mannosidase, alpha, class 2C, member 1 (MAN2C1) - coding DNA reference sequence

(used for variant description)

(last modified January 21, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_006715.3 in the MAN2C1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering MAN2C1 transcript NM_006715.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 ggtagcgccaggggccttccggaaagaggagcgagagcccggcg       c.-1

          .         .         .         .         .         .       g.5104
 ATGGCGGCTGCGCCGGCCTTGAAGCACTGGCGCACCACGCTGGAGCGGGTGGAGAAGTTC       c.60
 M  A  A  A  P  A  L  K  H  W  R  T  T  L  E  R  V  E  K  F         p.20

          .         .         .         .  | 02      .         .    g.5448
 GTGTCGCCGCTCTACTTTACCGACTGTAACCTCCGCGGCAG | GCTTTTTGGGGCCAGCTGC    c.120
 V  S  P  L  Y  F  T  D  C  N  L  R  G  R  |  L  F  G  A  S  C      p.40

          .         .         .         .         .         .       g.5508
 CCTGTGGCTGTGCTCTCCAGCTTCCTGACGCCGGAGAGACTTCCCTACCAGGAGGCAGTC       c.180
 P  V  A  V  L  S  S  F  L  T  P  E  R  L  P  Y  Q  E  A  V         p.60

          .         .         .         .        | 03.         .    g.6006
 CAGCGGGACTTCCGCCCCGCGCAGGTCGGCGACAGCTTCGGACCCAC | ATGGTGGACCTGC    c.240
 Q  R  D  F  R  P  A  Q  V  G  D  S  F  G  P  T  |  W  W  T  C      p.80

          .         .         .         .         .         .       g.6066
 TGGTTCCGGGTGGAGCTGACCATCCCAGAGGCATGGGTGGGCCAGGAAGTTCACCTTTGC       c.300
 W  F  R  V  E  L  T  I  P  E  A  W  V  G  Q  E  V  H  L  C         p.100

          .         .         .         .         .  | 04      .    g.7044
 TGGGAAAGTGATGGAGAAGGTCTGGTGTGGCGTGATGGAGAACCTGTCCAG | GGTTTAACC    c.360
 W  E  S  D  G  E  G  L  V  W  R  D  G  E  P  V  Q   | G  L  T      p.120

          .         .         .         .         .         .       g.7104
 AAAGAGGGTGAGAAGACCAGCTATGTCCTGACTGACAGGCTGGGGGAAAGAGACCCCCGA       c.420
 K  E  G  E  K  T  S  Y  V  L  T  D  R  L  G  E  R  D  P  R         p.140

    | 05     .         .         .         .         .         .    g.9020
 AG | CCTCACTCTCTATGTGGAAGTAGCCTGCAATGGGCTCCTGGGGGCCGGGAAGGGAAGC    c.480
 S  |  L  T  L  Y  V  E  V  A  C  N  G  L  L  G  A  G  K  G  S      p.160

          .         .         .         .         .         .       g.9080
 ATGATTGCAGCCCCTGACCCTGAGAAGATGTTCCAGCTGAGCCGGGCTGAGCTAGCTGTG       c.540
 M  I  A  A  P  D  P  E  K  M  F  Q  L  S  R  A  E  L  A  V         p.180

          .         .         .         .         .         .       g.9140
 TTCCACCGGGATGTCCACATGCTCCTGGTGGATCTGGAGCTGCTGCTGGGCATAGCCAAG       c.600
 F  H  R  D  V  H  M  L  L  V  D  L  E  L  L  L  G  I  A  K         p.200

  | 06       .         .         .         .         .         .    g.9499
  | GGCCTCGGGAAGGACAACCAGCGCAGCTTCCAGGCCCTGTACACAGCCAATCAGATGGTG    c.660
  | G  L  G  K  D  N  Q  R  S  F  Q  A  L  Y  T  A  N  Q  M  V      p.220

          .         .         .         .         .         .       g.9559
 AACGTGTGTGACCCTGCCCAGCCCGAGACCTTCCCAGTGGCCCAGGCCCTGGCCTCCAGG       c.720
 N  V  C  D  P  A  Q  P  E  T  F  P  V  A  Q  A  L  A  S  R         p.240

          .         .         .         .         .         .       g.9619
 TTCTTTGGCCAACATGGGGGTGAAAGCCAACACACCATTCATGCCACAGGGCACTGCCAC       c.780
 F  F  G  Q  H  G  G  E  S  Q  H  T  I  H  A  T  G  H  C  H         p.260

          . | 07       .         .         .         .         .    g.10929
 ATTGATACAG | CCTGGCTTTGGCCCTTCAAAGAGACTGTGAGGAAATGTGCCCGGAGCTGG    c.840
 I  D  T  A |   W  L  W  P  F  K  E  T  V  R  K  C  A  R  S  W      p.280

          .         .         .         .         .        | 08.    g.11177
 GTGACCGCCCTGCAGCTCATGGAGCGGAACCCTGAGTTCATCTTTGCCTGCTCCCAG | GCG    c.900
 V  T  A  L  Q  L  M  E  R  N  P  E  F  I  F  A  C  S  Q   | A      p.300

          .         .         .         .         .         .       g.11237
 CAGCAGCTGGAATGGGTGAAGAGCCGCTACCCTGGCCTGTACTCCCGCATCCAGGAGTTT       c.960
 Q  Q  L  E  W  V  K  S  R  Y  P  G  L  Y  S  R  I  Q  E  F         p.320

          .         .         .         .         | 09         .    g.11692
 GCGTGCCGTGGGCAGTTTGTGCCTGTGGGGGGCACCTGGGTGGAGATG | GATGGGAACCTG    c.1020
 A  C  R  G  Q  F  V  P  V  G  G  T  W  V  E  M   | D  G  N  L      p.340

          .         .         .         .         .         .       g.11752
 CCCAGTGGAGAGGCCATGGTGAGGCAGTTTTTGCAGGGCCAGAACTTCTTTCTGCAGGAG       c.1080
 P  S  G  E  A  M  V  R  Q  F  L  Q  G  Q  N  F  F  L  Q  E         p.360

          .         .  | 10      .         .         .         .    g.11946
 TTTGGGAAGATGTGCTCTGAG | TTCTGGCTGCCGGACACCTTTGGCTACTCAGCACAGCTC    c.1140
 F  G  K  M  C  S  E   | F  W  L  P  D  T  F  G  Y  S  A  Q  L      p.380

          .         .         .         .         .         .       g.12006
 CCCCAGATCATGCACGGCTGTGGCATCAGGCGCTTTCTCACCCAGAAATTGAGCTGGAAT       c.1200
 P  Q  I  M  H  G  C  G  I  R  R  F  L  T  Q  K  L  S  W  N         p.400

          .         | 11         .         .         .         .    g.12288
 TTGGTGAACTCCTTCCCA | CACCATACATTTTTCTGGGAGGGCCTGGATGGCTCCCGTGTA    c.1260
 L  V  N  S  F  P   | H  H  T  F  F  W  E  G  L  D  G  S  R  V      p.420

          .         .         .         .         .     | 12   .    g.12442
 CTGGTCCACTTCCCACCTGGCGACTCCTATGGGATGCAGGGCAGCGTGGAGGAG | GTGCTG    c.1320
 L  V  H  F  P  P  G  D  S  Y  G  M  Q  G  S  V  E  E   | V  L      p.440

          .         .         .         .         .         .       g.12502
 AAGACCGTGGCCAACAACCGGGACAAGGGGCGGGCCAACCACAGTGCCTTCCTCTTTGGC       c.1380
 K  T  V  A  N  N  R  D  K  G  R  A  N  H  S  A  F  L  F  G         p.460

          .         .         .         .         .         .       g.12562
 TTTGGGGATGGGGGTGGTGGCCCCACCCAGACCATGCTGGACCGCCTGAAGCGCCTGAGC       c.1440
 F  G  D  G  G  G  G  P  T  Q  T  M  L  D  R  L  K  R  L  S         p.480

          .         . | 13       .         .         .         .    g.12979
 AATACGGATGGGCTGCCCAG | GGTGCAGCTATCTTCTCCAAGACAGCTCTTCTCAGCACTG    c.1500
 N  T  D  G  L  P  R  |  V  Q  L  S  S  P  R  Q  L  F  S  A  L      p.500

          .         .         .         .         .         .       g.13039
 GAGAGTGACTCAGAGCAGCTGTGCACGTGGGTTGGGGAGCTCTTCTTGGAGCTGCACAAT       c.1560
 E  S  D  S  E  Q  L  C  T  W  V  G  E  L  F  L  E  L  H  N         p.520

          .         .     | 14   .         .         .         .    g.13452
 GGCACATACACCACCCATGCCCAG | ATCAAGAAGGGGAACCGGGAATGTGAGCGGATCCTG    c.1620
 G  T  Y  T  T  H  A  Q   | I  K  K  G  N  R  E  C  E  R  I  L      p.540

          .         .         .         .         .         .       g.13512
 CACGACGTGGAGCTGCTCAGTAGCCTGGCCCTGGCCCGCAGTGCCCAGTTCCTATACCCA       c.1680
 H  D  V  E  L  L  S  S  L  A  L  A  R  S  A  Q  F  L  Y  P         p.560

          .         .       | 15 .         .         .         .    g.13673
 GCAGCCCAGCTGCAGCACCTCTGGAG | GCTCCTTCTTCTGAACCAGTTCCATGATGTGGTG    c.1740
 A  A  Q  L  Q  H  L  W  R  |  L  L  L  L  N  Q  F  H  D  V  V      p.580

          .         .         .         .         .   | 16     .    g.13860
 ACTGGAAGCTGCATCCAGATGGTGGCAGAGGAAGCCATGTGCCATTATGAAG | ACATCCGT    c.1800
 T  G  S  C  I  Q  M  V  A  E  E  A  M  C  H  Y  E  D |   I  R      p.600

          .         .         .         .         .         .       g.13920
 TCCCATGGCAATACACTGCTCAGCGCTGCAGCCGCAGCCCTGTGTGCTGGGGAGCCAGGT       c.1860
 S  H  G  N  T  L  L  S  A  A  A  A  A  L  C  A  G  E  P  G         p.620

          .         .         .         .         .         .       g.13980
 CCTGAGGGCCTCCTCATCGTCAACACACTGCCCTGGAAGCGGATCGAAGTGATGGCCCTG       c.1920
 P  E  G  L  L  I  V  N  T  L  P  W  K  R  I  E  V  M  A  L         p.640

          .         .         | 17         .         .         .    g.14234
 CCCAAACCGGGCGGGGCCCACAGCCTAG | CCCTGGTGACAGTGCCCAGCATGGGCTATGCT    c.1980
 P  K  P  G  G  A  H  S  L  A |   L  V  T  V  P  S  M  G  Y  A      p.660

          .         .         .         .         .         .       g.14294
 CCTGTTCCTCCCCCCACCTCACTGCAGCCCCTGCTGCCCCAGCAGCCTGTGTTCGTAGTG       c.2040
 P  V  P  P  P  T  S  L  Q  P  L  L  P  Q  Q  P  V  F  V  V         p.680

        | 18 .         .         .         .         .         .    g.14528
 CAAGAG | ACTGATGGCTCCGTGACTCTGGACAATGGCATCATCCGAGTGAAGCTGGACCCA    c.2100
 Q  E   | T  D  G  S  V  T  L  D  N  G  I  I  R  V  K  L  D  P      p.700

          .         .         .         .  | 19      .         .    g.14838
 ACTGGTCGCCTGACGTCCTTGGTCCTGGTGGCCTCTGGCAG | GGAGGCCATTGCTGAGGGC    c.2160
 T  G  R  L  T  S  L  V  L  V  A  S  G  R  |  E  A  I  A  E  G      p.720

          .         .         .         .         .         .       g.14898
 GCCGTGGGGAACCAGTTTGTGCTATTTGATGATGTCCCCTTGTACTGGGATGCATGGGAC       c.2220
 A  V  G  N  Q  F  V  L  F  D  D  V  P  L  Y  W  D  A  W  D         p.740

          .         .       | 20 .         .         .         .    g.15043
 GTCATGGACTACCACCTGGAGACACG | GAAGCCTGTGCTGGGCCAGGCAGGGACCCTGGCA    c.2280
 V  M  D  Y  H  L  E  T  R  |  K  P  V  L  G  Q  A  G  T  L  A      p.760

          .         .         .         .         .         .       g.15103
 GTGGGCACCGAGGGCGGCCTGCGGGGCAGCGCCTGGTTCTTGCTACAGATCAGCCCCAAC       c.2340
 V  G  T  E  G  G  L  R  G  S  A  W  F  L  L  Q  I  S  P  N         p.780

          .         .         .         .         .         .       g.15163
 AGTCGGCTTAGCCAGGAGGTTGTGCTGGACGTTGGCTGCCCCTATGTCCGCTTCCACACC       c.2400
 S  R  L  S  Q  E  V  V  L  D  V  G  C  P  Y  V  R  F  H  T         p.800

     | 21    .         .         .         .         .         .    g.15340
 GAG | GTACACTGGCATGAGGCCCACAAGTTCCTGAAGGTGGAGTTCCCTGCTCGCGTGCGG    c.2460
 E   | V  H  W  H  E  A  H  K  F  L  K  V  E  F  P  A  R  V  R      p.820

          .         .         .         .         .         .       g.15400
 AGTTCCCAGGCCACCTATGAGATCCAGTTTGGGCACCTGCAGCGACCTACCCACTACAAT       c.2520
 S  S  Q  A  T  Y  E  I  Q  F  G  H  L  Q  R  P  T  H  Y  N         p.840

          .         .        | 22.         .         .         .    g.16758
 ACCTCTTGGGACTGGGCTCGATTTGAG | GTGTGGGCCCATCGCTGGATGGATCTGTCAGAA    c.2580
 T  S  W  D  W  A  R  F  E   | V  W  A  H  R  W  M  D  L  S  E      p.860

          .         .         .         .         .         .       g.16818
 CACGGCTTTGGGCTGGCCCTGCTCAACGACTGCAAGTATGGCGCGTCAGTGCGAGGCAGC       c.2640
 H  G  F  G  L  A  L  L  N  D  C  K  Y  G  A  S  V  R  G  S         p.880

          .        | 23.         .         .         .         .    g.16985
 ATCCTCAGCCTCTCGCT | CTTGCGGGCGCCTAAAGCCCCGGACGCTACTGCTGACACGGGG    c.2700
 I  L  S  L  S  L  |  L  R  A  P  K  A  P  D  A  T  A  D  T  G      p.900

          .         .         .        | 24.         .         .    g.17201
 CGCCACGAGTTCACCTATGCACTGATGCCGCACAAGG | GCTCTTTCCAGGATGCTGGCGTT    c.2760
 R  H  E  F  T  Y  A  L  M  P  H  K  G |   S  F  Q  D  A  G  V      p.920

          .         .         .         .         .         .       g.17261
 ATCCAAGCTGCCTACAGCCTAAACTTCCCCCTGTTGGCTCTGCCAGCCCCCAGCCCAGCG       c.2820
 I  Q  A  A  Y  S  L  N  F  P  L  L  A  L  P  A  P  S  P  A         p.940

          .         .         .         .         .         .       g.17321
 CCCGCCACCTCCTGGAGTGCGTTTTCCGTGTCTTCACCCGCGGTCGTATTGGAGACCGTC       c.2880
 P  A  T  S  W  S  A  F  S  V  S  S  P  A  V  V  L  E  T  V         p.960

        | 25 .         .         .         .         .         .    g.17462
 AAGCAG | GCGGAGAGCAGCCCCCAGCGCCGCTCGCTGGTCCTGAGGCTGTATGAGGCCCAC    c.2940
 K  Q   | A  E  S  S  P  Q  R  R  S  L  V  L  R  L  Y  E  A  H      p.980

          .         .         .         .         .       | 26 .    g.17599
 GGCAGCCACGTGGACTGCTGGCTGCACTTGTCGCTGCCGGTTCAGGAGGCCATCCT | CTGC    c.3000
 G  S  H  V  D  C  W  L  H  L  S  L  P  V  Q  E  A  I  L  |  C      p.1000

          .         .         .         .         .         .       g.17659
 GATCTCTTGGAGCGACCAGACCCTGCTGGCCACTTGACCCTTCGGGACAACCGCCTGAAG       c.3060
 D  L  L  E  R  P  D  P  A  G  H  L  T  L  R  D  N  R  L  K         p.1020

          .         .         .         .         .         .       g.17719
 CTCACCTTTTCTCCCTTCCAAGTGCTGTCCCTGTTGCTCGTGCTTCAGCCTCCGCCACAC       c.3120
 L  T  F  S  P  F  Q  V  L  S  L  L  L  V  L  Q  P  P  P  H         p.1040

                                                                    g.17722
 TGA                                                                c.3123
 X                                                                  p.1040

          .         .         .         .         .         .       g.17782
 gtccctggggctggggttttgtttgtagaaggctctggggactcctaatttctgcttccc       c.*60

          .         .         .         .         .                 g.17836
 cagcctaaagcagggatcagtcttttcttgtggaataaatccttggatcgggaa             c.*114

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mannosidase, alpha, class 2C, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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