mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (MAP3K1) - coding DNA reference sequence

(used for variant description)

(last modified April 28, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_005921.1 in the MAP3K1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031884.1, covering MAP3K1 transcript NM_005921.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        caccagaaacccaagttggaa       c.-481

 .         .         .         .         .         .                g.5081
 ctaattctttctttcggaaggtgcaactcccctcccgcgagctccgcggtgccgggccga       c.-421

 .         .         .         .         .         .                g.5141
 gattgccgagaggaagcggcgcagcgctgccgccaaggctcctcctgtcgccggtgcggc       c.-361

 .         .         .         .         .         .                g.5201
 cgggactacctggcggcgcggcgcgtgcagcgcgcagagtcccgggagcccacgcctccg       c.-301

 .         .         .         .         .         .                g.5261
 cctccgcccccgccccctccgcctcccagtccacctcgcccgcccgccctctcgcccggc       c.-241

 .         .         .         .         .         .                g.5321
 ggagagcacagcccactccctcccacctgcggccgccgggccgccctccacccacacctc       c.-181

 .         .         .         .         .         .                g.5381
 tgccgcaggccggacccagtgcgcccgcccgtcggtcagtccaggccaggcgcccggcgg       c.-121

 .         .         .         .         .         .                g.5441
 gccgcgctcacgcagttggcgcaggaggccttacgctggcggcgcagtgcccgccccctg       c.-61

 .         .         .         .         .         .                g.5501
 cgctctccccgccccctccctccctcgcaggggccgagcgaatgtagcccgcgagagaaa       c.-1

          .         .         .         .         .         .       g.5561
 ATGGCGGCGGCGGCGGGGAATCGCGCCTCGTCGTCGGGATTCCCGGGCGCCAGGGCTACG       c.60
 M  A  A  A  A  G  N  R  A  S  S  S  G  F  P  G  A  R  A  T         p.20

          .         .         .         .         .         .       g.5621
 AGCCCTGAGGCAGGCGGCGGCGGAGGAGCCCTCAAGGCGAGCAGCGCGCCCGCGGCTGCC       c.120
 S  P  E  A  G  G  G  G  G  A  L  K  A  S  S  A  P  A  A  A         p.40

          .         .         .         .         .         .       g.5681
 GCGGGACTGCTGCGGGAGGCGGGCAGCGGGGGCCGCGAGCGGGCGGACTGGCGGCGGCGG       c.180
 A  G  L  L  R  E  A  G  S  G  G  R  E  R  A  D  W  R  R  R         p.60

          .         .         .         .         .         .       g.5741
 CAGCTGCGCAAAGTGCGGAGTGTGGAGCTGGACCAGCTGCCTGAGCAGCCGCTCTTCCTT       c.240
 Q  L  R  K  V  R  S  V  E  L  D  Q  L  P  E  Q  P  L  F  L         p.80

          .         .         .         .         .         .       g.5801
 GCCGCCTCACCGCCGGCCTCCTCGACTTCCCCGTCGCCGGAGCCCGCGGACGCAGCGGGG       c.300
 A  A  S  P  P  A  S  S  T  S  P  S  P  E  P  A  D  A  A  G         p.100

          .         .         .         .         .         .       g.5861
 AGTGGGACCGGCTTCCAGCCTGTGGCGGTGCCGCCGCCCCACGGAGCCGCGAGCCGCGGC       c.360
 S  G  T  G  F  Q  P  V  A  V  P  P  P  H  G  A  A  S  R  G         p.120

          .         .         .         .         .         .       g.5921
 GGCGCCCACCTTACCGAGTCGGTGGCGGCGCCGGACAGCGGCGCCTCGAGTCCCGCAGCG       c.420
 G  A  H  L  T  E  S  V  A  A  P  D  S  G  A  S  S  P  A  A         p.140

          .         .         .         .         .         .       g.5981
 GCCGAGCCCGGGGAGAAGCGGGCGCCCGCCGCCGAGCCGTCTCCTGCAGCGGCCCCCGCC       c.480
 A  E  P  G  E  K  R  A  P  A  A  E  P  S  P  A  A  A  P  A         p.160

    | 02     .         .         .         .         .         .    g.46585
 GG | TCGTGAGATGGAGAATAAAGAAACTCTCAAAGGGTTGCACAAGATGGATGATCGTCCA    c.540
 G  |  R  E  M  E  N  K  E  T  L  K  G  L  H  K  M  D  D  R  P      p.180

          .         .         .         .         .         .       g.46645
 GAGGAACGAATGATCAGGGAGAAACTGAAGGCAACCTGTATGCCAGCCTGGAAGCACGAA       c.600
 E  E  R  M  I  R  E  K  L  K  A  T  C  M  P  A  W  K  H  E         p.200

          .         .         .    | 03    .         .         .    g.49669
 TGGTTGGAAAGGAGAAATAGGCGAGGGCCTGTG | GTGGTAAAACCAATCCCAGTTAAAGGA    c.660
 W  L  E  R  R  N  R  R  G  P  V   | V  V  K  P  I  P  V  K  G      p.220

          .         .         .         .         .         .       g.49729
 GATGGATCTGAAATGAATCACTTAGCAGCTGAGTCTCCAGGAGAGGTCCAGGCAAGTGCG       c.720
 D  G  S  E  M  N  H  L  A  A  E  S  P  G  E  V  Q  A  S  A         p.240

          .         .         .         .         .         .       g.49789
 GCTTCACCAGCTTCCAAAGGCCGACGCAGTCCTTCTCCTGGCAACTCCCCATCAGGTCGC       c.780
 A  S  P  A  S  K  G  R  R  S  P  S  P  G  N  S  P  S  G  R         p.260

          .         .         .         .         .     | 04   .    g.54667
 ACAGTGAAATCAGAATCTCCAGGAGTAAGGAGAAAAAGAGTTTCCCCAGTGCCT | TTTCAG    c.840
 T  V  K  S  E  S  P  G  V  R  R  K  R  V  S  P  V  P   | F  Q      p.280

          .         .         .         .         .         .       g.54727
 AGTGGCAGAATCACACCACCCCGAAGAGCCCCTTCACCAGATGGCTTCTCACCATATAGC       c.900
 S  G  R  I  T  P  P  R  R  A  P  S  P  D  G  F  S  P  Y  S         p.300

          .         .         .         .         .         .       g.54787
 CCTGAGGAAACAAACCGCCGTGTTAACAAAGTGATGCGGGCCAGACTGTACTTACTGCAG       c.960
 P  E  E  T  N  R  R  V  N  K  V  M  R  A  R  L  Y  L  L  Q         p.320

          .         .         .         .         .         .       g.54847
 CAGATAGGGCCTAACTCTTTCCTGATTGGAGGAGACAGCCCAGACAATAAATACCGGGTG       c.1020
 Q  I  G  P  N  S  F  L  I  G  G  D  S  P  D  N  K  Y  R  V         p.340

          .      | 05  .         .         .         .         .    g.55312
 TTTATTGGGCCTCAG | AACTGCAGCTGTGCACGTGGAACATTCTGTATTCATCTGCTATTT    c.1080
 F  I  G  P  Q   | N  C  S  C  A  R  G  T  F  C  I  H  L  L  F      p.360

          .         .         .         .         .         .       g.55372
 GTGATGCTCCGGGTGTTTCAACTAGAACCTTCAGACCCAATGTTATGGAGAAAAACTTTA       c.1140
 V  M  L  R  V  F  Q  L  E  P  S  D  P  M  L  W  R  K  T  L         p.380

          .   | 06     .         .         .         .         .    g.55804
 AAGAATTTTGAG | GTTGAGAGTTTGTTCCAGAAATATCACAGTAGGCGTAGCTCAAGGATC    c.1200
 K  N  F  E   | V  E  S  L  F  Q  K  Y  H  S  R  R  S  S  R  I      p.400

          .         .         .         .         .         .       g.55864
 AAAGCTCCATCTCGTAACACCATCCAGAAGTTTGTTTCACGCATGTCAAATTCTCATACA       c.1260
 K  A  P  S  R  N  T  I  Q  K  F  V  S  R  M  S  N  S  H  T         p.420

          .         .         .         .  | 07      .         .    g.61856
 TTGTCATCATCTAGTACTTCTACGTCTAGTTCAGAAAACAG | CATAAAGGATGAAGAGGAA    c.1320
 L  S  S  S  S  T  S  T  S  S  S  E  N  S  |  I  K  D  E  E  E      p.440

          .         .         .         .         .         .       g.61916
 CAGATGTGTCCTATTTGCTTGTTGGGCATGCTTGATGAAGAAAGTCTTACAGTGTGTGAA       c.1380
 Q  M  C  P  I  C  L  L  G  M  L  D  E  E  S  L  T  V  C  E         p.460

          .         .         .         .    | 08    .         .    g.62585
 GACGGCTGCAGGAACAAGCTGCACCACCACTGCATGTCAATTT | GGGCAGAAGAGTGTAGA    c.1440
 D  G  C  R  N  K  L  H  H  H  C  M  S  I  W |   A  E  E  C  R      p.480

          .         .         .         .         .         .       g.62645
 AGAAATAGAGAACCTTTAATATGTCCCCTTTGTAGATCTAAGTGGAGATCTCATGATTTC       c.1500
 R  N  R  E  P  L  I  C  P  L  C  R  S  K  W  R  S  H  D  F         p.500

       | 09  .         .         .         .         .         .    g.62807
 TACAG | CCACGAGTTGTCAAGTCCTGTGGATTCCCCTTCTTCCCTCAGAGCTGCACAGCAG    c.1560
 Y  S  |  H  E  L  S  S  P  V  D  S  P  S  S  L  R  A  A  Q  Q      p.520

          .         .         .         .         .         .       g.62867
 CAAACCGTACAGCAGCAGCCTTTGGCTGGATCACGAAGGAATCAAGAGAGCAATTTTAAC       c.1620
 Q  T  V  Q  Q  Q  P  L  A  G  S  R  R  N  Q  E  S  N  F  N         p.540

          .         .         .         .         .         .       g.62927
 CTTACTCATTATGGAACTCAGCAAATCCCTCCTGCTTACAAAGATTTAGCTGAGCCATGG       c.1680
 L  T  H  Y  G  T  Q  Q  I  P  P  A  Y  K  D  L  A  E  P  W         p.560

        | 10 .         .         .         .         .         .    g.65013
 ATTCAG | GTGTTTGGAATGGAACTCGTTGGCTGCTTATTTTCTAGAAACTGGAATGTGAGA    c.1740
 I  Q   | V  F  G  M  E  L  V  G  C  L  F  S  R  N  W  N  V  R      p.580

          .         .         .         .         .         .       g.65073
 GAGATGGCCCTCAGGCGTCTTTCCCATGATGTCAGTGGGGCCCTGCTGTTGGCAAATGGG       c.1800
 E  M  A  L  R  R  L  S  H  D  V  S  G  A  L  L  L  A  N  G         p.600

          .         .         .         .         .         .       g.65133
 GAGAGCACTGGAAATTCTGGGGGCAGCAGTGGAAGCAGCCCGAGTGGGGGAGCCACCAGT       c.1860
 E  S  T  G  N  S  G  G  S  S  G  S  S  P  S  G  G  A  T  S         p.620

          .         .         .         .         .         .       g.65193
 GGGTCTTCCCAGACCAGTATCTCAGGAGATGTGGTGGAGGCATGCTGCAGCGTTCTGTCA       c.1920
 G  S  S  Q  T  S  I  S  G  D  V  V  E  A  C  C  S  V  L  S         p.640

          .         .         .         .      | 11  .         .    g.68922
 ATGGTCTGTGCTGACCCTGTCTACAAAGTGTACGTTGCTGCTTTA | AAAACATTGAGAGCC    c.1980
 M  V  C  A  D  P  V  Y  K  V  Y  V  A  A  L   | K  T  L  R  A      p.660

          .         .         .         .         .         .       g.68982
 ATGCTGGTATATACTCCTTGCCACAGTTTAGCGGAAAGAATCAAACTTCAGAGACTTCTC       c.2040
 M  L  V  Y  T  P  C  H  S  L  A  E  R  I  K  L  Q  R  L  L         p.680

          .         .         .         .        | 12.         .    g.70651
 CAGCCAGTTGTAGACACCATCCTAGTCAAATGTGCAGATGCCAATAG | CCGCACAAGTCAG    c.2100
 Q  P  V  V  D  T  I  L  V  K  C  A  D  A  N  S  |  R  T  S  Q      p.700

          .         .         .         .         .         .       g.70711
 CTGTCCATATCAACACTGTTGGAACTGTGCAAAGGCCAAGCAGGAGAGTTGGCAGTTGGC       c.2160
 L  S  I  S  T  L  L  E  L  C  K  G  Q  A  G  E  L  A  V  G         p.720

          .          | 13        .         .         .         .    g.71051
 AGAGAAATACTAAAAGCTG | GATCCATTGGTATTGGTGGTGTTGATTATGTCTTAAATTGT    c.2220
 R  E  I  L  K  A  G |   S  I  G  I  G  G  V  D  Y  V  L  N  C      p.740

          .         .         .         .         .         .       g.71111
 ATTCTTGGAAACCAAACTGAATCAAACAATTGGCAAGAACTTCTTGGCCGCCTTTGTCTT       c.2280
 I  L  G  N  Q  T  E  S  N  N  W  Q  E  L  L  G  R  L  C  L         p.760

          .         .         .         .         .         .       g.71171
 ATAGATAGACTGTTGTTGGAATTTCCTGCTGAATTTTATCCTCATATTGTCAGTACTGAT       c.2340
 I  D  R  L  L  L  E  F  P  A  E  F  Y  P  H  I  V  S  T  D         p.780

          .         .          | 14        .         .         .    g.71528
 GTTTCACAAGCTGAGCCTGTTGAAATCAG | GTATAAGAAGCTGCTGTCCCTCTTAACCTTT    c.2400
 V  S  Q  A  E  P  V  E  I  R  |  Y  K  K  L  L  S  L  L  T  F      p.800

          .         .         .         .         .         .       g.71588
 GCTTTGCAGTCCATTGATAATTCCCACTCAATGGTTGGCAAACTTTCCAGAAGGATCTAC       c.2460
 A  L  Q  S  I  D  N  S  H  S  M  V  G  K  L  S  R  R  I  Y         p.820

          .         .         .         .         .         .       g.71648
 TTGAGTTCTGCAAGAATGGTTACTACAGTACCCCATGTGTTTTCAAAACTGTTAGAAATG       c.2520
 L  S  S  A  R  M  V  T  T  V  P  H  V  F  S  K  L  L  E  M         p.840

          .         .         .         .         .         .       g.71708
 CTGAGTGTTTCCAGTTCCACTCACTTCACCAGGATGCGTCGCCGTTTGATGGCTATTGCA       c.2580
 L  S  V  S  S  S  T  H  F  T  R  M  R  R  R  L  M  A  I  A         p.860

          .         .         .         .         .         .       g.71768
 GATGAGGTGGAAATTGCCGAAGCCATCCAGTTGGGCGTAGAAGACACTTTGGATGGTCAA       c.2640
 D  E  V  E  I  A  E  A  I  Q  L  G  V  E  D  T  L  D  G  Q         p.880

          .         .         .         .         .         .       g.71828
 CAGGACAGCTTCTTGCAGGCATCTGTTCCCAACAACTATCTGGAAACCACAGAGAACAGT       c.2700
 Q  D  S  F  L  Q  A  S  V  P  N  N  Y  L  E  T  T  E  N  S         p.900

          .         .         .         .         .         .       g.71888
 TCCCCTGAGTGCACAGTCCATTTAGAGAAAACTGGAAAAGGATTATGTGCTACAAAATTG       c.2760
 S  P  E  C  T  V  H  L  E  K  T  G  K  G  L  C  A  T  K  L         p.920

          .         .         .         .         .         .       g.71948
 AGTGCCAGTTCAGAGGACATTTCTGAGAGACTGGCCAGCATTTCAGTAGGACCTTCTAGT       c.2820
 S  A  S  S  E  D  I  S  E  R  L  A  S  I  S  V  G  P  S  S         p.940

          .         .         .         .         .         .       g.72008
 TCAACAACAACAACAACAACAACAACAGAGCAACCAAAGCCAATGGTTCAAACAAAAGGC       c.2880
 S  T  T  T  T  T  T  T  T  E  Q  P  K  P  M  V  Q  T  K  G         p.960

          .         .         .         .         .         .       g.72068
 AGACCCCACAGTCAGTGTTTGAACTCCTCTCCTTTATCTCATCATTCCCAATTAATGTTT       c.2940
 R  P  H  S  Q  C  L  N  S  S  P  L  S  H  H  S  Q  L  M  F         p.980

          .         .         .         .         .         .       g.72128
 CCAGCCTTGTCAACCCCTTCTTCTTCTACCCCATCTGTACCAGCTGGCACTGCAACAGAT       c.3000
 P  A  L  S  T  P  S  S  S  T  P  S  V  P  A  G  T  A  T  D         p.1000

          .         .         .         .         .         .       g.72188
 GTCTCTAAGCATAGACTTCAGGGATTCATTCCCTGCAGAATACCTTCTGCATCTCCTCAA       c.3060
 V  S  K  H  R  L  Q  G  F  I  P  C  R  I  P  S  A  S  P  Q         p.1020

          .         .         .         .         .         .       g.72248
 ACACAGCGCAAGTTTTCTCTACAATTCCACAGAAACTGTCCTGAAAACAAAGACTCAGAT       c.3120
 T  Q  R  K  F  S  L  Q  F  H  R  N  C  P  E  N  K  D  S  D         p.1040

          .         .         .         .         .         .       g.72308
 AAACTTTCCCCAGTCTTTACTCAGTCAAGACCCTTGCCCTCCAGTAACATACACAGGCCA       c.3180
 K  L  S  P  V  F  T  Q  S  R  P  L  P  S  S  N  I  H  R  P         p.1060

          .         .         .         .         .         .       g.72368
 AAGCCATCTAGACCTACCCCAGGTAATACAAGTAAACAGGGAGATCCCTCAAAAAATAGC       c.3240
 K  P  S  R  P  T  P  G  N  T  S  K  Q  G  D  P  S  K  N  S         p.1080

          .         .         .         .         .         .       g.72428
 ATGACACTTGATCTGAACAGTAGTTCCAAATGTGATGACAGCTTTGGCTGTAGCAGCAAT       c.3300
 M  T  L  D  L  N  S  S  S  K  C  D  D  S  F  G  C  S  S  N         p.1100

          .         .         .         .         .         .       g.72488
 AGTAGTAATGCTGTTATACCCAGTGACGAGACAGTGTTCACCCCAGTAGAGGAGAAATGC       c.3360
 S  S  N  A  V  I  P  S  D  E  T  V  F  T  P  V  E  E  K  C         p.1120

          .         .         .         .         .         .       g.72548
 AGATTAGATGTCAATACAGAGCTCAACTCCAGTATTGAGGACCTTCTTGAAGCATCTATG       c.3420
 R  L  D  V  N  T  E  L  N  S  S  I  E  D  L  L  E  A  S  M         p.1140

          .         .         .         .         .         .       g.72608
 CCTTCAAGTGATACAACAGTAACTTTTAAGTCAGAAGTTGCTGTCCTGTCTCCTGAAAAG       c.3480
 P  S  S  D  T  T  V  T  F  K  S  E  V  A  V  L  S  P  E  K         p.1160

          .         .         .         .         .         .       g.72668
 GCTGAAAATGATGATACCTACAAAGATGATGTGAATCATAATCAAAAGTGCAAAGAGAAG       c.3540
 A  E  N  D  D  T  Y  K  D  D  V  N  H  N  Q  K  C  K  E  K         p.1180

          .         .         .         .         .         .       g.72728
 ATGGAAGCTGAAGAAGAAGAAGCTTTAGCAATTGCCATGGCAATGTCAGCGTCTCAGGAT       c.3600
 M  E  A  E  E  E  E  A  L  A  I  A  M  A  M  S  A  S  Q  D         p.1200

          .         .         .         .         .         .       g.72788
 GCCCTCCCCATAGTTCCTCAGCTGCAGGTTGAAAATGGAGAAGATATCATCATTATTCAA       c.3660
 A  L  P  I  V  P  Q  L  Q  V  E  N  G  E  D  I  I  I  I  Q         p.1220

        | 15 .         .         .         .         .         .    g.73508
 CAGGAT | ACACCAGAGACTCTACCAGGACATACCAAAGCAAAACAACCGTATAGAGAAGAC    c.3720
 Q  D   | T  P  E  T  L  P  G  H  T  K  A  K  Q  P  Y  R  E  D      p.1240

          .         .         .         .         .         .       g.73568
 ACTGAATGGCTGAAAGGTCAACAGATAGGCCTTGGAGCATTTTCTTCTTGTTATCAGGCT       c.3780
 T  E  W  L  K  G  Q  Q  I  G  L  G  A  F  S  S  C  Y  Q  A         p.1260

          .         .         .          | 16        .         .    g.74612
 CAAGATGTGGGAACTGGAACTTTAATGGCTGTTAAACAG | GTGACTTATGTCAGAAACACA    c.3840
 Q  D  V  G  T  G  T  L  M  A  V  K  Q   | V  T  Y  V  R  N  T      p.1280

          .         .         .         .         .         .       g.74672
 TCTTCTGAGCAAGAAGAAGTAGTAGAAGCACTAAGAGAAGAGATAAGAATGATGAGCCAT       c.3900
 S  S  E  Q  E  E  V  V  E  A  L  R  E  E  I  R  M  M  S  H         p.1300

          .         .         .         .         .         .       g.74732
 CTGAATCATCCAAACATCATTAGGATGTTGGGAGCCACGTGTGAGAAGAGCAATTACAAT       c.3960
 L  N  H  P  N  I  I  R  M  L  G  A  T  C  E  K  S  N  Y  N         p.1320

          .         .   | 17     .         .         .         .    g.75897
 CTCTTCATTGAATGGATGGCAG | GGGGATCGGTGGCTCATTTGCTGAGTAAATATGGAGCC    c.4020
 L  F  I  E  W  M  A  G |   G  S  V  A  H  L  L  S  K  Y  G  A      p.1340

          .         .         .         .         .         .       g.75957
 TTCAAAGAATCAGTAGTTATTAACTACACTGAACAGTTACTCCGTGGCCTTTCGTATCTC       c.4080
 F  K  E  S  V  V  I  N  Y  T  E  Q  L  L  R  G  L  S  Y  L         p.1360

          .         .         .     | 18   .         .         .    g.77331
 CATGAAAACCAAATCATTCACAGAGATGTCAAAG | GTGCCAATTTGCTAATTGACAGCACT    c.4140
 H  E  N  Q  I  I  H  R  D  V  K  G |   A  N  L  L  I  D  S  T      p.1380

          .         .         .         .         .         .       g.77391
 GGTCAGAGACTAAGAATTGCAGATTTTGGAGCTGCAGCCAGGTTGGCATCAAAAGGAACT       c.4200
 G  Q  R  L  R  I  A  D  F  G  A  A  A  R  L  A  S  K  G  T         p.1400

          .         .         .         .         .        | 19.    g.78156
 GGTGCAGGAGAGTTTCAGGGACAATTACTGGGGACAATTGCATTTATGGCACCTGAG | GTA    c.4260
 G  A  G  E  F  Q  G  Q  L  L  G  T  I  A  F  M  A  P  E   | V      p.1420

          .         .         .         .         .         .       g.78216
 CTAAGAGGTCAACAGTATGGAAGGAGCTGTGATGTATGGAGTGTTGGCTGTGCTATTATA       c.4320
 L  R  G  Q  Q  Y  G  R  S  C  D  V  W  S  V  G  C  A  I  I         p.1440

          .         .         .         .         .         .       g.78276
 GAAATGGCTTGTGCAAAACCACCATGGAATGCAGAAAAACACTCCAATCATCTTGCTTTG       c.4380
 E  M  A  C  A  K  P  P  W  N  A  E  K  H  S  N  H  L  A  L         p.1460

           | 20        .         .         .         .         .    g.83509
 ATATTTAAG | ATTGCTAGTGCAACTACTGCTCCATCGATCCCTTCACATTTGTCTCCTGGT    c.4440
 I  F  K   | I  A  S  A  T  T  A  P  S  I  P  S  H  L  S  P  G      p.1480

          .         .         .         .         .         .       g.83569
 TTACGAGATGTGGCTCTTCGTTGTTTAGAACTTCAACCTCAGGACAGACCTCCATCAAGA       c.4500
 L  R  D  V  A  L  R  C  L  E  L  Q  P  Q  D  R  P  P  S  R         p.1500

          .         .         .                                     g.83608
 GAGCTACTGAAGCATCCAGTCTTTCGTACTACATGGTAG                            c.4539
 E  L  L  K  H  P  V  F  R  T  T  W  X                              p.1512

          .         .         .         .         .         .       g.83668
 ccaattatgcagatcaactacagtagaaacaggatgctcaacaagagaaaaaaaacttgt       c.*60

          .         .         .         .         .         .       g.83728
 ggggaaccacattgatattctactggccatgatgccactgaacagctatgaacgaggcca       c.*120

          .         .         .         .         .         .       g.83788
 gtggggaacccttacctaagtatgtgattgacaaatcatgatctgtacctaagctcagta       c.*180

          .         .         .         .         .         .       g.83848
 tgcaaaagcccaaactagtgcagaaactgtaaactgtgcctttcaaagaactggccctag       c.*240

          .         .         .         .         .         .       g.83908
 gtgaacaggaaaacaatgaagtttgcatgactaaattgcagaagcataattttatttttt       c.*300

          .         .         .         .         .         .       g.83968
 tggagcactttttcagcaatattagcggctgaggggctcaggatctattttaatatttca       c.*360

          .         .         .         .         .         .       g.84028
 attattcttccatttcatatagtgatcacaagcagggggttctgcaattccgttcaaatt       c.*420

          .         .         .         .         .         .       g.84088
 ttttgtcactggctataaaatcagtatctgcctcttttaggtcagagtatgctatgagta       c.*480

          .         .         .         .         .         .       g.84148
 gcaatacatacatatatttttaaaagttgatacttctttatgacccacagttgaccttta       c.*540

          .         .         .         .         .         .       g.84208
 ttttcttaaataccagggcagttgtggctcattgtgcattttactgttggcccattcatt       c.*600

          .         .         .         .         .         .       g.84268
 tcgtttttggaaattatggttttgtattttcatgtttatttacattcatttttgtttatt       c.*660

          .         .         .         .         .         .       g.84328
 cagggaaagctgatctttttttcaaaccagaaaaaaaaaatgaactagatatgaagtaga       c.*720

          .         .         .         .         .         .       g.84388
 gttcattaaatatcttgctattgtcagagtttttaaaatatagacttaattttgtttttt       c.*780

          .         .         .         .         .         .       g.84448
 taaattggaatacaataaagtactacctacatttgagtcagtcaccactcttattgtgca       c.*840

          .         .         .         .         .         .       g.84508
 ggttaagtacaagttaactaaaaataaactgtcctctctggtgcaactcacaaccaagat       c.*900

          .         .         .         .         .         .       g.84568
 caagattaccttaaaatttatttgaattttttagatgttttggttgtcaaactgtaggaa       c.*960

          .         .         .         .         .         .       g.84628
 acttcacaacatttaagtcttactctgtatgtaacaatccatcattcaccttcactactg       c.*1020

          .         .         .         .         .         .       g.84688
 gtagtaacatagagctgccattttccttttaccatgcatcatctctttacagtaggcctg       c.*1080

          .         .         .         .         .         .       g.84748
 gcagatcattttttaaaaagattattcaactaccaatcagtaatgtttttaaacagtaca       c.*1140

          .         .         .         .         .         .       g.84808
 tttgctttgaacttggaaaatgtgttcagaaagaaaaatggaattgaatttcatttatac       c.*1200

          .         .         .         .         .         .       g.84868
 actaattccttggattttgcacagttacctaacggttttagtctggagttaaattcagat       c.*1260

          .         .         .         .         .         .       g.84928
 gcatggaatcctgaaggaaaatggtagctttttaatctttttgtgtgtgtgtgagtcttt       c.*1320

          .         .         .         .         .         .       g.84988
 taaatcaagtactgattaactattaagtacaactttgagattttagttttaactcttcag       c.*1380

          .         .         .         .         .         .       g.85048
 aagccagtgtgaaatagaattggttattctcaaagactcaggataaactaaataagctat       c.*1440

          .         .         .         .         .         .       g.85108
 atatagagtacatttaaaatgtacaacacaaattggaaataaaataagttacaagataag       c.*1500

          .         .         .         .         .         .       g.85168
 tttacagggatatattgcttacaatttttaaaaggcagtttgttttttatgtgaatatgt       c.*1560

          .         .         .         .         .         .       g.85228
 ttcttagtgaaattttacattcctttgttttggaagattggcgatatttgaagagttaaa       c.*1620

          .         .         .         .         .         .       g.85288
 aatagtacagaaatgtgaagtttggtatctctaaatgtgttgtacttgactttctttttt       c.*1680

          .         .         .         .         .         .       g.85348
 attttgtttttttttttttttgactacttagaattttcacaattctaataagattgtttc       c.*1740

          .         .         .         .         .         .       g.85408
 caagtctctcatgtgcaagctttaaaggatgcactcttgccattttatgtactggaagat       c.*1800

          .         .         .         .         .         .       g.85468
 cattggtcagatgaatactgtgtctgacaaaaatgtaaactgtataaactgaggaacctc       c.*1860

          .         .         .         .         .         .       g.85528
 agctaatcagtattactttgtagatcaccatgcccaccacatttcaaactcaaactatct       c.*1920

          .         .         .         .         .         .       g.85588
 gtagatttcaaaatccattgtgtttgagtttgtttgcagttccctcagcttgctggtaat       c.*1980

          .         .         .         .         .         .       g.85648
 tgtggtgttttgttttttgttttgttttcaatgcaaatgtgatgtaatattcttattttc       c.*2040

          .         .         .         .         .         .       g.85708
 tttggatcaaagctggactggaaattgtatcgtgtaattatttttgtgttcttaatgtta       c.*2100

          .         .         .         .         .         .       g.85768
 tttggtactcaagttgtaaataacgtctactactgtttattccagtttctactacctcag       c.*2160

          .         .         .         .         .         .       g.85828
 gtgtcctatagatttttcttctaccaaagttcactttcacaatgaaattatatttgctgt       c.*2220

          .         .         .         .         .         .       g.85888
 gtgactatgattcctaagatttccagggcttaagggctaacttctattagcaccttactg       c.*2280

          .         .         .         .         .         .       g.85948
 tgtaagcaaatgttacaaaaaaaaaaaaaaaaaatctctgggttaagaaaatttggctta       c.*2340

          .         .         .         .         .         .       g.86008
 aatgtatcctttgttattttaaatatattgagatattttaattaaaatttttaccccatt       c.*2400

          .         .         .         .         .         .       g.86068
 gaaccgattttatagtatttgtacctattttggtgtttttgtctttatagtaaataaaag       c.*2460

          .                                                         g.86080
 tttttgaacaaa                                                       c.*2472

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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