lamin B1 (LMNB1) - coding DNA reference sequence

(used for variant description)

(last modified September 19, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_005573.3 in the LMNB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008360.2, covering LMNB1 transcript NM_005573.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               ggagcgggggataaggttaccacgcccgcggtggccggggacactc       c.-841

 .         .         .         .         .         .                g.5106
 tgagtttcgcgtgtggcttttagggacgtttatatttgaatttccctgaaccgccgagtg       c.-781

 .         .         .         .         .         .                g.5166
 tgggcggtggcgcagatccgtcccggaaacctccgggctccttcccgcctttctcaggcc       c.-721

 .         .         .         .         .         .                g.5226
 cggcccctccaaggggtccccgcggggcggcgggagggccctgggcccagagccgcgcgg       c.-661

 .         .         .         .         .         .                g.5286
 gtgggcagtcccaggcgtccttccttacagccctgagcctggtccgggaaccgcccagcc       c.-601

 .         .         .         .         .         .                g.5346
 gggagggccgagctgacggttgcccaagggccagattttaaatttacaggcccggccccc       c.-541

 .         .         .         .         .         .                g.5406
 gaaccgccgaagcgcgctgcctgctccccattggcccatggtagtcacgtggaggcgccg       c.-481

 .         .         .         .         .         .                g.5466
 gggcgtgccggccatgttggggagtgcggcgccgcggcccgcgccacctccgccccccgc       c.-421

 .         .         .         .         .         .                g.5526
 ggcttgcctccagcccgcccctcccggccctcctccccccgcccgccgctccgtgcagcc       c.-361

 .         .         .         .         .         .                g.5586
 tgagaggaaacaaagtgctgcgagcaggagacggcggcggcgcgaaccctgctgggcctc       c.-301

 .         .         .         .         .         .                g.5646
 cagtcaccctcgtcttgcattttcccgcgtgcgtgtgtgagtgggtgtgtgtgttttctt       c.-241

 .         .         .         .         .         .                g.5706
 acaaagggtatttcgcgatcgatcgattgattcgtagttcccccccgcgcgcctttgccc       c.-181

 .         .         .         .         .         .                g.5766
 tttgtgctgtaatcgagctcccgccatcccaggtgcttctccgttcctctaaacgccagc       c.-121

 .         .         .         .         .         .                g.5826
 gtctggacgtgagcgcaggtcgccggtttgtgccttcggtccccgcttcgccccctgccg       c.-61

 .         .         .         .         .         .                g.5886
 tcccctccttatcacggtcccgctcgcggcctcgccgccccgctgtctccgccgcccgcc       c.-1

          .         .         .         .         .         .       g.5946
 ATGGCGACTGCGACCCCCGTGCCGCCGCGGATGGGCAGCCGCGCTGGCGGCCCCACCACG       c.60
 M  A  T  A  T  P  V  P  P  R  M  G  S  R  A  G  G  P  T  T         p.20

          .         .         .         .         .         .       g.6006
 CCGCTGAGCCCCACGCGCCTGTCGCGGCTCCAGGAGAAGGAGGAGCTGCGCGAGCTCAAT       c.120
 P  L  S  P  T  R  L  S  R  L  Q  E  K  E  E  L  R  E  L  N         p.40

          .         .         .         .         .         .       g.6066
 GACCGGCTGGCGGTGTACATCGACAAGGTGCGCAGCCTGGAGACGGAGAACAGCGCGCTG       c.180
 D  R  L  A  V  Y  I  D  K  V  R  S  L  E  T  E  N  S  A  L         p.60

          .         .         .         .         .         .       g.6126
 CAGCTGCAGGTGACGGAGCGCGAGGAGGTGCGCGGCCGTGAGCTCACCGGCCTCAAGGCG       c.240
 Q  L  Q  V  T  E  R  E  E  V  R  G  R  E  L  T  G  L  K  A         p.80

          .         .         .         .         .         .       g.6186
 CTCTACGAGACCGAGCTGGCCGACGCGCGACGCGCGCTCGACGACACGGCCCGCGAGCGC       c.300
 L  Y  E  T  E  L  A  D  A  R  R  A  L  D  D  T  A  R  E  R         p.100

          .         .         .         .         .          | 02    g.33154
 GCCAAGCTGCAGATCGAGCTGGGCAAGTGCAAGGCGGAACACGACCAGCTGCTCCTCAA | C    c.360
 A  K  L  Q  I  E  L  G  K  C  K  A  E  H  D  Q  L  L  L  N  |      p.120

          .         .         .         .         .         .       g.33214
 TATGCTAAGAAGGAATCTGATCTTAATGGCGCCCAGATCAAGCTTCGAGAATATGAAGCA       c.420
 Y  A  K  K  E  S  D  L  N  G  A  Q  I  K  L  R  E  Y  E  A         p.140

          .         .         .         .         .         .       g.33274
 GCACTGAATTCGAAAGATGCAGCTCTTGCTACTGCACTTGGTGACAAAAAAAGTTTAGAG       c.480
 A  L  N  S  K  D  A  A  L  A  T  A  L  G  D  K  K  S  L  E         p.160

          .         .         .       | 03 .         .         .    g.33972
 GGAGATTTGGAGGATCTGAAGGATCAGATTGCCCAG | TTGGAAGCCTCCTTAGCTGCAGCC    c.540
 G  D  L  E  D  L  K  D  Q  I  A  Q   | L  E  A  S  L  A  A  A      p.180

          .         .         .         .         .         .       g.34032
 AAAAAACAGTTAGCAGATGAAACTTTACTTAAAGTAGATTTGGAGAATCGTTGTCAGAGC       c.600
 K  K  Q  L  A  D  E  T  L  L  K  V  D  L  E  N  R  C  Q  S         p.200

          .         .         .         .   | 04     .         .    g.38575
 CTTACTGAGGACTTGGAGTTTCGCAAAAGCATGTATGAAGAG | GAGATTAACGAGACCAGA    c.660
 L  T  E  D  L  E  F  R  K  S  M  Y  E  E   | E  I  N  E  T  R      p.220

          .         .         .         .         .         .       g.38635
 AGGAAGCATGAAACGCGCTTGGTAGAGGTGGATTCTGGGCGTCAAATTGAGTATGAGTAC       c.720
 R  K  H  E  T  R  L  V  E  V  D  S  G  R  Q  I  E  Y  E  Y         p.240

          .         .         .         .         .         .       g.38695
 AAGCTGGCGCAAGCCCTTCATGAGATGAGAGAGCAACATGATGCCCAAGTGAGGCTGTAT       c.780
 K  L  A  Q  A  L  H  E  M  R  E  Q  H  D  A  Q  V  R  L  Y         p.260

          .         .         .    | 05    .         .         .    g.40177
 AAGGAGGAGCTGGAGCAGACTTACCATGCCAAA | CTTGAGAATGCCAGACTGTCATCAGAG    c.840
 K  E  E  L  E  Q  T  Y  H  A  K   | L  E  N  A  R  L  S  S  E      p.280

          .         .         .         .         .         .       g.40237
 ATGAATACTTCTACTGTCAACAGTGCCAGGGAAGAACTGATGGAAAGCCGCATGAGAATT       c.900
 M  N  T  S  T  V  N  S  A  R  E  E  L  M  E  S  R  M  R  I         p.300

          .         .         .          | 06        .         .    g.47320
 GAGAGCCTTTCATCCCAGCTTTCTAATCTACAGAAAGAG | TCTAGAGCATGTTTGGAAAGG    c.960
 E  S  L  S  S  Q  L  S  N  L  Q  K  E   | S  R  A  C  L  E  R      p.320

          .         .         .         .         .         .       g.47380
 ATTCAAGAATTAGAGGACTTGCTTGCTAAAGAAAAAGACAACTCTCGTCGCATGCTGACA       c.1020
 I  Q  E  L  E  D  L  L  A  K  E  K  D  N  S  R  R  M  L  T         p.340

          .         .         .         .         .         .       g.47440
 GACAAAGAGAGAGAGATGGCGGAAATAAGGGATCAAATGCAGCAACAGCTGAATGACTAT       c.1080
 D  K  E  R  E  M  A  E  I  R  D  Q  M  Q  Q  Q  L  N  D  Y         p.360

          .         .         .         .         .         .       g.47500
 GAACAGCTTCTTGATGTAAAGTTAGCCCTGGACATGGAAATCAGTGCTTACAGGAAACTC       c.1140
 E  Q  L  L  D  V  K  L  A  L  D  M  E  I  S  A  Y  R  K  L         p.380

          .         . | 07       .         .         .         .    g.49327
 TTAGAAGGCGAAGAAGAGAG | GTTGAAGCTGTCTCCAAGCCCTTCTTCCCGTGTGACAGTA    c.1200
 L  E  G  E  E  E  R  |  L  K  L  S  P  S  P  S  S  R  V  T  V      p.400

          .         .         .         .         .         .       g.49387
 TCCCGAGCATCCTCAAGTCGTAGTGTACGTACAACTAGAGGAAAGCGGAAGAGGGTTGAT       c.1260
 S  R  A  S  S  S  R  S  V  R  T  T  R  G  K  R  K  R  V  D         p.420

          .         .         .         .         .         .       g.49447
 GTGGAAGAATCAGAGGCGAGTAGTAGTGTTAGCATCTCTCATTCCGCCTCAGCCACTGGA       c.1320
 V  E  E  S  E  A  S  S  S  V  S  I  S  H  S  A  S  A  T  G         p.440

          .         .         .         .         .         .       g.49507
 AATGTTTGCATCGAAGAAATTGATGTTGATGGGAAATTTATCCGCTTGAAGAACACTTCT       c.1380
 N  V  C  I  E  E  I  D  V  D  G  K  F  I  R  L  K  N  T  S         p.460

        | 08 .         .         .         .         .         .    g.51212
 GAACAG | GATCAACCAATGGGAGGCTGGGAGATGATCAGAAAAATTGGAGACACATCAGTC    c.1440
 E  Q   | D  Q  P  M  G  G  W  E  M  I  R  K  I  G  D  T  S  V      p.480

          .         .         .         .         .  | 09      .    g.54374
 AGTTATAAATATACCTCAAGATATGTGCTGAAGGCAGGCCAGACTGTTACA | ATTTGGGCT    c.1500
 S  Y  K  Y  T  S  R  Y  V  L  K  A  G  Q  T  V  T   | I  W  A      p.500

          .         .         .         .         .         .       g.54434
 GCAAACGCTGGTGTCACAGCCAGCCCCCCAACTGACCTCATCTGGAAGAACCAGAACTCG       c.1560
 A  N  A  G  V  T  A  S  P  P  T  D  L  I  W  K  N  Q  N  S         p.520

          .         .         .         .         .  | 10      .    g.61080
 TGGGGCACTGGCGAAGATGTGAAGGTTATATTGAAAAATTCTCAGGGAGAG | GAGGTTGCT    c.1620
 W  G  T  G  E  D  V  K  V  I  L  K  N  S  Q  G  E   | E  V  A      p.540

          .         .         .         .         .         .       g.61140
 CAAAGAAGTACAGTCTTTAAAACAACCATACCTGAAGAAGAGGAGGAGGAGGAAGAAGCA       c.1680
 Q  R  S  T  V  F  K  T  T  I  P  E  E  E  E  E  E  E  E  A         p.560

          .         .         .          | 11        .         .    g.64621
 GCTGGAGTGGTTGTTGAGGAAGAACTTTTCCACCAGCAG | GGAACCCCAAGAGCATCCAAT    c.1740
 A  G  V  V  V  E  E  E  L  F  H  Q  Q   | G  T  P  R  A  S  N      p.580

          .         .                                               g.64642
 AGAAGCTGTGCAATTATGTAA                                              c.1761
 R  S  C  A  I  M  X                                                p.586

          .         .         .         .         .         .       g.64702
 aattttcaactgtcttcctcaaaataaagaagtatggtaatctttacctgtatacagtgc       c.*60

          .         .         .         .         .         .       g.64762
 agagccttctcagaagcacagaatatttttatatttcctttatgtgaatttttaagctgc       c.*120

          .         .         .         .         .         .       g.64822
 aaatctgatggccttaatttcctttttgacactgaaagttttgtaaaagaaatcatgtcc       c.*180

          .         .         .         .         .         .       g.64882
 atacactttgttgcaagatgtgaattattgacactgaacttaataactgtgtactgttcg       c.*240

          .         .         .         .         .         .       g.64942
 gaaggggttcctcaaattttttgactttttttgtatgtgtgttttttctttttttttaag       c.*300

          .         .         .         .         .         .       g.65002
 ttcttatgaggaggggagggtaaataaaccactgtgcgtcttggtgtaatttgaagattg       c.*360

          .         .         .         .         .         .       g.65062
 ccccatctagactagcaatctcttcattattctctgctatatataaaacggtgctgtgag       c.*420

          .         .         .         .         .         .       g.65122
 ggaggggaaaagcatttttcaatatattgaacttttgtactgaatttttttgtaataagc       c.*480

          .         .         .         .         .         .       g.65182
 aatcaaggttataattttttttaaaatagaaattttgtaagaaggcaatattaacctaat       c.*540

          .         .         .         .         .         .       g.65242
 caccatgtaagcactctggatgatggattccacaaaacttggttttatggttacttcttc       c.*600

          .         .         .         .         .         .       g.65302
 tcttagattcttaattcatgaggagggtgggggagggaggtggagggagggaagggtttc       c.*660

          .         .         .         .         .         .       g.65362
 tctattaaaatgcattcgttgtgttttttaagatagtgtaacttgcttaaatttcttatg       c.*720

          .         .         .                                     g.65398
 tgacattaacaaataaaaaagctcttttaatattga                               c.*756

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lamin B1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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