LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (LFNG) - coding DNA reference sequence

(used for variant description)

(last modified December 19, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_001040167.1 in the LFNG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering LFNG transcript NM_001040167.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.12333
                                            gcggccgccaccccacc       c.-1

          .         .         .         .         .         .       g.12393
 ATGCTCAAGCGCTGCGGCCGGCGCCTGCTGCTGGCGCTGGCGGGCGCGCTGCTCGCCTGC       c.60
 M  L  K  R  C  G  R  R  L  L  L  A  L  A  G  A  L  L  A  C         p.20

          .         .         .         .         .         .       g.12453
 CTGCTGGTGCTCACCGCCGACCCGCCGCCGCCTCCACTGCCCGCCGAGCGCGGCCGGCGC       c.120
 L  L  V  L  T  A  D  P  P  P  P  P  L  P  A  E  R  G  R  R         p.40

          .         .         .         .         .         .       g.12513
 GCGCTGCGCAGCCTGGCGGGCCCCGCGGGGGCTGCCCCGGCGCCCGGGCTGGGGGCGGCG       c.180
 A  L  R  S  L  A  G  P  A  G  A  A  P  A  P  G  L  G  A  A         p.60

          .         .         .         .         .         .       g.12573
 GCGGCGGCGCCCGGGGCGCTGGTCCGCGACGTGCACAGTCTGTCCGAGTACTTCAGCCTG       c.240
 A  A  A  P  G  A  L  V  R  D  V  H  S  L  S  E  Y  F  S  L         p.80

          .         .         .         .         .         .       g.12633
 CTCACCCGCGCGCGCAGAGATGCGGGCCCGCCGCCCGGGGCTGCCCCCCGCCCCGCCGAC       c.300
 L  T  R  A  R  R  D  A  G  P  P  P  G  A  A  P  R  P  A  D         p.100

          .         .         .         .         .         .       g.12693
 GGCCACCCGCGCCCCCTGGCCGAGCCGCTCGCGCCCCGAGACGTCTTCATCGCTGTCAAG       c.360
 G  H  P  R  P  L  A  E  P  L  A  P  R  D  V  F  I  A  V  K         p.120

          .         .         .         .         .         .       g.12753
 ACCACCAAAAAGTTCCACCGCGCGCGCCTCGACCTGCTGCTGGAGACCTGGATCTCGCGC       c.420
 T  T  K  K  F  H  R  A  R  L  D  L  L  L  E  T  W  I  S  R         p.140

          .   | 02     .         .         .         .         .    g.17214
 CACAAGGAGATG | ACGTTCATCTTCACTGACGGGGAAGATGAGGCCCTGGCCAGGCACACG    c.480
 H  K  E  M   | T  F  I  F  T  D  G  E  D  E  A  L  A  R  H  T      p.160

   | 03      .         .         .         .         .         .    g.17749
 G | GCAACGTGGTCATCACAAACTGCTCGGCCGCCCACAGCCGCCAGGCGCTGTCCTGCAAG    c.540
 G |   N  V  V  I  T  N  C  S  A  A  H  S  R  Q  A  L  S  C  K      p.180

          .         .         .         .  | 04      .         .    g.17904
 ATGGCCGTGGAGTATGACCGCTTCATCGAGTCCGGCAGGAA | GTGGTTCTGCCACGTGGAC    c.600
 M  A  V  E  Y  D  R  F  I  E  S  G  R  K  |  W  F  C  H  V  D      p.200

          .         .         .         .         .         .       g.17964
 GATGACAACTACGTCAACCTGCGGGCCCTGCTGCGGCTGCTGGCCAGCTACCCGCACACG       c.660
 D  D  N  Y  V  N  L  R  A  L  L  R  L  L  A  S  Y  P  H  T         p.220

          .         .         .         .         .         .       g.18024
 CGGGACGTCTACGTCGGCAAGCCCAGCCTGGACAGGCCCATCCAGGCCATGGAGCGGGTC       c.720
 R  D  V  Y  V  G  K  P  S  L  D  R  P  I  Q  A  M  E  R  V         p.240

          .      | 05  .         .         .         .         .    g.18201
 AGCGAGAACAAGGTG | CGTCCTGTCCACTTCTGGTTTGCCACGGGCGGCGCTGGCTTCTGC    c.780
 S  E  N  K  V   | R  P  V  H  F  W  F  A  T  G  G  A  G  F  C      p.260

          .         .         .         .  | 06      .         .    g.18734
 ATCAGCCGTGGGCTGGCTCTGAAGATGAGCCCGTGGGCCAG | CGGGGGTCACTTCATGAAT    c.840
 I  S  R  G  L  A  L  K  M  S  P  W  A  S  |  G  G  H  F  M  N      p.280

          .         .         .         .         .         .       g.18794
 ACGGCTGAGCGGATCCGGCTGCCTGATGACTGCACCATCGGCTACATCGTGGAGGCCCTG       c.900
 T  A  E  R  I  R  L  P  D  D  C  T  I  G  Y  I  V  E  A  L         p.300

          .         .         .         .         .         .       g.18854
 CTGGGTGTGCCCCTCATCCGCAGCGGCCTCTTCCACTCCCACCTGGAGAACCTGCAGCAG       c.960
 L  G  V  P  L  I  R  S  G  L  F  H  S  H  L  E  N  L  Q  Q         p.320

          .         .        | 07.         .         .         .    g.19340
 GTGCCCACCTCGGAGCTCCACGAGCAG | GTGACGCTGAGCTACGGTATGTTTGAAAACAAG    c.1020
 V  P  T  S  E  L  H  E  Q   | V  T  L  S  Y  G  M  F  E  N  K      p.340

          .         .         .         .         .    | 08    .    g.19624
 CGGAACGCCGTCCACGTGAAGGGGCCCTTCTCGGTGGAGGCCGACCCATCCAG | GTTCCGC    c.1080
 R  N  A  V  H  V  K  G  P  F  S  V  E  A  D  P  S  R  |  F  R      p.360

          .         .         .         .         .         .       g.19684
 TCCATCCACTGCCACCTGTACCCGGACACACCCTGGTGTCCCCGCACTGCCATCTTCTAG       c.1140
 S  I  H  C  H  L  Y  P  D  T  P  W  C  P  R  T  A  I  F  X         p.379

          .         .         .         .         .         .       g.19744
 tggccatggctgagacccaatccctgggcgcccctggtatccaaagggcccagggaccct       c.*60

          .         .         .         .         .         .       g.19804
 gttgcgctgccctggcctcggcattcgaggctcccctagggccgtgcctgtgcgtgtgcg       c.*120

          .         .         .         .         .         .       g.19864
 tgtgcgtgtgtgtgtgtgtgtactgcatgcccacccgggtagcaggctgctgggcagttc       c.*180

          .         .         .         .         .         .       g.19924
 tgctctgtggaggggcgggcaccagcgccacttatgtgcctctgctccgagggccagtgg       c.*240

          .         .         .         .         .         .       g.19984
 gctgcagggcctgcttggaggaaggatttgtgtgtcggaggccactccgagggcaattct       c.*300

          .         .         .         .         .         .       g.20044
 gttaggatttttggatctttctacagctacggggctccgggctactttgcagggatgcga       c.*360

          .         .         .         .         .         .       g.20104
 tgcgtaggtgcctttctcttcctgctgaccacaagctctgtgctgggggtacctgtgccc       c.*420

          .         .         .         .         .         .       g.20164
 tgaagtcctggcccctgtgtcatagccccaagtacgactcactgagccatgctcattgca       c.*480

          .         .         .         .         .         .       g.20224
 ggggaggctgggtctgggggtgcgtgacccaatccccttcctcctggcctggacgctgtg       c.*540

          .         .         .         .         .         .       g.20284
 gcttaagagtaacagcagccaccgcccagttccagtggccccacgaagcccccagtggct       c.*600

          .         .         .         .         .         .       g.20344
 ggctgtccagctgggcaaacagtggcacccctcccagctcttctgagtggggagtcttcc       c.*660

          .         .         .         .         .         .       g.20404
 aggcctcctcagaggtcttccctttgcctccccaggacagggtgagtcagagctcagcat       c.*720

          .         .         .         .         .         .       g.20464
 ttaatctcctctccaaagtagagagcaagtcgcccacagtgggcgtgtctgtaaatattg       c.*780

          .         .         .         .         .         .       g.20524
 tgacagtatttttttactgtgctgttttttttgaaaggggatgggtaaaaagtagggtgt       c.*840

          .         .         .         .         .         .       g.20584
 tcttgttttttgcttgggagggtgggggtgggggagggtcttattttatcttatcttttc       c.*900

          .         .         .         .         .         .       g.20644
 tgtggatcagaaaaaacagaagccaaactcggggtcatctttgtttttaaagctgaagtg       c.*960

          .         .         .         .         .         .       g.20704
 ggactgtctggcactctgtgtatttatgcgttccagcatctggaacctcccatccctgcc       c.*1020

          .         .         .         .         .         .       g.20764
 ctcctcctgtgtagctgccacctccccgctgggcccagcatggctcacctgtcccgtggg       c.*1080

          .         .         .         .         .         .       g.20824
 ctgtgtttcttgttgtttttctctttgcaaagacatagctaggaaagcgaatgataaggg       c.*1140

          .         .         .         .         .         .       g.20884
 aaaagttctcagggaattgaagtgttgttgctatggtgacgtccttttgctgtgaataaa       c.*1200

          .                                                         g.20901
 ggtgctctttgcagcaa                                                  c.*1217

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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