MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1) - coding DNA reference sequence

(used for variant description)

(last modified April 16, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003550.2 in the MAD1L1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011518.1, covering MAD1L1 transcript NM_003550.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          agt       c.-301

 .         .         .         .         .         .                g.5063
 gtcgcgataaatgggcgccggcggagcggagggagatccgagcggcggcggcaagctggc       c.-241

 .         .    | 02    .         .         .         .             g.7230
 tgcgagcggctgag | gagctgggatacactcttcctctcctctcctcaacagcagcactcc    c.-181

 .         .         .         .         .         .                g.7290
 aagctcgccggcctttggtctccaggacttgtcccagcagcccctcgaactgagaattac       c.-121

 .         .         .         .         .         .                g.7350
 accatcggacccctggctctgaggccttcagacttggactgtgtcacactgccaggcttc       c.-61

 .         .         .         .         .          | 03            g.7815
 cagggctccaacttgcagacggcctgttgtgggacagtctctgtaatcgc | gaaagcaacc    c.-1

          .         .         .         .         .         .       g.7875
 ATGGAAGACCTGGGGGAAAACACCATGGTTTTATCCACCCTGAGATCTTTGAACAACTTC       c.60
 M  E  D  L  G  E  N  T  M  V  L  S  T  L  R  S  L  N  N  F         p.20

          .         .         .         .         .         .       g.7935
 ATCTCTCAGCGTGTGGAGGGAGGCTCTGGACTGGATATTTCTACCTCGGCCCCAGGTTCT       c.120
 I  S  Q  R  V  E  G  G  S  G  L  D  I  S  T  S  A  P  G  S         p.40

          .         .         . | 04       .         .         .    g.12428
 CTGCAGATGCAGTACCAGCAGAGCATGCAG | CTGGAGGAAAGAGCAGAGCAGATCCGTTCG    c.180
 L  Q  M  Q  Y  Q  Q  S  M  Q   | L  E  E  R  A  E  Q  I  R  S      p.60

          .         .         .         .         .         .       g.12488
 AAGTCCCACCTCATCCAGGTGGAGCGGGAGAAAATGCAGATGGAGCTGAGTCACAAGAGG       c.240
 K  S  H  L  I  Q  V  E  R  E  K  M  Q  M  E  L  S  H  K  R         p.80

          .         .         .         .         .  | 05      .    g.15203
 GCTCGAGTGGAGCTGGAGAGAGCAGCCAGCACCAGTGCCAGGAACTACGAG | CGTGAGGTC    c.300
 A  R  V  E  L  E  R  A  A  S  T  S  A  R  N  Y  E   | R  E  V      p.100

          .         .         .         .         .         .       g.15263
 GACCGCAACCAGGAGCTCCTGACGCGCATCCGGCAGCTTCAGGAGCGGGAGGCCGGGGCG       c.360
 D  R  N  Q  E  L  L  T  R  I  R  Q  L  Q  E  R  E  A  G  A         p.120

          .         .         .         .         .         .       g.15323
 GAGGAGAAGATGCAGGAGCAGCTGGAGCGCAACAGGCAGTGTCAGCAGAACTTGGATGCT       c.420
 E  E  K  M  Q  E  Q  L  E  R  N  R  Q  C  Q  Q  N  L  D  A         p.140

          .         .         .         .         .  | 06      .    g.18501
 GCCAGCAAGAGGCTGCGTGAGAAAGAGGACAGTCTGGCCCAGGCTGGCGAG | ACCATCAAC    c.480
 A  S  K  R  L  R  E  K  E  D  S  L  A  Q  A  G  E   | T  I  N      p.160

          .         .         .         .         .         .       g.18561
 GCACTGAAGGGGAGGATCTCGGAACTGCAGTGGAGCGTGATGGACCAGGAGATGCGGGTG       c.540
 A  L  K  G  R  I  S  E  L  Q  W  S  V  M  D  Q  E  M  R  V         p.180

          .         .         .         .         .       | 07 .    g.19909
 AAGCGCCTGGAGTCGGAGAAGCAGGAGCTGCAGGAGCAGCTGGACCTGCAACACAA | AAAA    c.600
 K  R  L  E  S  E  K  Q  E  L  Q  E  Q  L  D  L  Q  H  K  |  K      p.200

          .         .         .         .         .         .       g.19969
 TGCCAGGAAGCCAATCAGAAAATCCAGGAACTCCAGGCCAGCCAAGAAGCAAGAGCAGAC       c.660
 C  Q  E  A  N  Q  K  I  Q  E  L  Q  A  S  Q  E  A  R  A  D         p.220

          .         | 08         .         .         .         .    g.21703
 CACGAGCAGCAGATTAAG | GATCTGGAGCAGAAGCTGTCCCTGCAAGAGCAGGATGCAGCG    c.720
 H  E  Q  Q  I  K   | D  L  E  Q  K  L  S  L  Q  E  Q  D  A  A      p.240

          .         .         .         .         .         .       g.21763
 ATTGTGAAGAACATGAAGTCTGAGCTGGTACGGCTCCCTAGGCTGGAACGGGAGCTGAAG       c.780
 I  V  K  N  M  K  S  E  L  V  R  L  P  R  L  E  R  E  L  K         p.260

          .         .          | 09        .         .         .    g.21980
 CAGCTGCGGGAGGAGAGCGCGCACCTGCG | GGAGATGAGAGAGACCAACGGGCTGCTCCAG    c.840
 Q  L  R  E  E  S  A  H  L  R  |  E  M  R  E  T  N  G  L  L  Q      p.280

          .         .         .         .         .         .       g.22040
 GAAGAGCTGGAAGGGCTGCAGAGGAAGCTGGGGCGCCAGGAGAAGATGCAGGAGACGCTG       c.900
 E  E  L  E  G  L  Q  R  K  L  G  R  Q  E  K  M  Q  E  T  L         p.300

          .         .     | 10   .         .         .         .    g.24711
 GTTGGCTTGGAGCTGGAGAACGAG | AGGCTGCTGGCCAAGCTGCAAAGCTGGGAGAGACTG    c.960
 V  G  L  E  L  E  N  E   | R  L  L  A  K  L  Q  S  W  E  R  L      p.320

          .         .       | 11 .         .         .         .    g.88744
 GACCAGACCATGGGCCTGAGCATCAG | GACTCCAGAAGACCTTTCCAGATTCGTGGTTGAG    c.1020
 D  Q  T  M  G  L  S  I  R  |  T  P  E  D  L  S  R  F  V  V  E      p.340

          .         .         .         .         .    | 12    .    g.168617
 CTGCAGCAGAGGGAGCTTGCCTTGAAGGACAAGAACAGCGCCGTCACCAGCAG | CGCCCGG    c.1080
 L  Q  Q  R  E  L  A  L  K  D  K  N  S  A  V  T  S  S  |  A  R      p.360

          .         .         .         .         .         .       g.168677
 GGGCTGGAGAAGGCCAGGCAGCAGCTGCAGGAGGAGCTCCGGCAGGTCAGCGGCCAGCTG       c.1140
 G  L  E  K  A  R  Q  Q  L  Q  E  E  L  R  Q  V  S  G  Q  L         p.380

          .         .         .         .         .         .       g.168737
 TTGGAGGAGAGGAAGAAGCGCGAGACCCACGAGGCGCTGGCCCGGAGGCTCCAGAAACGG       c.1200
 L  E  E  R  K  K  R  E  T  H  E  A  L  A  R  R  L  Q  K  R         p.400

          .         | 13         .         .         .         .    g.223348
 GTCCTGCTGCTCACCAAG | GAGCGGGACGGTATGCGGGCCATCCTGGGGTCCTACGACAGC    c.1260
 V  L  L  L  T  K   | E  R  D  G  M  R  A  I  L  G  S  Y  D  S      p.420

          .         .         .         .         .         .       g.223408
 GAGCTGACCCCGGCCGAGTACTCACCCCAGCTGACGCGGCGCATGCGGGAGGCTGAGGAT       c.1320
 E  L  T  P  A  E  Y  S  P  Q  L  T  R  R  M  R  E  A  E  D         p.440

          .         .         .          | 14        .         .    g.235848
 ATGGTGCAGAAGGTGCACAGCCACAGCGCCGAGATGGAG | GCTCAGCTGTCGCAGGCCCTG    c.1380
 M  V  Q  K  V  H  S  H  S  A  E  M  E   | A  Q  L  S  Q  A  L      p.460

          .         .         .       | 15 .         .         .    g.257431
 GAGGAGCTGGGAGGCCAGAAACAAAGAGCAGACATG | CTGGAGATGGAGCTGAAGATGCTG    c.1440
 E  E  L  G  G  Q  K  Q  R  A  D  M   | L  E  M  E  L  K  M  L      p.480

          .         .         .         .         .         .       g.257491
 AAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGGACACG       c.1500
 K  S  Q  S  S  S  A  E  Q  S  F  L  F  S  R  E  E  A  D  T         p.500

       | 16  .         .         .         .         .         .    g.280284
 CTCAG | GTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGG    c.1560
 L  R  |  L  K  V  E  E  L  E  G  E  R  S  R  L  E  E  E  K  R      p.520

          .         .         .       | 17 .         .         .    g.301074
 ATGCTGGAGGCACAGCTGGAGCGGCGAGCTCTGCAG | GGTGACTATGACCAGAGCAGGACC    c.1620
 M  L  E  A  Q  L  E  R  R  A  L  Q   | G  D  Y  D  Q  S  R  T      p.540

          .         .         .         .         .         .       g.301134
 AAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCGAGGAC       c.1680
 K  V  L  H  M  S  L  N  P  T  S  V  A  R  Q  R  L  R  E  D         p.560

          .         .         .         .         .         .       g.301194
 CACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGA       c.1740
 H  S  Q  L  Q  A  E  C  E  R  L  R  G  L  L  R  A  M  E  R         p.580

          .         .         .         .         .         .       g.301254
 GGAGGCACCGTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAG       c.1800
 G  G  T  V  P  A  D  L  E  A  A  A  A  S  L  P  S  S  K  E         p.600

         | 18.         .         .         .         .         .    g.339610
 GTGGCAG | AGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCAAGGAG    c.1860
 V  A  E |   L  K  K  Q  V  E  S  A  E  L  K  N  Q  R  L  K  E      p.620

          .         .         .         .         .         .       g.339670
 GTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAG       c.1920
 V  F  Q  T  K  I  Q  E  F  R  K  A  C  Y  T  L  T  G  Y  Q         p.640

          .         .         .         .         .         .       g.339730
 ATCGACATCACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGC       c.1980
 I  D  I  T  T  E  N  Q  Y  R  L  T  S  L  Y  A  E  H  P  G         p.660

          .         | 19         .         .         .         .    g.421761
 GACTGCCTCATCTTCAAG | GCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGGAGACA    c.2040
 D  C  L  I  F  K   | A  T  S  P  S  G  S  K  M  Q  L  L  E  T      p.680

          .         .         .         .         .         .       g.421821
 GAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATC       c.2100
 E  F  S  H  T  V  G  E  L  I  E  V  H  L  R  R  Q  D  S  I         p.700

          .         .         .         .         .                 g.421878
 CCTGCCTTCCTCAGCTCGCTCACCCTCGAGCTCTTCAGCCGCCAGACCGTGGCGTAG          c.2157
 P  A  F  L  S  S  L  T  L  E  L  F  S  R  Q  T  V  A  X            p.718

          .         .         .         .         .         .       g.421938
 cctgcaggctcgggggcatagccggagccactctgcttggcctgacctgcaggtcccctg       c.*60

          .         .         .         .         .         .       g.421998
 ccccgccagccacaggctgggtgcacgtcctgcctctccagccccacagggcagcagcat       c.*120

          .         .         .         .         .         .       g.422058
 gactgacagacacgctgggacctacgtcgggcttcctgctggggcggccagcaccctctc       c.*180

          .         .         .         .         .         .       g.422118
 cacgtgcagaccccatgcgtcccggagcctggtgtgtgggcgtcggccaccagcctgggt       c.*240

          .         .         .                                     g.422156
 tcctcaccttgtgaaataaaatcttctcccctagacac                             c.*278

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The MAD1 mitotic arrest deficient-like 1 (yeast) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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