v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (MAF) - coding DNA reference sequence

(used for variant description)

(last modified October 18, 2016)

This file was created to facilitate the description of sequence variants on transcript NM_005360.4 in the MAF gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016440.1, covering MAF transcript NM_005360.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5043
                  gaggctttaaaatcttttttcatcttctagctgtagctcgggc       c.-781

 .         .         .         .         .         .                g.5103
 tgcttgtcggcttggcctccccctcccccctttgctctctgcctcgtctttccccaggac       c.-721

 .         .         .         .         .         .                g.5163
 ttcgctattttgcttttttaaaaaaaggcaagaaagaactaaactcccccctccctctcc       c.-661

 .         .         .         .         .         .                g.5223
 tccagtcgggctgcacctctgccttgcactttgcacagaggtagagagcgcgcgagggag       c.-601

 .         .         .         .         .         .                g.5283
 agagaggaaagaaaaaaaataataaagagagccaagcagaagaggaggcgagaagcatga       c.-541

 .         .         .         .         .         .                g.5343
 agtgttaactcccccgtgccaaggcccgcgccgcccggacagacgcccgccgcgcctcca       c.-481

 .         .         .         .         .         .                g.5403
 gccccgagcggacgccgcgcgcgccctgcctgcagcccgggccggcgaggcgagcccttc       c.-421

 .         .         .         .         .         .                g.5463
 cttatgcaaagcgcgcagcggagcggcgagcgggggacgccgcgcaccgggccgggctcc       c.-361

 .         .         .         .         .         .                g.5523
 tccagcttcgccgccgcagccaccaccgccgccaccgcagctcgcggaggatcttcccga       c.-301

 .         .         .         .         .         .                g.5583
 gcctgaagccgccggctcggcgcgcaaggaggcgagcgagcaaggaggggccggggcgag       c.-241

 .         .         .         .         .         .                g.5643
 cgagggagcacattggcgtgagcaggggggagggagggcgggcgcggggggcgcgggcag       c.-181

 .         .         .         .         .         .                g.5703
 ggcgggggggtgtgtgtgtgagcgcgctcggaggtttcgggccagccaccgccgcgcaag       c.-121

 .         .         .         .         .         .                g.5763
 ctagaagcgccccagcccggcaagctggctcacccgctggccacccagcacagcccgctg       c.-61

 .         .         .         .         .         .                g.5823
 gcccctctcctgcagcccatctggcggagcggcggcggcggcggcggcggcggcaggaga       c.-1

          .         .         .         .         .         .       g.5883
 ATGGCATCAGAACTGGCAATGAGCAACTCCGACCTGCCCACCAGTCCCCTGGCCATGGAA       c.60
 M  A  S  E  L  A  M  S  N  S  D  L  P  T  S  P  L  A  M  E         p.20

          .         .         .         .         .         .       g.5943
 TATGTTAATGACTTCGATCTGATGAAGTTTGAAGTGAAAAAGGAACCGGTGGAGACCGAC       c.120
 Y  V  N  D  F  D  L  M  K  F  E  V  K  K  E  P  V  E  T  D         p.40

          .         .         .         .         .         .       g.6003
 CGCATCATCAGCCAGTGCGGCCGTCTCATCGCCGGGGGCTCGCTGTCCTCCACCCCCATG       c.180
 R  I  I  S  Q  C  G  R  L  I  A  G  G  S  L  S  S  T  P  M         p.60

          .         .         .         .         .         .       g.6063
 AGCACGCCGTGCAGCTCGGTGCCCCCTTCCCCCAGCTTCTCGGCGCCCAGCCCGGGCTCG       c.240
 S  T  P  C  S  S  V  P  P  S  P  S  F  S  A  P  S  P  G  S         p.80

          .         .         .         .         .         .       g.6123
 GGCAGCGAGCAGAAGGCGCACCTGGAAGACTACTACTGGATGACCGGCTACCCGCAGCAG       c.300
 G  S  E  Q  K  A  H  L  E  D  Y  Y  W  M  T  G  Y  P  Q  Q         p.100

          .         .         .         .         .         .       g.6183
 CTGAACCCCGAGGCGCTGGGCTTCAGCCCCGAGGACGCGGTCGAGGCGCTCATCAGCAAC       c.360
 L  N  P  E  A  L  G  F  S  P  E  D  A  V  E  A  L  I  S  N         p.120

          .         .         .         .         .         .       g.6243
 AGCCACCAGCTCCAGGGCGGCTTCGATGGCTACGCGCGCGGGGCGCAGCAGCTGGCCGCG       c.420
 S  H  Q  L  Q  G  G  F  D  G  Y  A  R  G  A  Q  Q  L  A  A         p.140

          .         .         .         .         .         .       g.6303
 GCGGCCGGGGCCGGTGCCGGCGCCTCCTTGGGCGGCAGCGGCGAGGAGATGGGCCCCGCC       c.480
 A  A  G  A  G  A  G  A  S  L  G  G  S  G  E  E  M  G  P  A         p.160

          .         .         .         .         .         .       g.6363
 GCCGCCGTGGTGTCCGCCGTGATCGCCGCGGCCGCCGCGCAGAGCGGCGCGGGCCCGCAC       c.540
 A  A  V  V  S  A  V  I  A  A  A  A  A  Q  S  G  A  G  P  H         p.180

          .         .         .         .         .         .       g.6423
 TACCACCACCACCACCACCACGCCGCCGGCCACCACCACCACCCGACGGCCGGCGCGCCC       c.600
 Y  H  H  H  H  H  H  A  A  G  H  H  H  H  P  T  A  G  A  P         p.200

          .         .         .         .         .         .       g.6483
 GGCGCCGCGGGCAGCGCGGCCGCCTCGGCCGGTGGCGCTGGGGGCGCGGGCGGCGGTGGC       c.660
 G  A  A  G  S  A  A  A  S  A  G  G  A  G  G  A  G  G  G  G         p.220

          .         .         .         .         .         .       g.6543
 CCGGCCAGCGCTGGGGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGGGGCGCGGCG       c.720
 P  A  S  A  G  G  G  G  G  G  G  G  G  G  G  G  G  G  A  A         p.240

          .         .         .         .         .         .       g.6603
 GGGGCGGGGGGCGCCCTGCACCCGCACCACGCCGCCGGCGGCCTGCACTTCGACGACCGC       c.780
 G  A  G  G  A  L  H  P  H  H  A  A  G  G  L  H  F  D  D  R         p.260

          .         .         .         .         .         .       g.6663
 TTCTCCGACGAGCAGCTGGTGACCATGTCTGTGCGCGAGCTGAACCGGCAGCTGCGCGGG       c.840
 F  S  D  E  Q  L  V  T  M  S  V  R  E  L  N  R  Q  L  R  G         p.280

          .         .         .         .         .         .       g.6723
 GTCAGCAAGGAGGAGGTGATCCGGCTGAAGCAGAAGAGGCGGACCCTGAAAAACCGCGGC       c.900
 V  S  K  E  E  V  I  R  L  K  Q  K  R  R  T  L  K  N  R  G         p.300

          .         .         .         .         .         .       g.6783
 TATGCCCAGTCCTGCCGCTTCAAGAGGGTGCAGCAGAGACACGTCCTGGAGTCGGAGAAG       c.960
 Y  A  Q  S  C  R  F  K  R  V  Q  Q  R  H  V  L  E  S  E  K         p.320

          .         .         .         .         .         .       g.6843
 AACCAGCTGCTGCAGCAAGTCGACCACCTCAAGCAGGAGATCTCCAGGCTGGTGCGCGAG       c.1020
 N  Q  L  L  Q  Q  V  D  H  L  K  Q  E  I  S  R  L  V  R  E         p.340

          .         .         .         .         .         .       g.6903
 AGGGACGCGTACAAGGAGAAATACGAGAAGTTGGTGAGCAGCGGCTTCCGAGAAAACGGC       c.1080
 R  D  A  Y  K  E  K  Y  E  K  L  V  S  S  G  F  R  E  N  G         p.360

          .         .         .         | 02         .         .    g.11194
 TCGAGCAGCGACAACCCGTCCTCTCCCGAGTTTTTCAT | AACTGAGCCCACTCGCAAGTTG    c.1140
 S  S  S  D  N  P  S  S  P  E  F  F  I  |  T  E  P  T  R  K  L      p.380

          .         .         .         .         .         .       g.11254
 GAGCCATCAGTGGGATACGCCACATTTTGGAAGCCCCAGCATCGTGTACTTACCAGTGTG       c.1200
 E  P  S  V  G  Y  A  T  F  W  K  P  Q  H  R  V  L  T  S  V         p.400

          .                                                         g.11266
 TTCACAAAATGA                                                       c.1212
 F  T  K  X                                                         p.403

          .         .         .         .         .         .       g.11326
 aatttgtgtgagagctgtacattaaaaaaaatcatcattattattattatttgcagtcat       c.*60

          .         .         .         .         .         .       g.11386
 ggagaaccacctacccctgacttctgtttagtctcctttttaaataaaaattactgtgtt       c.*120

          .         .         .         .         .         .       g.11446
 agagaagaaggctattaaatgtagtagttaactatgcctcttgtctgggggtttcataga       c.*180

          .         .         .         .         .         .       g.11506
 gaccggtaggaaagcgcactcctgcttttcgatttatggtgtgtgcaagtaaacaggtgc       c.*240

          .         .         .         .         .         .       g.11566
 attgctttcaacctgccatactagttttaaaaattcactgaaattacaaagatacatata       c.*300

          .         .         .         .         .         .       g.11626
 tatgcatatatataatggaaagtttcccggaatgcaacaattagcattttaaaatcatat       c.*360

          .         .         .         .         .         .       g.11686
 ataggcatgcacattctaaatagtactttttcatgcttcattgtttctctggcagataat       c.*420

          .         .         .         .         .         .       g.11746
 tttactaagaagaaaaatagatattcgactccccttccctaaacaaatccacgggcagag       c.*480

          .         .         .         .         .         .       g.11806
 gctccagcggagccgagccccctggttttctcgtaggccctagacggtgttgcatttatc       c.*540

          .         .         .         .         .         .       g.11866
 agtgatgtcaaacgtgctcatttgtcagacatagctgtaaatgaaaacaatgtgtggcaa       c.*600

          .                                                         g.11878
 aatacaaagtta                                                       c.*612

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.