.10818
 GAGGTGGGGCGCCGGCTGGAGCGCTGGCTCTCTCGGCTTCTGCTCTGGGCCAGCCTAGGG       c.660
 E  V  G  R  R  L  E  R  W  L  S  R  L  L  L  W  A  S  L  G         p.220

          .         .         .         .         .         .       g.10878
 CTACTGCTCGTCTTCCTGGGCATCCTTTGGGTGAAGATGGGCAAGCCCTCAGCGCCGCAG       c.720
 L  L  L  V  F  L  G  I  L  W  V  K  M  G  K  P  S  A  P  Q         p.240

          .       | 02 .         .         .         .        | 03. g.14850
 GAGGCGGAGGACAACA | TGAAGTTATTGCCAGTGGACTGTGAGAGAAAAACAGATGAG | TTC c.780
 E  A  E  D  N  M |   K  L  L  P  V  D  C  E  R  K  T  D  E   | F   p.260

          .         .         .         .         .         .       g.14910
 TGTCAGGCCAAGCAGAAGGCAGCCTTGCTGGAGCTGCTGCATGAACTCTACAATTTCCTG       c.840
 C  Q  A  K  Q  K  A  A  L  L  E  L  L  H  E  L  Y  N  F  L         p.280

          .    | 04    .         .         .         .         .    g.18168
 GCCATCCAAGCTG | GTAATTTTGAGTGTGGAAATCCAGAGAATCTAAAAAGCAAATGCATT    c.900
 A  I  Q  A  G |   N  F  E  C  G  N  P  E  N  L  K  S  K  C  I      p.300

          .         .         . | 05       .         .         .    g.19125
 CCTGTTATGGAAGCCCAAGAATATATAGCC | AATGTGACCAGCAGCTCCTCCGCCAAGTTT    c.960
 P  V  M  E  A  Q  E  Y  I  A   | N  V  T  S  S  S  S  A  K  F      p.320

          .         .         .         .         . | 06       .    g.20897
 GAAGCCGCACTGACCTGGATACTGAGCAGTAACAAGGACGTGGGCATCTG | GTTGAAAGGA    c.1020
 E  A  A  L  T  W  I  L  S  S  N  K  D  V  G  I  W  |  L  K  G      p.340

          .         .         .         .         .         .       g.20957
 GAAGACCAGTCTGAATTGGTGACGACTGTGGACAAGGTGGTCTGCCTGGAATCTGCCCAC       c.1080
 E  D  Q  S  E  L  V  T  T  V  D  K  V  V  C  L  E  S  A  H         p.360

          .         .         .         .         .         .       g.21017
 CCCCGCATGGGTGTTGGCTGCCGCCTGAGCCGGGCCTTGCTCACTGCTGTCACCAACGTG       c.1140
 P  R  M  G  V  G  C  R  L  S  R  A  L  L  T  A  V  T  N  V         p.380

          .       | 07 .         .         .         .         .    g.22079
 CTCATCTTCTTCTGGT | GCTTGGCTTTTTTGTGGGGGCTCCTAATTCTCCTAAAATATCGG    c.1200
 L  I  F  F  W  C |   L  A  F  L  W  G  L  L  I  L  L  K  Y  R      p.400

          .         .         .         .         .         | 08    g.22220
 TGGCGAAAGTTAGAAGAGGAGGAACAAGCCATGTATGAGATGGTGAAGAAGATTATAG | AC    c.1260
 W  R  K  L  E  E  E  E  Q  A  M  Y  E  M  V  K  K  I  I  D |       p.420

          .         .         .         .         .         .       g.22280
 GTGGTCCAGGACCATTACGTGGACTGGGAGCAGGACATGGAGCGCTATCCATATGTAGGC       c.1320
 V  V  Q  D  H  Y  V  D  W  E  Q  D  M  E  R  Y  P  Y  V  G         p.440

          .         .         .         .  | 09      .         .    g.26515
 ATCCTGCACGTGCGCGACAGCTTGATCCCTCCACAGAGCCG | GAGGCGCATGAAGCGTGTC    c.1380
 I  L  H  V  R  D  S  L  I  P  P  Q  S  R  |  R  R  M  K  R  V      p.460

          .         .         .         .         .         .       g.26575
 TGGGACCGAGCTGTGGAGTTCCTGGCCTCCAACGAATCCCGGATCCAGACGGAGTCCCAC       c.1440
 W  D  R  A  V  E  F  L  A  S  N  E  S  R  I  Q  T  E  S  H         p.480

          .         .         .         .         .         .       g.26635
 CGCGTTGCAGGAGAGGACATGCTGGTGTGGAGATGGACTAAGCCCTCTTCCTTCTCTGAC       c.1500
 R  V  A  G  E  D  M  L  V  W  R  W  T  K  P  S  S  F  S  D         p.500

          .                                                         g.26647
 TCAGAGCGATAA                                                       c.1512
 S  E  R  X                                                         p.503

          .         .         .         .         .         .       g.26707
 gccccgggcggggacttgttcccggtcagcctgtcccaggacagcccactccagaggcac       c.*60

          .         .         .         .         .         .       g.26767
 aggagggtcaccaggcctgcggtgctgaattcacacttgccttgactttcagtctcgtcc       c.*120

          .         .         .         .         .         .       g.26827
 tgacacgattccaaaggtctgccatactcttcagaggagttcggctcgcaggaaaatgtg       c.*180

          .         .         .         .         .         .       g.26887
 ggcttcctttaaagggagggggagaagccagggtgatagcccagactctgccctgttgtg       c.*240

          .         .         .         .         .         .       g.26947
 ctggcagaaacggggagaagggttgagttttcatgaatagaaaacaagagcagcagctgt       c.*300

          .         .         .         .         .         .       g.27007
 caggcccagctgacaagcgtggggctggtgggctggggcatggccacgccagggagtctg       c.*360

          .         .         .         .         .         .       g.27067
 tcacctgggaggtggggcagggatggtgtttcgggtggcgggatggggagcagcttggtc       c.*420

          .         .         .         .         .         .       g.27127
 catgtgccttcagggggttgttacttgagagctccagggtgaagggagaaagcctgtgct       c.*480

          .         .         .         .         .         .       g.27187
 ctggctggctgggcctctatcctgaagagggaaggtgctagaaattagaacaagtgactg       c.*540

          .         .         .         .         .         .       g.27247
 taggggggaccgtctagaaacaccaggcccagacacacggtccctcaggtcaggaggagt       c.*600

          .         .         .         .         .         .       g.27307
 gagcagccggcacagcctcctgggaggatcccgaagtagggactggggctgagagcagag       c.*660

          .         .         .         .         .         .       g.27367
 aggagggtcgggcagccccagggcgggcgggcccgcctcagtgttgcttctcacagaagc       c.*720

          .         .         .         .         .         .       g.27427
 tgcgactctagaccaggcctgcagccagaacgccgattccgggagcttgggagccctgcg       c.*780

          .         .         .         .         .         .       g.27487
 tcagggcccagagcctcgcacttgctgtgtgcgaagatcgccttgctttactgtgaccac       c.*840

          .         .         .         .         .         .       g.27547
 agccccgacgcggggctgtttaacaagaacttcagcgcagccggcgtttctgttaccccg       c.*900

          .         .         .         .         .         .       g.27607
 gccgcggctcttggcggcgggagaggcgcagtggctgcaggctgccccctgccggccaca       c.*960

          .         .         .         .         .         .       g.27667
 agggagcagcgtccgcgccgccgcccaccggccctcccgccagctcctcagcctgctccc       c.*1020

          .         .         .         .         .         .       g.27727
 tgggaggcaggctccagaagcaccccgacggggggccttattaagtgcgagaagcctctc       c.*1080

          .         .         .         .         .         .       g.27787
 cagcgagtcttccccgtgtgtcctcatctgcggcaggcaggagagggggagcaaacagga       c.*1140

          .         .         .         .         .         .       g.27847
 aattccacagctgcctccagaaacattaaccacccctctctagtcttactggtatttttt       c.*1200

          .         .         .         .         .         .       g.27907
 gtttccttaataaagctccagtctccctcatttgagcaatactctcatttcctctgatgt       c.*1260

          .         .         .         .         .         .       g.27967
 ctggatgatcggcagggcaggaatctgagcgctggccccgtggtgaggccatgttctcat       c.*1320

          .         .         .         .         .         .       g.28027
 aatcaggctccagccagaaaaataagaaacaccgcaacaggcttcagtatcagggctgaa       c.*1380

          .         .         .                                     g.28062
 actgctggatgaataaactatttattaaaaacgga                                c.*1415

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The LEM domain containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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