leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 (LRIT3) - coding DNA reference sequence

(used for variant description)

(last modified December 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_198506.4 in the LRIT3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033249.1, covering LRIT3 transcript NM_198506.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           taacctctaaaaggagca       c.-1

          .         .         .         .         .         .       g.5078
 ATGCATCTCTTTGCATGTCTGTGCATTGTCCTTAGCTTTTTGGAAGGAGTGGGCTGTTTG       c.60
 M  H  L  F  A  C  L  C  I  V  L  S  F  L  E  G  V  G  C  L         p.20

          .         .         .         .         .       | 02 .    g.8324
 TGTCCTTCACAGTGCACCTGTGATTATCACGGCAGAAATGACGGCTCAGGATCAAG | GTTG    c.120
 C  P  S  Q  C  T  C  D  Y  H  G  R  N  D  G  S  G  S  R  |  L      p.40

          .         .         .         .         .         .       g.8384
 GTGCTATGTAATGACATGGATATGAACGAGCTGCCTACGAACCTCCCCGTGGACACTGTG       c.180
 V  L  C  N  D  M  D  M  N  E  L  P  T  N  L  P  V  D  T  V         p.60

          .         .         .         .         .         .       g.8444
 AAGCTTCGCATAGAGAAGACTGTCATCCGCAGAATCTCTGCGGAGGCCTTCTATTACCTG       c.240
 K  L  R  I  E  K  T  V  I  R  R  I  S  A  E  A  F  Y  Y  L         p.80

          .         .         .         .         .         .       g.8504
 GTGGAGCTCCAGTATCTCTGGGTGACTTACAATTCCGTGGCCAGCATTGACCCCAGCAGC       c.300
 V  E  L  Q  Y  L  W  V  T  Y  N  S  V  A  S  I  D  P  S  S         p.100

          .         .         .         .         .         .       g.8564
 TTTTACAACCTGAAGCAACTGCATGAGTTGCGCTTGGATGGGAATTCTCTGGCTGCTTTC       c.360
 F  Y  N  L  K  Q  L  H  E  L  R  L  D  G  N  S  L  A  A  F         p.120

          .         .         .         .         .         .       g.8624
 CCTTGGGCATCTCTGCTGGACATGCCCCTTCTGAGGACCCTGGACTTGCACAATAACAAA       c.420
 P  W  A  S  L  L  D  M  P  L  L  R  T  L  D  L  H  N  N  K         p.140

          .         .         .         .         .         .       g.8684
 ATAACCAGTGTGCCAAATGAGGCGCTCAGGTATCTGAAGAACCTTGCCTACTTGGATTTA       c.480
 I  T  S  V  P  N  E  A  L  R  Y  L  K  N  L  A  Y  L  D  L         p.160

          .         .         .         .         .         .       g.8744
 TCAAGCAACAGACTCACCACATTGCCACCAGATTTCCTGGAGAGCTGGACTCATTTAGTT       c.540
 S  S  N  R  L  T  T  L  P  P  D  F  L  E  S  W  T  H  L  V         p.180

          .         .         .         .          | 03        .    g.24468
 TCAACACCTTCTGGAGTCCTGGACCTTTCCCCAAGCAGGATTATTCTTG | GTCTACAGGAC    c.600
 S  T  P  S  G  V  L  D  L  S  P  S  R  I  I  L  G |   L  Q  D      p.200

          .         .         .         .         .         .       g.24528
 AATCCTTGGTTCTGTGACTGTCATATTTCCAAAATGATTGAGTTGTCAAAGGTCGTTGAC       c.660
 N  P  W  F  C  D  C  H  I  S  K  M  I  E  L  S  K  V  V  D         p.220

          .         .         .         .         .         .       g.24588
 CCTGCTATAGTGCTTCTGGATCCACTGATGACTTGCAGTGAACCTGAGCGCCTCACAGGA       c.720
 P  A  I  V  L  L  D  P  L  M  T  C  S  E  P  E  R  L  T  G         p.240

          .         .         .         .         .         .       g.24648
 ATTTTGTTTCAGCGGGCTGAATTGGAGCATTGTCTGAAACCATCAGTGATGACCTCAGCC       c.780
 I  L  F  Q  R  A  E  L  E  H  C  L  K  P  S  V  M  T  S  A         p.260

          .         .         .         .         .         .       g.24708
 ACCAAAATCATGTCTGCTCTGGGCAGTAATGTTCTACTGCGGTGTGATGCCACTGGCTTC       c.840
 T  K  I  M  S  A  L  G  S  N  V  L  L  R  C  D  A  T  G  F         p.280

          .         .         .         .         .      | 04  .    g.26466
 CCCACCCCACAGATCACATGGACCAGATCTGACAGCTCGCCAGTTAATTATACAG | TAATA    c.900
 P  T  P  Q  I  T  W  T  R  S  D  S  S  P  V  N  Y  T  V |   I      p.300

          .         .         .         .         .         .       g.26526
 CAAGAATCTCCAGAGGAAGGAGTCAGATGGTCCATAATGAGCTTGACAGGCATTTCTTCC       c.960
 Q  E  S  P  E  E  G  V  R  W  S  I  M  S  L  T  G  I  S  S         p.320

          .         .         .         .         .         .       g.26586
 AAAGACGCTGGGGATTACAAATGTAAGGCCAAAAATCTGGCTGGGATGTCAGAAGCTGTG       c.1020
 K  D  A  G  D  Y  K  C  K  A  K  N  L  A  G  M  S  E  A  V         p.340

          .         .         .         .         .         .       g.26646
 GTTACTGTGACAGTGCTTGGCATTACCACAACTCCAATACCACCAGACACTTCTGAAAGA       c.1080
 V  T  V  T  V  L  G  I  T  T  T  P  I  P  P  D  T  S  E  R         p.360

          .         .         .         .         .         .       g.26706
 ACTGGAGATCATCCTGAGTGGGATGTCCAGCCGGGATCTGGAAGATCTACATCTGTATCT       c.1140
 T  G  D  H  P  E  W  D  V  Q  P  G  S  G  R  S  T  S  V  S         p.380

          .         .         .         .         .         .       g.26766
 AGCGCATCATCATATCTTTGGTCCTCTTCCTTCTCCCCCACATCTTCTTTTTCTGCTTCT       c.1200
 S  A  S  S  Y  L  W  S  S  S  F  S  P  T  S  S  F  S  A  S         p.400

          .         .         .         .         .         .       g.26826
 ACTTTGTCTCCTCCCTCTACTGCTTCCTTCTCTTTATCTCCTTTCTCCTCCTCCACTGTT       c.1260
 T  L  S  P  P  S  T  A  S  F  S  L  S  P  F  S  S  S  T  V         p.420

          .         .         .         .         .         .       g.26886
 TCTTCAACCACAACTCTGAGCACAAGCATCTCAGCAAGTACCACCATGGCCAACAAGCGA       c.1320
 S  S  T  T  T  L  S  T  S  I  S  A  S  T  T  M  A  N  K  R         p.440

          .         .         .         .         .         .       g.26946
 TCATTCCAGCTCCACCAAGGTGGGAAAAGAAATTTAAAGGTGGCAAAGAATGGAAGTAAG       c.1380
 S  F  Q  L  H  Q  G  G  K  R  N  L  K  V  A  K  N  G  S  K         p.460

          .         .         .         .         .         .       g.27006
 CTTCCTCCAGCCAGCACAAGTAAGAAAGAAGAGCTGGCATTGTTGGATCAAACAATGCTT       c.1440
 L  P  P  A  S  T  S  K  K  E  E  L  A  L  L  D  Q  T  M  L         p.480

          .         .         .         .         .         .       g.27066
 ACGGAGACAAATGCCGCAATAGAAAACCTCAGGGTGGTCAGTGAGACTAAAGAGAGTGTG       c.1500
 T  E  T  N  A  A  I  E  N  L  R  V  V  S  E  T  K  E  S  V         p.500

          .         .         .         .         .         .       g.27126
 ACATTGACGTGGAATATGATCAACACCACACATAACTCTGCAGTGACTGTGTTGTATTCC       c.1560
 T  L  T  W  N  M  I  N  T  T  H  N  S  A  V  T  V  L  Y  S         p.520

          .         .         .         .         .         .       g.27186
 AAGTATGGTGGGAAGGACCTGCTGCTGTTGAATGCAGACTCCAGCAAGAACCAAGTAACC       c.1620
 K  Y  G  G  K  D  L  L  L  L  N  A  D  S  S  K  N  Q  V  T         p.540

          .         .         .         .         .         .       g.27246
 ATAGATGGCTTGGAACCCGGTGGGCAATACATGGCCTGTGTCTGTCCAAAAGGAGTGCCT       c.1680
 I  D  G  L  E  P  G  G  Q  Y  M  A  C  V  C  P  K  G  V  P         p.560

          .         .         .         .         .         .       g.27306
 CCCCAGAAAGACCAATGCATCACCTTTTCTACTGAAAGAGTTGAAGGAGATGATTCTCAA       c.1740
 P  Q  K  D  Q  C  I  T  F  S  T  E  R  V  E  G  D  D  S  Q         p.580

          .         .         .         .         .         .       g.27366
 TGGTCTCTCCTTCTCGTGGTGACCAGTACTGCCTGTGTTGTTATCTTACCATTGATTTGT       c.1800
 W  S  L  L  L  V  V  T  S  T  A  C  V  V  I  L  P  L  I  C         p.600

          .         .         .         .         .         .       g.27426
 TTCTTGTTGTACAAAGTTTGCAAACTGCAATGTAAATCAGAACCTTTTTGGGAAGATGAT       c.1860
 F  L  L  Y  K  V  C  K  L  Q  C  K  S  E  P  F  W  E  D  D         p.620

          .         .         .         .         .         .       g.27486
 TTGGCAAAGGAGACTTATATCCAATTTGAGACCCTGTTTCCCAGGTCTCAAAGTGTAGGT       c.1920
 L  A  K  E  T  Y  I  Q  F  E  T  L  F  P  R  S  Q  S  V  G         p.640

          .         .         .         .         .         .       g.27546
 GAGCTCTGGACACGAAGCCACAGGGATGACTCAGAGAAATTGCTGCTTTGTTCTAGGTCA       c.1980
 E  L  W  T  R  S  H  R  D  D  S  E  K  L  L  L  C  S  R  S         p.660

          .         .         .         .         .         .       g.27606
 AGTGTGGAATCTCAGGTGACTTTTAAAAGTGAAGGTTCCAGACCAGAGTATTATTGCTAA       c.2040
 S  V  E  S  Q  V  T  F  K  S  E  G  S  R  P  E  Y  Y  C  X         p.679

          .         .         .         .         .         .       g.27666
 ggttctgcagctcaggtgcatgtgagctacaaaactagcatctaagggtataattgaccc       c.*60

          .         .         .         .         .         .       g.27726
 taggtttggatgacttttggacagactttcacattgtacatgaaaatcacaaatggaatg       c.*120

          .         .         .         .         .         .       g.27786
 cttttaagtatgtttaaaaaataccatgagacctctgaactgaaaagacaaataatgttg       c.*180

          .         .         .         .         .         .       g.27846
 attttttttcttgtgtggaaaaggtctacagaaataatttttagagtggtgcttaataaa       c.*240

          .         .         .         .         .         .       g.27906
 ttattaatactttttagggtaatgttttagttcttaaaaataagttcatgtgaaagtagc       c.*300

          .         .         .         .         .         .       g.27966
 aagtgaactctgtatttaaaaatatagttttttgagtcatgaggaaacattagcaaaacc       c.*360

          .         .         .         .         .         .       g.28026
 agctaagccttgatgtttattcatgttcgaagtgcattatagcatttgctgtggatgttt       c.*420

          .         .         .         .         .         .       g.28086
 tctgacattgcctaatggagagcgtgggatcataaaggattttgtgttcactaaggttaa       c.*480

          .         .         .         .         .         .       g.28146
 atctaactcacgggagagagagggctctgtctcttggtaccattatgcattgtgatacta       c.*540

          .         .         .         .         .         .       g.28206
 tagagttgtgttcatatttcttgtaagaaaaatttttgcttttctttagaaatataggta       c.*600

          .         .         .         .         .         .       g.28266
 ttagcaaaagtaagtatacaaagaggattatgacaaatagaccatttctttaaaaatggt       c.*660

          .         .         .         .         .         .       g.28326
 aactgttgcatttaaacacatcgactgacagattatatggatatttaaaaataactttaa       c.*720

          .         .         .         .         .         .       g.28386
 atcaatcttttaatattttgctgtttgctcttatgttctcccttctttcttccttccttg       c.*780

          .         .         .         .         .         .       g.28446
 tcttccctccctttccttccttcattctttctttcttctgctctgtcagaagatatacaa       c.*840

          .         .         .         .         .         .       g.28506
 gtagccaaagcatcacgagccaagctgtttgtcttttgccatattgtcttttgattctct       c.*900

          .         .         .         .         .         .       g.28566
 tgataaagagaaagcttttgaaattacttactgccctttgaaagtctgttttacaacccc       c.*960

          .         .         .         .         .         .       g.28626
 aaaggatattttaggactttaaaagggaagcttcagtggattcatttggttagattcttt       c.*1020

          .         .         .         .         .         .       g.28686
 tcctaggttaaaaacatcggggaacttaaatacataggaaaggagttcacaaataaaatt       c.*1080

          .         .         .         .         .         .       g.28746
 tagtttttttagaaagagaatattttaataactgtagtatactacaagaaacatctcatg       c.*1140

          .         .         .         .         .         .       g.28806
 gctttaagattaacgatagcgataaggcccactcaagcatctcacagtggtgatattaca       c.*1200

          .         .         .         .         .         .       g.28866
 tgtcacttagcaggatgcaacctggcctagggatttccagaagacaaggccacctcagca       c.*1260

          .         .         .         .         .         .       g.28926
 cagatgcaactttcataaattttagaacaaagcctaaccttactagattaaacttgctct       c.*1320

          .         .         .         .         .         .       g.28986
 atgaaagaaacacttggtaattgacccagactgaatacatgtataagaaatgggaaagat       c.*1380

          .         .         .         .         .         .       g.29046
 ctcccaaactctgagaacggtcctcaaatagaagctctcctagtcagttggtcatctgac       c.*1440

          .         .         .         .         .         .       g.29106
 ctctgactatatccggcctatgacaccagccagctcctgctttctgtcttgtaagagcac       c.*1500

          .         .                                               g.29132
 tgctggaataaactacttgagcatta                                         c.*1526

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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