melanoma antigen family D, 2 (MAGED2) - coding DNA reference sequence

(used for variant description)

(last modified February 17, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_014599.4 in the MAGED2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012844.1, covering MAGED2 transcript NM_014599.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5665
                      ggagggcagtctccgagtttcggaggggcttggagtgag       c.-61

 .         .         .         . | 02       .         .             g.6594
 tggacgcactcgggaattgtaggaggacgag | gctcagctcttgccaggccaaattgagac    c.-1

          .         .         .         .      | 03  .         .    g.6999
 ATGTCTGACACAAGCGAGAGTGGTGCAGGTCTAACTCGCTTCCAG | GCTGAAGCTTCAGAA    c.60
 M  S  D  T  S  E  S  G  A  G  L  T  R  F  Q   | A  E  A  S  E      p.20

          .         .         .         .         .         .       g.7059
 AAGGACAGTAGCTCGATGATGCAGACTCTGTTGACAGTGACCCAGAATGTGGAGGTCCCA       c.120
 K  D  S  S  S  M  M  Q  T  L  L  T  V  T  Q  N  V  E  V  P         p.40

          .         .         .         .         .         .       g.7119
 GAGACACCGAAGGCCTCAAAGGCACTGGAGGTCTCAGAGGATGTGAAGGTCTCAAAAGCC       c.180
 E  T  P  K  A  S  K  A  L  E  V  S  E  D  V  K  V  S  K  A         p.60

          .         .         .         .         .         .       g.7179
 TCTGGGGTCTCAAAGGCCACAGAGGTCTCAAAGACCCCAGAGGCTCGGGAGGCACCTGCC       c.240
 S  G  V  S  K  A  T  E  V  S  K  T  P  E  A  R  E  A  P  A         p.80

          .         .         .         .         .         .       g.7239
 ACCCAGGCCTCATCTACTACTCAGCTGACTGATACCCAGGTTCTGGCAGCTGAAAACAAG       c.300
 T  Q  A  S  S  T  T  Q  L  T  D  T  Q  V  L  A  A  E  N  K         p.100

          .         .         .         .         .         .       g.7299
 AGTCTAGCAGCTGACACCAAGAAACAGAATGCTGACCCGCAGGCTGTGACAATGCCTGCC       c.360
 S  L  A  A  D  T  K  K  Q  N  A  D  P  Q  A  V  T  M  P  A         p.120

          .         .         .         .         .         .       g.7359
 ACTGAGACCAAAAAGGTCAGCCATGTGGCTGATACAAAGGTCAATACAAAGGCTCAGGAG       c.420
 T  E  T  K  K  V  S  H  V  A  D  T  K  V  N  T  K  A  Q  E         p.140

          .         .         .         .         .         .       g.7419
 ACTGAGGCTGCACCCTCTCAGGCCCCAGCAGATGAACCTGAGCCTGAGAGTGCAGCTGCC       c.480
 T  E  A  A  P  S  Q  A  P  A  D  E  P  E  P  E  S  A  A  A         p.160

          .         .         .         .         .        | 04.    g.8086
 CAGTCTCAGGAGAATCAGGATACTCGGCCCAAGGTCAAAGCCAAGAAAGCCCGAAAG | GTG    c.540
 Q  S  Q  E  N  Q  D  T  R  P  K  V  K  A  K  K  A  R  K   | V      p.180

          .         .         .         .         .         .       g.8146
 AAGCATCTGGATGGGGAAGAGGATGGCAGCAGTGATCAGAGTCAGGCTTCTGGAACCACA       c.600
 K  H  L  D  G  E  E  D  G  S  S  D  Q  S  Q  A  S  G  T  T         p.200

          .         .         .         .         .         .       g.8206
 GGTGGCCGAAGGGTCTCAAAGGCCCTAATGGCCTCAATGGCCCGCAGGGCTTCAAGGGGT       c.660
 G  G  R  R  V  S  K  A  L  M  A  S  M  A  R  R  A  S  R  G         p.220

          .         .         .         .         .         .       g.8266
 CCCATAGCCTTTTGGGCCCGCAGGGCATCAAGGACTCGGTTGGCTGCTTGGGCCCGGAGA       c.720
 P  I  A  F  W  A  R  R  A  S  R  T  R  L  A  A  W  A  R  R         p.240

          .         .         .         .         .         .       g.8326
 GCCTTGCTCTCCCTGAGATCACCTAAAGCCCGTAGGGGCAAGGCTCGCCGTAGAGCTGCC       c.780
 A  L  L  S  L  R  S  P  K  A  R  R  G  K  A  R  R  R  A  A         p.260

          .         .         .         .         .         .       g.8386
 AAGCTCCAGTCATCCCAAGAGCCTGAAGCACCACCACCTCGGGATGTGGCCCTTTTGCAA       c.840
 K  L  Q  S  S  Q  E  P  E  A  P  P  P  R  D  V  A  L  L  Q         p.280

        | 05 .         .         .         .         .         .    g.8566
 GGGAGG | GCAAATGATTTGGTGAAGTACCTTTTGGCTAAAGACCAGACGAAGATTCCCATC    c.900
 G  R   | A  N  D  L  V  K  Y  L  L  A  K  D  Q  T  K  I  P  I      p.300

          . | 06       .         .         .         .         .    g.8886
 AAGCGCTCGG | ACATGCTGAAGGACATCATCAAAGAATACACTGATGTGTACCCCGAAATC    c.960
 K  R  S  D |   M  L  K  D  I  I  K  E  Y  T  D  V  Y  P  E  I      p.320

          .         .         . | 07       .         .         .    g.9449
 ATTGAACGAGCAGGCTATTCCTTGGAGAAG | GTATTTGGGATTCAATTGAAGGAAATTGAT    c.1020
 I  E  R  A  G  Y  S  L  E  K   | V  F  G  I  Q  L  K  E  I  D      p.340

          .         .         .         .         .         .       g.9509
 AAGAATGACCACTTGTACATTCTTCTCAGCACCTTAGAGCCCACTGATGCAGGCATACTG       c.1080
 K  N  D  H  L  Y  I  L  L  S  T  L  E  P  T  D  A  G  I  L         p.360

       | 08  .         .         .         .         .         .    g.10262
 GGAAC | GACTAAGGACTCACCCAAGCTGGGTCTGCTCATGGTGCTTCTTAGCATCATCTTC    c.1140
 G  T  |  T  K  D  S  P  K  L  G  L  L  M  V  L  L  S  I  I  F      p.380

          .         .      | 09  .         .         .         .    g.10415
 ATGAATGGAAATCGGTCCAGTGAGG | CTGTCATCTGGGAGGTGCTGCGCAAGTTGGGGCTG    c.1200
 M  N  G  N  R  S  S  E  A |   V  I  W  E  V  L  R  K  L  G  L      p.400

          | 10         .         .         .         .         .    g.10802
 CGCCCTGG | GATACATCATTCACTCTTTGGGGACGTGAAGAAGCTCATCACTGATGAGTTT    c.1260
 R  P  G  |  I  H  H  S  L  F  G  D  V  K  K  L  I  T  D  E  F      p.420

          .  | 11      .         .         .         .         .    g.11972
 GTGAAGCAGAA | GTACCTGGACTATGCCAGAGTCCCCAATAGCAATCCCCCTGAATATGAG    c.1320
 V  K  Q  K  |  Y  L  D  Y  A  R  V  P  N  S  N  P  P  E  Y  E      p.440

          .         .         .         .         .         .       g.12032
 TTCTTCTGGGGCCTGCGCTCTTACTATGAGACCAGCAAGATGAAAGTCCTCAAGTTTGCC       c.1380
 F  F  W  G  L  R  S  Y  Y  E  T  S  K  M  K  V  L  K  F  A         p.460

        | 12 .         .         .         .         .         .    g.12564
 TGCAAG | GTACAAAAGAAGGATCCCAAGGAATGGGCAGCTCAGTACCGAGAGGCGATGGAA    c.1440
 C  K   | V  Q  K  K  D  P  K  E  W  A  A  Q  Y  R  E  A  M  E      p.480

          .         .         .         .         .         .       g.12624
 GCGGATTTGAAGGCTGCAGCTGAGGCTGCAGCTGAAGCCAAGGCTAGGGCCGAGATTAGA       c.1500
 A  D  L  K  A  A  A  E  A  A  A  E  A  K  A  R  A  E  I  R         p.500

          .         .         .         .         .         .       g.12684
 GCTCGAATGGGCATTGGGCTCGGCTCGGAGAATGCTGCCGGGCCCTGCAACTGGGACGAA       c.1560
 A  R  M  G  I  G  L  G  S  E  N  A  A  G  P  C  N  W  D  E         p.520

          .         .         .         .         .         .       g.12744
 GCTGATATCGGACCCTGGGCCAAAGCCCGGATCCAGGCGGGAGCAGAAGCTAAAGCCAAA       c.1620
 A  D  I  G  P  W  A  K  A  R  I  Q  A  G  A  E  A  K  A  K         p.540

          .         .         .         .         .         .       g.12804
 GCCCAAGAGAGTGGCAGTGCCAGCACTGGTGCCAGTACCAGTACCAATAACAGTGCCAGT       c.1680
 A  Q  E  S  G  S  A  S  T  G  A  S  T  S  T  N  N  S  A  S         p.560

          .         .         .         .         .         .       g.12864
 GCCAGTGCCAGCACCAGTGGTGGCTTCAGTGCTGGTGCCAGCCTGACCGCCACTCTCACA       c.1740
 A  S  A  S  T  S  G  G  F  S  A  G  A  S  L  T  A  T  L  T         p.580

          .         .         .         .         .         .       g.12924
 TTTGGGCTCTTCGCTGGCCTTGGTGGAGCTGGTGCCAGCACCAGTGGCAGCTCTGGTGCC       c.1800
 F  G  L  F  A  G  L  G  G  A  G  A  S  T  S  G  S  S  G  A         p.600

          .         .                                           g.12945
 TGTGGTTTCTCCTACAAGTGA |                                           c.1822
 C  G  F  S  Y  K  X                                             p.606

          | 13         .         .         .         .         .    g.13195
 gattttag | atattgttaatcctgccagtctttctcttcaagccagggtgcatcctcagaa    c.*60

          .         .         .         .         .         .       g.13255
 acctactcaacacagcactctaggcagccactatcaatcaattgaagttgacactctgca       c.*120

          .         .                                               g.13275
 ttaaatctatttgccatttc                                               c.*140

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Melanoma antigen family D, 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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