LIM homeobox 3 (LHX3) - coding DNA reference sequence

(used for variant description)

(last modified April 25, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_014564.3 in the LHX3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008097.1, covering LHX3 transcript NM_014564.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.7010
  cgcagcgcccagcagcacccggagtcgcttggacgccggttcggggctattgcggggtg       c.-61

 .         .         .         .         .         .                g.7070
 gcgtcgctgggcccgggaaagttcgggactggagagtggcgacgccgggcggcgggaccc       c.-1

          .         .         .         .         .         .       g.7130
 ATGGAGGCGCGCGGGGAGCTGGGCCCGGCCCGGGAGTCGGCGGGAGGCGACCTGCTGCTA       c.60
 M  E  A  R  G  E  L  G  P  A  R  E  S  A  G  G  D  L  L  L         p.20

          .         .         .     | 02   .         .         .    g.9382
 GCACTGCTGGCGCGGAGGGCGGACCTGCGCCGAG | AGATCCCGCTGTGCGCTGGCTGTGAC    c.120
 A  L  L  A  R  R  A  D  L  R  R  E |   I  P  L  C  A  G  C  D      p.40

          .         .         .         .         .         .       g.9442
 CAGCACATCCTGGACCGCTTCATCCTCAAGGCTCTGGACCGCCACTGGCACAGCAAGTGT       c.180
 Q  H  I  L  D  R  F  I  L  K  A  L  D  R  H  W  H  S  K  C         p.60

          .         .         .         .         .         .       g.9502
 CTCAAGTGCAGCGACTGCCACACGCCACTGGCCGAGCGCTGCTTCAGCCGAGGGGAGAGC       c.240
 L  K  C  S  D  C  H  T  P  L  A  E  R  C  F  S  R  G  E  S         p.80

          .         .       | 03 .         .         .         .    g.10263
 GTTTACTGCAAGGACGACTTTTTCAA | GCGCTTCGGGACCAAGTGCGCCGCGTGCCAGCTG    c.300
 V  Y  C  K  D  D  F  F  K  |  R  F  G  T  K  C  A  A  C  Q  L      p.100

          .         .         .         .         .         .       g.10323
 GGCATCCCGCCCACGCAGGTGGTGCGCCGCGCCCAGGACTTCGTGTACCACCTGCACTGC       c.360
 G  I  P  P  T  Q  V  V  R  R  A  Q  D  F  V  Y  H  L  H  C         p.120

          .         .         .         .         .         .       g.10383
 TTTGCCTGCGTCGTGTGCAAGCGGCAGCTGGCCACGGGCGACGAGTTCTACCTCATGGAG       c.420
 F  A  C  V  V  C  K  R  Q  L  A  T  G  D  E  F  Y  L  M  E         p.140

          .         .         .         .          | 04        .    g.11061
 GACAGCCGGCTCGTGTGCAAGGCGGACTACGAAACCGCCAAGCAGCGAG | AGGCCGAGGCC    c.480
 D  S  R  L  V  C  K  A  D  Y  E  T  A  K  Q  R  E |   A  E  A      p.160

          .         .         .         .         .         .       g.11121
 ACGGCCAAGCGGCCGCGCACGACCATCACCGCCAAGCAGCTGGAGACGCTGAAGAGCGCT       c.540
 T  A  K  R  P  R  T  T  I  T  A  K  Q  L  E  T  L  K  S  A         p.180

          .         .         .         .         .         .       g.11181
 TACAACACCTCGCCCAAGCCGGCGCGCCACGTGCGCGAGCAGCTCTCGTCCGAGACGGGC       c.600
 Y  N  T  S  P  K  P  A  R  H  V  R  E  Q  L  S  S  E  T  G         p.200

          .         .  | 05      .         .         .         .    g.11328
 CTGGACATGCGCGTGGTGCAG | GTTTGGTTCCAGAACCGCCGGGCCAAGGAGAAGAGGCTG    c.660
 L  D  M  R  V  V  Q   | V  W  F  Q  N  R  R  A  K  E  K  R  L      p.220

          .         .         .         .         .         .       g.11388
 AAGAAGGACGCCGGCCGGCAGCGCTGGGGGCAGTATTTCCGCAACATGAAGCGCTCCCGC       c.720
 K  K  D  A  G  R  Q  R  W  G  Q  Y  F  R  N  M  K  R  S  R         p.240

          .         .         .         .         .         .       g.11448
 GGCGGCTCCAAGTCGGACAAGGACAGCGTTCAGGAGGGGCAGGACAGCGACGCTGAGGTC       c.780
 G  G  S  K  S  D  K  D  S  V  Q  E  G  Q  D  S  D  A  E  V         p.260

          . | 06       .         .         .         .         .    g.12416
 TCCTTCCCCG | ATGAGCCTTCCTTGGCGGAAATGGGCCCGGCCAATGGCCTCTACGGGAGC    c.840
 S  F  P  D |   E  P  S  L  A  E  M  G  P  A  N  G  L  Y  G  S      p.280

          .         .         .         .         .         .       g.12476
 TTGGGGGAACCCACCCAGGCCTTGGGCCGGCCCTCGGGAGCCCTGGGCAACTTCTCCCTG       c.900
 L  G  E  P  T  Q  A  L  G  R  P  S  G  A  L  G  N  F  S  L         p.300

          .         .         .         .         .         .       g.12536
 GAGCATGGAGGCCTGGCAGGCCCAGAGCAGTACCGAGAGCTGCGTCCCGGCAGCCCCTAC       c.960
 E  H  G  G  L  A  G  P  E  Q  Y  R  E  L  R  P  G  S  P  Y         p.320

          .         .         .         .         .         .       g.12596
 GGTGTCCCCCCATCCCCCGCCGCCCCGCAGAGCCTCCCTGGCCCCCAGCCCCTCCTCTCC       c.1020
 G  V  P  P  S  P  A  A  P  Q  S  L  P  G  P  Q  P  L  L  S         p.340

          .         .         .         .         .         .       g.12656
 AGCCTGGTGTACCCAGACACCAGCTTGGGCCTTGTGCCCTCGGGAGCCCCCGGCGGGCCC       c.1080
 S  L  V  Y  P  D  T  S  L  G  L  V  P  S  G  A  P  G  G  P         p.360

          .         .         .         .         .         .       g.12716
 CCACCCATGAGGGTGCTGGCAGGGAACGGACCCAGTTCTGACCTATCCACGGGGAGCAGC       c.1140
 P  P  M  R  V  L  A  G  N  G  P  S  S  D  L  S  T  G  S  S         p.380

          .         .         .         .         .         .       g.12776
 GGGGGTTACCCCGACTTCCCTGCCAGCCCCGCCTCCTGGCTGGATGAGGTAGACCACGCT       c.1200
 G  G  Y  P  D  F  P  A  S  P  A  S  W  L  D  E  V  D  H  A         p.400

                                                                    g.12785
 CAGTTCTGA                                                          c.1209
 Q  F  X                                                            p.402

          .         .         .         .         .         .       g.12845
 cccaggcccggctccaccctgcacctcacacgagggagctgcccctgggtgggcggctcg       c.*60

          .         .         .         .         .         .       g.12905
 gggctgctggggtttccgaggaagtggggccagggcgtcaagggagggctggtgccttcg       c.*120

          .         .         .         .         .         .       g.12965
 gagcctcccactgccgaccgcacagctccctctctgggggctgagggacccacctggccc       c.*180

          .         .         .         .         .         .       g.13025
 ctcctctgacacagggctggcccgccaggtggcctcccagcaagccagccttttttgtaa       c.*240

          .         .         .         .         .         .       g.13085
 gcaaatttctcccctttattgaccaattaactgagcacttgctgctatttctagacatga       c.*300

          .         .         .         .         .         .       g.13145
 aatgtcaccttgctgaggcccagcccagcccagcatagcccgagggctggaaaaacgctt       c.*360

          .         .         .         .         .         .       g.13205
 tcatctctaaaactgagaaatcatcataattgtgctttcacttcccaggctccatgtgtc       c.*420

          .         .         .         .         .         .       g.13265
 ttggagccgtcaccccgaggctccctctttaggtcggagattggccttgcctgtcgaggc       c.*480

          .         .         .         .         .         .       g.13325
 aagaggctgcagaggcggggacacacctgtgtcctccgggagaggccccctcctctcccc       c.*540

          .         .         .         .         .         .       g.13385
 agaccacagggggcctctctgcctccagccccaccttccccgggagaagctttccccaat       c.*600

          .         .         .         .         .         .       g.13445
 ccccaggtctctagatcattctgttctcgagtatcctgtggaggaggcaaaaatgcctgg       c.*660

          .         .         .         .         .         .       g.13505
 cgccccttctctccaagctcaattctctaagcccctcagggtctcctcctcaccccaccc       c.*720

          .         .         .         .         .         .       g.13565
 caggcccttggtgtccaggctgcacccacagatgtctgttgccaaacagcctgccctccc       c.*780

          .         .         .         .         .         .       g.13625
 tgccggagccggctctgccagccccagattgggaagtctccccgctggagaagggtgggg       c.*840

          .         .         .         .         .         .       g.13685
 ctcctctgagcctgccctgcctcctccatcagatcctttgggaagaagtttctgggagat       c.*900

          .         .         .         .         .         .       g.13745
 gcccgcagctgtgcgtgccccagacacaaaggctggcctgtgtgtaagtcaaagtcactc       c.*960

          .         .         .         .         .         .       g.13805
 ccgcaaacctgaatctcgagctacctattggttctgtgaatgttctgtgtcttttattta       c.*1020

          .         .         .         .         .                 g.13860
 ttctcgggtgatcagctctttccaagacttcaataaatttgtcagttacagtcaa            c.*1075

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The LIM homeobox 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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