low density lipoprotein receptor-related protein 4 (LRP4) - coding DNA reference sequence

(used for variant description)

(last modified November 21, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_002334.3 in the LRP4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021394.1, covering LRP4 transcript NM_002334.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          gtg       c.-241

 .         .         .         .         .         .                g.5063
 gccggggctgcggcgcggggggcggggcggtcgggcccgggacaccccctcccggtcccc       c.-181

 .         .         .         .         .         .                g.5123
 tggcggggcagcgtcggctctggcagcactggaggcggcggcggcccgagggcgacttgc       c.-121

 .         .         .         .         .         .                g.5183
 ggggcgcgcaggccgccgtgcacccgggacgcttccccctcggggaccctccgcgggctt       c.-61

 .         .         .         .         .         .                g.5243
 ctccgccgcgccgtccggcgggagccggcgggaccccgggcgagcggcgcgggcggcacc       c.-1

          .         .         .         .         .   | 02     .    g.20701
 ATGAGGCGGCAGTGGGGCGCGCTGCTGCTTGGCGCCCTGCTCTGCGCACACG | GCCTGGCC    c.60
 M  R  R  Q  W  G  A  L  L  L  G  A  L  L  C  A  H  G |   L  A      p.20

          .         .         .         .         .         .       g.20761
 AGCAGCCCCGAGTGTGCTTGTGGTCGGAGCCACTTCACATGTGCAGTGAGTGCTCTTGGA       c.120
 S  S  P  E  C  A  C  G  R  S  H  F  T  C  A  V  S  A  L  G         p.40

          .         .         .         .         .         .       g.20821
 GAGTGTACCTGCATCCCTGCCCAGTGGCAGTGTGATGGAGACAATGACTGCGGGGACCAC       c.180
 E  C  T  C  I  P  A  Q  W  Q  C  D  G  D  N  D  C  G  D  H         p.60

          .          | 03        .         .         .         .    g.23285
 AGCGATGAGGATGGATGTA | TACTACCTACCTGTTCCCCTCTTGACTTTCACTGTGACAAT    c.240
 S  D  E  D  G  C  I |   L  P  T  C  S  P  L  D  F  H  C  D  N      p.80

          .         .         .         .         .         .       g.23345
 GGCAAGTGCATCCGCCGCTCCTGGGTGTGTGACGGGGACAACGACTGTGAGGATGACTCG       c.300
 G  K  C  I  R  R  S  W  V  C  D  G  D  N  D  C  E  D  D  S         p.100

          .       | 04 .         .         .         .         .    g.23690
 GATGAGCAGGACTGTC | CCCCCCGGGAGTGTGAGGAGGACGAGTTTCCCTGCCAGAATGGC    c.360
 D  E  Q  D  C  P |   P  R  E  C  E  E  D  E  F  P  C  Q  N  G      p.120

          .         .         .         .         .         .       g.23750
 TACTGCATCCGGAGTCTGTGGCACTGCGATGGTGACAATGACTGTGGCGACAACAGCGAT       c.420
 Y  C  I  R  S  L  W  H  C  D  G  D  N  D  C  G  D  N  S  D         p.140

          . | 05       .         .         .         .         .    g.24169
 GAGCAGTGTG | ACATGCGCAAGTGCTCCGACAAGGAGTTCCGCTGTAGTGACGGAAGCTGC    c.480
 E  Q  C  D |   M  R  K  C  S  D  K  E  F  R  C  S  D  G  S  C      p.160

          .         .         .         .         .         .       g.24229
 ATTGCTGAGCATTGGTACTGCGACGGTGACACCGACTGCAAAGATGGCTCCGATGAGGAG       c.540
 I  A  E  H  W  Y  C  D  G  D  T  D  C  K  D  G  S  D  E  E         p.180

         | 06.         .         .         .         .         .    g.24643
 AACTGTC | CCTCAGCAGTGCCAGCGCCCCCCTGCAACCTGGAGGAGTTCCAGTGTGCCTAT    c.600
 N  C  P |   S  A  V  P  A  P  P  C  N  L  E  E  F  Q  C  A  Y      p.200

          .         .         .         .         .         .       g.24703
 GGACGCTGCATCCTCGACATCTACCACTGCGATGGCGACGATGACTGTGGAGACTGGTCA       c.660
 G  R  C  I  L  D  I  Y  H  C  D  G  D  D  D  C  G  D  W  S         p.220

          .       | 07 .         .         .         .         .    g.24989
 GACGAGTCTGACTGCT | CCTCCCACCAGCCCTGCCGCTCTGGGGAGTTCATGTGTGACAGT    c.720
 D  E  S  D  C  S |   S  H  Q  P  C  R  S  G  E  F  M  C  D  S      p.240

          .         .         .         .         .         .       g.25049
 GGCCTGTGCATCAATGCAGGCTGGCGCTGCGATGGTGACGCGGACTGTGATGACCAGTCT       c.780
 G  L  C  I  N  A  G  W  R  C  D  G  D  A  D  C  D  D  Q  S         p.260

          .       | 08 .         .         .         .         .    g.26672
 GATGAGCGCAACTGCA | CCACCTCCATGTGTACGGCAGAACAGTTCCGCTGTCACTCAGGC    c.840
 D  E  R  N  C  T |   T  S  M  C  T  A  E  Q  F  R  C  H  S  G      p.280

          .         .         .         .         .         .       g.26732
 CGCTGTGTCCGCCTGTCCTGGCGCTGTGATGGGGAGGACGACTGTGCAGACAACAGCGAT       c.900
 R  C  V  R  L  S  W  R  C  D  G  E  D  D  C  A  D  N  S  D         p.300

          .         .   | 09     .         .         .         .    g.27325
 GAAGAGAACTGTGAGAATACAG | GAAGCCCCCAATGTGCCTTGGACCAGTTCCTGTGTTGG    c.960
 E  E  N  C  E  N  T  G |   S  P  Q  C  A  L  D  Q  F  L  C  W      p.320

          .         .         .         .         .         .       g.27385
 AATGGGCGCTGCATTGGGCAGAGGAAGCTGTGCAACGGGGTCAACGACTGTGGTGACAAC       c.1020
 N  G  R  C  I  G  Q  R  K  L  C  N  G  V  N  D  C  G  D  N         p.340

          .         .         | 10         .         .         .    g.27636
 AGCGACGAAAGCCCACAGCAGAATTGCC | GGCCCCGGACGGGTGAGGAGAACTGCAATGTT    c.1080
 S  D  E  S  P  Q  Q  N  C  R |   P  R  T  G  E  E  N  C  N  V      p.360

          .         .         .         .         .         .       g.27696
 AACAACGGTGGCTGTGCCCAGAAGTGCCAGATGGTGCGGGGGGCAGTGCAGTGTACCTGC       c.1140
 N  N  G  G  C  A  Q  K  C  Q  M  V  R  G  A  V  Q  C  T  C         p.380

          .         .         .         .    | 11    .         .    g.28348
 CACACAGGCTACCGGCTCACAGAGGATGGGCACACGTGCCAAG | ATGTGAATGAATGTGCC    c.1200
 H  T  G  Y  R  L  T  E  D  G  H  T  C  Q  D |   V  N  E  C  A      p.400

          .         .         .         .         .         .       g.28408
 GAGGAGGGGTATTGCAGCCAGGGCTGCACCAACAGCGAAGGGGCTTTCCAATGCTGGTGT       c.1260
 E  E  G  Y  C  S  Q  G  C  T  N  S  E  G  A  F  Q  C  W  C         p.420

          .         .         .         .          | 12        .    g.28814
 GAAACAGGCTATGAACTACGGCCCGACCGGCGCAGCTGCAAGGCTCTGG | GGCCAGAGCCT    c.1320
 E  T  G  Y  E  L  R  P  D  R  R  S  C  K  A  L  G |   P  E  P      p.440

          .         .         .         .         .         .       g.28874
 GTGCTGCTGTTCGCCAATCGCATCGACATCCGGCAGGTGCTGCCACACCGCTCTGAGTAC       c.1380
 V  L  L  F  A  N  R  I  D  I  R  Q  V  L  P  H  R  S  E  Y         p.460

          .         .         .         .         .         .       g.28934
 ACACTGCTGCTTAACAACCTGGAGAATGCCATTGCCCTTGATTTCCACCACCGCCGCGAG       c.1440
 T  L  L  L  N  N  L  E  N  A  I  A  L  D  F  H  H  R  R  E         p.480

          .         .         .         .         .         .       g.28994
 CTTGTCTTCTGGTCAGATGTCACCCTGGACCGGATCCTCCGTGCCAACCTCAACGGCAGC       c.1500
 L  V  F  W  S  D  V  T  L  D  R  I  L  R  A  N  L  N  G  S         p.500

          .         .         .         . | 13       .         .    g.30513
 AACGTGGAGGAGGTTGTGTCTACTGGGCTGGAGAGCCCAG | GGGGCCTGGCTGTGGATTGG    c.1560
 N  V  E  E  V  V  S  T  G  L  E  S  P  G |   G  L  A  V  D  W      p.520

          .         .         .         .         .         .       g.30573
 GTCCATGACAAACTCTACTGGACCGACTCAGGCACCTCGAGGATTGAGGTGGCCAATCTG       c.1620
 V  H  D  K  L  Y  W  T  D  S  G  T  S  R  I  E  V  A  N  L         p.540

          .         .         .         .         .         .       g.30633
 GATGGGGCCCACCGGAAAGTGTTGCTGTGGCAGAACCTGGAGAAGCCCCGGGCCATTGCC       c.1680
 D  G  A  H  R  K  V  L  L  W  Q  N  L  E  K  P  R  A  I  A         p.560

          .        | 14.         .         .         .         .    g.33171
 TTGCATCCCATGGAGGG | TACCATTTACTGGACAGACTGGGGCAACACCCCCCGTATTGAG    c.1740
 L  H  P  M  E  G  |  T  I  Y  W  T  D  W  G  N  T  P  R  I  E      p.580

          .         .         .         .         .         .       g.33231
 GCCTCCAGCATGGATGGCTCTGGACGCCGCATCATTGCCGATACCCATCTCTTCTGGCCC       c.1800
 A  S  S  M  D  G  S  G  R  R  I  I  A  D  T  H  L  F  W  P         p.600

          .         .         .         .         .         .       g.33291
 AATGGCCTCACCATCGACTATGCCGGGCGCCGTATGTACTGGGTGGATGCTAAGCACCAT       c.1860
 N  G  L  T  I  D  Y  A  G  R  R  M  Y  W  V  D  A  K  H  H         p.620

          .         .         .         .         .      | 15  .    g.33507
 GTCATCGAGAGGGCCAATCTGGATGGGAGTCACCGTAAGGCTGTCATTAGCCAGG | GCCTC    c.1920
 V  I  E  R  A  N  L  D  G  S  H  R  K  A  V  I  S  Q  G |   L      p.640

          .         .         .         .         .         .       g.33567
 CCGCATCCCTTCGCCATCACAGTGTTTGAAGACAGCCTGTACTGGACAGACTGGCACACC       c.1980
 P  H  P  F  A  I  T  V  F  E  D  S  L  Y  W  T  D  W  H  T         p.660

          .         .         .         .         .         .       g.33627
 AAGAGCATCAATAGCGCTAACAAATTTACGGGGAAGAACCAGGAAATCATTCGCAACAAA       c.2040
 K  S  I  N  S  A  N  K  F  T  G  K  N  Q  E  I  I  R  N  K         p.680

          .         .         .         .         .   | 16     .    g.34097
 CTCCACTTCCCTATGGACATCCACACCTTGCACCCCCAGCGCCAACCTGCAG | GGAAAAAC    c.2100
 L  H  F  P  M  D  I  H  T  L  H  P  Q  R  Q  P  A  G |   K  N      p.700

          .         .         .         .         .         .       g.34157
 CGCTGTGGGGACAACAACGGAGGCTGCACGCACCTGTGTCTGCCCAGTGGCCAGAACTAC       c.2160
 R  C  G  D  N  N  G  G  C  T  H  L  C  L  P  S  G  Q  N  Y         p.720

          .         .         .         .         .      | 17  .    g.37094
 ACCTGTGCCTGCCCCACTGGCTTCCGCAAGATCAGCAGCCACGCCTGTGCCCAGA | GTCTT    c.2220
 T  C  A  C  P  T  G  F  R  K  I  S  S  H  A  C  A  Q  S |   L      p.740

          .         .         .         .         .         .       g.37154
 GACAAGTTCCTGCTTTTTGCCCGAAGGATGGACATCCGTCGAATCAGCTTTGACACAGAG       c.2280
 D  K  F  L  L  F  A  R  R  M  D  I  R  R  I  S  F  D  T  E         p.760

          .         .         .         .         .         .       g.37214
 GACCTGTCTGATGATGTCATCCCACTGGCTGACGTGCGCAGTGCTGTGGCCCTTGACTGG       c.2340
 D  L  S  D  D  V  I  P  L  A  D  V  R  S  A  V  A  L  D  W         p.780

          .         .         .         .         .         .       g.37274
 GACTCCCGGGATGACCACGTGTACTGGACAGATGTCAGCACTGATACCATCAGCAGGGCC       c.2400
 D  S  R  D  D  H  V  Y  W  T  D  V  S  T  D  T  I  S  R  A         p.800

          .         .     | 18   .         .         .         .    g.37486
 AAGTGGGATGGAACAGGACAGGAG | GTGGTAGTGGATACCAGTTTGGAGAGCCCAGCTGGC    c.2460
 K  W  D  G  T  G  Q  E   | V  V  V  D  T  S  L  E  S  P  A  G      p.820

          .         .         .         .       | 19 .         .    g.39660
 CTGGCCATTGATTGGGTCACCAACAAACTGTACTGGACAGATGCAG | GTACAGACCGGATT    c.2520
 L  A  I  D  W  V  T  N  K  L  Y  W  T  D  A  G |   T  D  R  I      p.840

          .         .         .         .         .         .       g.39720
 GAAGTAGCCAACACAGATGGCAGCATGAGAACAGTACTCATCTGGGAGAACCTTGATCGT       c.2580
 E  V  A  N  T  D  G  S  M  R  T  V  L  I  W  E  N  L  D  R         p.860

          .         .         .   | 20     .         .         .    g.41747
 CCTCGGGACATCGTGGTGGAACCCATGGGCGG | GTACATGTATTGGACTGACTGGGGTGCG    c.2640
 P  R  D  I  V  V  E  P  M  G  G  |  Y  M  Y  W  T  D  W  G  A      p.880

          .         .         .         .         .         .       g.41807
 AGCCCCAAGATTGAACGAGCTGGCATGGATGCCTCAGGCCGCCAAGTCATTATCTCTTCT       c.2700
 S  P  K  I  E  R  A  G  M  D  A  S  G  R  Q  V  I  I  S  S         p.900

          .         .         .         .         .         .       g.41867
 AATCTGACCTGGCCTAATGGGTTAGCTATTGATTATGGGTCCCAGCGTCTATACTGGGCT       c.2760
 N  L  T  W  P  N  G  L  A  I  D  Y  G  S  Q  R  L  Y  W  A         p.920

          .         .         .         .         .     | 21   .    g.44313
 GACGCCGGCATGAAGACAATTGAATTTGCTGGACTGGATGGCAGTAAGAGGAAG | GTGCTG    c.2820
 D  A  G  M  K  T  I  E  F  A  G  L  D  G  S  K  R  K   | V  L      p.940

          .         .         .         .         .         .       g.44373
 ATTGGAAGCCAGCTCCCCCACCCATTTGGGCTGACCCTCTATGGAGAGCGCATCTATTGG       c.2880
 I  G  S  Q  L  P  H  P  F  G  L  T  L  Y  G  E  R  I  Y  W         p.960

          .         .         .         .         .         .       g.44433
 ACTGACTGGCAGACCAAGAGCATACAGAGCGCTGACCGGCTGACAGGGCTGGACCGGGAG       c.2940
 T  D  W  Q  T  K  S  I  Q  S  A  D  R  L  T  G  L  D  R  E         p.980

          .         .         .         .         .         .       g.44493
 ACTCTGCAGGAGAACCTGGAAAACCTAATGGACATCCATGTCTTCCACCGCCGCCGGCCC       c.3000
 T  L  Q  E  N  L  E  N  L  M  D  I  H  V  F  H  R  R  R  P         p.1000

      | 22   .         .         .         .         .         .    g.44640
 CCAG | TGTCTACACCATGTGCTATGGAGAATGGCGGCTGTAGCCACCTGTGTCTTAGGTCC    c.3060
 P  V |   S  T  P  C  A  M  E  N  G  G  C  S  H  L  C  L  R  S      p.1020

          .         .         .         .         .         .       g.44700
 CCAAATCCAAGCGGATTCAGCTGTACCTGCCCCACAGGCATCAACCTGCTGTCTGATGGC       c.3120
 P  N  P  S  G  F  S  C  T  C  P  T  G  I  N  L  L  S  D  G         p.1040

          .       | 23 .         .         .         .         .    g.46327
 AAGACCTGCTCACCAG | GCATGAACAGTTTCCTCATCTTCGCCAGGAGGATAGACATTCGC    c.3180
 K  T  C  S  P  G |   M  N  S  F  L  I  F  A  R  R  I  D  I  R      p.1060

          .         .         .         .         .         .       g.46387
 ATGGTCTCCCTGGACATCCCTTATTTTGCTGATGTGGTGGTACCAATCAACATTACCATG       c.3240
 M  V  S  L  D  I  P  Y  F  A  D  V  V  V  P  I  N  I  T  M         p.1080

          .         .         .        | 24.         .         .    g.46815
 AAGAACACCATTGCCATTGGAGTAGACCCCCAGGAAG | GAAAGGTGTACTGGTCTGACAGC    c.3300
 K  N  T  I  A  I  G  V  D  P  Q  E  G |   K  V  Y  W  S  D  S      p.1100

          .         .         .         .         .         .       g.46875
 ACACTGCACAGGATCAGTCGTGCCAATCTGGATGGCTCACAGCATGAGGACATCATCACC       c.3360
 T  L  H  R  I  S  R  A  N  L  D  G  S  Q  H  E  D  I  I  T         p.1120

      | 25   .         .         .         .         .         .    g.47041
 ACAG | GGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGG    c.3420
 T  G |   L  Q  T  T  D  G  L  A  V  D  A  I  G  R  K  V  Y  W      p.1140

          .         .         .         .         .         .       g.47101
 ACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGTG       c.3480
 T  D  T  G  T  N  R  I  E  V  G  N  L  D  G  S  M  R  K  V         p.1160

          .         .         .         .         .       | 26 .    g.47660
 TTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGG | GTTT    c.3540
 L  V  W  Q  N  L  D  S  P  R  A  I  V  L  Y  H  E  M  G  |  F      p.1180

          .         .         .         .         .         .       g.47720
 ATGTACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCA       c.3600
 M  Y  W  T  D  W  G  E  N  A  K  L  E  R  S  G  M  D  G  S         p.1200

          .         .         .         .         .         .       g.47780
 GACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAAG       c.3660
 D  R  A  V  L  I  N  N  N  L  G  W  P  N  G  L  T  V  D  K         p.1220

          .         .         .          | 27        .         .    g.47962
 GCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAG | CGAATTGAGGCTGCTGACCTG    c.3720
 A  S  S  Q  L  L  W  A  D  A  H  T  E   | R  I  E  A  A  D  L      p.1240

          .         .         .         .         .         .       g.48022
 AATGGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTG       c.3780
 N  G  A  N  R  H  T  L  V  S  P  V  Q  H  P  Y  G  L  T  L         p.1260

          .         .         .         .         .         .       g.48082
 CTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAAG       c.3840
 L  D  S  Y  I  Y  W  T  D  W  Q  T  R  S  I  H  R  A  D  K         p.1280

          .         .         .         .         .         .       g.48142
 GGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAG       c.3900
 G  T  G  S  N  V  I  L  V  R  S  N  L  P  G  L  M  D  M  Q         p.1300

          .         .      | 28  .         .         .         .    g.48554
 GCTGTGGACCGGGCACAGCCACTAG | GTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGC    c.3960
 A  V  D  R  A  Q  P  L  G |   F  N  K  C  G  S  R  N  G  G  C      p.1320

          .         .         .         .         .         .       g.48614
 TCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCAG       c.4020
 S  H  L  C  L  P  R  P  S  G  F  S  C  A  C  P  T  G  I  Q         p.1340

          .         .         .         .         .         .       g.48674
 CTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGC       c.4080
 L  K  G  D  G  K  T  C  D  P  S  P  E  T  Y  L  L  F  S  S         p.1360

          .         .         .         .         .         .       g.48734
 CGTGGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCT       c.4140
 R  G  S  I  R  R  I  S  L  D  T  S  D  H  T  D  V  H  V  P         p.1380

          .         .         .         .         .         .       g.48794
 GTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTAT       c.4200
 V  P  E  L  N  N  V  I  S  L  D  Y  D  S  V  D  G  K  V  Y         p.1400

          .         .          | 29        .         .         .    g.50060
 TACACAGATGTGTTCCTGGATGTTATCAG | GCGAGCAGACCTGAACGGCAGCAACATGGAG    c.4260
 Y  T  D  V  F  L  D  V  I  R  |  R  A  D  L  N  G  S  N  M  E      p.1420

          .         .         .         .         .         .       g.50120
 ACAGTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGG       c.4320
 T  V  I  G  R  G  L  K  T  T  D  G  L  A  V  D  W  V  A  R         p.1440

          .         .         .         .         .         .       g.50180
 AACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTCC       c.4380
 N  L  Y  W  T  D  T  G  R  N  T  I  E  A  S  R  L  D  G  S         p.1460

          .         .         .         .         .         .       g.50240
 TGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCC       c.4440
 C  R  K  V  L  I  N  N  S  L  D  E  P  R  A  I  A  V  F  P         p.1480

          | 30         .         .         .         .         .    g.50440
 AGGAAGGG | GTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAAC    c.4500
 R  K  G  |  Y  L  F  W  T  D  W  G  H  I  A  K  I  E  R  A  N      p.1500

          .         .         .         .         .         .       g.50500
 TTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCTT       c.4560
 L  D  G  S  E  R  K  V  L  I  N  T  D  L  G  W  P  N  G  L         p.1520

          .         .    | 31    .         .         .         .    g.52026
 ACCCTGGACTATGATACCCGCAG | GATCTACTGGGTGGATGCGCATCTGGACCGGATCGAG    c.4620
 T  L  D  Y  D  T  R  R  |  I  Y  W  V  D  A  H  L  D  R  I  E      p.1540

          .         .         .         .         .         .       g.52086
 AGTGCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTT       c.4680
 S  A  D  L  N  G  K  L  R  Q  V  L  V  S  H  V  S  H  P  F         p.1560

          .   | 32     .         .         .         .         .    g.54538
 GCCCTCACACAG | CAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCAG    c.4740
 A  L  T  Q   | Q  D  R  W  I  Y  W  T  D  W  Q  T  K  S  I  Q      p.1580

          .         .         .         .         .         .       g.54598
 CGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTC       c.4800
 R  V  D  K  Y  S  G  R  N  K  E  T  V  L  A  N  V  E  G  L         p.1600

          .         .         .        | 33.         .         .    g.54932
 ATGGATATCATCGTGGTTTCCCCTCAGCGGCAGACAG | GGACCAATGCCTGTGGTGTGAAC    c.4860
 M  D  I  I  V  V  S  P  Q  R  Q  T  G |   T  N  A  C  G  V  N      p.1620

          .         .         .         .         .         .       g.54992
 AATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCCT       c.4920
 N  G  G  C  T  H  L  C  F  A  R  A  S  D  F  V  C  A  C  P         p.1640

          .         .         .  | 34      .         .         .    g.55537
 GACGAACCTGATAGCCGGCCCTGCTCCCTTG | TGCCTGGCCTGGTACCACCAGCTCCTAGG    c.4980
 D  E  P  D  S  R  P  C  S  L  V |   P  G  L  V  P  P  A  P  R      p.1660

          .         .         .         .         .         .       g.55597
 GCTACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTAT       c.5040
 A  T  G  M  S  E  K  S  P  V  L  P  N  T  P  P  T  T  L  Y         p.1680

          .         .         .         .        | 35.         .    g.58449
 TCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAG | ATGCTCTGAAAGG    c.5100
 S  S  T  T  R  T  R  T  S  L  E  E  V  E  G  R  |  C  S  E  R      p.1700

          .         .         .         .         .      | 36  .    g.59092
 GATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAG | GGGAA    c.5160
 D  A  R  L  G  L  C  A  R  S  N  D  A  V  P  A  A  P  G |   E      p.1720

          .         .         .         .         .         .       g.59152
 GGACTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTG       c.5220
 G  L  H  I  S  Y  A  I  G  G  L  L  S  I  L  L  I  L  V  V         p.1740

          .         .    | 37    .         .         .         .    g.60912
 ATTGCAGCTTTGATGCTGTACAG | ACACAAAAAATCCAAGTTCACTGATCCTGGAATGGGG    c.5280
 I  A  A  L  M  L  Y  R  |  H  K  K  S  K  F  T  D  P  G  M  G      p.1760

          .         .         .         .         .         .       g.60972
 AACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCA       c.5340
 N  L  T  Y  S  N  P  S  Y  R  T  S  T  Q  E  V  K  I  E  A         p.1780

          .         .         .         .      | 38  .         .    g.64322
 ATCCCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAG | GGAGGGCCTGACCAT    c.5400
 I  P  K  P  A  M  Y  N  Q  L  C  Y  K  K  E   | G  G  P  D  H      p.1800

          .         .         .         .         .         .       g.64382
 AACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGAT       c.5460
 N  Y  T  K  E  K  I  K  I  V  E  G  I  C  L  L  S  G  D  D         p.1820

          .         .         .         .         .         .       g.64442
 GCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCAT       c.5520
 A  E  W  D  D  L  K  Q  L  R  S  S  R  G  G  L  L  R  D  H         p.1840

          .         .         .         .         .         .       g.64502
 GTATGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACA       c.5580
 V  C  M  K  T  D  T  V  S  I  Q  A  S  S  G  S  L  D  D  T         p.1860

          .         .         .         .         .         .       g.64562
 GAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGCC       c.5640
 E  T  E  Q  L  L  Q  E  E  Q  S  E  C  S  S  V  H  T  A  A         p.1880

          .         .         .         .         .         .       g.64622
 ACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCC       c.5700
 T  P  E  R  R  G  S  L  P  D  T  G  W  K  H  E  R  K  L  S         p.1900

          .                                                         g.64640
 TCAGAGAGCCAGGTCTAA                                                 c.5718
 S  E  S  Q  V  X                                                   p.1905

          .         .         .         .         .         .       g.64700
 atgcccacattctcttccctgcctgcctgttccttctcctttatggacgtctagtccttg       c.*60

          .         .         .         .         .         .       g.64760
 tgctcgcttacaccgcaggccccgcttctgtgtgcttgtcctcctcctcctcccacccca       c.*120

          .         .         .         .         .         .       g.64820
 taactgttcctaagccttcaccggagctgtttaccacgtgagtccataactacctgtgca       c.*180

          .         .         .         .         .         .       g.64880
 caagaaatgatggcacatcacgagaatttagacctggattttaccatgaacctcacatct       c.*240

          .         .         .         .         .         .       g.64940
 tgtactccatcctgggccccctgaaactgcttattcgtgattcctcaccagcgtagagct       c.*300

          .         .         .         .         .         .       g.65000
 ccacctcccctttccccagtaccctcagtgcctgcttctcagtgctgatgcagctgatga       c.*360

          .         .         .         .         .         .       g.65060
 cccaggactgcgctctgccccatcacagccagcatgactgcttctctgagagaacttgcc       c.*420

          .         .         .         .         .         .       g.65120
 catcaggggctgggacatgggggtgtgggtaaagacagggatgaaggatagaggctgaga       c.*480

          .         .         .         .         .         .       g.65180
 gaagaaggaagaatcagcccagcaggtatgggcatctgggaaacctccagcctcaagtgt       c.*540

          .         .         .         .         .         .       g.65240
 gttggtaacatgaaaaagctttggggggtagttggatctgggtgtctggtccattgctgg       c.*600

          .         .         .         .         .         .       g.65300
 cagtggacattattcttgccctaagagacactgccttttcagcagcagatactggtgaga       c.*660

          .         .         .         .         .         .       g.65360
 tgggggtggctcaggctgttcttcctcctcctagaatgtctggagctgtttctacattca       c.*720

          .         .         .         .         .         .       g.65420
 gataactgggtcccctatcacaaggctactggctaataggaattccctcctggtgccacc       c.*780

          .         .         .         .         .         .       g.65480
 actggccagtacctttcctaagtctttgctcaaattaaccaggttgtgagccagtggctt       c.*840

          .         .         .         .         .         .       g.65540
 gagtgaatgttaggccttgggggctgagtctctgaaaagtctaagaagctctgcctagac       c.*900

          .         .         .         .         .         .       g.65600
 caaatatggtatacctcctgacccctctctccctcatgtcctgggattctggggaagaga       c.*960

          .         .         .         .         .         .       g.65660
 cctagaaacaagctttcaaagaaaaaccagaagttgtcataaatggtcagaaagaacgat       c.*1020

          .         .         .         .         .         .       g.65720
 caggttggagacttgggaaacccagggcctaaagagaagtatccatgagggtcaaacttc       c.*1080

          .         .         .         .         .         .       g.65780
 ctgttgaacttcctatgttctttctcaagtgctcagggatctaagttagtggacagcaag       c.*1140

          .         .         .         .         .         .       g.65840
 cctgtggctacggggtggtgatgttcctcttccagctgtcccctcagctaaggggcttag       c.*1200

          .         .         .         .         .         .       g.65900
 tttccatgtgggatgccatcacttggttcatgctcattcacacaaagggcacgtgtctca       c.*1260

          .         .         .         .         .         .       g.65960
 gcctggtatcagggaaattgagacttatttttgccctaaaacgtctccctagctgttctt       c.*1320

          .         .         .         .         .         .       g.66020
 cgtggggtttttttgtttgtttttttgcctaatttgctttttctgaccaagccttgtggc       c.*1380

          .         .         .         .         .         .       g.66080
 accagcaatctccaaagtcctgtggtgggagggctgaataaataaaaatacaaagaggtg       c.*1440

          .         .         .         .         .         .       g.66140
 ggtaaggagtaggaaggtagagagcaccactgatgaggccctcctagcccatggcagacc       c.*1500

          .         .         .         .         .         .       g.66200
 cagacctcttctcccccaggaattagaagtggcaggagagaacaacaggggctgggaatg       c.*1560

          .         .         .         .         .         .       g.66260
 gaggggagaatttctaggggaagtttcctgagttgaaacttctcctgtggttactggtat       c.*1620

          .         .         .         .         .         .       g.66320
 tgagaaatcagctaccaaagtgaaaaaggacaagatcaattcttttctagtcagttctaa       c.*1680

          .         .         .         .         .         .       g.66380
 gactgctagagagagataccaggcccttagccttgctctcagtagcgtcagccccagttc       c.*1740

          .         .         .         .         .         .       g.66440
 tgagcctccccacattacacttaacaagcagtaaaggagtgagcactttgggtccttaga       c.*1800

          .         .         .         .         .         .       g.66500
 ctcatgtctggggaggaagagcaagtagaaaagtggcattttcttgattggaaaggggga       c.*1860

          .         .         .         .         .         .       g.66560
 aggatcttattgcacttgggctgttcagaatgtagaaaggacatatttgaggaagtatct       c.*1920

          .         .         .         .         .         .       g.66620
 atttgagcactgatttactctgtaaaaagcaaaatctctctgtcctaaactaatggaagc       c.*1980

          .         .         .         .         .         .       g.66680
 gattctcccatgctcatgtgtaatggttttaacgttactcactggagagattggactttc       c.*2040

          .         .         .         .         .         .       g.66740
 tggagttatttaaccactatgttcagtattttaggactttatgataatttaatataaatt       c.*2100

          .         .         .         .         .         .       g.66800
 tagcttttcttaatcaccttgcctggcttggagtcatgactaatcctgcacctgctctgt       c.*2160

          .         .         .         .         .         .       g.66860
 ctggcagacccatgctgtggaaaacctgcttacagacatcacttttaagtcctttgtgga       c.*2220

          .         .         .         .                           g.66906
 tgtgggcacagtgaagagcaataaagagtgtgaggttcctgctgga                     c.*2266

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Low density lipoprotein receptor-related protein 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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