lipase A, lysosomal acid, cholesterol esterase (LIPA) - coding DNA reference sequence

(used for variant description)

(last modified March 5, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001127605.1 in the LIPA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008194.1, covering LIPA transcript NM_001127605.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           ttcccggtggctggctgc       c.-181

 .         .         .         .         .         .                g.5078
 tctgattggctgaacaaatagtccgagggtggtgggcatccgccctcccgacaaggcaga       c.-121

 .         .         .         .         .         .                g.5138
 ccaggccccctgcaggtcccctatccgcaccccggcccctgagagctggcactgcgactc       c.-61

 .         .         .         .         .         .         | 02    g.9255
 gagacagcggcccggcaggacagctccaggtgagagtgccggcgccgcggcgctgccag | a    c.-1

          .         .         .         .         .         .       g.9315
 ATGAAAATGCGGTTCTTGGGGTTGGTGGTCTGTTTGGTTCTCTGGACCCTGCATTCTGAG       c.60
 M  K  M  R  F  L  G  L  V  V  C  L  V  L  W  T  L  H  S  E         p.20

          .         .         .         .         .  | 03      .    g.11119
 GGGTCTGGAGGGAAACTGACAGCTGTGGATCCTGAAACAAACATGAATGTG | AGTGAAATT    c.120
 G  S  G  G  K  L  T  A  V  D  P  E  T  N  M  N  V   | S  E  I      p.40

          .         .         .         .         .         .       g.11179
 ATCTCTTACTGGGGATTCCCTAGTGAGGAATACCTAGTTGAGACAGAAGATGGATATATT       c.180
 I  S  Y  W  G  F  P  S  E  E  Y  L  V  E  T  E  D  G  Y  I         p.60

          .         .         .         .          | 04        .    g.28516
 CTGTGCCTTAACCGAATTCCTCATGGGAGGAAGAACCATTCTGACAAAG | GTCCCAAACCA    c.240
 L  C  L  N  R  I  P  H  G  R  K  N  H  S  D  K  G |   P  K  P      p.80

          .         .         .         .         .         .       g.28576
 GTTGTCTTCCTGCAACATGGCTTGCTGGCAGATTCTAGTAACTGGGTCACAAACCTTGCC       c.300
 V  V  F  L  Q  H  G  L  L  A  D  S  S  N  W  V  T  N  L  A         p.100

          .         .         .         .         .         .       g.28636
 AACAGCAGCCTGGGCTTCATTCTTGCTGATGCTGGTTTTGACGTGTGGATGGGCAACAGC       c.360
 N  S  S  L  G  F  I  L  A  D  A  G  F  D  V  W  M  G  N  S         p.120

          .         .         .         .         .         .       g.28696
 AGAGGAAATACCTGGTCTCGGAAACATAAGACACTCTCAGTTTCTCAGGATGAATTCTGG       c.420
 R  G  N  T  W  S  R  K  H  K  T  L  S  V  S  Q  D  E  F  W         p.140

          | 05         .         .         .         .         .    g.29951
 GCTTTCAG | TTATGATGAGATGGCAAAATATGACCTACCAGCTTCCATTAACTTCATTCTG    c.480
 A  F  S  |  Y  D  E  M  A  K  Y  D  L  P  A  S  I  N  F  I  L      p.160

          .         .         .         .         .         | 06    g.31677
 AATAAAACTGGCCAAGAACAAGTGTATTATGTGGGTCATTCTCAAGGCACCACTATAG | GT    c.540
 N  K  T  G  Q  E  Q  V  Y  Y  V  G  H  S  Q  G  T  T  I  G |       p.180

          .         .         .         .         .         .       g.31737
 TTTATAGCATTTTCACAGATCCCTGAGCTGGCTAAAAGGATTAAAATGTTTTTTGCCCTG       c.600
 F  I  A  F  S  Q  I  P  E  L  A  K  R  I  K  M  F  F  A  L         p.200

          .         .         .         .         .         .       g.31797
 GGTCCTGTGGCTTCCGTCGCCTTCTGTACTAGCCCTATGGCCAAATTAGGACGATTACCA       c.660
 G  P  V  A  S  V  A  F  C  T  S  P  M  A  K  L  G  R  L  P         p.220

          .      | 07  .         .         .         .         .    g.33118
 GATCATCTCATTAAG | GACTTATTTGGAGACAAAGAATTTCTTCCCCAGAGTGCGTTTTTG    c.720
 D  H  L  I  K   | D  L  F  G  D  K  E  F  L  P  Q  S  A  F  L      p.240

          .         .         .         .         .         .       g.33178
 AAGTGGCTGGGTACCCACGTTTGCACTCATGTCATACTGAAGGAGCTCTGTGGAAATCTC       c.780
 K  W  L  G  T  H  V  C  T  H  V  I  L  K  E  L  C  G  N  L         p.260

          .         .         .         .   | 08     .         .    g.34339
 TGTTTTCTTCTGTGTGGATTTAATGAGAGAAATTTAAATATG | TCTAGAGTGGATGTATAT    c.840
 C  F  L  L  C  G  F  N  E  R  N  L  N  M   | S  R  V  D  V  Y      p.280

          .         .         .         .         .     | 09   .    g.40900
 ACAACACATTCTCCTGCTGGAACTTCTGTGCAAAACATGTTACACTGGAGCCAG | GCTGTT    c.900
 T  T  H  S  P  A  G  T  S  V  Q  N  M  L  H  W  S  Q   | A  V      p.300

          .         .         .         .         .         .       g.40960
 AAATTCCAAAAGTTTCAAGCCTTTGACTGGGGAAGCAGTGCCAAGAATTATTTTCATTAC       c.960
 K  F  Q  K  F  Q  A  F  D  W  G  S  S  A  K  N  Y  F  H  Y         p.320

        | 10 .         .         .         .         .         .    g.41896
 AACCAG | AGTTATCCTCCCACATACAATGTGAAGGACATGCTTGTGCCGACTGCAGTCTGG    c.1020
 N  Q   | S  Y  P  P  T  Y  N  V  K  D  M  L  V  P  T  A  V  W      p.340

          .         .         .         .         .         .       g.41956
 AGCGGGGGTCACGACTGGCTTGCAGATGTCTACGACGTCAATATCTTACTGACTCAGATC       c.1080
 S  G  G  H  D  W  L  A  D  V  Y  D  V  N  I  L  L  T  Q  I         p.360

          .         .         .         .         .         .       g.42016
 ACCAACTTGGTGTTCCATGAGAGCATTCCGGAATGGGAGCATCTTGACTTCATTTGGGGC       c.1140
 T  N  L  V  F  H  E  S  I  P  E  W  E  H  L  D  F  I  W  G         p.380

          .         .         .         .         .         .       g.42076
 CTGGATGCCCCTTGGAGGCTTTATAATAAAATTATTAATCTAATGAGGAAATATCAGTGA       c.1200
 L  D  A  P  W  R  L  Y  N  K  I  I  N  L  M  R  K  Y  Q  X         p.399

          .         .         .         .         .         .       g.42136
 aagctggacttgagctgtgtaccaccaagtcaatgattatgtcatgtgaaaatgtgtttg       c.*60

          .         .         .         .         .         .       g.42196
 cttcatttctgtaaaacacttgtttttctttcccaggtcttttgtttttttatatccaag       c.*120

          .         .         .         .         .         .       g.42256
 aaaatgataactttgaagatgcccagttcactctagtttcaattagaaacatactagcta       c.*180

          .         .         .         .         .         .       g.42316
 ttttttctttaattagggctggaataggaagccagtgtctcaaccatagtattgtctctt       c.*240

          .         .         .         .         .         .       g.42376
 taagtcttttaaatatcactgatgtgtaaaaaggtcattatatccattctgtttttaaaa       c.*300

          .         .         .         .         .         .       g.42436
 tttaaaatatattgactttttgcccttcataggacaaagtaatatatgtgttggaatttt       c.*360

          .         .         .         .         .         .       g.42496
 aaaattgtgttgtcattggtaaatctgtcactgacttaagcgaggtataaaagtacgcag       c.*420

          .         .         .         .         .         .       g.42556
 ttttcatgtccttgccttaaagagctctctagtctaacggtcttgtagttagagatctaa       c.*480

          .         .         .         .         .         .       g.42616
 atgacattttatcatgttttcctgcagcaggtgcatagtcaaatccagaaatatcacagc       c.*540

          .         .         .         .         .         .       g.42676
 tgtgccagtaataaggatgctaacaattaattttatcaaacctaactgtgacagctgtga       c.*600

          .         .         .         .         .         .       g.42736
 tttgacacgttttaattgctcaggttaaatgaaatagttttccggcgtcttcaaaaacaa       c.*660

          .         .         .         .         .         .       g.42796
 attgcactgataaaacaaaaacaaaagtatgttttaaatgctttgaagactgatacactc       c.*720

          .         .         .         .         .         .       g.42856
 aaccatctatattcatgagctctcaatttcatggcaggccatagttctacttatctgaga       c.*780

          .         .         .         .         .         .       g.42916
 agcaaatccctgtggagactataccactattttttctgagattaatgtactcttggagcc       c.*840

          .         .         .         .         .         .       g.42976
 cgctactgtcgttattgatcacatctgtgtgaagccaaagccccgtggttgcccatgaga       c.*900

          .         .         .         .         .         .       g.43036
 agtgtccttgttcattttcacccaaatgaagtgtgaacgtgatgttttcggatgcaaact       c.*960

          .         .         .         .         .         .       g.43096
 cagctcagggattcattttgtgtcttagttttatatgcatccttatttttaatacacctg       c.*1020

          .         .         .         .         .         .       g.43156
 cttcacgtccctatgttgggaagtccatatttgtctgcttttcttgcagcatcatttcct       c.*1080

          .         .         .         .         .         .       g.43216
 tacaatactgtccggtggacaaaatgacaattgatatgtttttctgatataattacttta       c.*1140

          .         .         .         .         .         .       g.43276
 gctgcactaacagtacaatgcttgttaatggttaatataggcagggcgaatactactttg       c.*1200

          .         .         .         .         .                 g.43335
 taacttttaaagtcttaaacttttcaataaaattgagtgagacttataggcccaaagaa        c.*1259

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lipase A, lysosomal acid, cholesterol esterase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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