limb region 1 homolog (mouse) (LMBR1) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_022458.3 in the LMBR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009240.1, covering LMBR1 transcript NM_022458.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          gactgcgcggcgcccgccctcccttagtcagagct       c.-181

 .         .         .         .         .         .                g.5095
 gctcgtctgaggctgctgaggcgacggccggtgtcgtggtcgcggtacctgttccaacac       c.-121

 .         .         .         .         .         .                g.5155
 ggctcgcgggcccgtgccggctccggtccccggcgcggctgtccgagcccctgcggcggg       c.-61

 .         .         .         .         .         .                g.5215
 cggacgatggtgtggcggagcacgcggacgcgggcggcgcggcggcgggcatgaaggagg       c.-1

          .         .         .         .         .         .       g.5275
 ATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAG       c.60
 M  E  G  Q  D  E  V  S  A  R  E  Q  H  F  H  S  Q  V  R  E         p.20

        | 02 .         .         .         .         .         .    g.61377
 TCCACG | ATATGTTTCCTTCTTTTTGCCATTCTCTACGTTGTTTCCTACTTCATCATCACA    c.120
 S  T   | I  C  F  L  L  F  A  I  L  Y  V  V  S  Y  F  I  I  T      p.40

          .          | 03        .         .         .          | 04 g.71465
 AGATACAAGAGAAAATCAG | ATGAACAAGAAGATGAAGATGCCATCGTCAACAGGATTTC | G c.180
 R  Y  K  R  K  S  D |   E  Q  E  D  E  D  A  I  V  N  R  I  S  |   p.60

          .         .         .         .         .         .       g.71525
 TTGTTTTTGAGCACGTTCACTCTCGCAGTGTCAGCTGGGGCTGTTTTGCTTTTACCCTTC       c.240
 L  F  L  S  T  F  T  L  A  V  S  A  G  A  V  L  L  L  P  F         p.80

          .         .         .         .         .         .       g.71585
 TCAATCATCAGCAATGAAATCCTGCTTTCTTTTCCTCAGAACTACTATATTCAGTGGCTA       c.300
 S  I  I  S  N  E  I  L  L  S  F  P  Q  N  Y  Y  I  Q  W  L         p.100

          .          | 05        .         .         .         .    g.101757
 AATGGCTCCCTGATTCATG | GTTTGTGGAATCTTGCTTCCCTTTTTTCCAACCTTTGTTTA    c.360
 N  G  S  L  I  H  G |   L  W  N  L  A  S  L  F  S  N  L  C  L      p.120

          .         .         .         .         .         .       g.101817
 TTTGTATTGATGCCCTTTGCCTTTTTCTTTCTGGAATCAGAAGGCTTTGCTGGCCTGAAA       c.420
 F  V  L  M  P  F  A  F  F  F  L  E  S  E  G  F  A  G  L  K         p.140

     | 06    .         .         .         .         .         .    g.134470
 AAG | GGAATCCGAGCCCGCATTTTAGAGACTTTGGTCATGCTTCTTCTTCTTGCGTTACTC    c.480
 K   | G  I  R  A  R  I  L  E  T  L  V  M  L  L  L  L  A  L  L      p.160

          .         .         .         .         .         .       g.134530
 ATTCTTGGGATAGTGTGGGTAGCTTCAGCACTCATTGACAACGATGCCGCAAGCATGGAA       c.540
 I  L  G  I  V  W  V  A  S  A  L  I  D  N  D  A  A  S  M  E         p.180

          . | 07       .         .         .         .         .    g.135082
 TCTTTATATG | ATCTCTGGGAGTTCTATCTACCCTATTTATATTCCTGTATATCATTGATG    c.600
 S  L  Y  D |   L  W  E  F  Y  L  P  Y  L  Y  S  C  I  S  L  M      p.200

          .          | 08        .         .         .         .    g.136051
 GGATGTTTGTTACTTCTCT | TGTGTACACCAGTTGGCCTTTCTCGTATGTTCACAGTGATG    c.660
 G  C  L  L  L  L  L |   C  T  P  V  G  L  S  R  M  F  T  V  M      p.220

          .         .     | 09   .         .         .         .    g.141779
 GGTCAGTTGCTAGTGAAGCCAACA | ATTCTTGAAGACCTGGATGAACAAATTTATATCATT    c.720
 G  Q  L  L  V  K  P  T   | I  L  E  D  L  D  E  Q  I  Y  I  I      p.240

          .         .         .        | 10.         .         .    g.163974
 ACCTTAGAGGAAGAAGCACTCCAGAGACGACTAAATG | GGCTGTCTTCATCGGTGGAATAC    c.780
 T  L  E  E  E  A  L  Q  R  R  L  N  G |   L  S  S  S  V  E  Y      p.260

          .         .         .         .         .         | 11    g.169490
 AACATAATGGAGTTGGAACAAGAACTTGAAAATGTAAAGACTCTTAAGACAAAATTAG | AG    c.840
 N  I  M  E  L  E  Q  E  L  E  N  V  K  T  L  K  T  K  L  E |       p.280

          .         .         .         .         .         .       g.169550
 AGGCGAAAAAAGGCTTCAGCATGGGAAAGAAATTTGGTGTATCCCGCTGTTATGGTTCTC       c.900
 R  R  K  K  A  S  A  W  E  R  N  L  V  Y  P  A  V  M  V  L         p.300

          .      | 12  .         .         .         .         .    g.170246
 CTTCTTATTGAGACA | TCCATCTCGGTCCTCTTGGTGGCTTGTAATATTCTTTGCCTATTG    c.960
 L  L  I  E  T   | S  I  S  V  L  L  V  A  C  N  I  L  C  L  L      p.320

          .         .         .    | 13    .         .         .    g.172398
 GTTGATGAAACAGCAATGCCAAAAGGAACAAGG | GGGCCTGGAATAGGAAATGCCTCTCTT    c.1020
 V  D  E  T  A  M  P  K  G  T  R   | G  P  G  I  G  N  A  S  L      p.340

          .         .         .         .        | 14.         .    g.172696
 TCTACGTTTGGTTTTGTGGGAGCTGCGCTTGAAATCATTTTGATTTT | CTATCTTATGGTG    c.1080
 S  T  F  G  F  V  G  A  A  L  E  I  I  L  I  F  |  Y  L  M  V      p.360

          .         .         .         .         .         .       g.172756
 TCCTCTGTTGTCGGCTTCTATAGCCTTCGATTTTTTGGAAACTTTACTCCCAAGAAAGAT       c.1140
 S  S  V  V  G  F  Y  S  L  R  F  F  G  N  F  T  P  K  K  D         p.380

          .         | 15         .         .         .         .    g.174072
 GACACAACTATGACAAAG | ATCATTGGAAATTGTGTGTCCATCTTGGTTTTGAGCTCTGCT    c.1200
 D  T  T  M  T  K   | I  I  G  N  C  V  S  I  L  V  L  S  S  A      p.400

          .         .      | 16  .         .         .         .    g.210052
 CTGCCTGTGATGTCGAGAACACTGG | GAATCACTAGATTTGATCTACTTGGCGACTTTGGA    c.1260
 L  P  V  M  S  R  T  L  G |   I  T  R  F  D  L  L  G  D  F  G      p.420

          .         .         .         .         .         .       g.210112
 AGGTTTAATTGGCTGGGAAATTTCTATATTGTATTATCCTACAATTTGCTTTTTGCTATT       c.1320
 R  F  N  W  L  G  N  F  Y  I  V  L  S  Y  N  L  L  F  A  I         p.440

          .         .         .         .         .         .       g.210172
 GTGACAACATTGTGTCTGGTCCGAAAATTCACCTCTGCAGTTCGAGAAGAACTTTTCAAG       c.1380
 V  T  T  L  C  L  V  R  K  F  T  S  A  V  R  E  E  L  F  K         p.460

         | 17.         .         .         .         .         .    g.214098
 GCCCTAG | GGCTTCATAAACTTCACTTACCAAATACTTCAAGGGATTCAGAAACAGCCAAG    c.1440
 A  L  G |   L  H  K  L  H  L  P  N  T  S  R  D  S  E  T  A  K      p.480

          .         .         .                                     g.214131
 CCTTCTGTAAATGGGCATCAGAAAGCACTGTGA                                  c.1473
 P  S  V  N  G  H  Q  K  A  L  X                                    p.490

          .         .         .         .         .         .       g.214191
 gacgcacagacggcgtcttctgccaccaagagacccgagaactccagattcacgacattc       c.*60

          .         .         .         .         .         .       g.214251
 ctgtcccatgtagaagcatttccattcaaccgtggcccctcttcagaacctagacctatc       c.*120

          .         .         .         .         .         .       g.214311
 agtgccatttttttttcataatctacgaagaacttggctatggctgatcttttttaaatt       c.*180

          .         .         .         .         .         .       g.214371
 taactttctgatggaccctgtagtttccagttaagtgcagattccttacagacatataga       c.*240

          .         .         .         .         .         .       g.214431
 acagcgcattcttctgtagacatttgctcatgttggtaaatacaatcacccatatgaaaa       c.*300

          .         .         .         .         .         .       g.214491
 aattgttttcacctgatatgaaaatgttagaaaaggcaaactccgggacttctaaagatt       c.*360

          .         .         .         .         .         .       g.214551
 tacttaaatcccattatgtactttattcagaatgtagaagctgacttgaaaggcatcctt       c.*420

          .         .         .         .         .         .       g.214611
 ggtactaagtgaagcttattcagaaaatgcatttttcaaatgcaatggcaactgcttgta       c.*480

          .         .         .         .         .         .       g.214671
 gatatcatttttgcagtgtatgttggagctgtaatggttgcaattatgtttcttatttcc       c.*540

          .         .         .         .         .         .       g.214731
 ttaaaagcaaaaagcgtagtttctgatttatgttatagaatgatactgattagactttga       c.*600

          .         .         .         .         .         .       g.214791
 gccaaggggaaaatactaaattcttttaaacctggagccttagagagccacaggaatatc       c.*660

          .         .         .         .         .         .       g.214851
 ttctgttgtacagtctaataagctgtggtaggaagtatcatgtaatcacagtttaatgac       c.*720

          .         .         .         .         .         .       g.214911
 agtttatgtatatatataattcagtattccctctgataacatagttgccagtgtttaata       c.*780

          .         .         .         .         .         .       g.214971
 cacttgtaacttggatttttaccttataggctatatgtatactcagttttttaaagcatt       c.*840

          .         .         .         .         .         .       g.215031
 tttttcagagatcacttaattccccatgcttctgcaatgcatataaaaactataaatgcc       c.*900

          .         .         .         .         .         .       g.215091
 gagtggtagaaactcctctttcttcatagtcctcaggctttggttacatttgcatatgcc       c.*960

          .         .         .         .         .         .       g.215151
 atttgaagcctccagcttttaccagtttaacatccaaagttcacagcatcagcattcatg       c.*1020

          .         .         .         .         .         .       g.215211
 gtgtaagaacagttttgcagtataacacgatctgataatcattcagttattaaattgtaa       c.*1080

          .         .         .         .         .         .       g.215271
 ataattattgggatggtttcttggctttaagtccactgaataaaaactatgaaattgcac       c.*1140

          .         .         .         .         .         .       g.215331
 tctgtgtcaaccatccactaggatagaataccgaaatctgtgcatgcaaaaataggagat       c.*1200

          .         .         .         .         .         .       g.215391
 gggcccatttgcacacaattcgtagttatgcagtctgctatataaatatgttcacatgca       c.*1260

          .         .         .         .         .         .       g.215451
 ctgtgtgtatgaaaatagatggtctgtgttcagacaaaagtaaaacatttttttcaaatt       c.*1320

          .         .         .         .         .         .       g.215511
 gttacatttaaaggttttctgggagaaatttatgaaacgcaggctgtgtctatttgacat       c.*1380

          .         .         .         .         .         .       g.215571
 cagaaatttccactttaaaccaaaataataagaaactttaatctgtatatttacaacctt       c.*1440

          .         .         .         .         .         .       g.215631
 tgttgagtacacttcccccttatttatacgtctgcatttccttccgagcttcacatcttt       c.*1500

          .         .         .         .         .         .       g.215691
 ctaaaatgcagcttggttttaaaataaaagaacattcattttgtgattctaaacaagctt       c.*1560

          .         .         .         .         .         .       g.215751
 cagtaaataccaccagtatagtactggtgaatttctcagcataaaatcgacatacctaaa       c.*1620

          .         .         .         .         .         .       g.215811
 aagttaataaaattcagctcttttccaatttcattgttatgcctattgaagtattaattg       c.*1680

          .         .         .         .         .         .       g.215871
 ccaggtttgatttttagtgaagcttggagtccatactttgagcagaccaagtgaagggaa       c.*1740

          .         .         .         .         .         .       g.215931
 gaacagaaagaaactcaggagtagagtaatatcacttctcacttacaccactttcaggca       c.*1800

          .         .         .         .         .         .       g.215991
 catccaaagagttcctagatacttggaaaatgtctgaaaatttttaagtaaaatactaaa       c.*1860

          .         .         .         .         .         .       g.216051
 cttttcagtgtttagctcaactttttgttcatttggaagtttctctccatccgaggactt       c.*1920

          .         .         .         .         .         .       g.216111
 aagccagttttggatttgtaagccctgagtacaatacacttcctggaggcatcctcactg       c.*1980

          .         .         .         .         .         .       g.216171
 ctgttgaagcaaaggatatgcatggggtggaaggacggcttcgaacctgggactcatatg       c.*2040

          .         .         .         .         .         .       g.216231
 ccttgagaacaaatagattgttacagccttgggctgctgcgtaatcacggttcctcgagg       c.*2100

          .         .         .         .         .         .       g.216291
 ctcttcctgagcacatgcccaagcatctgcctctggagagactgactccaaatgcaggtg       c.*2160

          .         .         .         .         .         .       g.216351
 cttccattggagctaggtcggaggctgctttatatgacgaactccagaaatggatgccag       c.*2220

          .         .         .         .         .         .       g.216411
 aatacggaggccaaacgttctgagtcctggtaaggacagtcgctctgggggtcctcattt       c.*2280

          .         .         .         .         .         .       g.216471
 tactgcagttcctgcacgccagtgaaagagaggagatagaccctggaaggcagagctgca       c.*2340

          .         .         .         .         .         .       g.216531
 gatgctcatcatcaggtcaattctggagctacagttttgtttctgactggatagggatgc       c.*2400

          .         .         .         .         .         .       g.216591
 accagtgactgtcacatcaagcagtccttttattctctctcctttagtatcgattttaaa       c.*2460

          .         .         .         .         .         .       g.216651
 gggcattaggcactatggttccagagtttcttggggaaaacttgcagattcttattaatt       c.*2520

          .         .         .         .         .         .       g.216711
 ggttctgcaatacttaaataaattattttacaattataagttttcagattataacatttg       c.*2580

          .         .         .         .         .         .       g.216771
 tattaatttttactgattttccaagatacttcttagatttactatttacgtagctttatg       c.*2640

          .         .         .         .         .         .       g.216831
 tacattctctgtaaaaatagacctctaaatatgaggctttacatgaaatttgtacacaca       c.*2700

          .         .         .         .         .         .       g.216891
 tacacactaatgttagctccttaaattgctgcactaaggtgctggttagtagagatggac       c.*2760

          .         .         .         .         .         .       g.216951
 ggagcctctcgcgttttgctctcagatgtgttaaaggcgcacgtgtacctgctctcagcg       c.*2820

          .         .         .         .         .         .       g.217011
 gcagtgcggcctccccatctgctgggtgcccatggccctccctgcagcctcagtgatgac       c.*2880

          .         .         .         .         .         .       g.217071
 ctcgtctgccagggacacaggttttcatcatttacaggctcttatgtgctagttttgttg       c.*2940

          .         .         .         .         .         .       g.217131
 gtagcacgttatttaatgcataaaggcagaattcttacaagtttttttttttaatgtgaa       c.*3000

          .         .         .         .         .         .       g.217191
 catagatgcagcaccgactttttaaacttgaaaaaactggtataatgttaacttttaaaa       c.*3060

          .         .         .         .         .         .       g.217251
 ataacatttggacacactagtaattgatttttgtttacagattgttttgtttacaaattg       c.*3120

          .         .         .         .         .         .       g.217311
 ttagtctttgtttctatgagatacttttagtgtgactttttaaatgtcttagaaattaaa       c.*3180

          .         .                                               g.217333
 agttgtacaaaaagtgatttca                                             c.*3202

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Limb region 1 homolog (mouse) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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