leucine rich repeat and Ig domain containing 1 (LINGO1) - coding DNA reference sequence

(used for variant description)

(last modified August 8, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_032808.5 in the LINGO1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering LINGO1 transcript NM_032808.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         ggagagacatgcgattggtgaccgagccgagcggaccgaaggcgcgcccgag       c.-1

        | 02 .         .         .         .         .         .    g.21521
 ATGCAG | GTGAGCAAGAGGATGCTGGCGGGGGGCGTGAGGAGCATGCCCAGCCCCCTCCTG    c.60
 M  Q   | V  S  K  R  M  L  A  G  G  V  R  S  M  P  S  P  L  L      p.20

          .         .         .         .         .         .       g.21581
 GCCTGCTGGCAGCCCATCCTCCTGCTGGTGCTGGGCTCAGTGCTGTCAGGCTCGGCCACG       c.120
 A  C  W  Q  P  I  L  L  L  V  L  G  S  V  L  S  G  S  A  T         p.40

          .         .         .         .         .         .       g.21641
 GGCTGCCCGCCCCGCTGCGAGTGCTCCGCCCAGGACCGCGCTGTGCTGTGCCACCGCAAG       c.180
 G  C  P  P  R  C  E  C  S  A  Q  D  R  A  V  L  C  H  R  K         p.60

          .         .         .         .         .         .       g.21701
 CGCTTTGTGGCAGTCCCCGAGGGCATCCCCACCGAGACGCGCCTGCTGGACCTAGGCAAG       c.240
 R  F  V  A  V  P  E  G  I  P  T  E  T  R  L  L  D  L  G  K         p.80

          .         .         .         .         .         .       g.21761
 AACCGCATCAAAACGCTCAACCAGGACGAGTTCGCCAGCTTCCCGCACCTGGAGGAGCTG       c.300
 N  R  I  K  T  L  N  Q  D  E  F  A  S  F  P  H  L  E  E  L         p.100

          .         .         .         .         .         .       g.21821
 GAGCTCAACGAGAACATCGTGAGCGCCGTGGAGCCCGGCGCCTTCAACAACCTCTTCAAC       c.360
 E  L  N  E  N  I  V  S  A  V  E  P  G  A  F  N  N  L  F  N         p.120

          .         .         .         .         .         .       g.21881
 CTCCGGACGCTGGGTCTCCGCAGCAACCGCCTGAAGCTCATCCCGCTAGGCGTCTTCACT       c.420
 L  R  T  L  G  L  R  S  N  R  L  K  L  I  P  L  G  V  F  T         p.140

          .         .         .         .         .         .       g.21941
 GGCCTCAGCAACCTGACCAAGCTGGACATCAGCGAGAACAAGATCGTTATCCTACTGGAC       c.480
 G  L  S  N  L  T  K  L  D  I  S  E  N  K  I  V  I  L  L  D         p.160

          .         .         .         .         .         .       g.22001
 TACATGTTTCAGGACCTGTACAACCTCAAGTCACTGGAGGTTGGCGACAATGACCTCGTC       c.540
 Y  M  F  Q  D  L  Y  N  L  K  S  L  E  V  G  D  N  D  L  V         p.180

          .         .         .         .         .         .       g.22061
 TACATCTCTCACCGCGCCTTCAGCGGCCTCAACAGCCTGGAGCAGCTGACGCTGGAGAAA       c.600
 Y  I  S  H  R  A  F  S  G  L  N  S  L  E  Q  L  T  L  E  K         p.200

          .         .         .         .         .         .       g.22121
 TGCAACCTGACCTCCATCCCCACCGAGGCGCTGTCCCACCTGCACGGCCTCATCGTCCTG       c.660
 C  N  L  T  S  I  P  T  E  A  L  S  H  L  H  G  L  I  V  L         p.220

          .         .         .         .         .         .       g.22181
 AGGCTCCGGCACCTCAACATCAATGCCATCCGGGACTACTCCTTCAAGAGGCTGTACCGA       c.720
 R  L  R  H  L  N  I  N  A  I  R  D  Y  S  F  K  R  L  Y  R         p.240

          .         .         .         .         .         .       g.22241
 CTCAAGGTCTTGGAGATCTCCCACTGGCCCTACTTGGACACCATGACACCCAACTGCCTC       c.780
 L  K  V  L  E  I  S  H  W  P  Y  L  D  T  M  T  P  N  C  L         p.260

          .         .         .         .         .         .       g.22301
 TACGGCCTCAACCTGACGTCCCTGTCCATCACACACTGCAATCTGACCGCTGTGCCCTAC       c.840
 Y  G  L  N  L  T  S  L  S  I  T  H  C  N  L  T  A  V  P  Y         p.280

          .         .         .         .         .         .       g.22361
 CTGGCCGTCCGCCACCTAGTCTATCTCCGCTTCCTCAACCTCTCCTACAACCCCATCAGC       c.900
 L  A  V  R  H  L  V  Y  L  R  F  L  N  L  S  Y  N  P  I  S         p.300

          .         .         .         .         .         .       g.22421
 ACCATTGAGGGCTCCATGTTGCATGAGCTGCTCCGGCTGCAGGAGATCCAGCTGGTGGGC       c.960
 T  I  E  G  S  M  L  H  E  L  L  R  L  Q  E  I  Q  L  V  G         p.320

          .         .         .         .         .         .       g.22481
 GGGCAGCTGGCCGTGGTGGAGCCCTATGCCTTCCGCGGCCTCAACTACCTGCGCGTGCTC       c.1020
 G  Q  L  A  V  V  E  P  Y  A  F  R  G  L  N  Y  L  R  V  L         p.340

          .         .         .         .         .         .       g.22541
 AATGTCTCTGGCAACCAGCTGACCACACTGGAGGAATCAGTCTTCCACTCGGTGGGCAAC       c.1080
 N  V  S  G  N  Q  L  T  T  L  E  E  S  V  F  H  S  V  G  N         p.360

          .         .         .         .         .         .       g.22601
 CTGGAGACACTCATCCTGGACTCCAACCCGCTGGCCTGCGACTGTCGGCTCCTGTGGGTG       c.1140
 L  E  T  L  I  L  D  S  N  P  L  A  C  D  C  R  L  L  W  V         p.380

          .         .         .         .         .         .       g.22661
 TTCCGGCGCCGCTGGCGGCTCAACTTCAACCGGCAGCAGCCCACGTGCGCCACGCCCGAG       c.1200
 F  R  R  R  W  R  L  N  F  N  R  Q  Q  P  T  C  A  T  P  E         p.400

          .         .         .         .         .         .       g.22721
 TTTGTCCAGGGCAAGGAGTTCAAGGACTTCCCTGATGTGCTACTGCCCAACTACTTCACC       c.1260
 F  V  Q  G  K  E  F  K  D  F  P  D  V  L  L  P  N  Y  F  T         p.420

          .         .         .         .         .         .       g.22781
 TGCCGCCGCGCCCGCATCCGGGACCGCAAGGCCCAGCAGGTGTTTGTGGACGAGGGCCAC       c.1320
 C  R  R  A  R  I  R  D  R  K  A  Q  Q  V  F  V  D  E  G  H         p.440

          .         .         .         .         .         .       g.22841
 ACGGTGCAGTTTGTGTGCCGGGCCGATGGCGACCCGCCGCCCGCCATCCTCTGGCTCTCA       c.1380
 T  V  Q  F  V  C  R  A  D  G  D  P  P  P  A  I  L  W  L  S         p.460

          .         .         .         .         .         .       g.22901
 CCCCGAAAGCACCTGGTCTCAGCCAAGAGCAATGGGCGGCTCACAGTCTTCCCTGATGGC       c.1440
 P  R  K  H  L  V  S  A  K  S  N  G  R  L  T  V  F  P  D  G         p.480

          .         .         .         .         .         .       g.22961
 ACGCTGGAGGTGCGCTACGCCCAGGTACAGGACAACGGCACGTACCTGTGCATCGCGGCC       c.1500
 T  L  E  V  R  Y  A  Q  V  Q  D  N  G  T  Y  L  C  I  A  A         p.500

          .         .         .         .         .         .       g.23021
 AACGCGGGCGGCAACGACTCCATGCCCGCCCACCTGCATGTGCGCAGCTACTCGCCCGAC       c.1560
 N  A  G  G  N  D  S  M  P  A  H  L  H  V  R  S  Y  S  P  D         p.520

          .         .         .         .         .         .       g.23081
 TGGCCCCATCAGCCCAACAAGACCTTCGCTTTCATCTCCAACCAGCCGGGCGAGGGAGAG       c.1620
 W  P  H  Q  P  N  K  T  F  A  F  I  S  N  Q  P  G  E  G  E         p.540

          .         .         .         .         .         .       g.23141
 GCCAACAGCACCCGCGCCACTGTGCCTTTCCCCTTCGACATCAAGACCCTCATCATCGCC       c.1680
 A  N  S  T  R  A  T  V  P  F  P  F  D  I  K  T  L  I  I  A         p.560

          .         .         .         .         .         .       g.23201
 ACCACCATGGGCTTCATCTCTTTCCTGGGCGTCGTCCTCTTCTGCCTGGTGCTGCTGTTT       c.1740
 T  T  M  G  F  I  S  F  L  G  V  V  L  F  C  L  V  L  L  F         p.580

          .         .         .         .         .         .       g.23261
 CTCTGGAGCCGGGGCAAGGGCAACACAAAGCACAACATCGAGATCGAGTATGTGCCCCGA       c.1800
 L  W  S  R  G  K  G  N  T  K  H  N  I  E  I  E  Y  V  P  R         p.600

          .         .         .         .         .         .       g.23321
 AAGTCGGACGCAGGCATCAGCTCCGCCGACGCGCCCCGCAAGTTCAACATGAAGATGATA       c.1860
 K  S  D  A  G  I  S  S  A  D  A  P  R  K  F  N  M  K  M  I         p.620

                                                                    g.23324
 TGA                                                                c.1863
 X                                                                  p.620

          .         .         .         .         .         .       g.23384
 ggccggggcggggggcagggacccccgggcggccgggcaggggaaggggcctggccgcca       c.*60

          .         .         .         .         .         .       g.23444
 cctgctcactctccagtccttcccacctcctccctacccttctacacacgttctctttct       c.*120

          .         .         .         .         .         .       g.23504
 ccctcccgcctccgtcccctgctgccccccgccagccctcaccacctgccctccttctac       c.*180

          .         .         .         .         .         .       g.23564
 caggacctcagaagcccagacctggggaccccacctacacaggggcattgacagactgga       c.*240

          .         .         .         .         .         .       g.23624
 gttgaaagccgacgaaccgacacgcggcagagtcaataattcaataaaaaagttacgaac       c.*300

          .         .         .         .         .         .       g.23684
 tttctctgtaacttgggtttcaataattatggatttttatgaaaacttgaaataataaaa       c.*360

          .         .         .         .         .         .       g.23744
 agagaaaaaaactatttcctatagctagtcggaatgcaaacttttgacgtcctgattgct       c.*420

          .         .         .         .         .         .       g.23804
 ccagggccctcttccaactcagtttcttgtttttctcttcctcctcctcctcttcttcct       c.*480

          .         .         .         .         .         .       g.23864
 cctttctcttctcttccccagtggggagggatcactcaggaaaacaggaaaggaggttcc       c.*540

          .         .         .         .         .         .       g.23924
 agccccacccacctgcccaccccgccccaggcaccatcaggagcaggctagggggcaggc       c.*600

          .         .         .         .         .         .       g.23984
 ctgggcccagctccgggctggctttttgcagggcgcaggtggaggggacaggtctgccga       c.*660

          .         .         .         .         .         .       g.24044
 tgggggtgggagcctgtctgctgggctgccaggcggcaccactgcaaggggtgggagcct       c.*720

          .         .         .         .         .         .       g.24104
 ggcttgggtgtggctgagactctggacagaggctggggtcctcctgggggacagcacagt       c.*780

          .         .         .         .         .         .       g.24164
 cagtggagagagccaggggctggaggtggggcccaccccagcctctggtcccagctctgc       c.*840

          .         .         .         .         .         .       g.24224
 tgctcacttgctgtgtggcctcaagcaggtcactggcctctctgggcctcagtctccaca       c.*900

          .         .         .         .         .         .       g.24284
 tctgtacaaatgggaacattaccccctgccctgcctacctcacagggctgttgtgaggaa       c.*960

          .         .         .         .         .                 g.24341
 ttgatgagatgatgtatgtgaaacactttgtaacctgtaaagcgctgtgcacacgtg          c.*1017

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Leucine rich repeat and Ig domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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