leiomodin 3 (fetal) (LMOD3) - coding DNA reference sequence

(used for variant description)

(last modified December 22, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_198271.3 in the LMOD3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering LMOD3 transcript NM_198271.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                aatatagatccggcaagagcttagctgtg       c.-181

 .         .         .         .         .         .                g.5089
 atcactcctagctgctcagcaaaccactgaggttcctgggaaaaaaaaaaaaatatctca       c.-121

 .         .         .         .         .         .                g.5149
 agggtgtgttaacttgggacactcgttaactgggggaccttcttgaggcttttttccttc       c.-61

 .         .         .         .         .         .                g.5209
 tttttaaaaatcatctttgattattcttcttttctagtaaaataatatttagaaaaaata       c.-1

          .         .         .         .         .         .       g.5269
 ATGTCAGAGCACAGCAGAAATTCAGATCAAGAAGAACTTCTCGATGAGGAGATTAATGAA       c.60
 M  S  E  H  S  R  N  S  D  Q  E  E  L  L  D  E  E  I  N  E         p.20

          .         .         .         .         .         .       g.5329
 GATGAAATCTTGGCCAACTTGTCTGCTGAAGAACTGAAAGAACTGCAGTCGGAAATGGAA       c.120
 D  E  I  L  A  N  L  S  A  E  E  L  K  E  L  Q  S  E  M  E         p.40

          .         .         .         .         .         .       g.5389
 GTCATGGCCCCTGACCCCAGCCTTCCCGTGGGAATGATTCAGAAAGATCAAACTGACAAG       c.180
 V  M  A  P  D  P  S  L  P  V  G  M  I  Q  K  D  Q  T  D  K         p.60

          .         .         .         .         .         .       g.5449
 CCACCGACAGGAAACTTCAATCATAAATCTCTTGTTGATTATATGTATTGGGAAAAGGCA       c.240
 P  P  T  G  N  F  N  H  K  S  L  V  D  Y  M  Y  W  E  K  A         p.80

          .         .         .         .         .     | 02   .    g.7541
 TCCAGGCGCATGCTGGAAGAGGAACGAGTTCCTGTCACCTTTGTGAAATCCGAG | GAAAAG    c.300
 S  R  R  M  L  E  E  E  R  V  P  V  T  F  V  K  S  E   | E  K      p.100

          .         .         .         .         .         .       g.7601
 ACTCAAGAAGAGCATGAAGAAATAGAAAAACGTAATAAAAATATGGCCCAGTATTTAAAA       c.360
 T  Q  E  E  H  E  E  I  E  K  R  N  K  N  M  A  Q  Y  L  K         p.120

          .         .         .         .         .         .       g.7661
 GAAAAGCTCAATAATGAAATAGTTGCAAATAAAAGAGAATCAAAGGGCAGCAGCAATATC       c.420
 E  K  L  N  N  E  I  V  A  N  K  R  E  S  K  G  S  S  N  I         p.140

          .         .         .         .         .         .       g.7721
 CAAGAAACAGATGAAGAAGATGAAGAAGAAGAAGATGATGATGATGACGACGAAGGAGAA       c.480
 Q  E  T  D  E  E  D  E  E  E  E  D  D  D  D  D  D  E  G  E         p.160

          .         .         .         .         .         .       g.7781
 GATGATGGTGAAGAGAGTGAAGAAACGAACAGAGAAGAGGAAGGCAAAGCAAAGGAACAA       c.540
 D  D  G  E  E  S  E  E  T  N  R  E  E  E  G  K  A  K  E  Q         p.180

          .         .         .         .         .         .       g.7841
 ATTAGAAATTGTGAGAACAACTGCCAGCAGGTAACTGACAAAGCATTCAAAGAACAGAGA       c.600
 I  R  N  C  E  N  N  C  Q  Q  V  T  D  K  A  F  K  E  Q  R         p.200

          .         .         .         .         .         .       g.7901
 GACAGACCAGAGGCCCAAGAACAAAGTGAGAAAAAAATATCGAAATTAGATCCTAAGAAG       c.660
 D  R  P  E  A  Q  E  Q  S  E  K  K  I  S  K  L  D  P  K  K         p.220

          .         .         .         .         .         .       g.7961
 TTAGCTCTAGACACCAGCTTTTTGAAGGTAAGTACAAGGCCTTCAGGAAACCAGACAGAC       c.720
 L  A  L  D  T  S  F  L  K  V  S  T  R  P  S  G  N  Q  T  D         p.240

          .         .         .         .         .         .       g.8021
 CTGGATGGGAGCTTGAGGAGAGTTAGGAAAAATGATCCTGACATGAAGGAACTCAACCTG       c.780
 L  D  G  S  L  R  R  V  R  K  N  D  P  D  M  K  E  L  N  L         p.260

          .         .         .         .         .         .       g.8081
 AACAACATTGAAAACATCCCCAAAGAAATGTTACTGGACTTTGTCAATGCAATGAAGAAA       c.840
 N  N  I  E  N  I  P  K  E  M  L  L  D  F  V  N  A  M  K  K         p.280

          .         .         .         .         .         .       g.8141
 AACAAGCACATCAAAACATTCAGTTTAGCCAATGTGGGTGCAGATGAGAATGTAGCATTT       c.900
 N  K  H  I  K  T  F  S  L  A  N  V  G  A  D  E  N  V  A  F         p.300

          .         .         .         .         .         .       g.8201
 GCCTTGGCTAACATGTTGCGTGAAAATAGAAGCATCACCACTCTCAACATCGAGTCCAAT       c.960
 A  L  A  N  M  L  R  E  N  R  S  I  T  T  L  N  I  E  S  N         p.320

          .         .         .         .         .         .       g.8261
 TTCATCACAGGTAAAGGGATTGTGGCCATCATGAGGTGTCTCCAGTTTAATGAGACGCTA       c.1020
 F  I  T  G  K  G  I  V  A  I  M  R  C  L  Q  F  N  E  T  L         p.340

          .         .         .         .         .         .       g.8321
 ACTGAGCTTCGGTTTCACAATCAGAGGCACATGTTGGGTCACCATGCTGAAATGGAAATA       c.1080
 T  E  L  R  F  H  N  Q  R  H  M  L  G  H  H  A  E  M  E  I         p.360

          .         .         .         .         .         .       g.8381
 GCCAGGCTTTTGAAGGCAAACAACACTCTCCTGAAGATGGGCTACCATTTTGAGCTTCCG       c.1140
 A  R  L  L  K  A  N  N  T  L  L  K  M  G  Y  H  F  E  L  P         p.380

          .         .         .         .         .         .       g.8441
 GGTCCCAGAATGGTGGTCACTAATCTGCTCACCAGGAATCAGGATAAACAAAGGCAGAAA       c.1200
 G  P  R  M  V  V  T  N  L  L  T  R  N  Q  D  K  Q  R  Q  K         p.400

          .         .         .         .         .         .       g.8501
 CGACAGGAAGAGCAAAAACAGCAGCAACTCAAGGAACAGAAGAAGCTGATAGCCATGTTA       c.1260
 R  Q  E  E  Q  K  Q  Q  Q  L  K  E  Q  K  K  L  I  A  M  L         p.420

          .         .         .         .         .         .       g.8561
 GAGAATGGGTTGGGGCTGCCCCCTGGGATGTGGGAGCTGTTGGGAGGACCCAAGCCAGAT       c.1320
 E  N  G  L  G  L  P  P  G  M  W  E  L  L  G  G  P  K  P  D         p.440

          .         .         .         .         .         .       g.8621
 TCCAGAATGCAGGAATTCTTCCAGCCACCGCCACCTCGGCCTCCCAACCCCCAAAATGTC       c.1380
 S  R  M  Q  E  F  F  Q  P  P  P  P  R  P  P  N  P  Q  N  V         p.460

          .         .         .         .         .         .       g.8681
 CCCTTTAGTCAACGCAGTGAAATGATGAAAAAGCCATCGCAGGCCCCGAAGTACAGGACA       c.1440
 P  F  S  Q  R  S  E  M  M  K  K  P  S  Q  A  P  K  Y  R  T         p.480

          .         .         .         .         .         .       g.8741
 GACCCTGACTCCTTCCGGGTGGTGAAGCTGAAGAGAATCCAGCGCAAATCTCGGATGCCG       c.1500
 D  P  D  S  F  R  V  V  K  L  K  R  I  Q  R  K  S  R  M  P         p.500

          .         .         .         .         .         .       g.8801
 GAAGCCAGAGAACCACCCGAGAAAACCAACCTCAAAGATGTCATCAAAACGCTCAAGCCA       c.1560
 E  A  R  E  P  P  E  K  T  N  L  K  D  V  I  K  T  L  K  P         p.520

          .         .         .         .         .         .       g.8861
 GTGCCGAGAAACAGGCCACCCCCATTGGTGGAAATCACTCCCAGAGATCAGCTGCTAAAC       c.1620
 V  P  R  N  R  P  P  P  L  V  E  I  T  P  R  D  Q  L  L  N         p.540

          .         .         .       | 03 .         .         .    g.18498
 GACATTCGTCACAGCAGTGTCGCCTATCTTAAACCT | GTGCAACTGCCAAAAGAACTGGCG    c.1680
 D  I  R  H  S  S  V  A  Y  L  K  P   | V  Q  L  P  K  E  L  A      p.560

                                                                    g.18501
 TAA                                                                c.1683
 X                                                                  p.560

          .         .         .         .         .         .       g.18561
 gaggcaacagagccatctagaagaacaagaaatggaaatagtgactcttggattacagca       c.*60

          .         .         .         .         .         .       g.18621
 tggagactatgtcagcagcaatactttaggatccacgtggcagaactggaaacaatgcta       c.*120

          .         .         .         .         .         .       g.18681
 ccatctgataagggtatttgtaaaaggcagaatgtttgggccatgaagaagtaggggctg       c.*180

          .         .         .         .         .         .       g.18741
 aagaggaaggtggaaggagataaaatataatatttagaggcaatattttctacttgcaat       c.*240

          .         .         .         .         .         .       g.18801
 caatttgagtgactcaggtgaaatttagagtcatatttcccgaagcagaagttaaagaaa       c.*300

          .         .         .         .         .         .       g.18861
 attttttaaacatttgctttattattgttttcttctggtaaataataaatataacagaag       c.*360

          .         .         .         .         .         .       g.18921
 tgttaactattgtattcccatttttttctccttccatctcttctgcggtaattcatcaca       c.*420

          .         .         .         .         .         .       g.18981
 tagtatcttaaagggaacaaataatgtttcatcctatggaaatgtgaaggatgaattgag       c.*480

          .         .         .         .         .         .       g.19041
 ctcctggcccttctgatgctttgaaatggaaggattgttccttagagcttctctgcagaa       c.*540

          .         .         .         .         .         .       g.19101
 tcagtggagattttcagtttcccaccctgcctggctttctctcttggtgactcccttggt       c.*600

          .         .         .         .         .         .       g.19161
 gttttggagtattctttctataggggtacctgtgaggggcagaacacgtaagccacagaa       c.*660

          .         .         .         .         .         .       g.19221
 catggtgaaaactaagtgtcactaggaaaagtaatgggaaagtaaaccctgcatatatga       c.*720

          .         .         .         .         .         .       g.19281
 aaacttcctggcagcaagttttcatatatagagggacaatgggagacagcatgctgtttt       c.*780

          .         .         .         .         .         .       g.19341
 tatagaaaagaagttttacataatatagttattgacaagcttttggttttggctaaatac       c.*840

          .         .         .         .         .         .       g.19401
 acacacacacacacacgctcatatgtgtttactctgtaagtctaatttgattttatcact       c.*900

          .         .         .         .         .         .       g.19461
 ctcaaacatattttaaaggaaacttgcttacaggaaggattaaacttgaactacttatcc       c.*960

          .         .         .         .         .         .       g.19521
 tattctttaaggcactccattgcctggccccaatttactaatcctgtcttatttcccaca       c.*1020

          .         .         .         .         .         .       g.19581
 aatcctttatactctactcgatgaaacatccttgtgcacacccttgtgcctttgctcgca       c.*1080

          .         .         .         .         .         .       g.19641
 ttaatccttccaagagacttccctcctgttctccattaatgaacgtcctacccagtcttc       c.*1140

          .         .         .         .         .         .       g.19701
 aactcccgggtcagatcctgtgtcctccataaaaaattttccagacaactccaatctgtc       c.*1200

          .         .         .         .         .         .       g.19761
 cttcttccaagttcctagaggccttaattattcattctagccactaggtgcatagaattt       c.*1260

          .         .         .         .         .         .       g.19821
 gagatttttgtaataatagaagtagtgtgaaccctagaaattagaaaatcaagctttggg       c.*1320

          .         .         .         .         .         .       g.19881
 ccaggtgcggtggctcatgcctgtaatcccagcactatgggaggccagggagggaggatc       c.*1380

          .         .         .         .         .         .       g.19941
 tccagaggtcaggagttcgagaccagcctggccaacatggtgaaaccccgtctctattaa       c.*1440

          .         .         .         .         .         .       g.20001
 aaatacaaaaattagctgggcatgatggcaggcacctgtaatcccagctactcgggaggc       c.*1500

          .         .         .         .         .         .       g.20061
 tgaggcaggagaattgcttgaactggggaggcagaggttgcagtgagacaagatcacgtc       c.*1560

          .         .         .         .         .         .       g.20121
 actgtactccagcctgggtgacagagtgatactccatctcaaaaaaaaaaaaaaaaaaaa       c.*1620

          .         .         .         .         .         .       g.20181
 aaaaaaaaaaaaaaaaaaaaacctttggtgccttttctctcttctttacctgagtaaata       c.*1680

          .         .         .         .         .         .       g.20241
 attggcacctgccttctttctccttttatgttatcataagtggcatgtatcaaaccaaac       c.*1740

          .         .         .         .         .         .       g.20301
 aggctaggggagaataggtctaattgtgacagacttaaaaacaacacattatttggaaag       c.*1800

          .         .         .         .         .         .       g.20361
 acaagccatgggaaagaaatatggcgtttctatttttttaagataatttagtatgtacaa       c.*1860

          .         .         .         .         .         .       g.20421
 aagtatccaaatttaaatatagttttcaatggctgatagttttgttttctcacccttcaa       c.*1920

          .         .         .         .         .         .       g.20481
 tatttctagaaaacatccttgcatacaaagcaggatagctaagaaagggctgtaacaaac       c.*1980

          .         .         .         .         .         .       g.20541
 aaaacttcaagtgtctagcacatactacatctaagaggctaaactctgataggaaaagca       c.*2040

          .         .         .         .         .         .       g.20601
 ctttaaacataattaaaagcttaatgtaaattagtagttgaaattctaggccggtgcggt       c.*2100

          .         .         .         .         .         .       g.20661
 ggctcatgcctgtaatcccagcactgtaggcggccgaggtgggtgaatcacatgaggtca       c.*2160

          .         .         .         .                           g.20708
 ggagttcaagaccagcctgaccaacatggtgaaaccccatttctact                    c.*2207

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Leiomodin 3 (fetal) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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