mannosidase, alpha, class 1B, member 1 (MAN1B1) - coding DNA reference sequence

(used for variant description)

(last modified March 20, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_016219.4 in the MAN1B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031978.1, covering MAN1B1 transcript NM_016219.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                actggccgcatag       c.-61

 .         .         .         .         .         .                g.5073
 agacgcagcgcacgcgcagtcgcgtatccgtgtgatgggcgggctgttgacggcgctgcg       c.-1

          .         .         .         .         .         .       g.5133
 ATGGCTGCCTGCGAGGGCAGGAGAAGCGGAGCTCTCGGTTCCTCTCAGTCGGACTTCCTG       c.60
 M  A  A  C  E  G  R  R  S  G  A  L  G  S  S  Q  S  D  F  L         p.20

          .         .         .         .         .         .       g.5193
 ACGCCGCCAGTGGGCGGGGCCCCTTGGGCCGTCGCCACCACTGTAGTCATGTACCCACCG       c.120
 T  P  P  V  G  G  A  P  W  A  V  A  T  T  V  V  M  Y  P  P         p.40

          .         .         .         .         .         .       g.5253
 CCGCCGCCGCCGCCTCATCGGGACTTCATCTCGGTGACGCTGAGCTTTGGCGAGAACTAT       c.180
 P  P  P  P  P  H  R  D  F  I  S  V  T  L  S  F  G  E  N  Y         p.60

          .         .         .          | 02        .         .    g.6169
 GACAACAGCAAGAGTTGGCGGCGGCGCTCGTGCTGGAGG | AAATGGAAGCAACTGTCGAGA    c.240
 D  N  S  K  S  W  R  R  R  S  C  W  R   | K  W  K  Q  L  S  R      p.80

          .         .         .         .         .         .       g.6229
 TTGCAGCGGAATATGATTCTCTTCCTCCTTGCCTTTCTGCTTTTCTGTGGACTCCTCTTC       c.300
 L  Q  R  N  M  I  L  F  L  L  A  F  L  L  F  C  G  L  L  F         p.100

          .         .         | 03         .         .         .    g.6974
 TACATCAACTTGGCTGACCATTGGAAAG | CTCTGGCTTTCAGGCTAGAGGAAGAGCAGAAG    c.360
 Y  I  N  L  A  D  H  W  K  A |   L  A  F  R  L  E  E  E  Q  K      p.120

          .         .         .         .         .         .       g.7034
 ATGAGGCCAGAAATTGCTGGGTTAAAACCAGCAAATCCACCCGTCTTACCAGCTCCTCAG       c.420
 M  R  P  E  I  A  G  L  K  P  A  N  P  P  V  L  P  A  P  Q         p.140

          .         .         .         .      | 04  .         .    g.14325
 AAGGCGGACACCGACCCTGAGAACTTACCTGAGATTTCGTCACAG | AAGACACAAAGACAC    c.480
 K  A  D  T  D  P  E  N  L  P  E  I  S  S  Q   | K  T  Q  R  H      p.160

          .         .         .         .         .         .       g.14385
 ATCCAGCGGGGACCACCTCACCTGCAGATTAGACCCCCAAGCCAAGACCTGAAGGATGGG       c.540
 I  Q  R  G  P  P  H  L  Q  I  R  P  P  S  Q  D  L  K  D  G         p.180

          .         .         .         .         .         .       g.14445
 ACCCAGGAGGAGGCCACAAAAAGGCAAGAAGCCCCTGTGGATCCCCGCCCGGAAGGAGAT       c.600
 T  Q  E  E  A  T  K  R  Q  E  A  P  V  D  P  R  P  E  G  D         p.200

          .         . | 05       .         .         .         .    g.15941
 CCGCAGAGGACAGTCATCAG | CTGGAGGGGAGCGGTGATCGAGCCTGAGCAGGGCACCGAG    c.660
 P  Q  R  T  V  I  S  |  W  R  G  A  V  I  E  P  E  Q  G  T  E      p.220

          .         .         .         .         .         .       g.16001
 CTCCCTTCAAGAAGAGCAGAAGTGCCCACCAAGCCTCCCCTGCCACCGGCCAGGACACAG       c.720
 L  P  S  R  R  A  E  V  P  T  K  P  P  L  P  P  A  R  T  Q         p.240

          . | 06       .         .         .         .         .    g.17819
 GGCACACCAG | TGCATCTGAACTATCGCCAGAAGGGCGTGATTGACGTCTTCCTGCATGCA    c.780
 G  T  P  V |   H  L  N  Y  R  Q  K  G  V  I  D  V  F  L  H  A      p.260

          .         .         .         .         .         .       g.17879
 TGGAAAGGATACCGCAAGTTTGCATGGGGCCATGACGAGCTGAAGCCTGTGTCCAGGTCC       c.840
 W  K  G  Y  R  K  F  A  W  G  H  D  E  L  K  P  V  S  R  S         p.280

          .         .         .         .         .         .       g.17939
 TTCAGTGAGTGGTTTGGCCTCGGTCTCACACTGATCGACGCGCTGGACACCATGTGGATC       c.900
 F  S  E  W  F  G  L  G  L  T  L  I  D  A  L  D  T  M  W  I         p.300

          .       | 07 .         .         .         .         .    g.19122
 TTGGGTCTGAGGAAAG | AATTTGAGGAAGCCAGGAAGTGGGTGTCGAAGAAGTTACACTTT    c.960
 L  G  L  R  K  E |   F  E  E  A  R  K  W  V  S  K  K  L  H  F      p.320

          .         .         .         .         .         .       g.19182
 GAAAAGGACGTGGACGTCAACCTGTTTGAGAGCACGATCCGCATCCTGGGGGGGCTCCTG       c.1020
 E  K  D  V  D  V  N  L  F  E  S  T  I  R  I  L  G  G  L  L         p.340

          .         .         .         .      | 08  .         .    g.19572
 AGTGCCTACCACCTGTCTGGGGACAGCCTCTTCCTGAGGAAAGCT | GAGGATTTTGGAAAT    c.1080
 S  A  Y  H  L  S  G  D  S  L  F  L  R  K  A   | E  D  F  G  N      p.360

          .         .         .         .         .         .       g.19632
 CGGCTAATGCCTGCCTTCAGAACACCATCCAAGATTCCTTACTCGGATGTGAACATCGGT       c.1140
 R  L  M  P  A  F  R  T  P  S  K  I  P  Y  S  D  V  N  I  G         p.380

          .         .         .         .         .         .       g.19692
 ACTGGAGTTGCCCACCCGCCACGGTGGACCTCCGACAGCACTGTGGCCGAGGTGACCAGC       c.1200
 T  G  V  A  H  P  P  R  W  T  S  D  S  T  V  A  E  V  T  S         p.400

          .         .         .         .         .     | 09   .    g.24204
 ATTCAGCTGGAGTTCCGGGAGCTCTCCCGTCTCACAGGGGATAAGAAGTTTCAG | GAGGCA    c.1260
 I  Q  L  E  F  R  E  L  S  R  L  T  G  D  K  K  F  Q   | E  A      p.420

          .         .         .         .         .         .       g.24264
 GTGGAGAAGGTGACACAGCACATCCACGGCCTGTCTGGGAAGAAGGATGGGCTGGTGCCC       c.1320
 V  E  K  V  T  Q  H  I  H  G  L  S  G  K  K  D  G  L  V  P         p.440

          .         .         .         .         .         .       g.24324
 ATGTTCATCAATACCCACAGTGGCCTCTTCACCCACCTGGGCGTATTCACGCTGGGCGCC       c.1380
 M  F  I  N  T  H  S  G  L  F  T  H  L  G  V  F  T  L  G  A         p.460

          .         .         .         .         .         .       g.24384
 AGGGCCGACAGCTACTATGAGTACCTGCTGAAGCAGTGGATCCAGGGCGGGAAGCAGGAG       c.1440
 R  A  D  S  Y  Y  E  Y  L  L  K  Q  W  I  Q  G  G  K  Q  E         p.480

       | 10  .         .         .         .         .         .    g.24817
 ACACA | GCTGCTGGAAGACTACGTGGAAGCCATCGAGGGTGTCAGAACGCACCTGCTGCGG    c.1500
 T  Q  |  L  L  E  D  Y  V  E  A  I  E  G  V  R  T  H  L  L  R      p.500

          .         .         .         .         .         .       g.24877
 CACTCCGAGCCCAGTAAGCTCACCTTTGTGGGGGAGCTTGCCCACGGCCGCTTCAGTGCC       c.1560
 H  S  E  P  S  K  L  T  F  V  G  E  L  A  H  G  R  F  S  A         p.520

        | 11 .         .         .         .         .         .    g.25377
 AAGATG | GACCACCTGGTGTGCTTCCTGCCAGGGACGCTGGCTCTGGGCGTCTACCACGGC    c.1620
 K  M   | D  H  L  V  C  F  L  P  G  T  L  A  L  G  V  Y  H  G      p.540

          .         .         .         .         .         .       g.25437
 CTGCCCGCCAGCCACATGGAGCTGGCCCAGGAGCTCATGGAGACTTGTTACCAGATGAAC       c.1680
 L  P  A  S  H  M  E  L  A  Q  E  L  M  E  T  C  Y  Q  M  N         p.560

          .         .         .         .         .         .       g.25497
 CGGCAGATGGAGACGGGGCTGAGTCCCGAGATCGTGCACTTCAACCTTTACCCCCAGCCG       c.1740
 R  Q  M  E  T  G  L  S  P  E  I  V  H  F  N  L  Y  P  Q  P         p.580

          .         .     | 12   .         .         .         .    g.25640
 GGCCGTCGGGACGTGGAGGTCAAG | CCAGCAGACAGGCACAACCTGCTGCGGCCAGAGACC    c.1800
 G  R  R  D  V  E  V  K   | P  A  D  R  H  N  L  L  R  P  E  T      p.600

          .         .         .         .         .         .       g.25700
 GTGGAGAGCCTGTTCTACCTGTACCGCGTCACAGGGGACCGCAAATACCAGGACTGGGGC       c.1860
 V  E  S  L  F  Y  L  Y  R  V  T  G  D  R  K  Y  Q  D  W  G         p.620

          .         .         .       | 13 .         .         .    g.26485
 TGGGAGATTCTGCAGAGCTTCAGCCGATTCACACGG | GTCCCCTCGGGTGGCTATTCTTCC    c.1920
 W  E  I  L  Q  S  F  S  R  F  T  R   | V  P  S  G  G  Y  S  S      p.640

          .         .         .         .         .         .       g.26545
 ATCAACAATGTCCAGGATCCTCAGAAGCCCGAGCCTAGGGACAAGATGGAGAGCTTCTTC       c.1980
 I  N  N  V  Q  D  P  Q  K  P  E  P  R  D  K  M  E  S  F  F         p.660

          .         .         .         .         .         .       g.26605
 CTGGGGGAGACGCTCAAGTATCTGTTCTTGCTCTTCTCCGATGACCCAAACCTGCTCAGC       c.2040
 L  G  E  T  L  K  Y  L  F  L  L  F  S  D  D  P  N  L  L  S         p.680

          .         .         .         .         .         .       g.26665
 CTGGATGCCTACGTGTTCAACACCGAAGCCCACCCTCTGCCTATCTGGACCCCTGCCTAG       c.2100
 L  D  A  Y  V  F  N  T  E  A  H  P  L  P  I  W  T  P  A  X         p.699

          .         .         .         .         .         .       g.26725
 ggtggatggctgctggtgtggggacttcgggtgggcagaggcaccttgctgggtctgtgg       c.*60

          .         .         .         .         .         .       g.26785
 cattttccaagggcccacgtagcaccggcaaccgccaagtggcccaggctctgaactggc       c.*120

          .         .         .         .         .         .       g.26845
 tctgggctcctcctcgtctctgctttaatcaggacaccgtgaggacaagtgaggccgtca       c.*180

          .         .         .         .         .         .       g.26905
 gtcttggtgtgatgcggggtgggctgggccgctggagcctccgcctgcttcctccagaag       c.*240

          .         .         .         .         .         .       g.26965
 acacgaatcatgactcacgattgctgaagcctgagcaggtctctgtgggccgaccagagg       c.*300

          .         .         .         .         .         .       g.27025
 ggggcttcgaggtggtccctggtactggggtgaccgagtggacagcccagggtgcagctc       c.*360

          .         .         .         .         .         .       g.27085
 tgcccgggctcgtgaagcctcagatgtccccaatccaagggtctggaggggctgccgtga       c.*420

          .         .         .         .         .         .       g.27145
 ctccagaggcctgaggctccagggctggctctggtgtttacaagctggactcagggatcc       c.*480

          .         .         .         .         .         .       g.27205
 tcctggccgccccgcagggggcttggagggctggacggcaagtccgtctagctcacgggc       c.*540

          .         .         .         .         .                 g.27261
 ccctccagtggaatgggtcttttcggtggagataaaagttgatttgctctaaccgc           c.*596

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mannosidase, alpha, class 1B, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 12
©2004-2015 Leiden University Medical Center