mitogen-activated protein kinase kinase kinase 7 (MAP3K7) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_145331.2 in the MAP3K7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011966.2, covering MAP3K7 transcript NM_145331.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.4945
   gtcctctctcgcggtatcatccggttgctgaggccctgtaataaaggtctcgcgaaat       c.-361

 .         .         .         .         .         .                g.5005
 ttgttctagaggtccaagtttgcttcttagcttactccaccccacccccaacctgtccct       c.-301

 .         .         .         .         .         .                g.5065
 ccttttctttccaagtcacaaaattctcccctcccctaccccggagtttacggccctcct       c.-241

 .         .         .         .         .         .                g.5125
 cctgtttccgatttcagcccggaaccggaagtgtagtgggcggggcccgtcggcggaaaa       c.-181

 .         .         .         .         .         .                g.5185
 cgcagcggagccagagccggacacggctgtggccgctgcctctacccccgccacggatcg       c.-121

 .         .         .         .         .         .                g.5245
 ccgggtagtaggactgcgcggctccaggctgagggtcggtccggaggcgggtgggcgcgg       c.-61

 .         .         .         .         .         .                g.5305
 gtctcacccggattgtccgggtggcaccgttcccggccccaccgggcgccgcgagggatc       c.-1

          .         .         .         .         .         .       g.5365
 ATGTCTACAGCCTCTGCCGCCTCCTCCTCCTCCTCGTCTTCGGCCGGTGAGATGATCGAA       c.60
 M  S  T  A  S  A  A  S  S  S  S  S  S  S  A  G  E  M  I  E         p.20

          .         .         .         .         .         .       g.5425
 GCCCCTTCCCAGGTCCTCAACTTTGAAGAGATCGACTACAAGGAGATCGAGGTGGAAGAG       c.120
 A  P  S  Q  V  L  N  F  E  E  I  D  Y  K  E  I  E  V  E  E         p.40

  | 02       .         .         .         .         .         .    g.20441
  | GTTGTTGGAAGAGGAGCCTTTGGAGTTGTTTGCAAAGCTAAGTGGAGAGCAAAAGATGTT    c.180
  | V  V  G  R  G  A  F  G  V  V  C  K  A  K  W  R  A  K  D  V      p.60

          .         .         .         .         .  | 03      .    g.23574
 GCTATTAAACAAATAGAAAGTGAATCTGAGAGGAAAGCGTTTATTGTAGAG | CTTCGGCAG    c.240
 A  I  K  Q  I  E  S  E  S  E  R  K  A  F  I  V  E   | L  R  Q      p.80

          .         .         .         .         .        | 04.    g.30524
 TTATCCCGTGTGAACCATCCTAATATTGTAAAGCTTTATGGAGCCTGCTTGAATCCA | GTG    c.300
 L  S  R  V  N  H  P  N  I  V  K  L  Y  G  A  C  L  N  P   | V      p.100

          .         .         .         .    | 05    .         .    g.31991
 TGTCTTGTGATGGAATATGCTGAAGGGGGCTCTTTATATAATG | TGCTGCATGGTGCTGAA    c.360
 C  L  V  M  E  Y  A  E  G  G  S  L  Y  N  V |   L  H  G  A  E      p.120

          .         .         .         .         .         .       g.32051
 CCATTGCCATATTATACTGCTGCCCACGCAATGAGTTGGTGTTTACAGTGTTCCCAAGGA       c.420
 P  L  P  Y  Y  T  A  A  H  A  M  S  W  C  L  Q  C  S  Q  G         p.140

          .         .         .         .         .         .       g.32111
 GTGGCTTATCTTCACAGCATGCAACCCAAAGCGCTAATTCACAGGGACCTGAAACCACCA       c.480
 V  A  Y  L  H  S  M  Q  P  K  A  L  I  H  R  D  L  K  P  P         p.160

    | 06     .         .         .         .         .         .    g.35622
 AA | CTTACTGCTGGTTGCAGGGGGGACAGTTCTAAAAATTTGTGATTTTGGTACAGCCTGT    c.540
 N  |  L  L  L  V  A  G  G  T  V  L  K  I  C  D  F  G  T  A  C      p.180

          .         .         .         .         .         .       g.35682
 GACATTCAGACACACATGACCAATAACAAGGGGAGTGCTGCTTGGATGGCACCTGAAGTT       c.600
 D  I  Q  T  H  M  T  N  N  K  G  S  A  A  W  M  A  P  E  V         p.200

         | 07.         .         .         .         .         .    g.38655
 TTTGAAG | GTAGTAATTACAGTGAAAAATGTGACGTCTTCAGCTGGGGTATTATTCTTTGG    c.660
 F  E  G |   S  N  Y  S  E  K  C  D  V  F  S  W  G  I  I  L  W      p.220

          .         .         .         .         .         .       g.38715
 GAAGTGATAACGCGTCGGAAACCCTTTGATGAGATTGGTGGCCCAGCTTTCCGAATCATG       c.720
 E  V  I  T  R  R  K  P  F  D  E  I  G  G  P  A  F  R  I  M         p.240

          .       | 08 .         .         .         .         .    g.40053
 TGGGCTGTTCATAATG | GTACTCGACCACCACTGATAAAAAATTTACCTAAGCCCATTGAG    c.780
 W  A  V  H  N  G |   T  R  P  P  L  I  K  N  L  P  K  P  I  E      p.260

          .         .         .         .         .         .       g.40113
 AGCCTGATGACTCGTTGTTGGTCTAAAGATCCTTCCCAGCGCCCTTCAATGGAGGAAATT       c.840
 S  L  M  T  R  C  W  S  K  D  P  S  Q  R  P  S  M  E  E  I         p.280

          .         .        | 09.         .         .         .    g.41672
 GTGAAAATAATGACTCACTTGATGCGG | TACTTTCCAGGAGCAGATGAGCCATTACAGTAT    c.900
 V  K  I  M  T  H  L  M  R   | Y  F  P  G  A  D  E  P  L  Q  Y      p.300

          .         .         .         .          | 10        .    g.44022
 CCTTGTCAGTATTCAGATGAAGGACAGAGCAACTCTGCCACCAGTACAG | GCTCATTCATG    c.960
 P  C  Q  Y  S  D  E  G  Q  S  N  S  A  T  S  T  G |   S  F  M      p.320

          .         .         .         .         .         .       g.44082
 GACATTGCTTCTACAAATACGAGTAACAAAAGTGACACTAATATGGAGCAAGTTCCTGCC       c.1020
 D  I  A  S  T  N  T  S  N  K  S  D  T  N  M  E  Q  V  P  A         p.340

          .         .         .         .         .         .       g.44142
 ACAAATGATACTATTAAGCGCTTAGAATCAAAATTGTTGAAAAATCAGGCAAAGCAACAG       c.1080
 T  N  D  T  I  K  R  L  E  S  K  L  L  K  N  Q  A  K  Q  Q         p.360

  | 11       .         .         .         .         .         .    g.44861
  | AGTGAATCTGGACGTTTAAGCTTGGGAGCCTCCCGTGGGAGCAGTGTGGAGAGCTTGCCC    c.1140
  | S  E  S  G  R  L  S  L  G  A  S  R  G  S  S  V  E  S  L  P      p.380

          .         .         .         .         .         .       g.44921
 CCAACCTCTGAGGGCAAGAGGATGAGTGCTGACATGTCTGAAATAGAAGCTAGGATCGCC       c.1200
 P  T  S  E  G  K  R  M  S  A  D  M  S  E  I  E  A  R  I  A         p.400

          . | 12       .         .         .         .         .    g.47606
 GCAACCACAG | CCTATTCCAAGCCTAAACGGGGCCACCGTAAAACTGCTTCATTTGGCAAC    c.1260
 A  T  T  A |   Y  S  K  P  K  R  G  H  R  K  T  A  S  F  G  N      p.420

          .         .         .  | 13      .         .         .    g.55816
 ATTCTGGATGTCCCTGAGATCGTCATATCAG | GCAACGGACAGCCAAGACGTAGATCCATC    c.1320
 I  L  D  V  P  E  I  V  I  S  G |   N  G  Q  P  R  R  R  S  I      p.440

          .         .         .       | 14 .         .         .    g.68429
 CAAGACTTGACTGTAACTGGAACAGAACCTGGTCAG | GTGAGCAGTAGGTCATCCAGTCCC    c.1380
 Q  D  L  T  V  T  G  T  E  P  G  Q   | V  S  S  R  S  S  S  P      p.460

          .         .         .         .         .         .       g.68489
 AGTGTCAGAATGATTACTACCTCAGGACCAACCTCAGAAAAGCCAACTCGAAGTCATCCA       c.1440
 S  V  R  M  I  T  T  S  G  P  T  S  E  K  P  T  R  S  H  P         p.480

          .         .   | 15     .         .         .         .    g.72907
 TGGACCCCTGATGATTCCACAG | ATACCAATGGATCAGATAACTCCATCCCAATGGCTTAT    c.1500
 W  T  P  D  D  S  T  D |   T  N  G  S  D  N  S  I  P  M  A  Y      p.500

          .         .     | 16   .         .         .         .    g.73662
 CTTACACTGGATCACCAACTACAG | CCTCTAGCACCGTGCCCAAACTCCAAAGAATCTATG    c.1560
 L  T  L  D  H  Q  L  Q   | P  L  A  P  C  P  N  S  K  E  S  M      p.520

          .         .         .         .         .         .       g.73722
 GCAGTGTTTGAACAGCATTGTAAAATGGCACAAGAATATATGAAAGTTCAAACAGAAATT       c.1620
 A  V  F  E  Q  H  C  K  M  A  Q  E  Y  M  K  V  Q  T  E  I         p.540

          .         . | 17       .         .         .         .    g.75547
 GCATTGTTATTACAGAGAAA | GCAAGAACTAGTTGCAGAACTGGACCAGGATGAAAAGGAC    c.1680
 A  L  L  L  Q  R  K  |  Q  E  L  V  A  E  L  D  Q  D  E  K  D      p.560

          .         .         .         .         .         .       g.75607
 CAGCAAAATACATCTCGCCTGGTACAGGAACATAAAAAGCTTTTAGATGAAAACAAAAGC       c.1740
 Q  Q  N  T  S  R  L  V  Q  E  H  K  K  L  L  D  E  N  K  S         p.580

          .         .         .         .         .         .       g.75667
 CTTTCTACTTACTACCAGCAATGCAAAAAACAACTAGAGGTCATCAGAAGTCAGCAGCAG       c.1800
 L  S  T  Y  Y  Q  Q  C  K  K  Q  L  E  V  I  R  S  Q  Q  Q         p.600

          .         .                                               g.75688
 AAACGACAAGGCACTTCATGA                                              c.1821
 K  R  Q  G  T  S  X                                                p.606

          .         .         .         .         .         .       g.75748
 ttctctgggaccgttacattttgaaatatgcaaagaaagactttttttttaaggaaagga       c.*60

          .         .         .         .         .         .       g.75808
 aaaccttataatgacgattcatgagtgttagctttttggcgtgttctgaatgccaactgc       c.*120

          .         .         .         .         .         .       g.75868
 ctatatttgctgcatttttttcattgtttattttccttttctcatggtggacatacaatt       c.*180

          .         .         .         .         .         .       g.75928
 ttactgtttcattgcataacatggtagcatctgtgacttgaatgagcagcactttgcaac       c.*240

          .         .         .         .         .         .       g.75988
 ttcaaaacagatgcagtgaactgtggctgtatatgcatgctcattgtgtgaaggctagcc       c.*300

          .         .         .         .         .         .       g.76048
 taacagaacaggaggtatcaaactagctgctatgtgcaaacagcgtccattttttcatat       c.*360

          .         .         .         .         .         .       g.76108
 tagaggtggaacctcaagaatgactttattcttgtatctcatctcaaaatattaataatt       c.*420

          .         .         .         .         .         .       g.76168
 tttttcccaaaagatggtatataccaagttaaagacagggtattataaatttagagtgat       c.*480

          .         .         .         .         .         .       g.76228
 tggtggtatattacggaaatacggaacctttagggatagttccgtgtaagggctttgatg       c.*540

          .         .         .         .         .         .       g.76288
 ccagcatccttggatcagtactgaactcagttccatccgtaaaatatgtaaaggtaagtg       c.*600

          .         .         .         .         .         .       g.76348
 gcagctgctctatttaatgaaagcagttttaccggattttgttagactaaaatttgattg       c.*660

          .         .         .         .         .         .       g.76408
 tgatacattgaacaaaatggaactcatttttttttaaggagtaaagatttttaattctgt       c.*720

          .         .         .         .         .         .       g.76468
 gattgtgtgtatgtgtgttgaaactgtaaagcttttatgactctaatattaatctcttaa       c.*780

          .         .         .         .         .         .       g.76528
 atgaaattaaaaggcaaaagaacatgattgagcttaaatgatcatttcttcctgcagtga       c.*840

          .         .         .         .         .         .       g.76588
 ttcttggattgttttctcatgtatttgaaaaaaaaaaaatgaagaaaaataatggaaaat       c.*900

          .         .         .         .         .         .       g.76648
 ggaagtaattactccagctaaaaaaagcttggacttagatttctttttatgataccaaat       c.*960

          .         .         .         .         .         .       g.76708
 gagaaataaaccaggcaaatcagaaggaagttaaagaagcaaatataaattcaacaagtg       c.*1020

          .         .         .         .         .         .       g.76768
 tcctaattatcctggatattggaatatttgattttccttacaatcccgttctagaatgcc       c.*1080

          .         .         .         .         .         .       g.76828
 tgccgcctttcaacactttcaagagaatttcaacacttacagagtatttatattgttaac       c.*1140

          .         .         .         .         .         .       g.76888
 agtaattttgctaccaaaaccttcagaataactttaataataaaatgacactgaaataat       c.*1200

          .         .         .         .         .         .       g.76948
 agactatacaaactctatattttttcagttggtgttaaaataagtcacattttgatacca       c.*1260

          .         .         .         .         .         .       g.77008
 gtacaagatgtcttttaaataaggatgtcatcagtctgatttttatagcattaatgtttt       c.*1320

          .         .         .         .         .         .       g.77068
 atgaagaaaaagttcaaaatgaaagcattaattgctgtgattattagaattctatcatga       c.*1380

          .         .         .         .         .         .       g.77128
 ctgtattgtagtttttgctctatttcagataagcaagatctaagaagttatcaaaactat       c.*1440

          .         .         .         .         .         .       g.77188
 tctttaaaatgctaaagcaggtaactttttcttccattattttttcctcctaccactgag       c.*1500

          .         .         .         .         .         .       g.77248
 ttttgtaatgaattccttgtgtatacaagcaatacaggtgaatactaaactgttattttt       c.*1560

          .         .         .         .         .         .       g.77308
 agcttcttcaaaagctattttagaaagcttcctggaaataaatgtcttctgtcatttaat       c.*1620

          .         .         .         .         .         .       g.77368
 ttaaataaaaggagtgttaattgttcccaaatttgattacctagctgaaacagatattgg       c.*1680

          .         .         .         .         .         .       g.77428
 attcagcatagtaatagtaaaataaaattggcagagaaaataactgtagactaggataaa       c.*1740

          .         .         .         .         .         .       g.77488
 gcatgactcctccatagcattgttgcttgtatgtacatctgtcactccactgaaagggac       c.*1800

          .         .         .         .         .         .       g.77548
 ctagtcactttaaagaggccttttatctcagcacgagatatccaagcgtgaatgctaagg       c.*1860

          .         .         .         .         .         .       g.77608
 cttgatgtttccattaggatttagcattcgagatttcagattttatttatagtcattgat       c.*1920

          .         .         .         .         .         .       g.77668
 gtgttttgctgtattataacacatttaagggaaattttattatggtttttacatgtagtc       c.*1980

          .         .         .         .         .         .       g.77728
 atttcataaaaatatccagataggtaaatggaagaaaatagtagattttagtcatggtac       c.*2040

          .         .         .         .         .         .       g.77788
 caaatgcaagaggctgttgaacagttgcttgtttgtttacagtaagttccttgagatttt       c.*2100

          .         .         .         .         .         .       g.77848
 cagtactgtagttgccctggacattgagtacagttcagccttactctgtttttaagtagt       c.*2160

          .         .         .         .         .         .       g.77908
 tgtgttgtcaatttcatgcttttaagtcctgatgatccttggagatgggagaaaaagata       c.*2220

          .         .         .         .         .         .       g.77968
 ccagggataattaaaatccacagccagtttcatcagtttcctcatccatcctgcaaataa       c.*2280

          .         .         .         .         .         .       g.78028
 aaatgttaacaaggagccaaacttattcgttctggttttacaatttattttgaccgtttt       c.*2340

          .         .         .         .         .         .       g.78088
 ttgggtgaaaattgcaaacagccaagcaagtggctggaatgccccagtctaagaaattca       c.*2400

          .         .         .         .         .         .       g.78148
 aaaacaatcactgagtaagccctaattacattaattacattttactcttgactccaggaa       c.*2460

          .         .         .         .         .         .       g.78208
 aagaaagcaagcttttatctaatctagagggaagtattcgtgagcaataaaaatcacttt       c.*2520

          .         .         .         .         .         .       g.78268
 tttgagttgaataataatcagttaagaatatttaccgcatagcaacacaacatataaaga       c.*2580

          .         .         .         .         .         .       g.78328
 tttgttacaagttgtttacggatgtttgactatttttgctgaagtattttagagtattga       c.*2640

          .         .         .         .         .         .       g.78388
 atgtcttctctcttcaagtttctttcatgttcctaatttcagctcctgtagccagagatc       c.*2700

          .         .         .         .         .         .       g.78448
 acaggtcttccctgtgaaactttggtttctttctataaatgtgtgtggttttcagcgctc       c.*2760

          .         .         .         .         .         .       g.78508
 aactcctgtcttcaaatggtagtaagttctacttctacttctgtcattcagaacatttta       c.*2820

          .         .         .         .         .         .       g.78568
 tgtcaaatgatgtaatgcagaaattcttgtgcatatttgtaactgaaggaagctttttag       c.*2880

          .         .         .         .                           g.78616
 atttatttttgtttttaataaaattcagattcctattctaaactggta                   c.*2928

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitogen-activated protein kinase kinase kinase 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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