leucine-rich repeat kinase 2 (LRRK2) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_198578.3 in the LRRK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011709.1, covering LRRK2 transcript NM_198578.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            g       c.-121

 .         .         .         .         .         .                g.5061
 cgctggctgcgggcggtgagctgagctcgcccccggggagctgtggccggcgcccctgcc       c.-61

 .         .         .         .         .         .                g.5121
 ggttccctgagcagcggacgttcatgctgggagggcggcgggttggaagcaggtgccacc       c.-1

          .         .         .         .         .         .       g.5181
 ATGGCTAGTGGCAGCTGTCAGGGGTGCGAAGAGGACGAGGAAACTCTGAAGAAGTTGATA       c.60
 M  A  S  G  S  C  Q  G  C  E  E  D  E  E  T  L  K  K  L  I         p.20

          .         .         .         .         .         .       g.5241
 GTCAGGCTGAACAATGTCCAGGAAGGAAAACAGATAGAAACGCTGGTCCAAATCCTGGAG       c.120
 V  R  L  N  N  V  Q  E  G  K  Q  I  E  T  L  V  Q  I  L  E         p.40

          .         .         .  | 02      .         .         .    g.5573
 GATCTGCTGGTGTTCACGTACTCCGAGCACG | CCTCCAAGTTATTTCAAGGCAAAAATATC    c.180
 D  L  L  V  F  T  Y  S  E  H  A |   S  K  L  F  Q  G  K  N  I      p.60

          .         .         .         .         .        | 03.    g.12266
 CATGTGCCTCTGTTGATCGTCTTGGACTCCTATATGAGAGTCGCGAGTGTGCAGCAG | GTG    c.240
 H  V  P  L  L  I  V  L  D  S  Y  M  R  V  A  S  V  Q  Q   | V      p.80

          .         .         .         .         .         .       g.12326
 GGTTGGTCACTTCTGTGCAAATTAATAGAAGTCTGTCCAGGTACAATGCAAAGCTTAATG       c.300
 G  W  S  L  L  C  K  L  I  E  V  C  P  G  T  M  Q  S  L  M         p.100

          .         .         .         .        | 04.         .    g.15628
 GGACCCCAGGATGTTGGAAATGATTGGGAAGTCCTTGGTGTTCACCA | ATTGATTCTTAAA    c.360
 G  P  Q  D  V  G  N  D  W  E  V  L  G  V  H  Q  |  L  I  L  K      p.120

          .         .         .         .         .         .       g.15688
 ATGCTAACAGTTCATAATGCCAGTGTAAACTTGTCAGTGATTGGACTGAAGACCTTAGAT       c.420
 M  L  T  V  H  N  A  S  V  N  L  S  V  I  G  L  K  T  L  D         p.140

          .       | 05 .         .         .         .         .    g.18002
 CTCCTCCTAACTTCAG | GTAAAATCACCTTGCTGATATTGGATGAAGAAAGTGATATTTTC    c.480
 L  L  L  T  S  G |   K  I  T  L  L  I  L  D  E  E  S  D  I  F      p.160

          .         .         .         .         .         .       g.18062
 ATGTTAATTTTTGATGCCATGCACTCATTTCCAGCCAATGATGAAGTCCAGAAACTTGGA       c.540
 M  L  I  F  D  A  M  H  S  F  P  A  N  D  E  V  Q  K  L  G         p.180

          .         .         .  | 06      .         .         .    g.20501
 TGCAAAGCTTTACATGTGCTGTTTGAGAGAG | TCTCAGAGGAGCAACTGACTGAATTTGTT    c.600
 C  K  A  L  H  V  L  F  E  R  V |   S  E  E  Q  L  T  E  F  V      p.200

          .         .         .         .         .         .       g.20561
 GAGAACAAAGATTATATGATATTGTTAAGTGCGTTAACAAATTTTAAAGATGAAGAGGAA       c.660
 E  N  K  D  Y  M  I  L  L  S  A  L  T  N  F  K  D  E  E  E         p.220

          .         .         .         .       | 07 .         .    g.23553
 ATTGTGCTTCATGTGCTGCATTGTTTACATTCCCTAGCGATTCCTT | GCAATAATGTGGAA    c.720
 I  V  L  H  V  L  H  C  L  H  S  L  A  I  P  C |   N  N  V  E      p.240

          .         .         .         .         .         .       g.23613
 GTCCTCATGAGTGGCAATGTCAGGTGTTATAATATTGTGGTGGAAGCTATGAAAGCATTC       c.780
 V  L  M  S  G  N  V  R  C  Y  N  I  V  V  E  A  M  K  A  F         p.260

          .         .         .         .         .         | 08    g.29817
 CCTATGAGTGAAAGAATTCAAGAAGTGAGTTGCTGTTTGCTCCATAGGCTTACATTAG | GT    c.840
 P  M  S  E  R  I  Q  E  V  S  C  C  L  L  H  R  L  T  L  G |       p.280

          .         .         .         .         .         .       g.29877
 AATTTTTTCAATATCCTGGTATTAAACGAAGTCCATGAGTTTGTGGTGAAAGCTGTGCAG       c.900
 N  F  F  N  I  L  V  L  N  E  V  H  E  F  V  V  K  A  V  Q         p.300

          .         .         .         .         .         | 09    g.31223
 CAGTACCCAGAGAATGCAGCATTGCAGATCTCAGCGCTCAGCTGTTTGGCCCTCCTCA | CT    c.960
 Q  Y  P  E  N  A  A  L  Q  I  S  A  L  S  C  L  A  L  L  T |       p.320

          .         .         .         .         .         .       g.31283
 GAGACTATTTTCTTAAATCAAGATTTAGAGGAAAAGAATGAGAATCAAGAGAATGATGAT       c.1020
 E  T  I  F  L  N  Q  D  L  E  E  K  N  E  N  Q  E  N  D  D         p.340

          .         .         .         .         .         .       g.31343
 GAGGGGGAAGAAGATAAATTGTTTTGGCTGGAAGCCTGTTACAAAGCATTAACGTGGCAT       c.1080
 E  G  E  E  D  K  L  F  W  L  E  A  C  Y  K  A  L  T  W  H         p.360

          .         .  | 10      .         .         .         .    g.31493
 AGAAAGAACAAGCACGTGCAG | GAGGCCGCATGCTGGGCACTAAATAATCTCCTTATGTAC    c.1140
 R  K  N  K  H  V  Q   | E  A  A  C  W  A  L  N  N  L  L  M  Y      p.380

          .         .         .         .  | 11      .         .    g.32918
 CAAAACAGTTTACATGAGAAGATTGGAGATGAAGATGGCCA | TTTCCCAGCTCATAGGGAA    c.1200
 Q  N  S  L  H  E  K  I  G  D  E  D  G  H  |  F  P  A  H  R  E      p.400

          .         .         .         .         .         .       g.32978
 GTGATGCTCTCCATGCTGATGCATTCTTCATCAAAGGAAGTTTTCCAGGCATCTGCGAAT       c.1260
 V  M  L  S  M  L  M  H  S  S  S  K  E  V  F  Q  A  S  A  N         p.420

          .         .         | 12         .         .         .    g.37269
 GCATTGTCAACTCTCTTAGAACAAAATG | TTAATTTCAGAAAAATACTGTTATCAAAAGGA    c.1320
 A  L  S  T  L  L  E  Q  N  V |   N  F  R  K  I  L  L  S  K  G      p.440

          .         .         .         .         .         .       g.37329
 ATACACCTGAATGTTTTGGAGTTAATGCAGAAGCATATACATTCTCCTGAAGTGGCTGAA       c.1380
 I  H  L  N  V  L  E  L  M  Q  K  H  I  H  S  P  E  V  A  E         p.460

          .         .         .         | 13         .         .    g.39491
 AGTGGCTGTAAAATGCTAAATCATCTTTTTGAAGGAAG | CAACACTTCCCTGGATATAATG    c.1440
 S  G  C  K  M  L  N  H  L  F  E  G  S  |  N  T  S  L  D  I  M      p.480

          .         .         .         .         .         .       g.39551
 GCAGCAGTGGTCCCCAAAATACTAACAGTTATGAAACGTCATGAGACATCATTACCAGTG       c.1500
 A  A  V  V  P  K  I  L  T  V  M  K  R  H  E  T  S  L  P  V         p.500

          .         .         .         .    | 14    .         .    g.43795
 CAGCTGGAGGCGCTTCGAGCTATTTTACATTTTATAGTGCCTG | GCATGCCAGAAGAATCC    c.1560
 Q  L  E  A  L  R  A  I  L  H  F  I  V  P  G |   M  P  E  E  S      p.520

          .         .         .         .         .         .       g.43855
 AGGGAGGATACAGAATTTCATCATAAGCTAAATATGGTTAAAAAACAGTGTTTCAAGAAT       c.1620
 R  E  D  T  E  F  H  H  K  L  N  M  V  K  K  Q  C  F  K  N         p.540

          .         .         .       | 15 .         .         .    g.54596
 GATATTCACAAACTGGTCCTAGCAGCTTTGAACAGG | TTCATTGGAAATCCTGGGATTCAG    c.1680
 D  I  H  K  L  V  L  A  A  L  N  R   | F  I  G  N  P  G  I  Q      p.560

          .         .         .         .         .         .       g.54656
 AAATGTGGATTAAAAGTAATTTCTTCTATTGTACATTTTCCTGATGCATTAGAGATGTTA       c.1740
 K  C  G  L  K  V  I  S  S  I  V  H  F  P  D  A  L  E  M  L         p.580

          .         .         .         .         .         .       g.54716
 TCCCTGGAAGGTGCTATGGATTCAGTGCTTCACACACTGCAGATGTATCCAGATGACCAA       c.1800
 S  L  E  G  A  M  D  S  V  L  H  T  L  Q  M  Y  P  D  D  Q         p.600

   | 16      .         .         .         .         .         .    g.54902
 G | AAATTCAGTGTCTGGGTTTAAGTCTTATAGGATACTTGATTACAAAGAAGAATGTGTTC    c.1860
 E |   I  Q  C  L  G  L  S  L  I  G  Y  L  I  T  K  K  N  V  F      p.620

          .         .         .         .         .         .       g.54962
 ATAGGAACTGGACATCTGCTGGCAAAAATTCTGGTTTCCAGCTTATACCGATTTAAGGAT       c.1920
 I  G  T  G  H  L  L  A  K  I  L  V  S  S  L  Y  R  F  K  D         p.640

          .         .  | 17      .         .         .         .    g.57916
 GTTGCTGAAATACAGACTAAA | GGATTTCAGACAATCTTAGCAATCCTCAAATTGTCAGCA    c.1980
 V  A  E  I  Q  T  K   | G  F  Q  T  I  L  A  I  L  K  L  S  A      p.660

          .         .         .         .         .         .       g.57976
 TCTTTTTCTAAGCTGCTGGTGCATCATTCATTTGACTTAGTAATATTCCATCAAATGTCT       c.2040
 S  F  S  K  L  L  V  H  H  S  F  D  L  V  I  F  H  Q  M  S         p.680

          .         .         . | 18       .         .         .    g.58110
 TCCAATATCATGGAACAAAAGGATCAACAG | TTTCTAAACCTCTGTTGCAAGTGTTTTGCA    c.2100
 S  N  I  M  E  Q  K  D  Q  Q   | F  L  N  L  C  C  K  C  F  A      p.700

          .         .         .         .         .         .       g.58170
 AAAGTAGCTATGGATGATTACTTAAAAAATGTGATGCTAGAGAGAGCGTGTGATCAGAAT       c.2160
 K  V  A  M  D  D  Y  L  K  N  V  M  L  E  R  A  C  D  Q  N         p.720

          .         .         .         .         .         .       g.58230
 AACAGCATCATGGTTGAATGCTTGCTTCTATTGGGAGCAGATGCCAATCAAGCAAAGGAG       c.2220
 N  S  I  M  V  E  C  L  L  L  L  G  A  D  A  N  Q  A  K  E         p.740

          .         .  | 19      .         .         .         .    g.63903
 GGATCTTCTTTAATTTGTCAG | GTATGTGAGAAAGAGAGCAGTCCCAAATTGGTGGAACTC    c.2280
 G  S  S  L  I  C  Q   | V  C  E  K  E  S  S  P  K  L  V  E  L      p.760

          .         .         .         .         .         .       g.63963
 TTACTGAATAGTGGATCTCGTGAACAAGATGTACGAAAAGCGTTGACGATAAGCATTGGG       c.2340
 L  L  N  S  G  S  R  E  Q  D  V  R  K  A  L  T  I  S  I  G         p.780

          .         .         .         .         .         .       g.64023
 AAAGGTGACAGCCAGATCATCAGCTTGCTCTTAAGGAGGCTGGCCCTGGATGTGGCCAAC       c.2400
 K  G  D  S  Q  I  I  S  L  L  L  R  R  L  A  L  D  V  A  N         p.800

          .         .         .         .         .         .       g.64083
 AATAGCATTTGCCTTGGAGGATTTTGTATAGGAAAAGTTGAACCTTCTTGGCTTGGTCCT       c.2460
 N  S  I  C  L  G  G  F  C  I  G  K  V  E  P  S  W  L  G  P         p.820

          .         .         .         . | 20       .         .    g.67360
 TTATTTCCAGATAAGACTTCTAATTTAAGGAAACAAACAA | ATATAGCATCTACACTAGCA    c.2520
 L  F  P  D  K  T  S  N  L  R  K  Q  T  N |   I  A  S  T  L  A      p.840

          .         .         .         .         .         .       g.67420
 AGAATGGTGATCAGATATCAGATGAAAAGTGCTGTGGAAGAAGGAACAGCCTCAGGCAGC       c.2580
 R  M  V  I  R  Y  Q  M  K  S  A  V  E  E  G  T  A  S  G  S         p.860

          .         .         .         .         .         .       g.67480
 GATGGAAATTTTTCTGAAGATGTGCTGTCTAAATTTGATGAATGGACCTTTATTCCTGAC       c.2640
 D  G  N  F  S  E  D  V  L  S  K  F  D  E  W  T  F  I  P  D         p.880

          .         .         .         .          | 21        .    g.73545
 TCTTCTATGGACAGTGTGTTTGCTCAAAGTGATGACCTGGATAGTGAAG | GAAGTGAAGGC    c.2700
 S  S  M  D  S  V  F  A  Q  S  D  D  L  D  S  E  G |   S  E  G      p.900

          .         .         .         .         .         .       g.73605
 TCATTTCTTGTGAAAAAGAAATCTAATTCAATTAGTGTAGGAGAATTTTACCGAGATGCC       c.2760
 S  F  L  V  K  K  K  S  N  S  I  S  V  G  E  F  Y  R  D  A         p.920

          .         .         .         .         | 22         .    g.74846
 GTATTACAGCGTTGCTCACCAAATTTGCAAAGACATTCCAATTCCTTG | GGGCCCATTTTT    c.2820
 V  L  Q  R  C  S  P  N  L  Q  R  H  S  N  S  L   | G  P  I  F      p.940

          .         .         .         .         .         | 23    g.75418
 GATCATGAAGATTTACTGAAGCGAAAAAGAAAAATATTATCTTCAGATGATTCACTCA | GG    c.2880
 D  H  E  D  L  L  K  R  K  R  K  I  L  S  S  D  D  S  L  R |       p.960

          .         .         .         .         .         .       g.75478
 TCATCAAAACTTCAATCCCATATGAGGCATTCAGACAGCATTTCTTCTCTGGCTTCTGAG       c.2940
 S  S  K  L  Q  S  H  M  R  H  S  D  S  I  S  S  L  A  S  E         p.980

          .         .         .         .         .         .       g.75538
 AGAGAATATATTACATCACTAGACCTTTCAGCAAATGAACTAAGAGATATTGATGCCCTA       c.3000
 R  E  Y  I  T  S  L  D  L  S  A  N  E  L  R  D  I  D  A  L         p.1000

          .         .         .         .         .         .       g.75598
 AGCCAGAAATGCTGTATAAGTGTTCATTTGGAGCATCTTGAAAAGCTGGAGCTTCACCAG       c.3060
 S  Q  K  C  C  I  S  V  H  L  E  H  L  E  K  L  E  L  H  Q         p.1020

          .         .         .       | 24 .         .         .    g.78256
 AATGCACTCACGAGCTTTCCACAACAGCTATGTGAA | ACTCTGAAGAGTTTGACACATTTG    c.3120
 N  A  L  T  S  F  P  Q  Q  L  C  E   | T  L  K  S  L  T  H  L      p.1040

          .         .         .         .         .         .       g.78316
 GACTTGCACAGTAATAAATTTACATCATTTCCTTCTTATTTGTTGAAAATGAGTTGTATT       c.3180
 D  L  H  S  N  K  F  T  S  F  P  S  Y  L  L  K  M  S  C  I         p.1060

          .         .         .         .         .         .       g.78376
 GCTAATCTTGATGTCTCTCGAAATGACATTGGACCCTCAGTGGTTTTAGATCCTACAGTG       c.3240
 A  N  L  D  V  S  R  N  D  I  G  P  S  V  V  L  D  P  T  V         p.1080

          .         .         .         .         .         .       g.78436
 AAATGTCCAACTCTGAAACAGTTTAACCTGTCATATAACCAGCTGTCTTTTGTACCTGAG       c.3300
 K  C  P  T  L  K  Q  F  N  L  S  Y  N  Q  L  S  F  V  P  E         p.1100

          .         .         .         .        | 25.         .    g.79111
 AACCTCACTGATGTGGTAGAGAAACTGGAGCAGCTCATTTTAGAAGG | AAATAAAATATCA    c.3360
 N  L  T  D  V  V  E  K  L  E  Q  L  I  L  E  G  |  N  K  I  S      p.1120

          .         .         .         .         .         .       g.79171
 GGGATATGCTCCCCCTTGAGACTGAAGGAACTGAAGATTTTAAACCTTAGTAAGAACCAC       c.3420
 G  I  C  S  P  L  R  L  K  E  L  K  I  L  N  L  S  K  N  H         p.1140

          .         .         .         .         .         .       g.79231
 ATTTCATCCCTATCAGAGAACTTTCTTGAGGCTTGTCCTAAAGTGGAGAGTTTCAGTGCC       c.3480
 I  S  S  L  S  E  N  F  L  E  A  C  P  K  V  E  S  F  S  A         p.1160

          .       | 26 .         .         .         .         .    g.82822
 AGAATGAATTTTCTTG | CTGCTATGCCTTTCTTGCCTCCTTCTATGACAATCCTAAAATTA    c.3540
 R  M  N  F  L  A |   A  M  P  F  L  P  P  S  M  T  I  L  K  L      p.1180

          .         .         .         .         . | 27       .    g.83947
 TCTCAGAACAAATTTTCCTGTATTCCAGAAGCAATTTTAAATCTTCCACA | CTTGCGGTCT    c.3600
 S  Q  N  K  F  S  C  I  P  E  A  I  L  N  L  P  H  |  L  R  S      p.1200

          .         .         .         .         .         .       g.84007
 TTAGATATGAGCAGCAATGATATTCAGTACCTACCAGGTCCCGCACACTGGAAATCTTTG       c.3660
 L  D  M  S  S  N  D  I  Q  Y  L  P  G  P  A  H  W  K  S  L         p.1220

          .         .         .         .         .         .       g.84067
 AACTTAAGGGAACTCTTATTTAGCCATAATCAGATCAGCATCTTGGACTTGAGTGAAAAA       c.3720
 N  L  R  E  L  L  F  S  H  N  Q  I  S  I  L  D  L  S  E  K         p.1240

          .         .         .         .         .        | 28.    g.85777
 GCATATTTATGGTCTAGAGTAGAGAAACTGCATCTTTCTCACAATAAACTGAAAGAG | ATT    c.3780
 A  Y  L  W  S  R  V  E  K  L  H  L  S  H  N  K  L  K  E   | I      p.1260

          .         .         .         .         .         .       g.85837
 CCTCCTGAGATTGGCTGTCTTGAAAATCTGACATCTCTGGATGTCAGTTACAACTTGGAA       c.3840
 P  P  E  I  G  C  L  E  N  L  T  S  L  D  V  S  Y  N  L  E         p.1280

          .         .         .         .         .         .       g.85897
 CTAAGATCCTTTCCCAATGAAATGGGGAAATTAAGCAAAATATGGGATCTTCCTTTGGAT       c.3900
 L  R  S  F  P  N  E  M  G  K  L  S  K  I  W  D  L  P  L  D         p.1300

          .         .         .         .         .          | 29    g.88457
 GAACTGCATCTTAACTTTGATTTTAAACATATAGGATGTAAAGCCAAAGACATCATAAG | G    c.3960
 E  L  H  L  N  F  D  F  K  H  I  G  C  K  A  K  D  I  I  R  |      p.1320

          .         .         .         .         .         .       g.88517
 TTTCTTCAACAGCGATTAAAAAAGGCTGTGCCTTATAACCGAATGAAACTTATGATTGTG       c.4020
 F  L  Q  Q  R  L  K  K  A  V  P  Y  N  R  M  K  L  M  I  V         p.1340

          .         .         .         .         .         .       g.88577
 GGAAATACTGGGAGTGGTAAAACCACCTTATTGCAGCAATTAATGAAAACCAAGAAATCA       c.4080
 G  N  T  G  S  G  K  T  T  L  L  Q  Q  L  M  K  T  K  K  S         p.1360

          .         .         .         .         .         .       g.88637
 GATCTTGGAATGCAAAGTGCCACAGTTGGCATAGATGTGAAAGACTGGCCTATCCAAATA       c.4140
 D  L  G  M  Q  S  A  T  V  G  I  D  V  K  D  W  P  I  Q  I         p.1380

          .         .         .         .          | 30        .    g.89106
 AGAGACAAAAGAAAGAGAGATCTCGTCCTAAATGTGTGGGATTTTGCAG | GTCGTGAGGAA    c.4200
 R  D  K  R  K  R  D  L  V  L  N  V  W  D  F  A  G |   R  E  E      p.1400

          .         .         .         .         .         .       g.89166
 TTCTATAGTACTCATCCCCATTTTATGACGCAGCGAGCATTGTACCTTGCTGTCTATGAC       c.4260
 F  Y  S  T  H  P  H  F  M  T  Q  R  A  L  Y  L  A  V  Y  D         p.1420

          .         .         .         .         .        | 31.    g.90423
 CTCAGCAAGGGACAGGCTGAAGTTGATGCCATGAAGCCTTGGCTCTTCAATATAAAG | GCT    c.4320
 L  S  K  G  Q  A  E  V  D  A  M  K  P  W  L  F  N  I  K   | A      p.1440

          .         .         .         .         .         .       g.90483
 CGCGCTTCTTCTTCCCCTGTGATTCTCGTTGGCACACATTTGGATGTTTCTGATGAGAAG       c.4380
 R  A  S  S  S  P  V  I  L  V  G  T  H  L  D  V  S  D  E  K         p.1460

          .         .         .         .         .         .       g.90543
 CAACGCAAAGCCTGCATGAGTAAAATCACCAAGGAACTCCTGAATAAGCGAGGGTTCCCT       c.4440
 Q  R  K  A  C  M  S  K  I  T  K  E  L  L  N  K  R  G  F  P         p.1480

          .         .         .         .         .         .       g.90603
 GCCATACGAGATTACCACTTTGTGAATGCCACCGAGGAATCTGATGCTTTGGCAAAACTT       c.4500
 A  I  R  D  Y  H  F  V  N  A  T  E  E  S  D  A  L  A  K  L         p.1500

          .         .         .       | 32 .         .         .    g.93985
 CGGAAAACCATCATAAACGAGAGCCTTAATTTCAAG | ATCCGAGATCAGCTTGTTGTTGGA    c.4560
 R  K  T  I  I  N  E  S  L  N  F  K   | I  R  D  Q  L  V  V  G      p.1520

          .         .         .         .         .         .       g.94045
 CAGCTGATTCCAGACTGCTATGTAGAACTTGAAAAAATCATTTTATCGGAGCGTAAAAAT       c.4620
 Q  L  I  P  D  C  Y  V  E  L  E  K  I  I  L  S  E  R  K  N         p.1540

          .         .         .         .         .         .       g.94105
 GTGCCAATTGAATTTCCCGTAATTGACCGGAAACGATTATTACAACTAGTGAGAGAAAAT       c.4680
 V  P  I  E  F  P  V  I  D  R  K  R  L  L  Q  L  V  R  E  N         p.1560

          .         .         .         .         .         | 33    g.95203
 CAGCTGCAGTTAGATGAAAATGAGCTTCCTCACGCAGTTCACTTTCTAAATGAATCAG | GA    c.4740
 Q  L  Q  L  D  E  N  E  L  P  H  A  V  H  F  L  N  E  S  G |       p.1580

          .         .         .         .         .         .       g.95263
 GTCCTTCTTCATTTTCAAGACCCAGCACTGCAGTTAAGTGACTTGTACTTTGTGGAACCC       c.4800
 V  L  L  H  F  Q  D  P  A  L  Q  L  S  D  L  Y  F  V  E  P         p.1600

          .         .        | 34.         .         .         .    g.100010
 AAGTGGCTTTGTAAAATCATGGCACAG | ATTTTGACAGTGAAAGTGGAAGGTTGTCCAAAA    c.4860
 K  W  L  C  K  I  M  A  Q   | I  L  T  V  K  V  E  G  C  P  K      p.1620

          .         .         .         .         .         .       g.100070
 CACCCTAAGGGCATTATTTCGCGTAGAGATGTGGAAAAATTTCTTTCAAAAAAAAGGAAA       c.4920
 H  P  K  G  I  I  S  R  R  D  V  E  K  F  L  S  K  K  R  K         p.1640

          .         .         .         .         .         .       g.100130
 TTTCCAAAGAACTACATGTCACAGTATTTTAAGCTCCTAGAAAAATTCCAGATTGCTTTG       c.4980
 F  P  K  N  Y  M  S  Q  Y  F  K  L  L  E  K  F  Q  I  A  L         p.1660

          .         .         .      | 35  .         .         .    g.101048
 CCAATAGGAGAAGAATATTTGCTGGTTCCAAGCAG | TTTGTCTGACCACAGGCCTGTGATA    c.5040
 P  I  G  E  E  Y  L  L  V  P  S  S  |  L  S  D  H  R  P  V  I      p.1680

          .         .         .         .         .         .       g.101108
 GAGCTTCCCCATTGTGAGAACTCTGAAATTATCATCCGACTATATGAAATGCCTTATTTT       c.5100
 E  L  P  H  C  E  N  S  E  I  I  I  R  L  Y  E  M  P  Y  F         p.1700

          .         .         .         .         .         .       g.101168
 CCAATGGGATTTTGGTCAAGATTAATCAATCGATTACTTGAGATTTCACCTTACATGCTT       c.5160
 P  M  G  F  W  S  R  L  I  N  R  L  L  E  I  S  P  Y  M  L         p.1720

          . | 36       .         .         .         .         .    g.102074
 TCAGGGAGAG | AACGAGCACTTCGCCCAAACAGAATGTATTGGCGACAAGGCATTTACTTA    c.5220
 S  G  R  E |   R  A  L  R  P  N  R  M  Y  W  R  Q  G  I  Y  L      p.1740

          .         .         .         .         .         .       g.102134
 AATTGGTCTCCTGAAGCTTATTGTCTGGTAGGATCTGAAGTCTTAGACAATCATCCAGAG       c.5280
 N  W  S  P  E  A  Y  C  L  V  G  S  E  V  L  D  N  H  P  E         p.1760

          .         .         .        | 37.         .         .    g.102331
 AGTTTCTTAAAAATTACAGTTCCTTCTTGTAGAAAAG | GCTGTATTCTTTTGGGCCAAGTT    c.5340
 S  F  L  K  I  T  V  P  S  C  R  K  G |   C  I  L  L  G  Q  V      p.1780

          .         .         .         .         .         .       g.102391
 GTGGACCACATTGATTCTCTCATGGAAGAATGGTTTCCTGGGTTGCTGGAGATTGATATT       c.5400
 V  D  H  I  D  S  L  M  E  E  W  F  P  G  L  L  E  I  D  I         p.1800

          .         .         .         .         .         .       g.102451
 TGTGGTGAAGGAGAAACTCTGTTGAAGAAATGGGCATTATATAGTTTTAATGATGGTGAA       c.5460
 C  G  E  G  E  T  L  L  K  K  W  A  L  Y  S  F  N  D  G  E         p.1820

          .         .         .         .          | 38        .    g.103160
 GAACATCAAAAAATCTTACTTGATGACTTGATGAAGAAAGCAGAGGAAG | GAGATCTCTTA    c.5520
 E  H  Q  K  I  L  L  D  D  L  M  K  K  A  E  E  G |   D  L  L      p.1840

          .         .         .         .         .         .       g.103220
 GTAAATCCAGATCAACCAAGGCTCACCATTCCAATATCTCAGATTGCCCCTGACTTGATT       c.5580
 V  N  P  D  Q  P  R  L  T  I  P  I  S  Q  I  A  P  D  L  I         p.1860

          .         .         .         .         .         .       g.103280
 TTGGCTGACCTGCCTAGAAATATTATGTTGAATAATGATGAGTTGGAATTTGAACAAGCT       c.5640
 L  A  D  L  P  R  N  I  M  L  N  N  D  E  L  E  F  E  Q  A         p.1880

          .       | 39 .         .         .         .         .    g.108393
 CCAGAGTTTCTCCTAG | GTGATGGCAGTTTTGGATCAGTTTACCGAGCAGCCTATGAAGGA    c.5700
 P  E  F  L  L  G |   D  G  S  F  G  S  V  Y  R  A  A  Y  E  G      p.1900

          .         .         .         .         .        | 40.    g.114959
 GAAGAAGTGGCTGTGAAGATTTTTAATAAACATACATCACTCAGGCTGTTAAGACAA | GAG    c.5760
 E  E  V  A  V  K  I  F  N  K  H  T  S  L  R  L  L  R  Q   | E      p.1920

          .         .         .         .         .         .       g.115019
 CTTGTGGTGCTTTGCCACCTCCACCACCCCAGTTTGATATCTTTGCTGGCAGCTGGGATT       c.5820
 L  V  V  L  C  H  L  H  H  P  S  L  I  S  L  L  A  A  G  I         p.1940

          .         .         .         .         .         .       g.115079
 CGTCCCCGGATGTTGGTGATGGAGTTAGCCTCCAAGGGTTCCTTGGATCGCCTGCTTCAG       c.5880
 R  P  R  M  L  V  M  E  L  A  S  K  G  S  L  D  R  L  L  Q         p.1960

          .         .         .         .         .         .       g.115139
 CAGGACAAAGCCAGCCTCACTAGAACCCTACAGCACAGGATTGCACTCCACGTAGCTGAT       c.5940
 Q  D  K  A  S  L  T  R  T  L  Q  H  R  I  A  L  H  V  A  D         p.1980

          | 41         .         .         .         .         .    g.120335
 GGTTTGAG | ATACCTCCACTCAGCCATGATTATATACCGAGACCTGAAACCCCACAATGTG    c.6000
 G  L  R  |  Y  L  H  S  A  M  I  I  Y  R  D  L  K  P  H  N  V      p.2000

          .         .         .         .         .         .       g.120395
 CTGCTTTTCACACTGTATCCCAATGCTGCCATCATTGCAAAGATTGCTGACTACGGCATT       c.6060
 L  L  F  T  L  Y  P  N  A  A  I  I  A  K  I  A  D  Y  G  I         p.2020

          .         .         .         .          | 42        .    g.126753
 GCTCAGTACTGCTGTAGAATGGGGATAAAAACATCAGAGGGCACACCAG | GGTTTCGTGCA    c.6120
 A  Q  Y  C  C  R  M  G  I  K  T  S  E  G  T  P  G |   F  R  A      p.2040

          .         .         .         .         .         .       g.126813
 CCTGAAGTTGCCAGAGGAAATGTCATTTATAACCAACAGGCTGATGTTTATTCATTTGGT       c.6180
 P  E  V  A  R  G  N  V  I  Y  N  Q  Q  A  D  V  Y  S  F  G         p.2060

          .         .         .         .         .         .       g.126873
 TTACTACTCTATGACATTTTGACAACTGGAGGTAGAATAGTAGAGGGTTTGAAGTTTCCA       c.6240
 L  L  L  Y  D  I  L  T  T  G  G  R  I  V  E  G  L  K  F  P         p.2080

          .         .         .         . | 43       .         .    g.128418
 AATGAGTTTGATGAATTAGAAATACAAGGAAAATTACCTG | ATCCAGTTAAAGAATATGGT    c.6300
 N  E  F  D  E  L  E  I  Q  G  K  L  P  D |   P  V  K  E  Y  G      p.2100

          .         .         .         .         .         .       g.128478
 TGTGCCCCATGGCCTATGGTTGAGAAATTAATTAAACAGTGTTTGAAAGAAAATCCTCAA       c.6360
 C  A  P  W  P  M  V  E  K  L  I  K  Q  C  L  K  E  N  P  Q         p.2120

          .         .  | 44      .         .         .         .    g.131567
 GAAAGGCCTACTTCTGCCCAG | GTCTTTGACATTTTGAATTCAGCTGAATTAGTCTGTCTG    c.6420
 E  R  P  T  S  A  Q   | V  F  D  I  L  N  S  A  E  L  V  C  L      p.2140

          .         .         .         .         .         .       g.131627
 ACGAGACGCATTTTATTACCTAAAAACGTAATTGTTGAATGCATGGTTGCTACACATCAC       c.6480
 T  R  R  I  L  L  P  K  N  V  I  V  E  C  M  V  A  T  H  H         p.2160

          .         .         .         .         .         .       g.131687
 AACAGCAGGAATGCAAGCATTTGGCTGGGCTGTGGGCACACCGACAGAGGACAGCTCTCA       c.6540
 N  S  R  N  A  S  I  W  L  G  C  G  H  T  D  R  G  Q  L  S         p.2180

          .         .         .       | 45 .         .         .    g.134312
 TTTCTTGACTTAAATACTGAAGGATACACTTCTGAG | GAAGTTGCTGATAGTAGAATATTG    c.6600
 F  L  D  L  N  T  E  G  Y  T  S  E   | E  V  A  D  S  R  I  L      p.2200

          .         .         .         .         .         .       g.134372
 TGCTTAGCCTTGGTGCATCTTCCTGTTGAAAAGGAAAGCTGGATTGTGTCTGGGACACAG       c.6660
 C  L  A  L  V  H  L  P  V  E  K  E  S  W  I  V  S  G  T  Q         p.2220

          .         .         .         .         .         .       g.134432
 TCTGGTACTCTCCTGGTCATCAATACCGAAGATGGGAAAAAGAGACATACCCTAGAAAAG       c.6720
 S  G  T  L  L  V  I  N  T  E  D  G  K  K  R  H  T  L  E  K         p.2240

          .         .         .         .         . | 46       .    g.136114
 ATGACTGATTCTGTCACTTGTTTGTATTGCAATTCCTTTTCCAAGCAAAG | CAAACAAAAA    c.6780
 M  T  D  S  V  T  C  L  Y  C  N  S  F  S  K  Q  S  |  K  Q  K      p.2260

          .         .         .         .         .         .       g.136174
 AATTTTCTTTTGGTTGGAACCGCTGATGGCAAGTTAGCAATTTTTGAAGATAAGACTGTT       c.6840
 N  F  L  L  V  G  T  A  D  G  K  L  A  I  F  E  D  K  T  V         p.2280

     | 47    .         .         .         .         .         .    g.139306
 AAG | CTTAAAGGAGCTGCTCCTTTGAAGATACTAAATATAGGAAATGTCAGTACTCCATTG    c.6900
 K   | L  K  G  A  A  P  L  K  I  L  N  I  G  N  V  S  T  P  L      p.2300

          .         .         .         .         .         .       g.139366
 ATGTGTTTGAGTGAATCCACAAATTCAACGGAAAGAAATGTAATGTGGGGAGGATGTGGC       c.6960
 M  C  L  S  E  S  T  N  S  T  E  R  N  V  M  W  G  G  C  G         p.2320

          .         .         .         .         .         .       g.139426
 ACAAAGATTTTCTCCTTTTCTAATGATTTCACCATTCAGAAACTCATTGAGACAAGAACA       c.7020
 T  K  I  F  S  F  S  N  D  F  T  I  Q  K  L  I  E  T  R  T         p.2340

          | 48         .         .         .         .         .    g.143443
 AGCCAACT | GTTTTCTTATGCAGCTTTCAGTGATTCCAACATCATAACAGTGGTGGTAGAC    c.7080
 S  Q  L  |  F  S  Y  A  A  F  S  D  S  N  I  I  T  V  V  V  D      p.2360

          .         .         .         .         .         .       g.143503
 ACTGCTCTCTATATTGCTAAGCAAAATAGCCCTGTTGTGGAAGTGTGGGATAAGAAAACT       c.7140
 T  A  L  Y  I  A  K  Q  N  S  P  V  V  E  V  W  D  K  K  T         p.2380

          .         .         .         .  | 49      .         .    g.144850
 GAAAAACTCTGTGGACTAATAGACTGCGTGCACTTTTTAAG | GGAGGTAATGGTAAAAGAA    c.7200
 E  K  L  C  G  L  I  D  C  V  H  F  L  R  |  E  V  M  V  K  E      p.2400

          .         .         .         .         .         .       g.144910
 AACAAGGAATCAAAACACAAAATGTCTTATTCTGGGAGAGTGAAAACCCTCTGCCTTCAG       c.7260
 N  K  E  S  K  H  K  M  S  Y  S  G  R  V  K  T  L  C  L  Q         p.2420

          .         .         .         .         .         .       g.144970
 AAGAACACTGCTCTTTGGATAGGAACTGGAGGAGGCCATATTTTACTCCTGGATCTTTCA       c.7320
 K  N  T  A  L  W  I  G  T  G  G  G  H  I  L  L  L  D  L  S         p.2440

          .         .         .         .         .         .       g.145030
 ACTCGTCGACTTATACGTGTAATTTACAACTTTTGTAATTCGGTCAGAGTCATGATGACA       c.7380
 T  R  R  L  I  R  V  I  Y  N  F  C  N  S  V  R  V  M  M  T         p.2460

          . | 50       .         .         .         .         .    g.147045
 GCACAGCTAG | GAAGCCTTAAAAATGTCATGCTGGTATTGGGCTACAACCGGAAAAATACT    c.7440
 A  Q  L  G |   S  L  K  N  V  M  L  V  L  G  Y  N  R  K  N  T      p.2480

          .         .   | 51     .         .         .         .    g.147671
 GAAGGTACACAAAAGCAGAAAG | AGATACAATCTTGCTTGACCGTTTGGGACATCAATCTT    c.7500
 E  G  T  Q  K  Q  K  E |   I  Q  S  C  L  T  V  W  D  I  N  L      p.2500

          .         .         .         .         .         .       g.147731
 CCACATGAAGTGCAAAATTTAGAAAAACACATTGAAGTGAGAAAAGAATTAGCTGAAAAA       c.7560
 P  H  E  V  Q  N  L  E  K  H  I  E  V  R  K  E  L  A  E  K         p.2520

          .         .                                               g.147755
 ATGAGACGAACATCTGTTGAGTAA                                           c.7584
 M  R  R  T  S  V  E  X                                             p.2527

          .         .         .         .         .         .       g.147815
 gagagaaataggaattgtctttggataggaaaattattctctcctcttgtaaatatttat       c.*60

          .         .         .         .         .         .       g.147875
 tttaaaaatgttcacatggaaagggtactcacattttttgaaatagctcgtgtgtatgaa       c.*120

          .         .         .         .         .         .       g.147935
 ggaatgttattatttttaatttaaatatatgtaaaaatacttaccagtaaatgtgtattt       c.*180

          .         .         .         .         .         .       g.147995
 taaagaactatttaaaacacaatgttatatttcttataaataccagttactttcgttcat       c.*240

          .         .         .         .         .         .       g.148055
 taattaatgaaaataaatctgtgaagtacctaatttaagtactcatactaaaatttataa       c.*300

          .         .         .         .         .         .       g.148115
 ggccgataattttttgttttcttgtctgtaatggaggtaaactttattttaaattctgtg       c.*360

          .         .         .         .         .         .       g.148175
 cttaagacaggactattgcttgtcgatttttctagaaatctgcacggtataatgaaaata       c.*420

          .         .         .         .         .         .       g.148235
 ttaagacagtttcccatgtaatgtattccttcttagattgcatcgaaatgcactatcata       c.*480

          .         .         .         .         .         .       g.148295
 tatgcttgtaaatattcaaatgaatttgcactaataaagtcctttgttggtatgtgaatt       c.*540

          .         .         .         .         .         .       g.148355
 ctctttgttgctgttgcaaacagtgcatcttacacaacttcactcaattcaaaagaaaac       c.*600

          .         .         .         .         .         .       g.148415
 tccattaaaagtactaatgaaaaaacatgacatactgtcaaagtcctcatatctaggaaa       c.*660

          .         .         .         .         .         .       g.148475
 gacacagaaactctctttgtcacagaaactctctgtgtctttcctagacataatagagtt       c.*720

          .         .         .         .         .         .       g.148535
 gtttttcaactctatgtttgaatgtggataccctgaattttgtataattagtgtaaatac       c.*780

          .         .         .         .         .         .       g.148595
 agtgttcagtccttcaagtgatatttttatttttttattcataccactagctacttgttt       c.*840

          .         .         .         .         .         .       g.148655
 tctaatctgcttcattctaatgcttatattcatcttttccctaaatttgtgatgctgcag       c.*900

          .         .         .         .         .         .       g.148715
 atcctacatcattcagatagaaacctttttttttttcagaattatagaattccacagctc       c.*960

          .         .         .         .         .         .       g.148775
 ctaccaagaccatgaggataaatatctaacacttttcagttgctgaaggagaaaggagct       c.*1020

          .         .         .         .         .         .       g.148835
 ttagttatgatggataaaaatatctgccaccctaggcttccaaattatacttaaattgtt       c.*1080

          .         .         .         .         .         .       g.148895
 tacatagcttaccacaataggagtatcagggccaaatacctatgtaataatttgaggtca       c.*1140

          .         .         .         .         .         .       g.148955
 tttctgctttaggaaaagtactttcggtaaattctttggccctgaccagtattcattatt       c.*1200

          .         .         .         .         .         .       g.149015
 tcagataattccctgtgataggacaactagtacatttaatattctcagaacttatggcat       c.*1260

          .         .         .         .         .         .       g.149075
 tttactatgtgaaaactttaaatttatttatattaagggtaatcaaattcttaaagatga       c.*1320

          .         .         .         .         .         .       g.149135
 aagattttctgtattttaaaggaagctatgctttaacttgttatgtaattaacaaaaaaa       c.*1380

          .         .         .         .         .         .       g.149195
 tcatatataatagagctctttgttccagtgttatctctttcattgttactttgtatttgc       c.*1440

          .         .         .         .         .         .       g.149255
 aattttttttaccaaagacaaattaaaaaaatgaataccatatttaaatggaataataaa       c.*1500

          .         .                                               g.149275
 ggttttttaaaaactttaaa                                               c.*1520

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Leucine-rich repeat kinase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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