leucine-zipper-like transcription regulator 1 (LZTR1) - coding DNA reference sequence

(used for variant description)

(last modified June 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_006767.3 in the LZTR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering LZTR1 transcript NM_006767.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  accgtcagcgcagggctcgccgggaaatgtggtttctccagcc       c.-61

 .         .         .         .         .         .                g.5103
 ggcccggggcggtggccgcaagttgggcttacagcgcggccgatccggcgtggacccggg       c.-1

          .         .         .         .         .         .       g.5163
 ATGGCTGGACCGGGCAGCACGGGGGGGCAGATCGGGGCTGCGGCCCTGGCAGGCGGCGCG       c.60
 M  A  G  P  G  S  T  G  G  Q  I  G  A  A  A  L  A  G  G  A         p.20

          .         .         .         .         .         .       g.5223
 CGGTCCAAGGTAGCCCCGAGCGTGGACTTCGACCATAGCTGCTCGGACAGTGTCGAGTAC       c.120
 R  S  K  V  A  P  S  V  D  F  D  H  S  C  S  D  S  V  E  Y         p.40

          .         .         .         .         .         .       g.5283
 CTGACGCTCAACTTCGGGCCCTTCGAAACAGTGCATCGCTGGCGGCGCCTCCCGCCCTGC       c.180
 L  T  L  N  F  G  P  F  E  T  V  H  R  W  R  R  L  P  P  C         p.60

          .         . | 02       .         .         .         .    g.5798
 GACGAGTTCGTGGGTGCCCG | GCGCAGCAAGCACACAGTGGTGGCCTATAAAGATGCCATT    c.240
 D  E  F  V  G  A  R  |  R  S  K  H  T  V  V  A  Y  K  D  A  I      p.80

          .         .    | 03    .         .         .         .    g.8609
 TATGTATTTGGTGGAGACAATGG | GAAGACCATGCTCAATGACCTCCTGCGGTTCGATGTG    c.300
 Y  V  F  G  G  D  N  G  |  K  T  M  L  N  D  L  L  R  F  D  V      p.100

          .         . | 04       .         .         .         .    g.10275
 AAAGACTGCTCCTGGTGCAG | GGCCTTTACCACTGGGACCCCACCGGCCCCCCGTTACCAC    c.360
 K  D  C  S  W  C  R  |  A  F  T  T  G  T  P  P  A  P  R  Y  H      p.120

          .         .         .         . | 05       .         .    g.10761
 CACTCGGCCGTCGTCTATGGGAGCAGCATGTTTGTCTTTG | GGGGTTACACTGGGGACATT    c.420
 H  S  A  V  V  Y  G  S  S  M  F  V  F  G |   G  Y  T  G  D  I      p.140

          .         .         .         .         .         .       g.10821
 TATTCCAATTCTAACTTGAAGAATAAAAACGACCTCTTTGAATACAAGTTTGCAACTGGC       c.480
 Y  S  N  S  N  L  K  N  K  N  D  L  F  E  Y  K  F  A  T  G         p.160

          .         .          | 06        .         .         .    g.11551
 CAGTGGACGGAGTGGAAAATTGAAGGACG | GTTGCCAGTCGCTAGGTCAGCCCATGGGGCC    c.540
 Q  W  T  E  W  K  I  E  G  R  |  L  P  V  A  R  S  A  H  G  A      p.180

          .         .         .         .         .    | 07    .    g.12363
 ACGGTGTACAGTGACAAGCTGTGGATCTTTGCTGGCTATGACGGCAACGCCAG | GTTGAAT    c.600
 T  V  Y  S  D  K  L  W  I  F  A  G  Y  D  G  N  A  R  |  L  N      p.200

          .         .         .         .         .  | 08      .    g.13126
 GACATGTGGACAATTGGCCTCCAGGACCGAGAGCTCACCTGCTGGGAGGAG | GTGGCCCAG    c.660
 D  M  W  T  I  G  L  Q  D  R  E  L  T  C  W  E  E   | V  A  Q      p.220

          .         .         .         .         .         .       g.13186
 AGTGGCGAGATCCCCCCATCTTGCTGCAACTTCCCCGTGGCTGTGTGCCGGGACAAGATG       c.720
 S  G  E  I  P  P  S  C  C  N  F  P  V  A  V  C  R  D  K  M         p.240

          .         .         .         .         .         .       g.13246
 TTTGTATTCTCTGGGCAAAGCGGAGCCAAAATAACCAACAACCTCTTCCAGTTTGAATTC       c.780
 F  V  F  S  G  Q  S  G  A  K  I  T  N  N  L  F  Q  F  E  F         p.260

          .  | 09      .         .         .         .         .    g.14408
 AAGGACAAGAC | GTGGACACGCATCCCAACTGAACACCTGCTCCGGGGCTCCCCACCACCC    c.840
 K  D  K  T  |  W  T  R  I  P  T  E  H  L  L  R  G  S  P  P  P      p.280

          .         .         .         .         .         .       g.14468
 CCGCAGCGGCGCTACGGGCATACCATGGTGGCCTTTGACCGCCACCTCTATGTGTTTGGG       c.900
 P  Q  R  R  Y  G  H  T  M  V  A  F  D  R  H  L  Y  V  F  G         p.300

          .         .         .         .         .         .       g.14528
 GGTGCGGCCGACAACACGCTGCCCAACGAGCTGCACTGCTATGACGTGGACTTCCAGACC       c.960
 G  A  A  D  N  T  L  P  N  E  L  H  C  Y  D  V  D  F  Q  T         p.320

          .         .         .    | 10    .         .         .    g.14972
 TGGGAGGTCGTCCAGCCCAGCTCCGACAGCGAG | GTTGGTGGGGCTGAAGTGCCCGAGCGA    c.1020
 W  E  V  V  Q  P  S  S  D  S  E   | V  G  G  A  E  V  P  E  R      p.340

          .         .         .         .         .         .       g.15032
 GCCTGTGCTTCCGAGGAGGTGCCCACCCTGACCTATGAGGAGCGGGTTGGCTTCAAGAAG       c.1080
 A  C  A  S  E  E  V  P  T  L  T  Y  E  E  R  V  G  F  K  K         p.360

          .         .         .         .         .         .       g.15092
 TCCCGAGATGTGTTTGGCCTGGACTTTGGCACCACCTCAGCCAAGCAGCCCACCCAGCCT       c.1140
 S  R  D  V  F  G  L  D  F  G  T  T  S  A  K  Q  P  T  Q  P         p.380

           | 11        .         .         .         .         .    g.15576
 GCCTCGGAG | CTGCCCAGTGGGAGGCTCTTCCACGCGGCTGCTGTCATCTCGGACGCCATG    c.1200
 A  S  E   | L  P  S  G  R  L  F  H  A  A  A  V  I  S  D  A  M      p.400

          .         .         .         .         .         .       g.15636
 TACATCTTCGGGGGCACGGTGGACAACAACATCCGCAGCGGGGAGATGTACAGGTTCCAG       c.1260
 Y  I  F  G  G  T  V  D  N  N  I  R  S  G  E  M  Y  R  F  Q         p.420

  | 12       .         .         .         .         .         .    g.16453
  | TTCTCCTGTTACCCTAAATGCACGCTGCACGAGGACTACGGGCGGCTGTGGGAGAGCCGC    c.1320
  | F  S  C  Y  P  K  C  T  L  H  E  D  Y  G  R  L  W  E  S  R      p.440

          .         .         .    | 13    .         .         .    g.16682
 CAGTTCTGCGACGTGGAGTTCGTGCTGGGTGAG | AAGGAGGAGTGCGTGCAGGGCCACGTA    c.1380
 Q  F  C  D  V  E  F  V  L  G  E   | K  E  E  C  V  Q  G  H  V      p.460

          .         .         .         .         .         .       g.16742
 GCCATTGTCACAGCGCGGAGCCGCTGGCTTCGCAGGAAGATCACGCAGGCGCGGGAGAGG       c.1440
 A  I  V  T  A  R  S  R  W  L  R  R  K  I  T  Q  A  R  E  R         p.480

           | 14        .         .         .         .         .    g.16886
 CTGGCCCAG | AAGCTGGAGCAGGAGGCCGCCCCAGTTCCCAGGGAGGCCCCCGGCGTGGCT    c.1500
 L  A  Q   | K  L  E  Q  E  A  A  P  V  P  R  E  A  P  G  V  A      p.500

          .         .         .         .         .         .       g.16946
 GCTGGTGGGGCCCGGCCGCCCCTGCTGCACGTGGCCATCCGGGAGGCCGAGGCCCGGCCC       c.1560
 A  G  G  A  R  P  P  L  L  H  V  A  I  R  E  A  E  A  R  P         p.520

          .         .         .         .         .      | 15  .    g.17294
 TTCGAGGTGCTCATGCAGTTCCTCTACACCGACAAGATCAAATACCCACGGAAAG | GCCAT    c.1620
 F  E  V  L  M  Q  F  L  Y  T  D  K  I  K  Y  P  R  K  G |   H      p.540

          .         .         .         .         .         .       g.17354
 GTGGAGGATGTGCTGCTCATCATGGATGTGTACAAACTGGCACTGAGCTTCCAGTTGTGC       c.1680
 V  E  D  V  L  L  I  M  D  V  Y  K  L  A  L  S  F  Q  L  C         p.560

          .         .         .         .         .         .       g.17414
 CGCCTGGAGCAGCTGTGCCGCCAGTACATCGAGGCCTCCGTGGACCTGCAGAACGTGCTG       c.1740
 R  L  E  Q  L  C  R  Q  Y  I  E  A  S  V  D  L  Q  N  V  L         p.580

          .         .         .         .      | 16  .         .    g.17616
 GTTGTGTGCGAGAGTGCCGCCCGGCTGCAGCTGAGCCAACTCAAG | GAGCACTGCCTGAAC    c.1800
 V  V  C  E  S  A  A  R  L  Q  L  S  Q  L  K   | E  H  C  L  N      p.600

          .         .         .         .         .         .       g.17676
 TTCGTGGTAAAGGAGTCCCACTTCAACCAGGTGATCATGATGAAGGAGTTCGAGCGCCTC       c.1860
 F  V  V  K  E  S  H  F  N  Q  V  I  M  M  K  E  F  E  R  L         p.620

          .         .         .         .         .         .       g.17736
 TCCTCTCCACTGATAGTGGAGATTGTGCGGCGGAAGCAGCAGCCGCCCCCTCGCACTCCC       c.1920
 S  S  P  L  I  V  E  I  V  R  R  K  Q  Q  P  P  P  R  T  P         p.640

          .         .   | 17     .         .         .         .    g.18515
 TTGGACCAGCCAGTGGACATTG | GCACATCTCTGATCCAGGACATGAAGGCATACCTGGAG    c.1980
 L  D  Q  P  V  D  I  G |   T  S  L  I  Q  D  M  K  A  Y  L  E      p.660

          .         .         .         .         .         .       g.18575
 GGAGCGGGCGCGGAATTCTGTGACATCACTCTGTTGCTTGACGGGCACCCACGGCCAGCC       c.2040
 G  A  G  A  E  F  C  D  I  T  L  L  L  D  G  H  P  R  P  A         p.680

          .         .          | 18        .         .         .    g.18725
 CACAAGGCTATCCTGGCCGCCCGCTCCAG | CTACTTTGAAGCCATGTTCCGGTCCTTCATG    c.2100
 H  K  A  I  L  A  A  R  S  S  |  Y  F  E  A  M  F  R  S  F  M      p.700

          .         .         .         .         .         .       g.18785
 CCCGAAGATGGGCAGGTGAACATCTCCATCGGGGAGATGGTGCCCAGCAGGCAGGCCTTC       c.2160
 P  E  D  G  Q  V  N  I  S  I  G  E  M  V  P  S  R  Q  A  F         p.720

          .         .         .         .         .          | 19    g.19428
 GAGTCCATGCTGCGCTACATCTACTACGGCGAGGTCAACATGCCGCCCGAGGACTCGCT | C    c.2220
 E  S  M  L  R  Y  I  Y  Y  G  E  V  N  M  P  P  E  D  S  L  |      p.740

          .         .         .         .         .         .       g.19488
 TACTTGTTTGCGGCCCCCTACTACTACGGCTTCTACAACAACCGGCTGCAGGCGTACTGC       c.2280
 Y  L  F  A  A  P  Y  Y  Y  G  F  Y  N  N  R  L  Q  A  Y  C         p.760

          .         .         .         .      | 20  .         .    g.19632
 AAGCAGAACCTGGAGATGAACGTGACGGTGCAGAACGTGCTGCAG | ATCCTGGAGGCAGCT    c.2340
 K  Q  N  L  E  M  N  V  T  V  Q  N  V  L  Q   | I  L  E  A  A      p.780

          .         .         .         .         .         .       g.19692
 GACAAAACGCAGGCACTGGACATGAAGCGGCACTGCCTGCACATCATTGTGCACCAGTTC       c.2400
 D  K  T  Q  A  L  D  M  K  R  H  C  L  H  I  I  V  H  Q  F         p.800

        | 21 .         .         .         .         .         .    g.20017
 ACCAAG | GTCTCCAAGTTGCCCACCCTGCGGTCGCTGAGCCAGCAGCTGCTGCTGGACATC    c.2460
 T  K   | V  S  K  L  P  T  L  R  S  L  S  Q  Q  L  L  L  D  I      p.820

          .         .         .         .         .         .       g.20077
 ATAGACTCCCTGGCCTCCCACATCTCAGACAAGCAGTGCGCAGAGCTGGGCGCCGACATC       c.2520
 I  D  S  L  A  S  H  I  S  D  K  Q  C  A  E  L  G  A  D  I         p.840

                                                                    g.20080
 TGA                                                                c.2523
 X                                                                  p.840

          .         .         .         .         .         .       g.20140
 ggccctgtggcgcctgcccattgtgaagaatcgccgtgcctgcctgccctgcctactgag       c.*60

          .         .         .         .         .         .       g.20200
 aagactaccggctatgcgcatgcctatggcagtgggtgcacctgccaggccaagggtcag       c.*120

          .         .         .         .         .         .       g.20260
 ggtgcccagagcctccaaagagagctgaggggatgtggggccccaaactcattaattcac       c.*180

          .         .         .         .         .         .       g.20320
 tgaagacacaggtcccacagggagcggatgatgaagcagaccccctcctgtcatcaccct       c.*240

          .         .         .         .         .         .       g.20380
 ctcctggtgtagtgtggatgcgaggccacggctcagtgatgggctcaccacccagaagtg       c.*300

          .         .         .         .         .         .       g.20440
 gggagagactttgggcctcccacccagtggggcttggcctggcttctgtggcctgggcgt       c.*360

          .         .         .         .         .         .       g.20500
 gttgtggactcaggcactggggcctgtcaccaaggctcctccaacatgcgggaggaggct       c.*420

          .         .         .         .         .         .       g.20560
 tagcagacttgcgctgcaccagcgaatctgcctgggctgctcctgtcccacccaccctca       c.*480

          .         .         .         .         .         .       g.20620
 ctgagatccatgtaaggggctcctcttcccacctggaacttgtgagtggggacccatgat       c.*540

          .         .         .         .         .         .       g.20680
 gtatgggtctcacctgacttgaggtgaattttggagtgaagggccctgaggtcagctccc       c.*600

          .         .         .         .         .         .       g.20740
 aggtcggtcgtgctgggccaggcctggttttcacaggggctgaaggatcccagtccacct       c.*660

          .         .         .         .         .         .       g.20800
 gtgtgcatgtcagggctcggccgggaagaagccagcaaagtcccccgtgtcccttgctga       c.*720

          .         .         .         .         .         .       g.20860
 gtattctgtcacagacaagcctccattaaagccacagcagtgctacccaccacacacacc       c.*780

          .         .         .         .         .         .       g.20920
 ttgctggcccggccaccactgctggcttcagccccttgagcagcccatggcttagcagac       c.*840

          .         .         .         .         .         .       g.20980
 ccccagatgtaggtcagtggccttacctgtctctatccatgctgtcaactcctgcctcca       c.*900

          .         .         .         .         .         .       g.21040
 cctggggtcacccagtcacattgggaagggctgtgaaggcctccaggctggccccttcca       c.*960

          .         .         .         .         .         .       g.21100
 ggggaatcctggaggcctggggtgggctcctgccccttctgccctgccttgcccctgcac       c.*1020

          .         .         .         .         .         .       g.21160
 tatgctcttggctcctgtggaaggagggctgccctcttgccctagtgagggccccatgtg       c.*1080

          .         .         .         .         .         .       g.21220
 gatccactctagtgctgggagccagcgctcccttactgggaacaggattccaggacccct       c.*1140

          .         .         .         .         .         .       g.21280
 ttcttgttgtggctgccatgaagccacagctccttggggaagtgacctgctctcctttgg       c.*1200

          .         .         .         .         .         .       g.21340
 gtgtatgcaggtgtgtggggggccctgagtggcaagttgcttagctaacaggagatccat       c.*1260

          .         .         .         .         .         .       g.21400
 aggcagcctgcaggctaggaagtggcctagtgcaagatgagctgggaacaagggaggaga       c.*1320

          .         .         .         .         .         .       g.21460
 gagcaggagctggggcagaggctgagccgggaggcccttgaggtgaggacacagcaggcc       c.*1380

          .         .         .         .         .         .       g.21520
 caggaccatggctggggaggatatgtcagcacctggaagtggagtgcaggctgcagcgcc       c.*1440

          .         .         .         .         .         .       g.21580
 cagccatgtgggccaggtgcattcactcagagtggggccacacacccatctacccagttt       c.*1500

          .         .         .         .         .         .       g.21640
 ccacaagatgtggctcctgccacacccacagggcagcctcctccaaatccctcctggagg       c.*1560

          .         .         .         .         .         .       g.21700
 ggcctacccagaagcctccttgaaccagtctgcaaccctgctctatgctgacccttgtca       c.*1620

          .         .         .         .         .         .       g.21760
 ctgaaccctgatctagacttatatgaataaatgaaattacatgccaagggccctaaaaag       c.*1680

                                                                    g.21769
 caaatttta                                                          c.*1689

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Leucine-zipper-like transcription regulator 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 10c
©2004-2014 Leiden University Medical Center