LDL receptor related protein 12 (LRP12) - coding DNA reference sequence

(used for variant description)

(last modified May 16, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_013437.4 in the LRP12 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering LRP12 transcript NM_013437.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      agagcgc       c.-121

 .         .         .         .         .         .                g.5067
 agggagcagccggtggctcggcggcggcggcggcggcggcggcggcgtcggcgtcgtcta       c.-61

 .         .         .         .         .         .                g.5127
 cctccagcttctcctccctcctcctccgtctcctcctctctctctccatctgctgtggtt       c.-1

          .         .         .         .         .         .       g.5187
 ATGGCCTGTCGCTGGAGCACAAAAGAGTCTCCGCGGTGGAGGTCTGCGTTGCTCTTGCTT       c.60
 M  A  C  R  W  S  T  K  E  S  P  R  W  R  S  A  L  L  L  L         p.20

          .          | 02        .         .         .         .    g.62102
 TTCCTCGCTGGGGTGTACG | GAAATGGTGCTCTTGCAGAACATTCTGAAAATGTGCATATT    c.120
 F  L  A  G  V  Y  G |   N  G  A  L  A  E  H  S  E  N  V  H  I      p.40

          .       | 03 .         .         .         .         .    g.84994
 TCAGGAGTGTCAACTG | CTTGTGGAGAGACTCCAGAGCAAATACGAGCACCAAGTGGCATA    c.180
 S  G  V  S  T  A |   C  G  E  T  P  E  Q  I  R  A  P  S  G  I      p.60

          .         .         .         .         .         .       g.85054
 ATCACAAGCCCAGGCTGGCCTTCTGAATATCCTGCAAAAATCAACTGTAGCTGGTTCATA       c.240
 I  T  S  P  G  W  P  S  E  Y  P  A  K  I  N  C  S  W  F  I         p.80

          .         .         .   | 04     .         .         .    g.94533
 AGGGCAAACCCAGGCGAAATCATTACTATAAG | TTTTCAGGATTTTGATATTCAAGGATCC    c.300
 R  A  N  P  G  E  I  I  T  I  S  |  F  Q  D  F  D  I  Q  G  S      p.100

          .         .         .         .         .         .       g.94593
 AGAAGGTGCAATTTGGACTGGTTGACAATAGAAACATACAAGAATATTGAAAGTTACAGA       c.360
 R  R  C  N  L  D  W  L  T  I  E  T  Y  K  N  I  E  S  Y  R         p.120

          .         .         .         .         .         .       g.94653
 GCTTGTGGTTCCACAATTCCACCTCCGTATATCTCTTCACAAGACCACATCTGGATTAGG       c.420
 A  C  G  S  T  I  P  P  P  Y  I  S  S  Q  D  H  I  W  I  R         p.140

          .         .         .         .         .      | 05  .    g.95953
 TTTCATTCGGATGACAACATCTCTAGAAAGGGTTTCAGACTGGCATATTTTTCAG | GGAAA    c.480
 F  H  S  D  D  N  I  S  R  K  G  F  R  L  A  Y  F  S  G |   K      p.160

          .         .         .         .         .         .       g.96013
 TCTGAGGAACCAAATTGTGCTTGTGATCAGTTTCGTTGTGGTAATGGAAAGTGTATACCA       c.540
 S  E  E  P  N  C  A  C  D  Q  F  R  C  G  N  G  K  C  I  P         p.180

          .         .         .         .         .         .       g.96073
 GAAGCCTGGAAATGTAATAACATGGATGAATGTGGAGATAGTTCCGATGAAGAGATCTGT       c.600
 E  A  W  K  C  N  N  M  D  E  C  G  D  S  S  D  E  E  I  C         p.200

          .         .         .         .         .         .       g.96133
 GCCAAAGAAGCAAATCCTCCAACTGCTGCTGCTTTTCAACCCTGTGCTTACAACCAGTTC       c.660
 A  K  E  A  N  P  P  T  A  A  A  F  Q  P  C  A  Y  N  Q  F         p.220

          .         .         .         .         .         .       g.96193
 CAGTGTTTATCCCGTTTTACCAAAGTTTACACTTGCCTCCCCGAATCTTTAAAATGTGAT       c.720
 Q  C  L  S  R  F  T  K  V  Y  T  C  L  P  E  S  L  K  C  D         p.240

          .         .         .         .         .         .       g.96253
 GGGAACATTGACTGCCTTGACCTAGGAGATGAGATAGACTGTGATGTGCCAACATGTGGG       c.780
 G  N  I  D  C  L  D  L  G  D  E  I  D  C  D  V  P  T  C  G         p.260

          .         .         .         .         .         .       g.96313
 CAATGGCTAAAATATTTTTATGGTACTTTTAATTCTCCCAATTATCCAGACTTTTATCCT       c.840
 Q  W  L  K  Y  F  Y  G  T  F  N  S  P  N  Y  P  D  F  Y  P         p.280

          .         .         .         .         .         .       g.96373
 CCTGGAAGCAATTGCACCTGGTTAATAGACACTGGTGATCACCGTAAAGTCATTTTACGC       c.900
 P  G  S  N  C  T  W  L  I  D  T  G  D  H  R  K  V  I  L  R         p.300

          .         .         .         .         .         .       g.96433
 TTCACTGACTTTAAACTTGATGGTACTGGTTATGGTGATTATGTCAAAATATATGATGGA       c.960
 F  T  D  F  K  L  D  G  T  G  Y  G  D  Y  V  K  I  Y  D  G         p.320

          .         .         .         .         .         .       g.96493
 TTAGAGGAGAATCCACACAAGCTTTTGCGTGTGTTGACAGCTTTTGATTCTCATGCACCT       c.1020
 L  E  E  N  P  H  K  L  L  R  V  L  T  A  F  D  S  H  A  P         p.340

          .         .         .         .         .         .       g.96553
 CTTACAGTTGTTTCTTCTTCTGGACAGATAAGGGTACATTTTTGTGCTGATAAAGTGAAT       c.1080
 L  T  V  V  S  S  S  G  Q  I  R  V  H  F  C  A  D  K  V  N         p.360

          .         .         .         .         .         .       g.96613
 GCTGCAAGGGGATTTAATGCTACTTACCAAGTAGATGGGTTCTGTTTGCCATGGGAAATA       c.1140
 A  A  R  G  F  N  A  T  Y  Q  V  D  G  F  C  L  P  W  E  I         p.380

          .         .         .         .         .         .       g.96673
 CCCTGTGGAGGTAACTGGGGGTGTTATACTGAGCAGCAGCGTTGTGATGGGTATTGGCAT       c.1200
 P  C  G  G  N  W  G  C  Y  T  E  Q  Q  R  C  D  G  Y  W  H         p.400

          .         .         .         .         .         .       g.96733
 TGCCCAAATGGAAGGGATGAAACCAATTGTACCATGTGCCAGAAGGAAGAATTTCCATGT       c.1260
 C  P  N  G  R  D  E  T  N  C  T  M  C  Q  K  E  E  F  P  C         p.420

          .         .         .         .         .         .       g.96793
 TCCCGAAATGGTGTCTGTTATCCTCGTTCTGATCGCTGCAACTACCAGAATCATTGCCCA       c.1320
 S  R  N  G  V  C  Y  P  R  S  D  R  C  N  Y  Q  N  H  C  P         p.440

          .         .         .         .         .         .       g.96853
 AATGGCTCAGATGAAAAAAACTGCTTTTTTTGCCAACCAGGAAATTTCCATTGTAAAAAC       c.1380
 N  G  S  D  E  K  N  C  F  F  C  Q  P  G  N  F  H  C  K  N         p.460

          .         .         .         .         .         .       g.96913
 AATCGTTGTGTGTTTGAAAGTTGGGTGTGTGATTCTCAAGATGACTGTGGTGATGGCAGC       c.1440
 N  R  C  V  F  E  S  W  V  C  D  S  Q  D  D  C  G  D  G  S         p.480

          .         .         .         .         .         .       g.96973
 GATGAAGAAAATTGCCCAGTAATCGTGCCTACAAGAGTCATCACTGCTGCCGTCATAGGG       c.1500
 D  E  E  N  C  P  V  I  V  P  T  R  V  I  T  A  A  V  I  G         p.500

          .         .         .         .         .         .       g.97033
 AGCCTCATCTGTGGCCTGTTACTCGTCATAGCATTGGGATGTACTTGTAAGCTTTATTCT       c.1560
 S  L  I  C  G  L  L  L  V  I  A  L  G  C  T  C  K  L  Y  S         p.520

          .         . | 06       .         .         .         .    g.98855
 CTGAGAATGTTTGAAAGAAG | ATCATTTGAAACACAGTTGTCAAGAGTGGAAGCAGAATTG    c.1620
 L  R  M  F  E  R  R  |  S  F  E  T  Q  L  S  R  V  E  A  E  L      p.540

          .         .         .         .         .         .       g.98915
 TTAAGAAGAGAAGCTCCTCCCTCGTATGGACAATTGATTGCTCAGGGTTTAATTCCACCA       c.1680
 L  R  R  E  A  P  P  S  Y  G  Q  L  I  A  Q  G  L  I  P  P         p.560

          .         .         .    | 07    .         .         .    g.102512
 GTTGAAGATTTTCCTGTTTGTTCACCTAATCAG | GCTTCTGTTTTGGAAAATCTGAGGCTA    c.1740
 V  E  D  F  P  V  C  S  P  N  Q   | A  S  V  L  E  N  L  R  L      p.580

          .         .         .         .         .         .       g.102572
 GCGGTACGATCTCAGCTTGGATTTACTTCAGTCAGGCTTCCTATGGCAGGCAGATCAAGC       c.1800
 A  V  R  S  Q  L  G  F  T  S  V  R  L  P  M  A  G  R  S  S         p.600

          .         .         .         .         .         .       g.102632
 AACATTTGGAACCGTATTTTTAATTTTGCAAGATCACGTCATTCTGGGTCATTGGCTTTG       c.1860
 N  I  W  N  R  I  F  N  F  A  R  S  R  H  S  G  S  L  A  L         p.620

          .         .         .         .         .         .       g.102692
 GTCTCAGCAGATGGAGATGAGGTTGTCCCTAGTCAGAGTACCAGTAGAGAACCTGAGAGA       c.1920
 V  S  A  D  G  D  E  V  V  P  S  Q  S  T  S  R  E  P  E  R         p.640

          .         .         .         .         .         .       g.102752
 AATCATACTCACAGAAGTTTGTTTTCCGTGGAGTCTGATGATACAGACACAGAAAATGAG       c.1980
 N  H  T  H  R  S  L  F  S  V  E  S  D  D  T  D  T  E  N  E         p.660

          .         .         .         .         .         .       g.102812
 AGAAGAGATATGGCAGGAGCATCTGGTGGGGTTGCAGCTCCTTTGCCTCAAAAAGTCCCT       c.2040
 R  R  D  M  A  G  A  S  G  G  V  A  A  P  L  P  Q  K  V  P         p.680

          .         .         .         .         .         .       g.102872
 CCCACAACGGCAGTAGAAGCGACAGTAGGAGCATGTGCAAGTTCCTCAACTCAGAGTACC       c.2100
 P  T  T  A  V  E  A  T  V  G  A  C  A  S  S  S  T  Q  S  T         p.700

          .         .         .         .         .         .       g.102932
 CGAGGTGGTCATGCAGATAATGGAAGGGATGTGACAAGTGTGGAACCCCCAAGTGTGAGT       c.2160
 R  G  G  H  A  D  N  G  R  D  V  T  S  V  E  P  P  S  V  S         p.720

          .         .         .         .         .         .       g.102992
 CCAGCACGTCACCAGCTTACAAGTGCACTCAGTCGTATGACTCAGGGGCTACGCTGGGTA       c.2220
 P  A  R  H  Q  L  T  S  A  L  S  R  M  T  Q  G  L  R  W  V         p.740

          .         .         .         .         .         .       g.103052
 CGTTTTACATTAGGACGATCAAGTTCCCTAAGTCAGAACCAGAGTCCTTTGAGACAACTT       c.2280
 R  F  T  L  G  R  S  S  S  L  S  Q  N  Q  S  P  L  R  Q  L         p.760

          .         .         .         .         .         .       g.103112
 GATAATGGGGTAAGTGGAAGAGAAGATGATGATGATGTTGAAATGCTAATTCCAATTTCT       c.2340
 D  N  G  V  S  G  R  E  D  D  D  D  V  E  M  L  I  P  I  S         p.780

          .         .         .         .         .         .       g.103172
 GATGGATCTTCAGACTTTGATGTGAATGACTGCTCCAGACCTCTTCTTGATCTTGCCTCA       c.2400
 D  G  S  S  D  F  D  V  N  D  C  S  R  P  L  L  D  L  A  S         p.800

          .         .         .         .         .         .       g.103232
 GATCAAGGACAAGGGCTTAGACAACCATATAATGCAACAAATCCTGGAGTAAGGCCAAGT       c.2460
 D  Q  G  Q  G  L  R  Q  P  Y  N  A  T  N  P  G  V  R  P  S         p.820

          .         .         .         .         .         .       g.103292
 AATCGAGATGGCCCCTGTGAGCGCTGTGGTATTGTCCACACTGCCCAGATACCAGACACT       c.2520
 N  R  D  G  P  C  E  R  C  G  I  V  H  T  A  Q  I  P  D  T         p.840

          .         .         .         .         .         .       g.103352
 TGCTTAGAAGTAACACTGAAAAACGAAACGAGTGATGATGAGGCTTTGTTACTTTGTTAG       c.2580
 C  L  E  V  T  L  K  N  E  T  S  D  D  E  A  L  L  L  C  X         p.859

          .         .         .         .         .         .       g.103412
 gtacgaatcacataagggagattgtatacaagttggagcaatatccatttattattttgt       c.*60

          .         .         .         .         .         .       g.103472
 aactttacagttaaactagttttagtttaaaaagaaaaaatgcagggtgatttcttatta       c.*120

          .         .         .         .         .         .       g.103532
 ttatatgttagcctgcatggttaaattcgacaacttgtaactctatgaacttagagttta       c.*180

          .         .         .         .         .         .       g.103592
 ctattttagcagctaaaaatgcatcacatattcatattgttcaataatgtcctttcattt       c.*240

          .         .         .         .         .         .       g.103652
 gtttctgattgttttcatcctgatactgtagttcactgtagaaatgtggctgctgaaact       c.*300

          .         .         .         .         .         .       g.103712
 catttgattgtcatttttatctatcctatgttaaatggtttgtttttacaaaataatacc       c.*360

          .         .         .         .         .         .       g.103772
 ttattttaattgaaacgtttatgcttttgccaacacatcttgtaacttaatatactagat       c.*420

          .         .         .         .         .         .       g.103832
 gttaaggttgttaatgtacaaaaaaaaaacccttatactcacctgcgttttcatttgttt       c.*480

          .         .         .         .         .         .       g.103892
 gacatttgtctattattggatttcattatcatatgaacttgtcagtgggaaacaaactgt       c.*540

          .         .         .         .         .         .       g.103952
 ctaaaaatttttctcttacgtttaacatacaatcatgtgaaatttaggcagagttcgata       c.*600

          .         .         .         .         .         .       g.104012
 aattactggcaaaaacaaaactcttttataaagattttctaatgttgactttaatactct       c.*660

          .         .         .         .         .         .       g.104072
 aacatggtacaaaccaaatggtaaaatcccaagtcatttcttttttcatctctatttagc       c.*720

          .         .         .         .         .         .       g.104132
 aacagaattaagtggatgaagatattctactatgcattaaatcttgaactttataaaaca       c.*780

          .         .         .         .         .         .       g.104192
 tgtacaaaaattgtacaagataagttccacctggtaatgtctttccctaatacagggttg       c.*840

          .         .         .         .         .         .       g.104252
 cgcttgcattggaccctagggatttgcactaaaattatatcaaggtctcagatgagctta       c.*900

          .         .         .         .         .         .       g.104312
 gtgcacaagcactatcactttaaatactattatttgctaccacagcaactatatatttcc       c.*960

          .         .         .         .         .         .       g.104372
 atagcttttggctgggggcgggggacatttttattacaacttgaaattgctttgctggtt       c.*1020

          .         .         .         .         .         .       g.104432
 tcatatttatttgttgtatttaaaaaatacattgttgtaagagtgattttttcaatatat       c.*1080

          .         .         .         .         .         .       g.104492
 tttattcctgggggggatcatgctacactctcaaaagaaaattaagaaatcattcagatc       c.*1140

          .         .         .         .         .         .       g.104552
 atcccccctttttaagtagtgtgaattgcaaaacccaacatattttttttactgtcagtt       c.*1200

          .         .         .         .         .         .       g.104612
 gcggtttatttattctttaactgtctgttttagtagtttaatgattatgaaaaatgtatc       c.*1260

          .         .         .         .         .         .       g.104672
 tgtgtgtgatttgctatttattaaattttaagtactttgctgaatgtcattttaaagcat       c.*1320

          .         .         .         .         .         .       g.104732
 gtttgaagtcttgtgtatttgtctgtgttaatgctgtcaggaggaactgactaagatgtt       c.*1380

          .         .         .         .         .         .       g.104792
 ttaatatgtatcaaaaattaaaatgattttttttattgccttgaggtactttttaaatca       c.*1440

                                                                    g.104794
 aa                                                                 c.*1442

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The LDL receptor related protein 12 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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