lipoma HMGIC fusion partner-like 5 (LHFPL5) - coding DNA reference sequence

(used for variant description)

(last modified November 6, 2023)

This file was created to facilitate the description of sequence variants on transcript NM_182548.3 in the LHFPL5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering LHFPL5 transcript NM_182548.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5017
                                            gggcgctggccgcggtg       c.-361

 .         .         .         .         .         .                g.5077
 ctgaaacggcgccctccgcggacggaggagggggcggggctctcgggagccgtgagccgg       c.-301

 .         .         .         .         .         .                g.5137
 gaagagggagacgggcagggcggcgccagcaggccctggtgggcttgggaggaggcagga       c.-241

 .         .         .         .         .         .                g.5197
 gactggagacagcctcggctagagcggacacaggcacctggcaagctttccttgaccaaa       c.-181

 .         .         .         .         .         .                g.5257
 tcaaggttgtccttgtcctattaagcctcttccccttgccttgaagggacctcacctggt       c.-121

 .         .         .         .         .         .                g.5317
 gccctgacctcagcctcctccccaaaccccgctggggagtgacctgcttctaggcctcca       c.-61

 .         .         .         .         .         .                g.5377
 tccacaaagctacggacttgcagcccacgggaccccagcccagggcctgctgccctcacc       c.-1

          .         .         .         .         .         .       g.5437
 ATGGTGAAATTGCTGCCGGCCCAGGAGGCAGCCAAGATCTACCATACCAACTATGTGCGG       c.60
 M  V  K  L  L  P  A  Q  E  A  A  K  I  Y  H  T  N  Y  V  R         p.20

          .         .         .         .         .         .       g.5497
 AACTCGCGAGCCGTGGGCGTGATGTGGGGTACCCTCACCATCTGCTTCTCCGTACTGGTC       c.120
 N  S  R  A  V  G  V  M  W  G  T  L  T  I  C  F  S  V  L  V         p.40

          .         .         .         .         .         .       g.5557
 ATGGCCCTCTTCATCCAGCCCTACTGGATCGGCGACAGCGTCAACACACCGCAGGCAGGC       c.180
 M  A  L  F  I  Q  P  Y  W  I  G  D  S  V  N  T  P  Q  A  G         p.60

          .         .         .         .         .         .       g.5617
 TACTTCGGCCTTTTCTCCTACTGCGTGGGTAACGTGCTGTCCTCCGAGCTCATCTGCAAG       c.240
 Y  F  G  L  F  S  Y  C  V  G  N  V  L  S  S  E  L  I  C  K         p.80

          .         .         .         .         .         .       g.5677
 GGCGGCCCCCTAGACTTCTCCTCCATCCCCTCTAGAGCCTTCAAGACTGCCATGTTCTTT       c.300
 G  G  P  L  D  F  S  S  I  P  S  R  A  F  K  T  A  M  F  F         p.100

          .         .         .         .         .         .       g.5737
 GTGGCCTTGGGCATGTTCCTCATCATTGGCTCCATCATCTGCTTCAGCCTGTTCTTCATC       c.360
 V  A  L  G  M  F  L  I  I  G  S  I  I  C  F  S  L  F  F  I         p.120

          .         .         .         .         .   | 02     .    g.14260
 TGCAACACGGCCACAGTCTATAAGATCTGTGCATGGATGCAGCTGGCTGCGG | CCACAGGC    c.420
 C  N  T  A  T  V  Y  K  I  C  A  W  M  Q  L  A  A  A |   T  G      p.140

          .         .         .         .         .         .       g.14320
 CTAATGATTGGCTGCCTGGTCTACCCTGATGGTTGGGACTCAAGTGAGGTGCGGCGCATG       c.480
 L  M  I  G  C  L  V  Y  P  D  G  W  D  S  S  E  V  R  R  M         p.160

          .         .         .         .         .         .       g.14380
 TGTGGGGAGCAGACGGGCAAGTACACGCTGGGCCACTGCACCATCCGCTGGGCCTTCATG       c.540
 C  G  E  Q  T  G  K  Y  T  L  G  H  C  T  I  R  W  A  F  M         p.180

          .         .         .         .         .         .       g.14440
 CTGGCCATCCTCAGCATTGGCGACGCCCTCATCCTCTCCTTCCTGGCCTTCGTGTTGGGC       c.600
 L  A  I  L  S  I  G  D  A  L  I  L  S  F  L  A  F  V  L  G         p.200

          .         .         .         .          | 03        .    g.19154
 TACCGGCAGGACAAGCTCCTCCCTGACGACTACAAGGCAGATGGAACCG | AGGAGGTGTGA    c.660
 Y  R  Q  D  K  L  L  P  D  D  Y  K  A  D  G  T  E |   E  V  X      p.219

          .       | 04 .         .         .         .         .    g.22732
 agcagctgaagggtcg | gtcatctatttcccagacacaggaaaactagggaatcaaattct    c.*60

          .         .         .         .         .         .       g.22792
 tcagagataagaacttgttcttccaagtttccttgttcctggctactataggcctgaagc       c.*120

          .         .         .         .         .         .       g.22852
 ctgaagccttttattataacactaaaactggacagtctcctgagacaagacctcctactg       c.*180

          .         .         .         .         .         .       g.22912
 tactctttctggggaagcagaactgcagtgacccacttcaaagatattcagaggctgagc       c.*240

          .         .         .         .         .         .       g.22972
 ggtgcagggagtgctcagttgctggggatgggatccaagtccatttcttagttccacaca       c.*300

          .         .         .         .         .         .       g.23032
 gcagcaaatcgcttcaccttcttgaagcctctcctctgtaaagcgagagggctaaatggg       c.*360

          .         .         .         .         .         .       g.23092
 tccatctctaggggccttccctcccaggtctgtgtctgatagcatacacacacacatata       c.*420

          .         .         .         .         .         .       g.23152
 tatacacacacacacacacacacacacacacacacacacatacatacacacacacatata       c.*480

          .         .         .         .         .         .       g.23212
 tatacacacacacacacacacacacacacacactctctctctctctcaaacacacacaaa       c.*540

          .         .         .         .         .         .       g.23272
 tgcccaaccagctctaagagggcactgaagaggtggctggacatgtgctgggtcattttt       c.*600

          .         .         .         .         .         .       g.23332
 agggtgaggtgtagggggtcttttgcttctcccttctcatattttgttttcttattgctg       c.*660

          .         .         .         .         .         .       g.23392
 ctcagaggggggtaaggaatggaggggccatcagaacttgaatcctttaacatccaccag       c.*720

          .         .         .         .         .         .       g.23452
 gaagttttatgaagagtgggtgataggatctaaaatctctgcagacttttttcctcccgg       c.*780

          .         .         .         .         .         .       g.23512
 gagccaaatatcacatttccttatggtgcccacactgactcaaccagaactggctaccag       c.*840

          .         .         .         .         .         .       g.23572
 cttcagaaatgtgttacttatgttcaagtaatttgttataggaatagatgacattttttt       c.*900

          .         .         .         .         .         .       g.23632
 ttttcaaaaactttggatttggcatatagtcatctatagggggattggttccaggatccc       c.*960

          .         .         .         .         .         .       g.23692
 ctgcagatgccaaaatacatggatgcccaagtcctcagctaaaaatagcgtagtatttgc       c.*1020

          .         .         .         .         .         .       g.23752
 atataacctatgcacatcctcctgtatactttaaatcatctctagattacttataatacc       c.*1080

          .         .         .                                     g.23782
 taatacaatgtaaatgctatgtaaatactc                                     c.*1110

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Lipoma HMGIC fusion partner-like 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.