mitogen-activated protein kinase 1 (MAPK1) - coding DNA reference sequence

(used for variant description)

(last modified July 30, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_002745.4 in the MAPK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023054.2, covering MAPK1 transcript NM_002745.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gcccctccctccgcccgcccgccggcccgcccgtcagtctggcaggcaggcaggcaatcg       c.-181

 .         .         .         .         .         .                g.5120
 gtccgagtggctgtcggctcttcagctctcccgctcggcgtcttccttcctcctcccggt       c.-121

 .         .         .         .         .         .                g.5180
 cagcgtcggcggctgcaccggcggcggcgcagtccctgcgggaggggcgacaagagctga       c.-61

 .         .         .         .         .         .                g.5240
 gcggcggccgccgagcgtcgagctcagcgcggcggaggcggcggcggcccggcagccaac       c.-1

          .         .         .         .         .         .       g.5300
 ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC       c.60
 M  A  A  A  A  A  A  G  A  G  P  E  M  V  R  G  Q  V  F  D         p.20

          .         .         .         .         .          | 02    g.64836
 GTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTG | C    c.120
 V  G  P  R  Y  T  N  L  S  Y  I  G  E  G  A  Y  G  M  V  C  |      p.40

          .         .         .         .         .         .       g.64896
 TCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAG       c.180
 S  A  Y  D  N  V  N  K  V  R  V  A  I  K  K  I  S  P  F  E         p.60

          .         .         .         .         .         .       g.64956
 CACCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACAT       c.240
 H  Q  T  Y  C  Q  R  T  L  R  E  I  K  I  L  L  R  F  R  H         p.80

          .         .         .         .         .         .       g.65016
 GAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAATGAAAGAT       c.300
 E  N  I  I  G  I  N  D  I  I  R  A  P  T  I  E  Q  M  K  D         p.100

    | 03     .         .         .         .         .         .    g.66700
 GT | ATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACAC    c.360
 V  |  Y  I  V  Q  D  L  M  E  T  D  L  Y  K  L  L  K  T  Q  H      p.120

          .         .         .         .         .         .       g.66760
 CTCAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATC       c.420
 L  S  N  D  H  I  C  Y  F  L  Y  Q  I  L  R  G  L  K  Y  I         p.140

          .         .         .         .         .         .       g.66820
 CATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCAACACCACC       c.480
 H  S  A  N  V  L  H  R  D  L  K  P  S  N  L  L  L  N  T  T         p.160

          .   | 04     .         .         .         .         .    g.73601
 TGTGATCTCAAG | ATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCAC    c.540
 C  D  L  K   | I  C  D  F  G  L  A  R  V  A  D  P  D  H  D  H      p.180

          .         .         .         .         .         .       g.73661
 ACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTG       c.600
 T  G  F  L  T  E  Y  V  A  T  R  W  Y  R  A  P  E  I  M  L         p.200

           | 05        .         .         .         .         .    g.83924
 AATTCCAAG | GGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAA    c.660
 N  S  K   | G  Y  T  K  S  I  D  I  W  S  V  G  C  I  L  A  E      p.220

          .         .         .         .         .         .       g.83984
 ATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATT       c.720
 M  L  S  N  R  P  I  F  P  G  K  H  Y  L  D  Q  L  N  H  I         p.240

      | 06   .         .         .         .         .         .    g.84349
 TTGG | GTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCT    c.780
 L  G |   I  L  G  S  P  S  Q  E  D  L  N  C  I  I  N  L  K  A      p.260

          .         .         .         .         .         .       g.84409
 AGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA       c.840
 R  N  Y  L  L  S  L  P  H  K  N  K  V  P  W  N  R  L  F  P         p.280

          .       | 07 .         .         .         .         .    g.99743
 AATGCTGACTCCAAAG | CTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAG    c.900
 N  A  D  S  K  A |   L  D  L  L  D  K  M  L  T  F  N  P  H  K      p.300

          .         .         .         .         .         .       g.99803
 AGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGT       c.960
 R  I  E  V  E  Q  A  L  A  H  P  Y  L  E  Q  Y  Y  D  P  S         p.320

        | 08 .         .         .         .         .         .    g.103415
 GACGAG | CCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAG    c.1020
 D  E   | P  I  A  E  A  P  F  K  F  D  M  E  L  D  D  L  P  K      p.340

          .         .         .         .         .         .       g.103475
 GAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCT       c.1080
 E  K  L  K  E  L  I  F  E  E  T  A  R  F  Q  P  G  Y  R  S         p.360

                                                                g.103478
 TAA |                                                             c.1084
 X                                                               p.360

           | 09        .         .         .         .         .    g.108492
 atttgtcag | gacaagggctcagaggactggacgtgctcagacatcggtgttcttcttccc    c.*60

          .         .         .         .         .         .       g.108552
 agttcttgacccctggtcctgtctccagcccgtcttggcttatccactttgactcctttg       c.*120

          .         .         .         .         .         .       g.108612
 agccgtttggaggggcggtttctggtagttgtggcttttatgctttcaaagaatttcttc       c.*180

          .         .         .         .         .         .       g.108672
 agtccagagaattcctcctggcagccctgtgtgtgtcacccattggtgacctgcggcagt       c.*240

          .         .         .         .         .         .       g.108732
 atgtacttcagtgcacctactgcttactgttgctttagtcactaattgctttctggtttg       c.*300

          .         .         .         .         .         .       g.108792
 aaagatgcagtggttcctccctctcctgaatccttttctacatgatgccctgctgaccat       c.*360

          .         .         .         .         .         .       g.108852
 gcagccgcaccagagagagattcttccccaattggctctagtcactggcatctcacttta       c.*420

          .         .         .         .         .         .       g.108912
 tgatagggaaggctactacctagggcactttaagtcagtgacagccccttatttgcactt       c.*480

          .         .         .         .         .         .       g.108972
 caccttttgaccataactgtttccccagagcaggagcttgtggaaataccttggctgatg       c.*540

          .         .         .         .         .         .       g.109032
 ttgcagcctgcagcaagtgcttccgtctccggaatccttggggagcacttgtccacgtct       c.*600

          .         .         .         .         .         .       g.109092
 tttctcatatcatggtagtcactaacatatataaggtatgtgctattggcccagctttta       c.*660

          .         .         .         .         .         .       g.109152
 gaaaatgcagtcatttttctaaataaaaaggaagtactgcacccagcagtgtcactctgt       c.*720

          .         .         .         .         .         .       g.109212
 agttactgtggtcacttgtaccatatagaggtgtaacacttgtcaagaagcgttatgtgc       c.*780

          .         .         .         .         .         .       g.109272
 agtacttaatgtttgtaagacttacaaaaaaagatttaaagtggcagcttcactcgacat       c.*840

          .         .         .         .         .         .       g.109332
 ttggtgagagaagtacaaaggttgcagtgctgagctgtgggcggtttctggggatgtccc       c.*900

          .         .         .         .         .         .       g.109392
 agggtggaactccacatgctggtgcatatacgcccttgagctacttcaaatgtgggtgtt       c.*960

          .         .         .         .         .         .       g.109452
 tcagtaaccacgttccatgcctgaggatttagcagagaggaacactgcgtctttaaatga       c.*1020

          .         .         .         .         .         .       g.109512
 gaaagtatacaattctttttccttctacagcatgtcagcatctcaagttcatttttcaac       c.*1080

          .         .         .         .         .         .       g.109572
 ctacagtataacaatttgtaataaagcctccaggagctcatgacgtgaagcactgttctg       c.*1140

          .         .         .         .         .         .       g.109632
 tcctcaagtactcaaatatttctgatactgctgagtcagactgtcagaaaaagctagcac       c.*1200

          .         .         .         .         .         .       g.109692
 taactcgtgtttggagctctatccatattttactgatctctttaagtatttgttcctgcc       c.*1260

          .         .         .         .         .         .       g.109752
 actgtgtactgtggagttgactcggtgttctgtcccagtgcggtgcctcctcttgacttc       c.*1320

          .         .         .         .         .         .       g.109812
 cccactgctctctgtggtgagaaatttgccttgttcaataattactgtaccctcgcatga       c.*1380

          .         .         .         .         .         .       g.109872
 ctgttacagctttctgtgcagagatgactgtccaagtgccacatgcctacgattgaaatg       c.*1440

          .         .         .         .         .         .       g.109932
 aaaactctattgttacctctgagttgtgttccacggaaaatgctatccagcagatcattt       c.*1500

          .         .         .         .         .         .       g.109992
 aggaaaaataattctatttttagcttttcatttctcagctgtccttttttcttgtttgat       c.*1560

          .         .         .         .         .         .       g.110052
 ttttgacagcaatggagaatgggttatataaagactgcctgctaatatgaacagaaatgc       c.*1620

          .         .         .         .         .         .       g.110112
 atttgtaattcatgaaaataaatgtacatcttctatcttcacattcatgttaagattcag       c.*1680

          .         .         .         .         .         .       g.110172
 tgttgctttcctctggatcagcgtgtctgaatggacagtcaggttcaggttgtgctgaac       c.*1740

          .         .         .         .         .         .       g.110232
 acagaaatgctcacaggcctcactttgccgcccaggcactggcccagcacttggatttac       c.*1800

          .         .         .         .         .         .       g.110292
 ataagatgagttagaaaggtacttctgtagggtcctttttacctctgctcggcagagaat       c.*1860

          .         .         .         .         .         .       g.110352
 cgatgctgtcatgttcctttattcacaatcttaggtctcaaatattctgtcaaaccctaa       c.*1920

          .         .         .         .         .         .       g.110412
 caaagaagccccgacatctcaggttggattccctggttctctctaaagagggcctgccct       c.*1980

          .         .         .         .         .         .       g.110472
 tgtgccccagaggtgctgctgggcacagccaagagttgggaagggccgccccacagtacg       c.*2040

          .         .         .         .         .         .       g.110532
 cagtcctcaccacccagcccagggtgctcacgctcaccactcctgtggctgaggaaggat       c.*2100

          .         .         .         .         .         .       g.110592
 agctggctcatcctcggaaaacagacccacatctctattcttgccctgaaatacgcgctt       c.*2160

          .         .         .         .         .         .       g.110652
 ttcacttgcgtgctcagagctgccgtctgaaggtccacacagcattgacgggacacagaa       c.*2220

          .         .         .         .         .         .       g.110712
 atgtgactgttaccggataacactgattagtcagttttcatttataaaaaagcattgaca       c.*2280

          .         .         .         .         .         .       g.110772
 gttttattactcttgtttctttttaaatggaaagttactattataaggttaatttggagt       c.*2340

          .         .         .         .         .         .       g.110832
 cctcttctaaatagaaaaccatatccttggctactaacatctggagactgtgagctcctt       c.*2400

          .         .         .         .         .         .       g.110892
 cccattccccttcctggtactgtggagtcagattggcatgaaaccactaacttcattcta       c.*2460

          .         .         .         .         .         .       g.110952
 gaatcattgtagccataagttgtgtgctttttattaatcatgccaaacataatgtaactg       c.*2520

          .         .         .         .         .         .       g.111012
 ggcagagaatggtcctaaccaaggtacctatgaaaagcgctagctatcatgtgtagtaga       c.*2580

          .         .         .         .         .         .       g.111072
 tgcatcattttggctcttcttacatttgtaaaaatgtacagattaggtcatcttaattca       c.*2640

          .         .         .         .         .         .       g.111132
 tattagtgacacggaacagcacctccactatttgtatgttcaaataagctttcagactaa       c.*2700

          .         .         .         .         .         .       g.111192
 tagcttttttggtgtctaaaatgtaagcaaaaaattcctgctgaaacattccagtccttt       c.*2760

          .         .         .         .         .         .       g.111252
 catttagtataaaagaaatactgaacaagccagtgggatggaattgaaagaactaatcat       c.*2820

          .         .         .         .         .         .       g.111312
 gaggactctgtcctgacacaggtcctcaaagctagcagagatacgcagacattgtggcat       c.*2880

          .         .         .         .         .         .       g.111372
 ctgggtagaagaatactgtattgtgtgtgcagtgcacagtgtgtggtgtgtgcacactca       c.*2940

          .         .         .         .         .         .       g.111432
 ttccttctgctcttgggcacaggcagtgggtgtagaggtaaccagtagctttgagaagct       c.*3000

          .         .         .         .         .         .       g.111492
 acatgtagctcaccagtggttttctctaaggaatcacaaaagtaaactacccaaccacat       c.*3060

          .         .         .         .         .         .       g.111552
 gccacgtaatatttcagccattcagaggaaactgttttctctttatttgcttatatgtta       c.*3120

          .         .         .         .         .         .       g.111612
 atatggtttttaaattggtaacttttatatagtatggtaacagtatgttaatacacacat       c.*3180

          .         .         .         .         .         .       g.111672
 acatacgcacacatgctttgggtccttccataatacttttatatttgtaaatcaatgttt       c.*3240

          .         .         .         .         .         .       g.111732
 tggagcaatcccaagtttaagggaaatatttttgtaaatgtaatggttttgaaaatctga       c.*3300

          .         .         .         .         .         .       g.111792
 gcaatccttttgcttatacatttttaaagcatttgtgctttaaaattgttatgctggtgt       c.*3360

          .         .         .         .         .         .       g.111852
 ttgaaacatgatactcctgtggtgcagatgagaagctataacagtgaatatgtggtttct       c.*3420

          .         .         .         .         .         .       g.111912
 cttacgtcatccaccttgacatgatgggtcagaaacaaatggaaatccagagcaagtcct       c.*3480

          .         .         .         .         .         .       g.111972
 ccagggttgcaccaggtttacctaaagcttgttgccttttcttgtgctgtttatgcgtgt       c.*3540

          .         .         .         .         .         .       g.112032
 agagcactcaagaaagttctgaaactgctttgtatctgctttgtactgttggtgccttct       c.*3600

          .         .         .         .         .         .       g.112092
 tggtattgtaccccaaaattctgcatagattatttagtataatggtaagttaaaaaatgt       c.*3660

          .         .         .         .         .         .       g.112152
 taaaggaagattttattaagaatctgaatgtttattcattatattgttacaatttaacat       c.*3720

          .         .         .         .         .         .       g.112212
 taacatttatttgtggtatttgtgatttggttaatctgtataaaaattgtaagtagaaag       c.*3780

          .         .         .         .         .         .       g.112272
 gtttatatttcatcttaattcttttgatgttgtaaacgtactttttaaaagatggattat       c.*3840

          .         .         .         .         .         .       g.112332
 ttgaatgtttatggcacctgacttgtaaaaaaaaaaaactacaaaaaaatccttagaatc       c.*3900

          .         .         .         .         .         .       g.112392
 attaaattgtgtccctgtattaccaaaataacacagcaccgtgcatgtatagtttaattg       c.*3960

          .         .         .         .         .         .       g.112452
 cagtttcatctgtgaaaacgtgaaattgtctagtccttcgttatgttccccagatgtctt       c.*4020

          .         .         .         .         .         .       g.112512
 ccagatttgctctgcatgtggtaacttgtgttagggctgtgagctgttcctcgagttgaa       c.*4080

          .         .         .         .         .         .       g.112572
 tggggatgtcagtgctcctagggttctccaggtggttcttcagaccttcacctgtggggg       c.*4140

          .         .         .         .         .         .       g.112632
 ggggggtaggcggtgcccacgcccatctcctcatcctcctgaacttctgcaaccccactg       c.*4200

          .         .         .         .         .         .       g.112692
 ctgggcagacatcctgggcaaccccttttttcagagcaagaagtcataaagataggattt       c.*4260

          .         .         .         .         .         .       g.112752
 cttggacatttggttcttatcaatattgggcattatgtaatgacttatttacaaaacaaa       c.*4320

          .         .         .         .         .         .       g.112812
 gatactggaaaatgttttggatgtggtgttatggaaagagcacaggccttggacccatcc       c.*4380

          .         .         .         .         .         .       g.112872
 agctgggttcagaactaccccctgcttataactgcggctggctgtgggccagtcattctg       c.*4440

          .         .         .         .         .         .       g.112932
 cgtctctgctttcttcctctgcttcagactgtcagctgtaaagtggaagcaatattactt       c.*4500

          .         .         .         .         .         .       g.112992
 gccttgtatatggtaaagattataaaaatacatttcaactgttcagcatagtacttcaaa       c.*4560

          .         .         .                                     g.113025
 gcaagtactcagtaaatagcaagtctttttaaa                                  c.*4593

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitogen-activated protein kinase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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