lipase maturation factor 1 (LMF1) - coding DNA reference sequence

(used for variant description)

(last modified January 29, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_022773.2 in the LMF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering LMF1 transcript NM_022773.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.15338
                                                         gcac       c.-1

          .         .         .         .         .         .       g.15398
 ATGCGCCCTGACAGCCCAACAATGGCGGCGCCCGCGGAGTCGCTGAGGAGGCGGAAGACT       c.60
 M  R  P  D  S  P  T  M  A  A  P  A  E  S  L  R  R  R  K  T         p.20

          .         .         .         .         .         .       g.15458
 GGGTACTCGGATCCGGAGCCTGAGTCGCCGCCCGCGCCGGGGCGTGGCCCCGCAGGCTCT       c.120
 G  Y  S  D  P  E  P  E  S  P  P  A  P  G  R  G  P  A  G  S         p.40

          .         .         .         .         .         .       g.15518
 CCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGATCGTGCTCCTGAAGGCCCTA       c.180
 P  A  H  L  H  T  G  T  F  W  L  T  R  I  V  L  L  K  A  L         p.60

          .    | 02    .         .         .         .         .    g.31699
 GCCTTCGTGTACT | TCGTGGCATTCCTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGT    c.240
 A  F  V  Y  F |   V  A  F  L  V  A  F  H  Q  N  K  Q  L  I  G      p.80

          .         .         .         .         .         .       g.31759
 GACAGGGGGCTGCTTCCCTGCAGAGTGTTCCTGAAGAACTTCCAGCAGTACTTCCAGGAC       c.300
 D  R  G  L  L  P  C  R  V  F  L  K  N  F  Q  Q  Y  F  Q  D         p.100

          .         .         .         .         .         .       g.31819
 AGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCTCTGGCTGATGGACTGGTCA       c.360
 R  T  S  W  E  V  F  S  Y  M  P  T  I  L  W  L  M  D  W  S         p.120

          .         .         .         .         .         .       g.31879
 GACATGAACTCCAACCTGGACTTGCTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTA       c.420
 D  M  N  S  N  L  D  L  L  A  L  L  G  L  G  I  S  S  F  V         p.140

          .         .         .         .         .         .       g.31939
 CTGATCACGGGCTGCGCCAACATGCTTCTCATGGCTGCCCTGTGGGGCCTCTACATGTCC       c.480
 L  I  T  G  C  A  N  M  L  L  M  A  A  L  W  G  L  Y  M  S         p.160

          .         .    | 03    .     | 04   .         .         . g.75265
 CTGGTTAATGTGGGCCATGTCTG | GTACTCTTTCG | GATGGGAGTCCCAGCTTCTGGAGACG c.540
 L  V  N  V  G  H  V  W  |  Y  S  F  G |   W  E  S  Q  L  L  E  T   p.180

          .         .         .         .         .         .       g.75325
 GGGTTCCTGGGGATCTTCCTGTGCCCTCTGTGGACGCTGTCAAGGCTGCCCCAGCATACC       c.600
 G  F  L  G  I  F  L  C  P  L  W  T  L  S  R  L  P  Q  H  T         p.200

          .         .         .         .         .         .       g.75385
 CCCACATCCCGGATTGTCCTGTGGGGCTTCCGGTGGCTGATCTTCAGGATCATGCTTGGA       c.660
 P  T  S  R  I  V  L  W  G  F  R  W  L  I  F  R  I  M  L  G         p.220

     | 05    .         .         .         .         .         .    g.93303
 GCA | GGCCTGATCAAGATCCGGGGGGACCGGTGCTGGCGAGACCTCACCTGCATGGACTTC    c.720
 A   | G  L  I  K  I  R  G  D  R  C  W  R  D  L  T  C  M  D  F      p.240

           | 06        .         .         .         .         .    g.106632
 CACTATGAG | ACCCAGCCGATGCCCAATCCTGTGGCGTACTACCTGCACCACTCACCCTGG    c.780
 H  Y  E   | T  Q  P  M  P  N  P  V  A  Y  Y  L  H  H  S  P  W      p.260

          .         .         .         .         .         .       g.106692
 TGGTTCCATCGCTTCGAGACGCTCAGCAACCACTTCATCGAGCTCCTGGTGCCCTTCTTC       c.840
 W  F  H  R  F  E  T  L  S  N  H  F  I  E  L  L  V  P  F  F         p.280

          .         .         .         .         .        | 07.    g.114980
 CTCTTCCTCGGCCGGCGGGCGTGCATCATCCACGGGGTGCTGCAGATCCTGTTCCAG | GCC    c.900
 L  F  L  G  R  R  A  C  I  I  H  G  V  L  Q  I  L  F  Q   | A      p.300

          .         .         .         .         .         .       g.115040
 GTCCTCATCGTCAGCGGGAACCTCAGCTTCCTGAACTGGCTGACTATGGTGCCCAGCCTG       c.960
 V  L  I  V  S  G  N  L  S  F  L  N  W  L  T  M  V  P  S  L         p.320

          .         .         .         .         .         .       g.115100
 GCCTGCTTTGATGACGCCACCCTGGGATTCTTGTTCCCCTCTGGGCCAGGCAGCCTGAAG       c.1020
 A  C  F  D  D  A  T  L  G  F  L  F  P  S  G  P  G  S  L  K         p.340

          .         .         .         .         .         | 08    g.115438
 GACCGAGTTCTGCAGATGCAGAGGGACATCCGAGGGGCCCGGCCCGAGCCCAGATTCG | GC    c.1080
 D  R  V  L  Q  M  Q  R  D  I  R  G  A  R  P  E  P  R  F  G |       p.360

          .         .         .         .         .         .       g.115498
 TCCGTGGTGCGGCGTGCAGCCAACGTCTCGCTGGGCGTCCTGCTGGCCTGGCTCAGCGTG       c.1140
 S  V  V  R  R  A  A  N  V  S  L  G  V  L  L  A  W  L  S  V         p.380

          .         .         .         .         .         .       g.115558
 CCCGTGGTCCTCAACTTGCTGAGCTCCAGGCAGGTCATGAACACCCACTTCAACTCTCTT       c.1200
 P  V  V  L  N  L  L  S  S  R  Q  V  M  N  T  H  F  N  S  L         p.400

          .         .         .   | 09     .         .         .    g.116280
 CACATCGTCAACACTTACGGGGCCTTCGGAAG | CATCACCAAGGAGCGGGCGGAGGTGATC    c.1260
 H  I  V  N  T  Y  G  A  F  G  S  |  I  T  K  E  R  A  E  V  I      p.420

          .         .         .         .         .         .       g.116340
 CTGCAGGGCACAGCCAGCTCCAACGCCAGCGCCCCCGATGCCATGTGGGAGGACTACGAG       c.1320
 L  Q  G  T  A  S  S  N  A  S  A  P  D  A  M  W  E  D  Y  E         p.440

          .         .         .         .         .         .       g.116400
 TTCAAGTGCAAGCCAGGTGACCCCAGCAGACGGCCCTGCCTCATCTCCCCGTACCACTAC       c.1380
 F  K  C  K  P  G  D  P  S  R  R  P  C  L  I  S  P  Y  H  Y         p.460

          .         .         .       | 10 .         .         .    g.117286
 CGCCTGGACTGGCTGATGTGGTTCGCGGCCTTCCAG | ACCTACGAGCACAACGACTGGATC    c.1440
 R  L  D  W  L  M  W  F  A  A  F  Q   | T  Y  E  H  N  D  W  I      p.480

          .         .         .         .         .         .       g.117346
 ATCCACCTGGCTGGCAAGCTCCTGGCCAGCGACGCCGAGGCCTTGTCCCTGCTGGCACAC       c.1500
 I  H  L  A  G  K  L  L  A  S  D  A  E  A  L  S  L  L  A  H         p.500

          .         .          | 11        .         .         .    g.131643
 AACCCCTTCGCGGGCAGGCCCCCGCCCAG | GTGGGTCCGAGGAGAGCACTACAGGTACAAG    c.1560
 N  P  F  A  G  R  P  P  P  R  |  W  V  R  G  E  H  Y  R  Y  K      p.520

          .         .         .         .         .         .       g.131703
 TTCAGCCGTCCTGGGGGCAGGCACGCCGCCGAGGGCAAGTGGTGGGTGCGGAAGAGGATC       c.1620
 F  S  R  P  G  G  R  H  A  A  E  G  K  W  W  V  R  K  R  I         p.540

          .         .         .         .         .         .       g.131763
 GGAGCCTACTTCCCTCCGCTCAGCCTGGAGGAGCTGAGGCCCTACTTCAGGGACCGTGGG       c.1680
 G  A  Y  F  P  P  L  S  L  E  E  L  R  P  Y  F  R  D  R  G         p.560

          .         .                                               g.131787
 TGGCCTCTGCCCGGGCCCCTCTAG                                           c.1704
 W  P  L  P  G  P  L  X                                             p.567

          .         .         .         .         .         .       g.131847
 acgtgcaccagaaataaaggcgaagacccagcccctcggcggctcagcaacgtttgccct       c.*60

          .         .         .         .         .         .       g.131907
 tccctgcgcccagcccaagctgggcatcgccaagagagacgtggagaggagagcggtggg       c.*120

          .         .         .         .         .         .       g.131967
 acccagcccccagcacgggggtccagggtggggtctgttgtcacatactgtggcggctcc       c.*180

          .         .         .         .         .         .       g.132027
 caggccctgcccacctggggccccacatccaggccaacccttgtcccaggcgccaggggc       c.*240

          .         .         .         .         .         .       g.132087
 tctgatctcccatccatcccaccctcctcccagaggcccagcctggggctgtgccgccca       c.*300

          .         .         .         .         .         .       g.132147
 caggagttgagacaatggccatcctgacaccttcctccactacagccctgaccatagacc       c.*360

          .         .         .         .         .         .       g.132207
 cagccaggtagctcttggggtctctagcgtcccagggcctggtttctgttccctcttcaa       c.*420

          .         .         .         .         .         .       g.132267
 tggtgtgttcccagccaggtcctgaccctcagagccaagtccctgtcacgtctggggcag       c.*480

          .         .         .         .         .         .       g.132327
 ccaaaccctcgccccacagggacctggacacgcccggccaggatgtggggttggatgggc       c.*540

          .         .         .         .         .         .       g.132387
 cattttctgtcctatccctcatctccacccccgccacagcctacacgcatcccacacatg       c.*600

          .         .         .         .         .         .       g.132447
 caggcacacacagcctgtgcacacatgtgttcttggcccggtttcatccccccatgactg       c.*660

          .         .         .         .         .         .       g.132507
 gtgtctgtgaggtgcagatggacacagcgcacacccagaccctccaccaggctgtgacct       c.*720

          .         .         .         .         .         .       g.132567
 cgctgcctctgaggccttgacaaggcccctcaatcggaggacagccggccgtgcacactt       c.*780

          .         .         .         .         .         .       g.132627
 tcatcatcgtcggacaaacagcgtctactgcacatttttcttattcctattcttgagcca       c.*840

          .         .         .         .         .                 g.132685
 tagctatggcatattcttctactattcctattataccacttaccagcttactcgaaaa         c.*898

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lipase maturation factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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