latent transforming growth factor beta binding protein 3 (LTBP3) - coding DNA reference sequence

(used for variant description)

(last modified November 8, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001130144.2 in the LTBP3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering LTBP3 transcript NM_001130144.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                cttgctccggcctcctcgctcctgcctga       c.-241

 .         .         .         .         .         .                g.5089
 gttcggggcctggtctgggcttcgtcctggggctgggaagtttctgcgctccccgctgtc       c.-181

 .         .         .         .         .         .                g.5149
 cagtctgcatctccgcgcctcccgccgggcccccgcggtcccctcccgcccgcttccccc       c.-121

 .         .         .         .         .         .                g.5209
 gctgccctccctcgctgccccctaccctctcccggggctcccggccctctactcccttcg       c.-61

 .         .         .         .         .         .                g.5269
 ggcgcgggcccctcgccccgcccgggcgcgccccccctcccccgggtcctgcggccccgg       c.-1

          .         .         .         .         .         .       g.5329
 ATGCCCGGGCCCCGAGGGGCTGCTGGCGGCCTGGCCCCTGAGATGCGCGGGGCGGGGGCG       c.60
 M  P  G  P  R  G  A  A  G  G  L  A  P  E  M  R  G  A  G  A         p.20

          .         .         .         .         .         .       g.5389
 GCGGGGCTGCTGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGGGCCTGGGCGGCAGG       c.120
 A  G  L  L  A  L  L  L  L  L  L  L  L  L  L  G  L  G  G  R         p.40

          .         .         .         .         .         .       g.5449
 GTCGAGGGGGGGCCGGCCGGCGAGCGGGGCGCAGGCGGGGGCGGGGCGCTGGCCCGCGAG       c.180
 V  E  G  G  P  A  G  E  R  G  A  G  G  G  G  A  L  A  R  E         p.60

          .         .         .         .         .         .       g.5509
 CGCTTCAAGGTGGTCTTTGCGCCGGTGATCTGCAAGCGGACCTGTCTCAAGGGCCAGTGT       c.240
 R  F  K  V  V  F  A  P  V  I  C  K  R  T  C  L  K  G  Q  C         p.80

          .         .         .         .         .         .       g.5569
 CGGGACAGTTGTCAGCAGGGCTCCAACATGACGCTCATCGGAGAGAACGGCCACAGCACA       c.300
 R  D  S  C  Q  Q  G  S  N  M  T  L  I  G  E  N  G  H  S  T         p.100

          .         .         .  | 02      .         .         .    g.8877
 GACACGCTCACGGGCTCCGGCTTCCGCGTGG | TGGTGTGCCCTCTCCCCTGCATGAATGGC    c.360
 D  T  L  T  G  S  G  F  R  V  V |   V  C  P  L  P  C  M  N  G      p.120

          .         .         .         .         .         .       g.8937
 GGCCAGTGCTCCTCGCGAAACCAGTGCCTGTGTCCCCCGGACTTCACTGGGCGCTTCTGC       c.420
 G  Q  C  S  S  R  N  Q  C  L  C  P  P  D  F  T  G  R  F  C         p.140

          .         .         .         .         .         .       g.8997
 CAGGTGCCCGCAGGAGGAGCCGGTGGGGGTACCGGCGGCTCAGGCCCCGGCCTGAGCAGG       c.480
 Q  V  P  A  G  G  A  G  G  G  T  G  G  S  G  P  G  L  S  R         p.160

          .         .         .         .         .         .       g.9057
 ACAGGGGCCCTGTCCACAGGGGCGCTGCCGCCCCTGGCTCCGGAGGGCGACTCTGTGGCC       c.540
 T  G  A  L  S  T  G  A  L  P  P  L  A  P  E  G  D  S  V  A         p.180

          .         .         .         .         .         .       g.9117
 AGCAAGCACGCCATCTACGCCGTCCAGGTGATCGCTGACCCTCCTGGGCCCGGGGAGGGG       c.600
 S  K  H  A  I  Y  A  V  Q  V  I  A  D  P  P  G  P  G  E  G         p.200

          .         .         .         .         .         .       g.9177
 CCTCCTGCCCAGCACGCAGCCTTCCTGGTGCCCCTAGGCCCGGGACAGATCTCAGCAGAA       c.660
 P  P  A  Q  H  A  A  F  L  V  P  L  G  P  G  Q  I  S  A  E         p.220

   | 03      .         .         .         .         .         .    g.9384
 G | TGCAGGCCCCGCCCCCCGTGGTGAATGTGCGCGTCCATCACCCGCCCGAGGCCTCAGTC    c.720
 V |   Q  A  P  P  P  V  V  N  V  R  V  H  H  P  P  E  A  S  V      p.240

          .         .         .         .         .         .       g.9444
 CAGGTGCACCGCATTGAGAGCTCGAACGCCGAGAGCGCAGCCCCCTCCCAGCACCTGCTG       c.780
 Q  V  H  R  I  E  S  S  N  A  E  S  A  A  P  S  Q  H  L  L         p.260

          .         .         .         .         .         .       g.9504
 CCGCACCCCAAGCCCTCGCACCCCCGGCCGCCCACCCAGAAGCCCCTGGGCCGCTGCTTT       c.840
 P  H  P  K  P  S  H  P  R  P  P  T  Q  K  P  L  G  R  C  F         p.280

          .         .     | 04   .         .         .         .    g.9734
 CAGGACACTCTGCCCAAGCAGCCG | TGTGGCAGCAACCCCCTCCCCGGCCTCACCAAGCAG    c.900
 Q  D  T  L  P  K  Q  P   | C  G  S  N  P  L  P  G  L  T  K  Q      p.300

          .         .         .         .         .         .       g.9794
 GAAGACTGCTGCGGTAGCATCGGCACTGCCTGGGGCCAGAGCAAGTGCCACAAGTGTCCC       c.960
 E  D  C  C  G  S  I  G  T  A  W  G  Q  S  K  C  H  K  C  P         p.320

          . | 05       .         .         .         .         .    g.10022
 CAGCTGCAGT | ACACAGGAGTGCAGAAGCCAGGGCCTGTACGTGGGGAAGTGGGCGCTGAC    c.1020
 Q  L  Q  Y |   T  G  V  Q  K  P  G  P  V  R  G  E  V  G  A  D      p.340

          .         .         .         .    | 06    .         .    g.10263
 TGTCCCCAGGGCTACAAGAGGCTTAACAGCACCCACTGCCAGG | ACATCAACGAGTGCGCA    c.1080
 C  P  Q  G  Y  K  R  L  N  S  T  H  C  Q  D |   I  N  E  C  A      p.360

          .         .         .         .         .         .       g.10323
 ATGCCGGGCGTGTGTCGCCATGGTGACTGCCTCAACAACCCTGGCTCCTATCGCTGTGTC       c.1140
 M  P  G  V  C  R  H  G  D  C  L  N  N  P  G  S  Y  R  C  V         p.380

          .         .         .         .       | 07 .         .    g.10836
 TGCCCACCTGGCCATAGTTTAGGCCCCTCCCGTACACAGTGCATTG | CAGACAAACCGGAG    c.1200
 C  P  P  G  H  S  L  G  P  S  R  T  Q  C  I  A |   D  K  P  E      p.400

          .         .         .         .         .         .       g.10896
 GAGAAGAGCCTGTGTTTCCGCCTGGTGAGCCCTGAGCACCAGTGCCAGCACCCACTGACC       c.1260
 E  K  S  L  C  F  R  L  V  S  P  E  H  Q  C  Q  H  P  L  T         p.420

          .         .         .         .         .         .       g.10956
 ACCCGCCTGACCCGCCAGCTCTGCTGCTGCAGTGTCGGCAAGGCCTGGGGCGCGCGGTGT       c.1320
 T  R  L  T  R  Q  L  C  C  C  S  V  G  K  A  W  G  A  R  C         p.440

          .         .      | 08  .         .         .         .    g.11106
 CAGCGCTGCCCAACAGATGGCACCG | CTGCGTTCAAGGAGATCTGCCCAGCTGGGAAGGGA    c.1380
 Q  R  C  P  T  D  G  T  A |   A  F  K  E  I  C  P  A  G  K  G      p.460

          .         .         .         .         .         .       g.11166
 TACCACATTCTCACCTCCCACCAGACGCTCACCATTCAGGGCGAGAGTGACTTTTCCCTT       c.1440
 Y  H  I  L  T  S  H  Q  T  L  T  I  Q  G  E  S  D  F  S  L         p.480

          .         .         .         .         .         .       g.11226
 TTCCTGCACCCTGACGGGCCACCCAAGCCCCAGCAGCTTCCGGAGAGCCCTAGCCAGGCT       c.1500
 F  L  H  P  D  G  P  P  K  P  Q  Q  L  P  E  S  P  S  Q  A         p.500

          .         .         .  | 09      .         | 10         . g.11766
 CCACCACCTGAGGACACAGAGGAAGAGAGAG | GGGTGACCACGGACTCA | CCGGTGAGTGAG c.1560
 P  P  P  E  D  T  E  E  E  R  G |   V  T  T  D  S   | P  V  S  E   p.520

          .         .         .         .         .         .       g.11826
 GAGAGGTCAGTGCAGCAGAGCCACCCAACTGCCACCACGACTCCTGCCCGGCCCTACCCC       c.1620
 E  R  S  V  Q  Q  S  H  P  T  A  T  T  T  P  A  R  P  Y  P         p.540

   | 11      .         .         .         .         .         .    g.12063
 G | AGCTGATCTCCCGTCCCTCGCCCCCGACCATGCGCTGGTTCCTGCCGGACTTGCCTCCT    c.1680
 E |   L  I  S  R  P  S  P  P  T  M  R  W  F  L  P  D  L  P  P      p.560

          .         .         .         . | 12       .         .    g.15203
 TCCCGCAGCGCCGTAGAGATCGCTCCCACTCAGGTCACAG | AGACTGATGAGTGCCGACTG    c.1740
 S  R  S  A  V  E  I  A  P  T  Q  V  T  E |   T  D  E  C  R  L      p.580

          .         .         .         .         .         .       g.15263
 AACCAGAACATCTGTGGCCACGGAGAGTGCGTGCCGGGCCCCCCTGACTACTCCTGCCAC       c.1800
 N  Q  N  I  C  G  H  G  E  C  V  P  G  P  P  D  Y  S  C  H         p.600

          .         .         .         .       | 13 .         .    g.15421
 TGCAACCCCGGCTACCGGTCACATCCCCAGCACCGCTACTGCGTGG | ATGTGAACGAGTGC    c.1860
 C  N  P  G  Y  R  S  H  P  Q  H  R  Y  C  V  D |   V  N  E  C      p.620

          .         .         .         .         .         .       g.15481
 GAGGCAGAGCCCTGTGGCCCGGGGAGGGGCATCTGCATGAACACCGGCGGCTCCTACAAT       c.1920
 E  A  E  P  C  G  P  G  R  G  I  C  M  N  T  G  G  S  Y  N         p.640

          .         .         .         .         .         | 14    g.15663
 TGCCACTGCAACCGCGGCTACCGCCTGCACGTGGGCGCCGGGGGGCGCTCGTGCGTGG | AC    c.1980
 C  H  C  N  R  G  Y  R  L  H  V  G  A  G  G  R  S  C  V  D |       p.660

          .         .         .         .         .         .       g.15723
 CTGAACGAATGCGCCAAGCCCCACCTGTGCGGCGACGGCGGCTTCTGCATCAACTTTCCC       c.2040
 L  N  E  C  A  K  P  H  L  C  G  D  G  G  F  C  I  N  F  P         p.680

          .         .         .         .         .         .       g.15783
 GGTCACTACAAGTGCAACTGCTACCCCGGCTACCGGCTCAAAGCCTCCCGGCCTCCTGTG       c.2100
 G  H  Y  K  C  N  C  Y  P  G  Y  R  L  K  A  S  R  P  P  V         p.700

         | 15.         .         .         .         .         .    g.16361
 TGCGAAG | ACATCGACGAGTGCCGGGACCCAAGCTCTTGCCCGGATGGCAAATGCGAGAAC    c.2160
 C  E  D |   I  D  E  C  R  D  P  S  S  C  P  D  G  K  C  E  N      p.720

          .         .         .         .         .         .       g.16421
 AAGCCCGGGAGCTTCAAGTGCATCGCCTGTCAGCCTGGCTACCGCAGCCAGGGGGGCGGG       c.2220
 K  P  G  S  F  K  C  I  A  C  Q  P  G  Y  R  S  Q  G  G  G         p.740

          . | 16       .         .         .         .         .    g.16714
 GCCTGTCGCG | ACGTGAACGAGTGCGCCGAGGGCAGCCCCTGCTCGCCTGGCTGGTGCGAG    c.2280
 A  C  R  D |   V  N  E  C  A  E  G  S  P  C  S  P  G  W  C  E      p.760

          .         .         .         .         .         .       g.16774
 AACCTCCCGGGCTCCTTCCGCTGCACCTGTGCCCAGGGCTACGCGCCCGCGCCCGACGGC       c.2340
 N  L  P  G  S  F  R  C  T  C  A  Q  G  Y  A  P  A  P  D  G         p.780

          .    | 17    .         .         .         .         .    g.19726
 CGCAGTTGCTTGG | ATGTGGACGAGTGTGAGGCTGGGGACGTGTGTGACAATGGCATCTGC    c.2400
 R  S  C  L  D |   V  D  E  C  E  A  G  D  V  C  D  N  G  I  C      p.800

          .         .         .         .         .         .       g.19786
 AGCAACACGCCAGGATCTTTCCAGTGTCAGTGCCTCTCTGGCTACCATCTGTCCAGGGAC       c.2460
 S  N  T  P  G  S  F  Q  C  Q  C  L  S  G  Y  H  L  S  R  D         p.820

          .       | 18 .         .         .         .         .    g.20048
 CGGAGCCACTGCGAGG | ACATTGATGAGTGTGACTTCCCTGCAGCCTGCATTGGGGGTGAC    c.2520
 R  S  H  C  E  D |   I  D  E  C  D  F  P  A  A  C  I  G  G  D      p.840

          .         .         .         .         .         .       g.20108
 TGCATCAATACCAATGGCTCCTACAGATGTCTTTGCCCCCAGGGGCATCGGCTGGTGGGT       c.2580
 C  I  N  T  N  G  S  Y  R  C  L  C  P  Q  G  H  R  L  V  G         p.860

          .       | 19 .         .         .         .         .    g.21544
 GGCAGGAAATGCCAAG | ACATAGATGAGTGCAGCCAGGACCCGAGCCTGTGCCTTCCCCAT    c.2640
 G  R  K  C  Q  D |   I  D  E  C  S  Q  D  P  S  L  C  L  P  H      p.880

          .         .         .         .         .         .       g.21604
 GGGGCCTGCAAGAACCTTCAGGGCTCCTATGTGTGTGTCTGCGATGAGGGCTTCACTCCC       c.2700
 G  A  C  K  N  L  Q  G  S  Y  V  C  V  C  D  E  G  F  T  P         p.900

          .         .      | 20  .         .         .         .    g.21970
 ACCCAGGACCAGCACGGTTGTGAGG | AGGTGGAGCAGCCCCACCACAAGAAGGAGTGCTAC    c.2760
 T  Q  D  Q  H  G  C  E  E |   V  E  Q  P  H  H  K  K  E  C  Y      p.920

          .         .         .         .         .         .       g.22030
 CTGAACTTCGATGACACAGTGTTCTGCGACAGCGTATTGGCCACCAACGTGACCCAGCAG       c.2820
 L  N  F  D  D  T  V  F  C  D  S  V  L  A  T  N  V  T  Q  Q         p.940

          .         .         .         .         .         .       g.22090
 GAGTGCTGCTGCTCTCTGGGGGCCGGCTGGGGCGACCACTGCGAAATCTACCCCTGCCCA       c.2880
 E  C  C  C  S  L  G  A  G  W  G  D  H  C  E  I  Y  P  C  P         p.960

          .    | 21    .         .         .         .         .    g.22321
 GTCTACAGCTCAG | CCGAGTTCCACAGCCTCTGCCCAGACGGAAAGGGCTACACCCAGGAC    c.2940
 V  Y  S  S  A |   E  F  H  S  L  C  P  D  G  K  G  Y  T  Q  D      p.980

          .         .         .        | 22.         .         .    g.22637
 AACAACATCGTCAACTACGGCATCCCAGCCCACCGTG | ACATCGACGAGTGCATGTTGTTC    c.3000
 N  N  I  V  N  Y  G  I  P  A  H  R  D |   I  D  E  C  M  L  F      p.1000

          .         .         .         .         .         .       g.22697
 GGGTCGGAGATTTGCAAGGAGGGCAAGTGCGTGAACACGCAGCCTGGCTACGAGTGCTAC       c.3060
 G  S  E  I  C  K  E  G  K  C  V  N  T  Q  P  G  Y  E  C  Y         p.1020

          .         .         .         .       | 23 .         .    g.22860
 TGCAAGCAGGGCTTCTACTACGACGGGAACCTGCTGGAATGCGTGG | ACGTGGACGAGTGC    c.3120
 C  K  Q  G  F  Y  Y  D  G  N  L  L  E  C  V  D |   V  D  E  C      p.1040

          .         .         .         .         .         .       g.22920
 CTGGACGAGTCCAACTGCCGGAACGGAGTGTGTGAGAACACGCGCGGCGGCTACCGCTGT       c.3180
 L  D  E  S  N  C  R  N  G  V  C  E  N  T  R  G  G  Y  R  C         p.1060

          .         .         .         .         .         .       g.22980
 GCCTGCACGCCCCCTGCCGAGTACAGTCCCGCGCAGCGCCAGTGCCTGAGCCCGGAAGAG       c.3240
 A  C  T  P  P  A  E  Y  S  P  A  Q  R  Q  C  L  S  P  E  E         p.1080

      | 24   .         .         .         .         .         .    g.23131
 ATGG | ACGTGGACGAGTGCCAGGACCCGGCAGCCTGCCGCCCTGGCCGCTGCGTCAACCTG    c.3300
 M  D |   V  D  E  C  Q  D  P  A  A  C  R  P  G  R  C  V  N  L      p.1100

          .         .         .         .         .         .       g.23191
 CCGGGCTCCTACCGCTGCGAGTGTCGCCCGCCCTGGGTGCCCGGGCCCTCCGGCCGCGAT       c.3360
 P  G  S  Y  R  C  E  C  R  P  P  W  V  P  G  P  S  G  R  D         p.1120

          .         .      | 25  .         .         .         .    g.23382
 TGCCAGCTCCCCGAGAGCCCGGCCG | AGCGTGCCCCGGAGCGGCGCGACGTGTGCTGGAGC    c.3420
 C  Q  L  P  E  S  P  A  E |   R  A  P  E  R  R  D  V  C  W  S      p.1140

          .         .         .         .         .         .       g.23442
 CAGCGCGGAGAGGACGGCATGTGCGCTGGCCCCCTGGCCGGGCCTGCCCTCACCTTCGAC       c.3480
 Q  R  G  E  D  G  M  C  A  G  P  L  A  G  P  A  L  T  F  D         p.1160

          .         .         .         .         .         .       g.23502
 GACTGCTGCTGCCGCCAGGGCCGCGGCTGGGGCGCCCAATGCCGACCGTGCCCGCCGCGC       c.3540
 D  C  C  C  R  Q  G  R  G  W  G  A  Q  C  R  P  C  P  P  R         p.1180

         | 26.         .         .         .         .         .    g.23653
 GGCGCGG | GGTCCCATTGCCCGACATCGCAGAGCGAGAGCAATTCCTTCTGGGACACAAGC    c.3600
 G  A  G |   S  H  C  P  T  S  Q  S  E  S  N  S  F  W  D  T  S      p.1200

          .         .         | 27         .         .         .    g.23801
 CCCCTGCTGTTGGGGAAGCCCCCAAGAG | ATGAGGACAGTTCAGAGGAGGATTCAGACGAG    c.3660
 P  L  L  L  G  K  P  P  R  D |   E  D  S  S  E  E  D  S  D  E      p.1220

          .         .         .         .         .         .       g.23861
 TGTCGCTGCGTGAGTGGCCGCTGCGTGCCGCGGCCGGGCGGCGCCGTGTGCGAGTGTCCC       c.3720
 C  R  C  V  S  G  R  C  V  P  R  P  G  G  A  V  C  E  C  P         p.1240

          .         .         .         . | 28       .         .    g.24017
 GGCGGCTTCCAGCTCGACGCCTCCCGCGCCCGCTGCGTGG | ATATCGACGAGTGCCGAGAG    c.3780
 G  G  F  Q  L  D  A  S  R  A  R  C  V  D |   I  D  E  C  R  E      p.1260

          .         .         .         .         .         .       g.24077
 CTGAACCAGCGCGGGCTGCTGTGCAAGAGCGAGCGCTGCGTGAACACCAGCGGCTCCTTC       c.3840
 L  N  Q  R  G  L  L  C  K  S  E  R  C  V  N  T  S  G  S  F         p.1280

          .         .         .         .         .         .       g.24137
 CGCTGCGTCTGCAAAGCCGGCTTCGCGCGCAGCCGCCCGCACGGGGCCTGCGTTCCCCAG       c.3900
 R  C  V  C  K  A  G  F  A  R  S  R  P  H  G  A  C  V  P  Q         p.1300

          .                                                         g.24149
 CGCCGCCGCTGA                                                       c.3912
 R  R  R  X                                                         p.1303

          .         .         .         .         .         .       g.24209
 cgccgccgacgccgccctcggcccagacctcggtgatcactgagggatttccgcgagctc       c.*60

          .         .         .         .         .         .       g.24269
 ggcctcacttctgccccgacttgtggctcggacccagggaccttcagggcccgcagaccc       c.*120

          .         .         .         .         .         .       g.24329
 tcccggcgccttgagacccgaggcgcccctaccggcccccctccccggttagcgggcggt       c.*180

          .         .         .         .         .         .       g.24389
 tgtaaggtctccggcgggcgctgcctgccttcctcccagagggtgtttcctagaaactga       c.*240

          .         .         .         .         .         .       g.24449
 taaatcagatcgtgcctctttacccttggctttcgaagcaaattgatgttcacgtctgac       c.*300

          .         .         .         .         .         .       g.24509
 gtgggcgcgggctgcgcagggcggcgccagaccccagccgcctcccaggggctagactga       c.*360

          .         .         .         .         .         .       g.24569
 gcccggcacaaggggtgtgaaatagaatttattgtggctctgattatgtacacgtgagat       c.*420

          .         .         .         .         .         .       g.24629
 ggcctggctgggccggccgggctcacatggtttgtacaataaatacatctgtggggcggg       c.*480

          .         .         .         .                           g.24670
 ctctccgcagccgggaagggccaccgccacggttcagtcca                          c.*521

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Latent transforming growth factor beta binding protein 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2021 Leiden University Medical Center