mitogen-activated protein kinase kinase kinase 20 (MAP3K20) - coding DNA reference sequence

(used for variant description)

(last modified May 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_016653.2 in the MAP3K20 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029373.1, covering MAP3K20 transcript NM_016653.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         actgtcttcctcattggcgc       c.-181

 .         .         .         .         .         .                g.5080
 cgtgcagagaggcggaatgttcaactcctaactgcggcggaaacgtgggagccgcgcggg       c.-121

 .         .         .         .         .         .                g.5140
 ccgctgtcgtcccaacccccgccgccctcgtcgcgcgcggggcctccgcgcccccggctg       c.-61

 .         .         .      | 02  .         .         .             g.20195
 ctgctcacgccccgcccgggagccag | attttgtggaagtataatactttgtcattatgag    c.-1

          .         .         .         .         .         .       g.20255
 ATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAA       c.60
 M  S  S  L  G  A  S  F  V  Q  I  K  F  D  D  L  Q  F  F  E         p.20

          .         .         .         .         .         .       g.20315
 AACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAG       c.120
 N  C  G  G  G  S  F  G  S  V  Y  R  A  K  W  I  S  Q  D  K         p.40

          .         .         .          | 03        .         .    g.98989
 GAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAG | GCAGAAATACTCAGTGTCCTC    c.180
 E  V  A  V  K  K  L  L  K  I  E  K  E   | A  E  I  L  S  V  L      p.60

          .         .         .         .         .         .       g.99049
 AGTCACAGAAACATCATCCAGTTTTATGGAGTAATTCTTGAACCTCCCAACTATGGCATT       c.240
 S  H  R  N  I  I  Q  F  Y  G  V  I  L  E  P  P  N  Y  G  I         p.80

         | 04.         .         .         .         .         .    g.112070
 GTCACAG | AATATGCTTCTCTGGGATCACTCTATGATTACATTAACAGTAACAGAAGTGAG    c.300
 V  T  E |   Y  A  S  L  G  S  L  Y  D  Y  I  N  S  N  R  S  E      p.100

          .         .         .         .          | 05        .    g.116732
 GAGATGGATATGGATCACATTATGACCTGGGCCACTGATGTAGCCAAAG | GAATGCATTAT    c.360
 E  M  D  M  D  H  I  M  T  W  A  T  D  V  A  K  G |   M  H  Y      p.120

          .         .         .         .         .      | 06  .    g.120063
 TTACATATGGAGGCTCCTGTCAAGGTGATTCACAGAGACCTCAAGTCAAGAAACG | TTGTT    c.420
 L  H  M  E  A  P  V  K  V  I  H  R  D  L  K  S  R  N  V |   V      p.140

          .         .     | 07   .         .         .         .    g.120239
 ATAGCTGCTGATGGAGTATTGAAG | ATCTGTGACTTTGGTGCCTCTCGGTTCCATAACCAT    c.480
 I  A  A  D  G  V  L  K   | I  C  D  F  G  A  S  R  F  H  N  H      p.160

          .         .         .         .         .         .       g.120299
 ACAACACACATGTCCTTGGTTGGAACTTTCCCATGGATGGCTCCAGAAGTTATCCAGAGT       c.540
 T  T  H  M  S  L  V  G  T  F  P  W  M  A  P  E  V  I  Q  S         p.180

          .         .         .         .   | 08     .         .    g.127207
 CTCCCTGTGTCAGAAACTTGTGACACATATTCCTATGGTGTG | GTTCTCTGGGAGATGCTA    c.600
 L  P  V  S  E  T  C  D  T  Y  S  Y  G  V   | V  L  W  E  M  L      p.200

          .         .         .         .         .         .       g.127267
 ACAAGGGAGGTCCCCTTTAAAGGTTTGGAAGGATTACAAGTAGCTTGGCTTGTAGTGGAA       c.660
 T  R  E  V  P  F  K  G  L  E  G  L  Q  V  A  W  L  V  V  E         p.220

           | 09        .         .         .         .         .    g.133010
 AAAAACGAG | AGATTAACCATTCCAAGCAGTTGCCCCAGAAGTTTTGCTGAACTGTTACAT    c.720
 K  N  E   | R  L  T  I  P  S  S  C  P  R  S  F  A  E  L  L  H      p.240

          .         .     | 10   .         .         .         .    g.138928
 CAGTGTTGGGAAGCTGATGCCAAG | AAACGGCCATCATTCAAGCAAATCATTTCAATCCTG    c.780
 Q  C  W  E  A  D  A  K   | K  R  P  S  F  K  Q  I  I  S  I  L      p.260

          .         .         .         .         .         .       g.138988
 GAGTCCATGTCAAATGACACGAGCCTTCCTGACAAGTGTAACTCATTCCTACACAACAAG       c.840
 E  S  M  S  N  D  T  S  L  P  D  K  C  N  S  F  L  H  N  K         p.280

          .  | 11      .         .         .         .         .    g.146327
 GCGGAGTGGAG | GTGCGAAATTGAGGCAACTCTTGAGAGGCTAAAGAAACTAGAGCGTGAT    c.900
 A  E  W  R  |  C  E  I  E  A  T  L  E  R  L  K  K  L  E  R  D      p.300

          .         .         .         .         .         .       g.146387
 CTCAGCTTTAAGGAGCAGGAGCTTAAAGAACGAGAAAGACGTTTAAAGATGTGGGAGCAA       c.960
 L  S  F  K  E  Q  E  L  K  E  R  E  R  R  L  K  M  W  E  Q         p.320

          .         .        | 12.         .         .         .    g.158885
 AAGCTGACAGAGCAGTCCAACACCCCG | CTGCTGCCTTCCTTTGAGATTGGTGCATGGACG    c.1020
 K  L  T  E  Q  S  N  T  P   | L  L  P  S  F  E  I  G  A  W  T      p.340

          .   | 13     .         .         .    | 14    .         . g.161500
 GAAGACGATGTG | TATTGTTGGGTTCAGCAGCTCGTCAGAAAAG | GTGACTCTTCAGCAGAG c.1080
 E  D  D  V   | Y  C  W  V  Q  Q  L  V  R  K  G |   D  S  S  A  E   p.360

          .         .         .         .         .         .       g.161560
 ATGAGTGTATATGCAAGCTTGTTTAAAGAAAACAACATTACAGGGAAGCGGCTGCTGCTG       c.1140
 M  S  V  Y  A  S  L  F  K  E  N  N  I  T  G  K  R  L  L  L         p.380

          .         .         .         .         .         .       g.161620
 CTGGAGGAAGAAGACCTGAAAGACATGGGCATTGTCTCCAAGGGGCATATCATTCACTTC       c.1200
 L  E  E  E  D  L  K  D  M  G  I  V  S  K  G  H  I  I  H  F         p.400

     | 15    .         .         .         .         .         .    g.167593
 AAG | TCAGCCATTGAGAAATTAACCCATGATTACATAAATTTGTTTCACTTCCCACCACTA    c.1260
 K   | S  A  I  E  K  L  T  H  D  Y  I  N  L  F  H  F  P  P  L      p.420

        | 16 .         .         .         .         .         .    g.168621
 ATTAAG | GACTCAGGAGGTGAACCTGAAGAAAATGAGGAAAAAATAGTGAACCTGGAACTG    c.1320
 I  K   | D  S  G  G  E  P  E  E  N  E  E  K  I  V  N  L  E  L      p.440

          .         .         .          | 17        .         .    g.187883
 GTTTTTGGTTTTCACTTGAAACCAGGAACTGGCCCACAG | GATTGTAAGTGGAAAATGTAT    c.1380
 V  F  G  F  H  L  K  P  G  T  G  P  Q   | D  C  K  W  K  M  Y      p.460

          .         .         .         .         .         .       g.187943
 ATGGAGATGGATGGGGATGAAATTGCAATAACCTACATAAAAGATGTGACATTCAACACT       c.1440
 M  E  M  D  G  D  E  I  A  I  T  Y  I  K  D  V  T  F  N  T         p.480

          .         .         .       | 18 .         .         .    g.190250
 AACCTACCTGATGCGGAGATTTTAAAGATGACAAAG | CCACCATTTGTAATGGAGAAGTGG    c.1500
 N  L  P  D  A  E  I  L  K  M  T  K   | P  P  F  V  M  E  K  W      p.500

          .         .         .         .         .  | 19      .    g.192917
 ATTGTAGGAATAGCAAAAAGTCAGACTGTGGAGTGCACTGTCACATATGAG | AGTGATGTT    c.1560
 I  V  G  I  A  K  S  Q  T  V  E  C  T  V  T  Y  E   | S  D  V      p.520

          .         .         .         .         .         .       g.192977
 AGAACTCCAAAAAGCACTAAACATGTCCATTCGATTCAGTGGAGTAGAACAAAACCTCAG       c.1620
 R  T  P  K  S  T  K  H  V  H  S  I  Q  W  S  R  T  K  P  Q         p.540

          .         .         .         .         .         .       g.193037
 GATGAAGTGAAAGCAGTCCAACTTGCCATTCAGACATTATTCACCAATTCAGATGGCAAC       c.1680
 D  E  V  K  A  V  Q  L  A  I  Q  T  L  F  T  N  S  D  G  N         p.560

          .         .   | 20     .         .         .         .    g.195251
 CCTGGAAGCAGGTCCGACTCAA | GTGCTGATTGCCAGTGGTTAGATACTCTGAGGATGCGG    c.1740
 P  G  S  R  S  D  S  S |   A  D  C  Q  W  L  D  T  L  R  M  R      p.580

          .         .         .         .         .         .       g.195311
 CAGATTGCATCCAACACTTCTTTACAGCGTTCCCAGAGCAATCCTATTCTGGGGTCACCG       c.1800
 Q  I  A  S  N  T  S  L  Q  R  S  Q  S  N  P  I  L  G  S  P         p.600

          .         .         .         .         .         .       g.195371
 TTCTTCTCACACTTTGATGGCCAGGATTCCTACGCTGCTGCTGTGAGACGGCCCCAGGTG       c.1860
 F  F  S  H  F  D  G  Q  D  S  Y  A  A  A  V  R  R  P  Q  V         p.620

          .         .         .         .         .         .       g.195431
 CCCATTAAGTATCAACAGATTACACCTGTGAACCAGTCCAGAAGCTCGTCTCCTACTCAG       c.1920
 P  I  K  Y  Q  Q  I  T  P  V  N  Q  S  R  S  S  S  P  T  Q         p.640

          .         .         .         .         .         .       g.195491
 TATGGACTGACCAAAAACTTCTCTTCCCTACATCTCAACTCTAGGGACAGTGGCTTTTCC       c.1980
 Y  G  L  T  K  N  F  S  S  L  H  L  N  S  R  D  S  G  F  S         p.660

          .         .         .         .         .         .       g.195551
 AGTGGCAATACTGACACCTCTTCAGAGAGGGGTCGATACTCAGACAGAAGCAGGAACAAA       c.2040
 S  G  N  T  D  T  S  S  E  R  G  R  Y  S  D  R  S  R  N  K         p.680

          .         .         .         .         .         .       g.195611
 TATGGACGTGGTAGTATATCACTCAATTCTTCTCCTAGAGGAAGATACAGTGGAAAGAGT       c.2100
 Y  G  R  G  S  I  S  L  N  S  S  P  R  G  R  Y  S  G  K  S         p.700

          .         .         .         .         .         .       g.195671
 CAGCATTCCACTCCTTCAAGAGGAAGATACCCTGGAAAGTTCTACAGGGTTTCTCAGTCA       c.2160
 Q  H  S  T  P  S  R  G  R  Y  P  G  K  F  Y  R  V  S  Q  S         p.720

          .         .         .         .         .         .       g.195731
 GCACTCAATCCTCACCAGTCGCCTGACTTCAAGAGAAGCCCCAGGGACCTCCACCAACCC       c.2220
 A  L  N  P  H  Q  S  P  D  F  K  R  S  P  R  D  L  H  Q  P         p.740

          .         .         .         .         .         .       g.195791
 AACACCATACCAGGGATGCCTTTGCACCCTGAGACTGACTCAAGAGCCAGTGAAGAGGAC       c.2280
 N  T  I  P  G  M  P  L  H  P  E  T  D  S  R  A  S  E  E  D         p.760

          .         .         .         .         .         .       g.195851
 AGCAAAGTCAGCGAAGGGGGCTGGACAAAAGTGGAATACCGGAAAAAGCCCCACAGGCCA       c.2340
 S  K  V  S  E  G  G  W  T  K  V  E  Y  R  K  K  P  H  R  P         p.780

          .         .         .         .         .         .       g.195911
 TCTCCCGCCAAAACCAATAAAGAGAGAGCCAGAGGGGACCACCGTGGATGGAGAAACTTT       c.2400
 S  P  A  K  T  N  K  E  R  A  R  G  D  H  R  G  W  R  N  F         p.800

                                                                    g.195914
 TGA                                                                c.2403
 X                                                                  p.800

          .         .         .         .         .         .       g.195974
 tgaattgaactacatagcttttctaagcaggttaaaaaaaaaaaaaaaaagaaatgtaat       c.*60

          .         .         .         .         .         .       g.196034
 ggtttttgataatatgatcccttcagattgaattaacgaaaagacaacacttccagtttt       c.*120

          .         .         .         .         .         .       g.196094
 tggattgggaaataccttctaattgagactatagccaaaccagggccaaaattatggata       c.*180

          .         .         .         .         .         .       g.196154
 ttggtcacccagtgatcataactaggcttgaaaatcactacacatattttctgccttgag       c.*240

          .         .         .         .         .         .       g.196214
 tgaacatttttagaggaaaggttatgccatctttttaccctaaccactgatattctggtt       c.*300

          .         .         .         .         .         .       g.196274
 agcagggccaggacaaggggaaggaaaatgaggtcaacaaaaaaatcaaatttttaggaa       c.*360

          .         .         .         .         .         .       g.196334
 aagataagatgaatgttactgatttttccttttggctgaggctgcaatatggcctggcaa       c.*420

          .         .         .         .         .         .       g.196394
 ggcactgttactgatcttgtctttaacattttgatattttgttcatcataatttttgcat       c.*480

          .         .         .         .         .         .       g.196454
 ttatttttttaaatattgcattaaaatatcatttagcttgattatcgagttttttggttt       c.*540

          .         .         .         .         .         .       g.196514
 gaggttttttgttgcttcttttttcttttctttctttccccctcttttttttggatgtcc       c.*600

          .         .         .         .         .         .       g.196574
 ccttaaattttgtgcccaaggcaggtacctcactcatctcatccttggctcagccctgct       c.*660

          .         .         .         .         .         .       g.196634
 ggttagtatttagtatttattttagtaagatatttgtgtctgtatgatggtcagagttga       c.*720

          .         .         .         .         .         .       g.196694
 actgatctggcttgtcatttttcagtaataaaaaaagttactgaatttaatgttgaatat       c.*780

          .         .         .         .         .         .       g.196754
 gatgcatatctcattcattacgatttatcagaaaccaaagatttaaattgcctagatttg       c.*840

          .         .         .         .         .         .       g.196814
 tggttctttctcttcctaagttcccagcgactgctttcaaatactattttctaaatttca       c.*900

          .         .         .         .         .         .       g.196874
 ccaaaggagcaaagaggataaaacaacactccataaaggcctcttgggatgtcagaaatc       c.*960

          .         .         .         .         .         .       g.196934
 taaaatctaaaagaaaacagacacagagcaagacaataacatcacaagctaaaagccaga       c.*1020

          .         .         .         .         .         .       g.196994
 gaaatttaaaattaccaacatccttgttggagtaagacagtaaatatcagccttgcagca       c.*1080

          .         .         .         .         .         .       g.197054
 agacagctctgagcagctgtgggcaaagaggtaaaccagtgggggtgcaaggagactgtc       c.*1140

          .         .         .         .         .         .       g.197114
 tgcagcttagggcagaaatggtgggatccaacttgtgaaatgcttcatgttttacaaacc       c.*1200

          .         .         .         .         .                 g.197173
 aaaaagtcaggtagcaacaaacttattgtatgtcaaatcaataaatgttactttcaata        c.*1259

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitogen-activated protein kinase kinase kinase 20 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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