lipin 1 (LPIN1) - coding DNA reference sequence

(used for variant description)

(last modified May 6, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_145693.2 in the LPIN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering LPIN1 transcript NM_145693.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.74042
                                    gaaggcgagctgcgctgacagccgg       c.-61

 .         .         .         .         .         . | 02           g.92963
 cggcgggctgggtgtttgcaatacaaaggcggccacgcgcggcgccgctcg | gtgcagacc    c.-1

          .         .         .         .         .         .       g.93023
 ATGAATTACGTGGGGCAGTTAGCCGGCCAGGTGTTTGTCACCGTGAAGGAGCTCTACAAG       c.60
 M  N  Y  V  G  Q  L  A  G  Q  V  F  V  T  V  K  E  L  Y  K         p.20

          .         .         .         .         .         .       g.93083
 GGGCTGAATCCCGCCACACTCTCAGGGTGCATTGACATCATTGTCATCCGCCAGCCCAAT       c.120
 G  L  N  P  A  T  L  S  G  C  I  D  I  I  V  I  R  Q  P  N         p.40

          .         .         .         .         .         .       g.93143
 GGAAACCTCCAATGCTCCCCTTTCCACGTCCGCTTTGGGAAGATGGGGGTCCTGCGCTCC       c.180
 G  N  L  Q  C  S  P  F  H  V  R  F  G  K  M  G  V  L  R  S         p.60

          .   | 03     .         .         .         .         .    g.95232
 CGAGAGAAAGTG | GTTGACATAGAAATCAATGGGGAATCTGTGGATTTGCATATGAAATTG    c.240
 R  E  K  V   | V  D  I  E  I  N  G  E  S  V  D  L  H  M  K  L      p.80

          .         .         .         .         | 04         .    g.98805
 GGAGATAATGGAGAAGCATTTTTTGTTCAAGAAACAGATAATGATCAG | GAAGTTATCCCT    c.300
 G  D  N  G  E  A  F  F  V  Q  E  T  D  N  D  Q   | E  V  I  P      p.100

          .         .         .         .         .         .       g.98865
 ATGCACCTGGCCACCTCCCCCATCCTGTCAGAAGGAGCTTCGAGAATGGAATGCCAGCTG       c.360
 M  H  L  A  T  S  P  I  L  S  E  G  A  S  R  M  E  C  Q  L         p.120

          .         .         .         .         .         .       g.98925
 AAAAGGGGCTCTGTGGACAGGATGAGAGGCCTGGACCCCAGCACGCCAGCCCAAGTGATC       c.420
 K  R  G  S  V  D  R  M  R  G  L  D  P  S  T  P  A  Q  V  I         p.140

          .         .         .         .         .         .       g.98985
 GCTCCCAGCGAGACGCCGTCAAGCAGCTCTGTAGTAAAGAAGAGAAGAAAAAGGAGGAGA       c.480
 A  P  S  E  T  P  S  S  S  S  V  V  K  K  R  R  K  R  R  R         p.160

          .         .         .         .         .         .       g.99045
 AAGTCACAGCTGGACAGCCTGAAGAGAGATGACAACATGAACACATCTGAGGATGAGGAC       c.540
 K  S  Q  L  D  S  L  K  R  D  D  N  M  N  T  S  E  D  E  D         p.180

          .         .         .         .         .       | 05 .    g.101045
 ATGTTCCCCATCGAGATGAGCTCGGATGAGGCCATGGAGCTGCTGGAGAGCAGCAG | AACT    c.600
 M  F  P  I  E  M  S  S  D  E  A  M  E  L  L  E  S  S  R  |  T      p.200

          .         .         .         .         .         .       g.101105
 CTTCCTAATGATATACCTCCATTCCAAGATGATATTCCTGAGGAAAACCTCTCCCTGGCT       c.660
 L  P  N  D  I  P  P  F  Q  D  D  I  P  E  E  N  L  S  L  A         p.220

          .         .         .         .         .         .       g.101165
 GTGATTTACCCTCAGTCAGCCTCATACCCTAATTCGGATAGAGAGTGGTCACCCACTCCC       c.720
 V  I  Y  P  Q  S  A  S  Y  P  N  S  D  R  E  W  S  P  T  P         p.240

    | 06     .         .         .         .         .         .    g.106998
 AG | TCCTTCCGGTTCCCGACCTTCAACACCTAAAAGTGATTCAGAATTGGTCAGCAAGTCC    c.780
 S  |  P  S  G  S  R  P  S  T  P  K  S  D  S  E  L  V  S  K  S      p.260

          .         .         .         .         .         .       g.107058
 ACGGAAAGGACAGGGCAGAAGAACCCAGAAATGCTTTGGCTGTGGGGAGAGCTGCCGCAG       c.840
 T  E  R  T  G  Q  K  N  P  E  M  L  W  L  W  G  E  L  P  Q         p.280

           | 07        .         .         .         .         .    g.109673
 GCTGCTAAG | TCTTCTTCTCCACACAAGATGAAAGAGTCCAGCCCATTGAGCAGTAGAAAA    c.900
 A  A  K   | S  S  S  P  H  K  M  K  E  S  S  P  L  S  S  R  K      p.300

          .         .         .         .         .         .       g.109733
 ATTTGTGATAAAAGTCACTTTCAGGCCATTCACAGCGAATCTTCAGACACTTTTAGTGAC       c.960
 I  C  D  K  S  H  F  Q  A  I  H  S  E  S  S  D  T  F  S  D         p.320

          .         .         .         .         .         .       g.109793
 CAATCGCCAACTCTGGTCGGTGGGGCACTTTTGGACCAGAACAAGCCTCAGACAGAAATG       c.1020
 Q  S  P  T  L  V  G  G  A  L  L  D  Q  N  K  P  Q  T  E  M         p.340

          .         .         .         .         .         .       g.109853
 CAGTTTGTGAATGAAGAAGACCTGGAGACCTTAGGAGCAGCAGCGCCACTCTTGCCCATG       c.1080
 Q  F  V  N  E  E  D  L  E  T  L  G  A  A  A  P  L  L  P  M         p.360

          .         .         .         .         .         .       g.109913
 ATCGAGGAGCTCAAACCCCCCTCTGCCAGTGTAGTCCAGACAGCAAACAAGACGGATTCT       c.1140
 I  E  E  L  K  P  P  S  A  S  V  V  Q  T  A  N  K  T  D  S         p.380

          .       | 08 .         .         .         .         .    g.111294
 CCTTCCAGGAAAAGAG | ATAAACGAAGCCGACATCTTGGTGCTGACGGCGTCTACTTGGAT    c.1200
 P  S  R  K  R  D |   K  R  S  R  H  L  G  A  D  G  V  Y  L  D      p.400

          .         .         .         .         . | 09       .    g.112317
 GACCTCACAGACATGGATCCTGAAGTGGCGGCCCTGTATTTTCCCAAAAA | CGGAGATCCT    c.1260
 D  L  T  D  M  D  P  E  V  A  A  L  Y  F  P  K  N  |  G  D  P      p.420

          .         .         .         .         .         .       g.112377
 TCCGGACTCGCAAAACATGCAAGCGACAACGGAGCCCGGTCAGCCAACCAGTCCCCGCAG       c.1320
 S  G  L  A  K  H  A  S  D  N  G  A  R  S  A  N  Q  S  P  Q         p.440

          .         .         .         .         .         .       g.112437
 TCGGTGGGCAGCTCGGGCGTGGACAGTGGCGTGGAGAGCACCTCGGACGGGCTGAGGGAC       c.1380
 S  V  G  S  S  G  V  D  S  G  V  E  S  T  S  D  G  L  R  D         p.460

          .         .         .         .         .         .       g.112497
 CTCCCTTCCATCGCCATCTCCCTCTGCGGGGGCCTCAGCGACCACCGGGAGATCACGAAA       c.1440
 L  P  S  I  A  I  S  L  C  G  G  L  S  D  H  R  E  I  T  K         p.480

   | 10      .         .         .         .         .         .    g.114554
 G | ATGCATTCCTGGAGCAAGCTGTGTCATATCAACAGTTTGTGGACAACCCCGCTATTATC    c.1500
 D |   A  F  L  E  Q  A  V  S  Y  Q  Q  F  V  D  N  P  A  I  I      p.500

          .         .         .      | 11  .         .         .    g.115833
 GATGACCCCAATCTCGTGGTAAAGATTGGGAGTAA | ATATTATAACTGGACAACAGCAGCA    c.1560
 D  D  P  N  L  V  V  K  I  G  S  K  |  Y  Y  N  W  T  T  A  A      p.520

          .         .         .         .      | 12  .         .    g.119350
 CCCCTCCTCCTGGCAATGCAGGCCTTCCAGAAACCTTTGCCAAAG | GCCACTGTGGAATCT    c.1620
 P  L  L  L  A  M  Q  A  F  Q  K  P  L  P  K   | A  T  V  E  S      p.540

          .         .         .         .         .         .       g.119410
 ATCATGAGGGATAAAATGCCCAAAAAGGGAGGAAGATGGTGGTTTTCATGGAGGGGAAGA       c.1680
 I  M  R  D  K  M  P  K  K  G  G  R  W  W  F  S  W  R  G  R         p.560

          .         | 13         .         .         .         .    g.122871
 AACACCACAATCAAGGAG | GAAAGTAAGCCAGAGCAGTGCTTGGCTGGCAAGGCCCATAGC    c.1740
 N  T  T  I  K  E   | E  S  K  P  E  Q  C  L  A  G  K  A  H  S      p.580

          .         .         .         | 14         .         .    g.130350
 ACCGGAGAGCAACCGCCGCAGCTCAGCTTGGCCACCAG | GGTAAAGCATGAATCATCCTCC    c.1800
 T  G  E  Q  P  P  Q  L  S  L  A  T  R  |  V  K  H  E  S  S  S      p.600

          .         .         .         .         .         .       g.130410
 AGTGATGAGGAGCGCGCAGCTGCCAAGCCATCAAACGCAGGCCACCTCCCTCTTCTGCCT       c.1860
 S  D  E  E  R  A  A  A  K  P  S  N  A  G  H  L  P  L  L  P         p.620

          .         .         .         .      | 15  .         .    g.131859
 AATGTCAGCTACAAGAAGACTCTCCGGCTGACTTCCGAGCAGCTT | AAAAGCTTGAAGTTG    c.1920
 N  V  S  Y  K  K  T  L  R  L  T  S  E  Q  L   | K  S  L  K  L      p.640

          .         .         .         .         .         .       g.131919
 AAGAATGGCCCCAACGACGTGGTTTTCAGTGTCACCACGCAGTACCAAGGCACGTGCCGC       c.1980
 K  N  G  P  N  D  V  V  F  S  V  T  T  Q  Y  Q  G  T  C  R         p.660

          .         .         .         .         .         .       g.131979
 TGTGAGGGCACCATCTATCTGTGGAACTGGGATGATAAAGTCATCATTTCTGATATTGAT       c.2040
 C  E  G  T  I  Y  L  W  N  W  D  D  K  V  I  I  S  D  I  D         p.680

          .     | 16   .         .         .         .         .    g.132537
 GGGACAATTACCAG | ATCAGATACTCTTGGCCACATTTTGCCCACCCTTGGGAAGGATTGG    c.2100
 G  T  I  T  R  |  S  D  T  L  G  H  I  L  P  T  L  G  K  D  W      p.700

          .         .         .         .  | 17      .         .    g.142528
 ACCCATCAGGGCATCGCTAAGCTGTACCATAAAGTGAGCCA | GAATGGATATAAATTTCTC    c.2160
 T  H  Q  G  I  A  K  L  Y  H  K  V  S  Q  |  N  G  Y  K  F  L      p.720

          .         .         .         .         .         .       g.142588
 TACTGTTCTGCCCGTGCCATCGGGATGGCGGACATGACGCGGGGCTACCTGCACTGGGTC       c.2220
 Y  C  S  A  R  A  I  G  M  A  D  M  T  R  G  Y  L  H  W  V         p.740

          .         .         .         .         .         .       g.142648
 AACGAGAGGGGCACGGTGCTGCCCCAGGGGCCCCTGCTGCTGAGTCCCAGCAGCCTCTTC       c.2280
 N  E  R  G  T  V  L  P  Q  G  P  L  L  L  S  P  S  S  L  F         p.760

          .     | 18   .         .         .         .         .    g.146951
 TCTGCCCTGCACAG | AGAAGTGATTGAAAAGAAGCCAGAAAAGTTTAAAGTCCAGTGTTTG    c.2340
 S  A  L  H  R  |  E  V  I  E  K  K  P  E  K  F  K  V  Q  C  L      p.780

          .         .         .         .         .         .       g.147011
 ACAGACATCAAAAACCTGTTTTTCCCCAACACAGAACCCTTTTATGCTGCTTTTGGAAAC       c.2400
 T  D  I  K  N  L  F  F  P  N  T  E  P  F  Y  A  A  F  G  N         p.800

           | 19        .         .         .         .         .    g.147883
 CGACCAGCT | GATGTGTATTCATACAAGCAAGTAGGAGTGTCTTTGAATAGAATATTTACC    c.2460
 R  P  A   | D  V  Y  S  Y  K  Q  V  G  V  S  L  N  R  I  F  T      p.820

          .         .         .         .         .    | 20    .    g.152060
 GTCAACCCTAAAGGAGAGCTGGTACAGGAACATGCAAAGACCAACATCTCTTC | GTATGTG    c.2520
 V  N  P  K  G  E  L  V  Q  E  H  A  K  T  N  I  S  S  |  Y  V      p.840

          .         .         .         .         .         .       g.152120
 AGACTCTGTGAAGTAGTCGACCACGTTTTCCCGTTGCTGAAAAGAAGCCATTCTTCAGAC       c.2580
 R  L  C  E  V  V  D  H  V  F  P  L  L  K  R  S  H  S  S  D         p.860

          .         .         .         .         .         .       g.152180
 TTTCCCTGTTCGGATACCTTCAGTAACTTCACCTTTTGGAGAGAGCCACTGCCACCTTTT       c.2640
 F  P  C  S  D  T  F  S  N  F  T  F  W  R  E  P  L  P  P  F         p.880

          .         .         .                                     g.152213
 GAAAACCAGGACATTCATTCTGCCTCAGCGTAA                                  c.2673
 E  N  Q  D  I  H  S  A  S  A  X                                    p.890

          .         .         .         .         .         .       g.152273
 aatgtcccaagcagcctcttgccagcagtgcagagcctggttgtcacccattaaaggata       c.*60

          .         .         .         .         .         .       g.152333
 ggtctccccggagtgcacagctccacctgggagcctggcgcgtcatcattggcctgacag       c.*120

          .         .         .         .         .         .       g.152393
 cagagagaattgagaagcatttctcccctgccccaccccggggctgacatttctaagcaa       c.*180

          .         .         .         .         .         .       g.152453
 gataggaagggagcactttctaggctaggagttgggtgcatttgtaccgtgaaaagcatt       c.*240

          .         .         .         .         .         .       g.152513
 cctcagttgtggcttaatgccagttacgacgctgcctttccggcctgctccagcaagtag       c.*300

          .         .         .         .         .         .       g.152573
 ctactggttcacgtgcagtttggggctgtgaaacctaggcagaaggcggctgtctgaggg       c.*360

          .         .         .         .         .         .       g.152633
 ctgtccccgcctaggacagggtcaatcgaggaatgccagatgtgcacggtttttggcaaa       c.*420

          .         .         .         .         .         .       g.152693
 gtagggggcacatttccattatagcaatgttagtgccaccaccttctgaacacagtgggg       c.*480

          .         .         .         .         .         .       g.152753
 agggctgtgaaggctcatgtgacctggatctgaggtctctgatagaaatctggacgccac       c.*540

          .         .         .         .         .         .       g.152813
 cgggtccaggcctggcctcagacttggccttgtggatgggccccttacagtatttgctga       c.*600

          .         .         .         .         .         .       g.152873
 ctagtctcatttttaggtgataaatttttctttaattcctttggttaaagatagtctatt       c.*660

          .         .         .         .         .         .       g.152933
 tcattggcatatctccccccagtttttgtggctcaaggctggaatatttatgccttaata       c.*720

          .         .         .         .         .         .       g.152993
 tatctatggcagacatttaagaatgcgctttatctagctcatggtaactttgcaacgcct       c.*780

          .         .         .         .         .         .       g.153053
 tagattaaaatgacagtaaatattactaaggcagtattttgaatgagtttgacactgccg       c.*840

          .         .         .         .         .         .       g.153113
 gcttccttccatccagcgaggtggtgctgacagtgtggacttgagcacacttatgccaaa       c.*900

          .         .         .         .         .         .       g.153173
 tgataatgatactgacttctgttgggagctctccaaagaaactggttggttttaagaaaa       c.*960

          .         .         .         .         .         .       g.153233
 tagtttcaagaagttcaactatattcttttagatattatgtattgttttactctgattag       c.*1020

          .         .         .         .         .         .       g.153293
 gttactgtgataggcatttattcatattctttctataccactgtcattaatatattaaaa       c.*1080

          .         .         .         .         .         .       g.153353
 agatgtatgtgttagactatcgaaagggccttattctctctttctcatagactgaccttc       c.*1140

          .         .         .         .         .         .       g.153413
 ttttggaatttctgagtcatttattttccttagctttttccactcaaattaagggcaagc       c.*1200

          .         .         .         .         .         .       g.153473
 gaaaaagtaataatttggcattctttaagcctacagaatgtgattctttcacttgtttat       c.*1260

          .         .         .         .         .         .       g.153533
 tacactggctcgtggacagaacaatttgaaaagtgaaagaattattttggtaaaagattt       c.*1320

          .         .         .         .         .         .       g.153593
 tgctttacttttcgaagcattatttttttaaagagtgttttactccaacgattgaaacat       c.*1380

          .         .         .         .         .         .       g.153653
 tttcctatttaaatttcattgttagaatcacaggaggcaaaaaatggaacggttgaatga       c.*1440

          .         .         .         .         .         .       g.153713
 aattttactctttctgtgaaagaaaatccacagagttgttgcctccgttgtagttggtgg       c.*1500

          .         .         .         .         .         .       g.153773
 gccccgttagcattggatgcctttgccaaatggttcatgtggacacacaaaggcaaacag       c.*1560

          .         .         .         .         .         .       g.153833
 atctgccatcgatcgcagatttctgtagaaacacggatgtgcatgtgcagattccctttt       c.*1620

          .         .         .         .         .         .       g.153893
 gcaggtattaaaaataattaaaaatagtcctgcctgaggttgcagtgagccgagcttgca       c.*1680

          .         .         .         .         .         .       g.153953
 ctactgcactccagcctgggtgacagagtaagactccatgtcaaaaaaaaaaaaaaaaaa       c.*1740

          .         .         .         .         .         .       g.154013
 aaaaaagtcctgccttaactaactcctctgcgcttgttcactagtaacctaaagaggcta       c.*1800

          .         .         .         .         .         .       g.154073
 tattcattctttatgcaatgagggtatttttgagtgaattttaactgctctgaactaagt       c.*1860

          .         .         .         .         .         .       g.154133
 ataagctcatgggcctgcaaaggttcagacggtttctcctttgcacccaggaggaacttt       c.*1920

          .         .         .         .         .         .       g.154193
 ggctgcgagaatggggggatgtatccctcatgcagttggcatccaggcagccctctgcag       c.*1980

          .         .         .         .         .         .       g.154253
 cagcacaccctgcaggcggagttttcagaggatgcaattttggatcccgaattttgatgt       c.*2040

          .         .         .         .         .         .       g.154313
 accttaaacttccacatcactgcaccctgaaacagagcatgctttccagaaagtcacact       c.*2100

          .         .         .         .         .         .       g.154373
 ctcagatctgtgtcaagttcaatgtgagccctggcaaggctggcatattaacacctgcct       c.*2160

          .         .         .         .         .         .       g.154433
 tctggcttctgaaagtgagatttgtatatgggctgcactcacgcatatacgagttggttt       c.*2220

          .         .         .         .         .         .       g.154493
 atctttgtgtacatgactataacccagtgatgctgaggtcatgtgctggaatgctgtatt       c.*2280

          .         .         .         .         .         .       g.154553
 tggaccacacatttcaaagttgccctatggaaatgaatcctacttagtgacaagtcatca       c.*2340

          .         .         .         .         .         .       g.154613
 aatgtttgtcacatgtgatgaagacaaatatgtatacctggcatagagaaaaatatatac       c.*2400

          .         .         .         .         .         .       g.154673
 ctggtacattggagaaaaataattacactttcaaagagaattccctttgcaattttatgt       c.*2460

          .         .         .         .         .         .       g.154733
 ttggatcaccactgtaagcacactttatttgcatttgatctgtatttgtatatgctgatg       c.*2520

          .         .         .         .         .         .       g.154793
 caatgataaaaatcactgtaatacttcattgtgttgtactggatgcaaagctagaaaata       c.*2580

          .         .         .                                     g.154831
 ttgcaataaatgagaccgatgaaagacttctctgaaaa                             c.*2618

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Lipin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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