lysyl oxidase (LOX) - coding DNA reference sequence

(used for variant description)

(last modified September 21, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_002317.5 in the LOX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering LOX transcript NM_002317.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              attacgtgaacaaat       c.-361

 .         .         .         .         .         .                g.5075
 agctgaggggcggccgggccagaacggcttgtgtaactttgcaaacgtgccagaaagttt       c.-301

 .         .         .         .         .         .                g.5135
 aaaatctctcctccttccttcactccagacactgcccgctctccgggactgccgcgccgc       c.-241

 .         .         .         .         .         .                g.5195
 tccccgttgccttccaggactgagaaaggggaaagggaagggtgccacgtccgagcagcc       c.-181

 .         .         .         .         .         .                g.5255
 gccttgactggggaagggtctgaatcccacccttggcattgcttggtggagactgagata       c.-121

 .         .         .         .         .         .                g.5315
 cccgtgctccgctcgcctccttggttgaagatttctccttccctcacgtgatttgagccc       c.-61

 .         .         .         .         .         .                g.5375
 cgtttttattttctgtgagccacgtcctcctcgagcggggtcaatctggcaaaaggagtg       c.-1

          .         .         .         .         .         .       g.5435
 ATGCGCTTCGCCTGGACCGTGCTCCTGCTCGGGCCTTTGCAGCTCTGCGCGCTAGTGCAC       c.60
 M  R  F  A  W  T  V  L  L  L  G  P  L  Q  L  C  A  L  V  H         p.20

          .         .         .         .         .         .       g.5495
 TGCGCCCCTCCCGCCGCCGGCCAACAGCAGCCCCCGCGCGAGCCGCCGGCGGCTCCGGGC       c.120
 C  A  P  P  A  A  G  Q  Q  Q  P  P  R  E  P  P  A  A  P  G         p.40

          .         .         .         .         .         .       g.5555
 GCCTGGCGCCAGCAGATCCAATGGGAGAACAACGGGCAGGTGTTCAGCTTGCTGAGCCTG       c.180
 A  W  R  Q  Q  I  Q  W  E  N  N  G  Q  V  F  S  L  L  S  L         p.60

          .         .         .         .         .         .       g.5615
 GGCTCACAGTACCAGCCTCAGCGCCGCCGGGACCCGGGCGCCGCCGTCCCTGGTGCAGCC       c.240
 G  S  Q  Y  Q  P  Q  R  R  R  D  P  G  A  A  V  P  G  A  A         p.80

          .         .         .         .         .         .       g.5675
 AACGCCTCCGCCCAGCAGCCCCGCACTCCGATCCTGCTGATCCGCGACAACCGCACCGCC       c.300
 N  A  S  A  Q  Q  P  R  T  P  I  L  L  I  R  D  N  R  T  A         p.100

          .         .         .         .         .         .       g.5735
 GCGGCGCGAACGCGGACGGCCGGCTCATCTGGAGTCACCGCTGGCCGCCCCAGGCCCACC       c.360
 A  A  R  T  R  T  A  G  S  S  G  V  T  A  G  R  P  R  P  T         p.120

          .         .         .         .         .         .       g.5795
 GCCCGTCACTGGTTCCAAGCTGGCTACTCGACATCTAGAGCCCGCGAAGCTGGCGCCTCG       c.420
 A  R  H  W  F  Q  A  G  Y  S  T  S  R  A  R  E  A  G  A  S         p.140

          .         .         .         .         .         .       g.5855
 CGCGCGGAGAACCAGACAGCGCCGGGAGAAGTTCCTGCGCTCAGTAACCTGCGGCCGCCC       c.480
 R  A  E  N  Q  T  A  P  G  E  V  P  A  L  S  N  L  R  P  P         p.160

          .         .         .         .         .         .       g.5915
 AGCCGCGTGGACGGCATGGTGGGCGACGACCCTTACAACCCCTACAAGTACTCTGACGAC       c.540
 S  R  V  D  G  M  V  G  D  D  P  Y  N  P  Y  K  Y  S  D  D         p.180

          .         .         .         .         .         .       g.5975
 AACCCTTATTACAACTACTACGATACTTATGAAAGGCCCAGACCTGGGGGCAGGTACCGG       c.600
 N  P  Y  Y  N  Y  Y  D  T  Y  E  R  P  R  P  G  G  R  Y  R         p.200

          .         .         .  | 02      .         .         .    g.6388
 CCCGGATACGGCACTGGCTACTTCCAGTACG | GTCTCCCAGACCTGGTGGCCGACCCCTAC    c.660
 P  G  Y  G  T  G  Y  F  Q  Y  G |   L  P  D  L  V  A  D  P  Y      p.220

          .         .         .         .         .         .       g.6448
 TACATCCAGGCGTCCACGTACGTGCAGAAGATGTCCATGTACAACCTGAGATGCGCGGCG       c.720
 Y  I  Q  A  S  T  Y  V  Q  K  M  S  M  Y  N  L  R  C  A  A         p.240

          .         . | 03       .         .         .         .    g.7859
 GAGGAAAACTGTCTGGCCAG | TACAGCATACAGGGCAGATGTCAGAGATTATGATCACAGG    c.780
 E  E  N  C  L  A  S  |  T  A  Y  R  A  D  V  R  D  Y  D  H  R      p.260

          .         .         .         .         .         .       g.7919
 GTGCTGCTCAGATTTCCCCAAAGAGTGAAAAACCAAGGGACATCAGATTTCTTACCCAGC       c.840
 V  L  L  R  F  P  Q  R  V  K  N  Q  G  T  S  D  F  L  P  S         p.280

          .         .         .         | 04         .         .    g.9213
 CGACCAAGATATTCCTGGGAATGGCACAGTTGTCATCA | ACATTACCACAGTATGGATGAG    c.900
 R  P  R  Y  S  W  E  W  H  S  C  H  Q  |  H  Y  H  S  M  D  E      p.300

          .         .         .         .         .         .       g.9273
 TTTAGCCACTATGACCTGCTTGATGCCAACACCCAGAGGAGAGTGGCTGAAGGCCACAAA       c.960
 F  S  H  Y  D  L  L  D  A  N  T  Q  R  R  V  A  E  G  H  K         p.320

          .         .         .         .         .         .       g.9333
 GCAAGTTTCTGTCTTGAAGACACATCCTGTGACTATGGCTACCACAGGCGATTTGCATGT       c.1020
 A  S  F  C  L  E  D  T  S  C  D  Y  G  Y  H  R  R  F  A  C         p.340

          .      | 05  .         .         .         .         .    g.12816
 ACTGCACACACACAG | GGATTGAGTCCTGGCTGTTATGATACCTATGGTGCAGACATAGAC    c.1080
 T  A  H  T  Q   | G  L  S  P  G  C  Y  D  T  Y  G  A  D  I  D      p.360

          .         .         .         .         .  | 06      .    g.13201
 TGCCAGTGGATTGATATTACAGATGTAAAACCTGGAAACTATATCCTAAAG | GTCAGTGTA    c.1140
 C  Q  W  I  D  I  T  D  V  K  P  G  N  Y  I  L  K   | V  S  V      p.380

          .         .         .         .         .         .       g.13261
 AACCCCAGCTACCTGGTTCCTGAATCTGACTATACCAACAATGTTGTGCGCTGTGACATT       c.1200
 N  P  S  Y  L  V  P  E  S  D  Y  T  N  N  V  V  R  C  D  I         p.400

          .         .         .         .        | 07.              g.16624
 CGCTACACAGGACATCATGCGTATGCCTCAGGCTGCACAATTTCACC | GTATTAG          c.1254
 R  Y  T  G  H  H  A  Y  A  S  G  C  T  I  S  P  |  Y  X            p.417

          .         .         .         .         .         .       g.16684
 aaggcaaagcaaaactcccaatggataaatcagtgcctggtgttctgaagtgggaaaaaa       c.*60

          .         .         .         .         .         .       g.16744
 tagactaacttcagtaggatttatgtattttgaaaaagagaacagaaaacaacaaaagaa       c.*120

          .         .         .         .         .         .       g.16804
 tttttgtttggactgttttcaataacaaagcacataactggattttgaacgcttaagtca       c.*180

          .         .         .         .         .         .       g.16864
 tcattacttgggaaatttttaatgtttattatttacatcactttgtgaattaacacagtg       c.*240

          .         .         .         .         .         .       g.16924
 tttcaattctgtaattacatatttgactctttcaaagaaatccaaatttctcatgttcct       c.*300

          .         .         .         .         .         .       g.16984
 tttgaaattgtagtgcaaaatggtcagtattatctaaatgaatgagccaaaatgactttg       c.*360

          .         .         .         .         .         .       g.17044
 aactgaaacttttctaaagtgctggaactttagtgaaacataataataatgggtttatat       c.*420

          .         .         .         .         .         .       g.17104
 atgtcatagcatagatgaatttagaaacaatgctcctactgtttaaatacatatggacac       c.*480

          .         .         .         .         .         .       g.17164
 atctggtgctgagaaagaaacaaacacattaccattggtgtcaagaaatattactatata       c.*540

          .         .         .         .         .         .       g.17224
 gcagagaaatggcaatacatgtactcagatagttacatccctatataaaaagtatgttta       c.*600

          .         .         .         .         .         .       g.17284
 catttaaaaaattagtagataacttcctttctttcaagtgcacaatttcattttgacttg       c.*660

          .         .         .         .         .         .       g.17344
 agtcaacttttgttttggaacaaattaagtaagggagctgcccaatcctgtctgatattt       c.*720

          .         .         .         .         .         .       g.17404
 cttgaggctgccctctatcattttatctttcccatgggcagagatgttgtaagtgggatt       c.*780

          .         .         .         .         .         .       g.17464
 cttaatatcaccattcttgggactggtatacataaggcagccgtgaaactggaaagtcat       c.*840

          .         .         .         .         .         .       g.17524
 tttgatgactgatgtgatacatccagaggtaaaatgcatttaaacatattaaagtatttg       c.*900

          .         .         .         .         .         .       g.17584
 ccaaagatacaattttcttgctgacataaaaatcacacaaacaagtcccccccaaaccac       c.*960

          .         .         .         .         .         .       g.17644
 aactgtctctcaaatagcttaaaaaaattgaaaaacattttaggatttttcaagttttct       c.*1020

          .         .         .         .         .         .       g.17704
 agattttaaaaagatgttcagctattagaggaatgttaaaaattttatattatctagaac       c.*1080

          .         .         .         .         .         .       g.17764
 acaggaacatcatcctgggttattcaggaatcagtcacacatgtgtgtgtgtctgagata       c.*1140

          .         .         .         .         .         .       g.17824
 tagtctaaattagcaaagcacatagtattacatacttgaggggttggtgaacaaaggaaa       c.*1200

          .         .         .         .         .         .       g.17884
 aatatactttctgcaaaaccaaggactgtgctgcgtaatgagacagctgtgatttcattt       c.*1260

          .         .         .         .         .         .       g.17944
 gaaactgtgaaaccatgtgccataatagaattttgagaattttgcttttacctaaattca       c.*1320

          .         .         .         .         .         .       g.18004
 agaaaatgaaattacacttttaagttagtggtgcttaagcataatttttcctatattaac       c.*1380

          .         .         .         .         .         .       g.18064
 cagtattaaaatctcaagtaagattttccagtgccagaacatgttaggtggaattttaaa       c.*1440

          .         .         .         .         .         .       g.18124
 agtgcctcggcatcctgtattacatgtcatagaattgtaaagtcaacatcaattactagt       c.*1500

          .         .         .         .         .         .       g.18184
 aatcattctgcactcactgggtgcatagcatggttagaggggctagagatggacagtcat       c.*1560

          .         .         .         .         .         .       g.18244
 caactggcggatatagcggtacatatgatccttagccaccagggcacaagcttaccagta       c.*1620

          .         .         .         .         .         .       g.18304
 gacaatacagacagagcttttgttgagctgtaactgagctatggaatagcttctttgatg       c.*1680

          .         .         .         .         .         .       g.18364
 tacctctttgccttaaattgctttttagttctaagattgtagaatgatcctttcaaattg       c.*1740

          .         .         .         .         .         .       g.18424
 taatcttttctaacagagatattttaatatacttgctttcttaaaaaacaaaaaaactac       c.*1800

          .         .         .         .         .         .       g.18484
 tgtcagtattaatactgagccagactggcatctacagatttcagatctatcattttattg       c.*1860

          .         .         .         .         .         .       g.18544
 attcttaagcttgtattaaaaactaggcaatatcatcatggatacataggagaagacaca       c.*1920

          .         .         .         .         .         .       g.18604
 tttacaatcattcattgggccttttatctgtctatccatccatcatcatttgaaggccta       c.*1980

          .         .         .         .         .         .       g.18664
 atatatgccaagtactcacatggtatgcattgagacataaaaaagactgtctataacctc       c.*2040

          .         .         .         .         .         .       g.18724
 aataagtattaaaaatcccattattacccataaggttcatcttatttcatttttagggaa       c.*2100

          .         .         .         .         .         .       g.18784
 taaaattacatgtctatgaaatttcaattttaagcactattgtttttcatgaccataatt       c.*2160

          .         .         .         .         .         .       g.18844
 tatttttaaaaataaattaaaggttaattatatgcatgtatgtatttctaataattaaaa       c.*2220

          .         .         .         .         .         .       g.18904
 atgtgttcaatccctgaaatgtctgccttttaaatataacacctactatttggttaattt       c.*2280

          .         .         .         .         .         .       g.18964
 tgacgatttttttttttcaattaggaagctaaaaatactactttattccttatatgaaca       c.*2340

          .         .         .         .         .         .       g.19024
 ttcatccccctcctggcacctctaaacacacccaaataactcacaagtactgatttaaca       c.*2400

          .         .         .         .         .         .       g.19084
 ctctgtattactgaacttctttgaactattttgaactttgaatctcttctctgaataact       c.*2460

          .         .         .         .         .         .       g.19144
 gccgaaactcaaagataataattagttgatgaaggttatcaattaataaaataacacaga       c.*2520

          .         .         .         .         .         .       g.19204
 ccagtcttaccaaactctaaatacattttaaaaaataggaactggcaatgataaaaagaa       c.*2580

          .         .         .         .         .         .       g.19264
 tgttgagtactgacaggagattggcttttacactaaaaaagacagaaaatggactaaata       c.*2640

          .         .         .         .         .         .       g.19324
 ggaacataatttcagagtttatgagtcagtttacaatatgccatattagcgatctcatga       c.*2700

          .         .         .         .         .         .       g.19384
 tgattcagaccacagtctgggttaaagatgtcttgacctctgaggctagcataacatata       c.*2760

          .         .         .         .         .         .       g.19444
 tgagaatacaacttgcctatttccagaaaatctgtatatttttatagaataactttattt       c.*2820

          .         .         .         .         .         .       g.19504
 acaatttctatcatccaattactcactaggcattatttgtagtactttttttctctttga       c.*2880

          .         .         .         .         .         .       g.19564
 aatctcataggatagtcacacttataaacattcccaatattcggattctagaagaaatgc       c.*2940

          .         .         .         .         .         .       g.19624
 aattcattaaaattttcctggcactgagagttaatctttagcagattgcatgaaaatact       c.*3000

          .         .         .         .         .         .       g.19684
 gaattcctggtaaggagatattttgttttaaaaataatgtgttttgatacgaatcagtgt       c.*3060

          .         .         .         .         .         .       g.19744
 attaactgataactaaaaagtactcttttttctatatatacatatttttttgaactcata       c.*3120

          .         .         .         .         .         .       g.19804
 ttcacaatcaacatattcaatcagtgagttaagtctcattcctagctaccaaaattcctg       c.*3180

          .         .         .         .         .         .       g.19864
 ggccacttttaaacactaaacatttcatttatcctctaagctaaaatggtgctgagttat       c.*3240

          .         .         .         .         .         .       g.19924
 ttaaatctgaatgtaaaatgcattaaatcttagcttgtggtatataaacatttaattaat       c.*3300

          .         .         .         .         .         .       g.19984
 ataaaactgcttgctataaactaagtaacatgtcatttggtgttaggtttttagtgaagt       c.*3360

          .         .         .         .         .         .       g.20044
 tttagcttctcccaaatttttcaggaatgttatttgtaagacgtgtaacttttttgaaga       c.*3420

          .         .         .         .         .         .       g.20104
 actcttattttaaatgctcagacattggctttatgttcctctttgcattctcatattctt       c.*3480

          .         .         .         .         .         .       g.20164
 ttattatacatctatactatgattgcaagattatataaaaatgccttgaataaatgattt       c.*3540

                                                                    g.20172
 caagtgtc                                                           c.*3548

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lysyl oxidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 28
©2004-2022 Leiden University Medical Center