mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) - coding DNA reference sequence

(used for variant description)

(last modified July 24, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_003668.3 in the MAPKAPK5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering MAPKAPK5 transcript NM_003668.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.4779
                                   gtcccggcgatgtgtggcgctgaggc       c.-481

 .         .         .         .         .         .                g.4839
 ggcggcgggagcagcggcgccgagctctgcttcggcttcggcttcggcttcgcggcggtg       c.-421

 .         .         .         .         .         .                g.4899
 caggcggcggaggcggaggcgcaggctcttctttaggacctggcgagcccaggtctaagc       c.-361

 .         .         .         .         .         .                g.4959
 ggcggccccgcgaggcccttgcacggcgccccgggtcgaggccctccccgcctcgcccta       c.-301

 .         .         .         .         .         .                g.5019
 ccccaggagcctgcctccccagctggggatgaggctaggaggcggccgcgtggggcccag       c.-241

 .         .         .         .         .         .                g.5079
 cacaaagacctgtccccaggggccgccgcctccgccgctgctgctgccgccagcctagag       c.-181

 .         .         .         .         .         .                g.5139
 ccgcccgccgaagcagagccggcgccggggtcctcatccccaccggtcccgaggggcggc       c.-121

 .         .         .         .         .         .                g.5199
 tgctgcccgtcgccacgaggcccaggggcccgagtgccgagccctttgctccctcggccg       c.-61

 .         .         .         .         .         .                g.5259
 cgcggggacagggctgctgagcagcctccgcctctcccggctgtgggggccccactgagt       c.-1

          .         .         .       | 02 .         .         .    g.27799
 ATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAG | GAAACTTCCATTTTAGAAGAATAC    c.60
 M  S  E  E  S  D  M  D  K  A  I  K   | E  T  S  I  L  E  E  Y      p.20

          .         .         .         .         . | 03       .    g.28691
 AGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAG | AGTCTGTGTA    c.120
 S  I  N  W  T  Q  K  L  G  A  G  I  S  G  P  V  R  |  V  C  V      p.40

          .         .         .         .         .         .       g.28751
 AAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGA       c.180
 K  K  S  T  Q  E  R  F  A  L  K  I  L  L  D  R  P  K  A  R         p.60

        | 04 .         .         .         .         .         .    g.30151
 AATGAG | GTACGTCTGCACATGATGTGTGCCACACACCCAAACATAGTTCAGATTATTGAA    c.240
 N  E   | V  R  L  H  M  M  C  A  T  H  P  N  I  V  Q  I  I  E      p.80

          .         .         .         .     | 05   .         .    g.31294
 GTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAG | GGCCCGACTCTTAATT    c.300
 V  F  A  N  S  V  Q  F  P  H  E  S  S  P  R  |  A  R  L  L  I      p.100

          .         .         .         .         .         .       g.31354
 GTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTT       c.360
 V  M  E  M  M  E  G  G  E  L  F  H  R  I  S  Q  H  R  H  F         p.120

          .         .         .    | 06    .         .         .    g.32823
 ACAGAGAAGCAAGCCAGCCAAGTAACAAAGCAG | ATAGCTTTGGCTCTGCGGCACTGTCAC    c.420
 T  E  K  Q  A  S  Q  V  T  K  Q   | I  A  L  A  L  R  H  C  H      p.140

          .         .         .         .         .         .       g.32883
 TTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAACTCT       c.480
 L  L  N  I  A  H  R  D  L  K  P  E  N  L  L  F  K  D  N  S         p.160

     | 07    .         .         .         .         .         .    g.33667
 TTG | GATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTG    c.540
 L   | D  A  P  V  K  L  C  D  F  G  F  A  K  I  D  Q  G  D  L      p.180

          .         .         .          | 08        .         .    g.42993
 ATGACACCCCAGTTCACCCCTTATTATGTAGCACCCCAG | GTACTGGAGGCGCAAAGAAGG    c.600
 M  T  P  Q  F  T  P  Y  Y  V  A  P  Q   | V  L  E  A  Q  R  R      p.200

          .         .         .         .         .         .       g.43053
 CATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAG       c.660
 H  Q  K  E  K  S  G  I  I  P  T  S  P  T  P  Y  T  Y  N  K         p.220

  | 09       .         .         .         .         .         .    g.46166
  | AGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCT    c.720
  | S  C  D  L  W  S  L  G  V  I  I  Y  V  M  L  C  G  Y  P  P      p.240

          .         .         .         .         .         .       g.46226
 TTTTACTCCAAACACCACAGCCGGACTATCCCAAAGGATATGCGAAGAAAGATCATGACA       c.780
 F  Y  S  K  H  H  S  R  T  I  P  K  D  M  R  R  K  I  M  T         p.260

          .         .         .         .         .         .       g.46286
 GGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTT       c.840
 G  S  F  E  F  P  E  E  E  W  S  Q  I  S  E  M  A  K  D  V         p.280

          | 10         .         .         .         .         .    g.48493
 GTGAGGAA | GCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGAC    c.900
 V  R  K  |  L  L  K  V  K  P  E  E  R  L  T  I  E  G  V  L  D      p.300

          .         .         .         .         .         .       g.48553
 CACCCCTGGCTCAATTCCACCGAGGCCCTGGATAATGTGCTGCCTTCTGCTCAGCTGATG       c.960
 H  P  W  L  N  S  T  E  A  L  D  N  V  L  P  S  A  Q  L  M         p.320

           | 11        .         .         .         .         .    g.51064
 ATGGACAAG | GCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATG    c.1020
 M  D  K   | A  V  V  A  G  I  Q  Q  A  H  A  E  Q  L  A  N  M      p.340

          .         .         .         .         .         .       g.51124
 AGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTG       c.1080
 R  I  Q  D  L  K  V  S  L  K  P  L  H  S  V  N  N  P  I  L         p.360

          .         . | 12       .         .         .         .    g.51450
 CGGAAGAGGAAGTTACTTGG | CACCAAGCCAAAGGACAGTGTCTATATCCACGACCATGAG    c.1140
 R  K  R  K  L  L  G  |  T  K  P  K  D  S  V  Y  I  H  D  H  E      p.380

          .         .         .         .         .         .       g.51510
 AATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGT       c.1200
 N  G  A  E  D  S  N  V  A  L  E  K  L  R  D  V  I  A  Q  C         p.400

          .       | 13 .         .         .         .         .    g.52609
 ATTCTCCCCCAGGCTG | GAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCT    c.1260
 I  L  P  Q  A  G |   E  N  E  D  E  K  L  N  E  V  M  Q  E  A      p.420

          .         .         .         .         .         .       g.52669
 TGGAAGTATAACCGGGAATGCAAACTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAAT       c.1320
 W  K  Y  N  R  E  C  K  L  L  R  D  T  L  Q  S  F  S  W  N         p.440

   | 14      .         .         .         .         .         .    g.55551
 G | GTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAGGTG    c.1380
 G |   R  G  F  T  D  K  V  D  R  L  K  L  A  E  I  V  K  Q  V      p.460

          .         .         .                                     g.55587
 ATAGAAGAGCAAACCACGTCCCACGAATCCCAATAA                               c.1416
 I  E  E  Q  T  T  S  H  E  S  Q  X                                 p.471

          .         .         .         .         .         .       g.55647
 tgacagcttcagactttgtttttttaacaatttgaaaaattattctttaatgtataaagt       c.*60

          .         .         .         .         .         .       g.55707
 aattttatgtaaattaataaatcataatttcatttccacattgattaaagctgctgtata       c.*120

          .         .         .         .         .         .       g.55767
 gatttagggtgcaggacttaataatagtatagttattgtttgtttttaagaaaagctcag       c.*180

          .         .         .         .         .         .       g.55827
 ttctagagacatactattactttaggactgtgtagttgtatatttgtaagatgacagatg       c.*240

          .         .         .         .         .         .       g.55887
 atgctgtcaagcaatattgttttatttgtaataaaatatacaaaaatcacttgccagcag       c.*300

          .         .         .         .         .         .       g.55947
 tagaaaaaggaccgactataccgacctttctgattagtaaacagttgaatcaaggactct       c.*360

                                                                    g.55950
 gga                                                                c.*363

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitogen-activated protein kinase-activated protein kinase 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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