MAP/microtubule affinity-regulating kinase 2 (MARK2) - coding DNA reference sequence

(used for variant description)

(last modified November 2, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001039469.2 in the MARK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering MARK2 transcript NM_001039469.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5039
                      aaacagagccgaagcttcgtcttcggaatcgaggaggag       c.-541

 .         .         .         .         .         .                g.5099
 agcgcgtccccggggtttaccttcttcggctgtttccggaattcacccgtagtctgtggc       c.-481

 .         .         .         .         .         .                g.5159
 cgggaggagaaggcgcgccccacctcccgtttctagccgcttcggatgtttccggctgct       c.-421

 .         .         .         .         .         .                g.5219
 gccggcgaaaagagccgagggccggcggtggtggcggccatgttgggagcagcaggtccg       c.-361

 .         .         .         .         .         .                g.5279
 gcggcggctgcctgtgtgccgggcgcggagcagtgccgctgagggcaggggaggagcgag       c.-301

 .         .         .         .         .         .                g.5339
 gcaggcggccggctgcggcggcagagagtaggcggagcggcgcggcccggccgaaaggcg       c.-241

 .         .         .         .         .         .                g.5399
 gcacagcccagccgggggtcgggggggtgcggtccggagccgctcggagccggcgcggcc       c.-181

 .         .         .         .         .         .                g.5459
 tagcccgagcggcgcatccccgggctggcgtgagcggctgcccggcctccccgcaccccc       c.-121

 .         .         .         .         .         .                g.5519
 ggccggggcccatgcggcgggtgctcctgctgtgagaagccccgcccggccgggctccgc       c.-61

 .         .         .         .         .         .                g.5579
 gccttcccttccctcccttcctccaagcttctcggttccctcccccgagataccggcgcc       c.-1

          .         .         .         .         .     | 02   .    g.61237
 ATGTCCAGCGCTCGGACCCCCCTACCCACGCTGAACGAGAGGGACACGGAGCAG | CCCACC    c.60
 M  S  S  A  R  T  P  L  P  T  L  N  E  R  D  T  E  Q   | P  T      p.20

          .         .         .         .         .         .       g.61297
 TTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCA       c.120
 L  G  H  L  D  S  K  P  S  S  K  S  N  M  I  R  G  R  N  S         p.40

          .         .         .         .         .         .       g.61357
 GCCACCTCTGCTGATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGC       c.180
 A  T  S  A  D  E  Q  P  H  I  G  N  Y  R  L  L  K  T  I  G         p.60

          .         .         .         .         .     | 03   .    g.61658
 AAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGACTGGGAAAGAG | GTAGCT    c.240
 K  G  N  F  A  K  V  K  L  A  R  H  I  L  T  G  K  E   | V  A      p.80

          .         .         .         .         | 04         .    g.64316
 GTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAA | CTATTCCGCGAA    c.300
 V  K  I  I  D  K  T  Q  L  N  S  S  S  L  Q  K   | L  F  R  E      p.100

          .         .         .        | 05.         .         .    g.64703
 GTAAGAATAATGAAGGTTTTGAATCATCCCAACATAG | TTAAATTATTTGAAGTGATTGAG    c.360
 V  R  I  M  K  V  L  N  H  P  N  I  V |   K  L  F  E  V  I  E      p.120

          .         .         .         .    | 06    .         .    g.64852
 ACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG | GAGAGGTATTTGATTAC    c.420
 T  E  K  T  L  Y  L  V  M  E  Y  A  S  G  G |   E  V  F  D  Y      p.140

          .         .         .         .         .     | 07   .    g.65130
 CTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAG | ATAGTG    c.480
 L  V  A  H  G  R  M  K  E  K  E  A  R  A  K  F  R  Q   | I  V      p.160

          .         .         .         .         .  | 08      .    g.65955
 TCTGCTGTGCAGTACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAG | GCAGAAAAC    c.540
 S  A  V  Q  Y  C  H  Q  K  F  I  V  H  R  D  L  K   | A  E  N      p.180

          .         .         .         .         .         .       g.66015
 CTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTGGCTTCAGCAATGAATTC       c.600
 L  L  L  D  A  D  M  N  I  K  I  A  D  F  G  F  S  N  E  F         p.200

          .         .         .         .         .         .       g.66075
 ACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTC       c.660
 T  F  G  N  K  L  D  T  F  C  G  S  P  P  Y  A  A  P  E  L         p.220

          .         .         .         .         .         .       g.66135
 TTCCAGGGCAAAAAATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTC       c.720
 F  Q  G  K  K  Y  D  G  P  E  V  D  V  W  S  L  G  V  I  L         p.240

          .         .         .         .         | 09         .    g.66643
 TATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACCTCAAG | GAGCTGCGGGAA    c.780
 Y  T  L  V  S  G  S  L  P  F  D  G  Q  N  L  K   | E  L  R  E      p.260

          .         .         .         .         .         .       g.66703
 CGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTG       c.840
 R  V  L  R  G  K  Y  R  I  P  F  Y  M  S  T  D  C  E  N  L         p.280

          .         .         .         .         | 10         .    g.66864
 CTTAAGAAATTTCTCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAG | CAAATCATGAAA    c.900
 L  K  K  F  L  I  L  N  P  S  K  R  G  T  L  E   | Q  I  M  K      p.300

          .         .         .         .         .         .       g.66924
 GATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGCCTTACGTGGAGCCACTC       c.960
 D  R  W  M  N  V  G  H  E  D  D  E  L  K  P  Y  V  E  P  L         p.320

          .         .         | 11         .         .         .    g.67061
 CCTGACTACAAGGACCCCCGGCGGACAG | AGCTGATGGTGTCCATGGGTTATACACGGGAA    c.1020
 P  D  Y  K  D  P  R  R  T  E |   L  M  V  S  M  G  Y  T  R  E      p.340

          .         .         .         .         .         .       g.67121
 GAGATCCAGGACTCGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTC       c.1080
 E  I  Q  D  S  L  V  G  Q  R  Y  N  E  V  M  A  T  Y  L  L         p.360

          .         .  | 12      .         .         .         .    g.68309
 CTGGGCTACAAGAGCTCCGAG | CTGGAAGGCGACACCATCACCCTGAAACCCCGGCCTTCA    c.1140
 L  G  Y  K  S  S  E   | L  E  G  D  T  I  T  L  K  P  R  P  S      p.380

          .         .         .         .         .         .       g.68369
 GCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCG       c.1200
 A  D  L  T  N  S  S  A  P  S  P  S  H  K  V  Q  R  S  V  S         p.400

          .         .         .     | 13   .         .         .    g.68699
 GCCAATCCCAAGCAGCGGCGCTTCAGCGACCAGG | CAGCTGGTCCTGCCATTCCCACCTCT    c.1260
 A  N  P  K  Q  R  R  F  S  D  Q  A |   A  G  P  A  I  P  T  S      p.420

          .         .         .         .         .         .       g.68759
 AATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATAAGCGGCCTGAGGAGGAC       c.1320
 N  S  Y  S  K  K  T  Q  S  N  N  A  E  N  K  R  P  E  E  D         p.440

          .         .         .         .         .         .       g.68819
 CGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGT       c.1380
 R  E  S  G  R  K  A  S  S  T  A  K  V  P  A  S  P  L  P  G         p.460

          .         .         .       | 14 .         .         .    g.69157
 CTGGAGAGGAAGAAGACCACCCCAACCCCCTCCACG | AACAGCGTCCTCTCCACCAGCACA    c.1440
 L  E  R  K  K  T  T  P  T  P  S  T   | N  S  V  L  S  T  S  T      p.480

          .         .         .         .         .         .       g.69217
 AATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCGGCCAGGCCTCCATCCAG       c.1500
 N  R  S  R  N  S  P  L  L  E  R  A  S  L  G  Q  A  S  I  Q         p.500

          .     | 15   .         .         .         .         .    g.70104
 AATGGCAAAGACAG | CCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCC    c.1560
 N  G  K  D  S  |  L  T  M  P  G  S  R  A  S  T  A  S  A  S  A      p.520

          .         .         .         .         .         .       g.70164
 GCAGTCTCTGCGGCCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCC       c.1620
 A  V  S  A  A  R  P  R  Q  H  Q  K  S  M  S  A  S  V  H  P         p.540

          .         .         .         .         .       | 16 .    g.70862
 AACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGGTGCCGCGGCCCAG | CACA    c.1680
 N  K  A  S  G  L  P  P  T  E  S  N  C  E  V  P  R  P  S  |  T      p.560

          .         .         .         .         .         .       g.70922
 GCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGA       c.1740
 A  P  Q  R  V  P  V  A  S  P  S  A  H  N  I  S  S  S  G  G         p.580

          .         .         .         .         .         .       g.70982
 GCCCCAGACCGAACTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGG       c.1800
 A  P  D  R  T  N  F  P  R  G  V  S  S  R  S  T  F  H  A  G         p.600

          .         .         .         .         .         .       g.71042
 CAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTGTGACCCCAGCCTCTCCC       c.1860
 Q  L  R  Q  V  R  D  Q  Q  N  L  P  Y  G  V  T  P  A  S  P         p.620

          .         .         .         .         .         .       g.71102
 TCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCC       c.1920
 S  G  H  S  Q  G  R  R  G  A  S  G  S  I  F  S  K  F  T  S         p.640

          .     | 17   .         .         .  | 18      .         . g.74351
 AAGTTTGTACGCAG | AAATCTGTCTTTCAGGTTTGCCAGAAG | GAACCTGAATGAACCTGAA c.1980
 K  F  V  R  R  |  N  L  S  F  R  F  A  R  R  |  N  L  N  E  P  E   p.660

          .         .       | 19 .         .         .         .    g.74983
 AGCAAAGACCGAGTGGAGACGCTCAG | ACCTCACGTGGTGGGCAGTGGCGGCAACGACAAA    c.2040
 S  K  D  R  V  E  T  L  R  |  P  H  V  V  G  S  G  G  N  D  K      p.680

          .         .         .         .         .         .       g.75043
 GAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTATGAAG       c.2100
 E  K  E  E  F  R  E  A  K  P  R  S  L  R  F  T  W  S  M  K         p.700

          .         .         .         .         .         .       g.75103
 ACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCG       c.2160
 T  T  S  S  M  E  P  N  E  M  M  R  E  I  R  K  V  L  D  A         p.720

          .         .         .         .         .         .       g.75163
 AACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGTGCATGCACGGCACGCCG       c.2220
 N  S  C  Q  S  E  L  H  E  K  Y  M  L  L  C  M  H  G  T  P         p.740

          .         .         .         .         .         .       g.75223
 GGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCTCTCTC       c.2280
 G  H  E  D  F  V  Q  W  E  M  E  V  C  K  L  P  R  L  S  L         p.760

          .         .         .         .         .         .       g.75283
 AACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCC       c.2340
 N  G  V  R  F  K  R  I  S  G  T  S  M  A  F  K  N  I  A  S         p.780

          .         .                                               g.75310
 AAAATAGCCAACGAGCTGAAGCTTTAA                                        c.2367
 K  I  A  N  E  L  K  L  X                                          p.788

          .         .         .         .         .         .       g.75370
 caggctgccaggagcgggggcggcgggggcgggccagctggacgggctgccggccgctgc       c.*60

          .         .         .         .         .         .       g.75430
 gccgccccacctgggcgagactgcagcgatggattggtgtgtctcccctgctggcacttc       c.*120

          .         .         .         .         .         .       g.75490
 tcccctccctggcccttctcagttttctcttacatgtttgtggggggtgggagattgttc       c.*180

          .         .         .         .         .         .       g.75550
 tccagcaccccacattcacccctgcccagagattcccccttctcctctcccctactggag       c.*240

          .         .         .         .         .         .       g.75610
 gcaaaggaaggggagggtggatgggggggcagggctccccctcggtactgcggttgcaca       c.*300

          .         .         .         .         .         .       g.75670
 gagtatttcgcctaaaccaagaaattttttattaccaaaaagaaaaaagaaaaaaaaaat       c.*360

          .         .         .         .         .         .       g.75730
 cccagcggccacctttcctccctgccccattgggacagtcgagactggatctgtggggtt       c.*420

          .         .         .         .         .         .       g.75790
 tcccgggagggtggctcagggctggaacactctcaggcaagagtggtggagctcccgtca       c.*480

          .         .         .         .         .         .       g.75850
 ggccctccgccaggcccactgtgggcttctcccctctcctccctccttcccctccaagca       c.*540

          .         .         .         .         .         .       g.75910
 aaccaccagaggtggccttcccctgacctcaggcccctgggctggaggcctgggcggtgg       c.*600

          .         .         .         .         .         .       g.75970
 ggcagggggcgggggtgctgcgcagccctgcagtgggtggggctgggggctgctccgggg       c.*660

          .         .         .         .         .         .       g.76030
 ctgctgaggctggagggccggcacaaggctccgcctccctccacactgtaccctctgccc       c.*720

          .         .         .         .         .         .       g.76090
 ctcctccccagagctgggcatttccttccacaagctgctgtggggacgtgtgttccctca       c.*780

          .         .         .         .         .         .       g.76150
 aagtctgtgccatcttctcccacccctcccgggtagaaggaggggctgaccccagggctg       c.*840

          .         .         .         .         .         .       g.76210
 ggagaggggaggggactggagggcagactggcttctcggtccccagggggccgcttgggc       c.*900

          .         .         .         .         .         .       g.76270
 tgttggtctccagagcagggccactgggcactctgtgatgggggagcctttgtctgaaag       c.*960

          .         .         .         .         .         .       g.76330
 cacagccccctcgcccttcctctccccatggcttccccttcattggcattaatctgggca       c.*1020

          .         .         .         .         .         .       g.76390
 ccagctctctccatagcagtgacttccctcaccactctcatctctcagccttgccttttc       c.*1080

          .         .         .         .         .         .       g.76450
 ttcctgacactgtcgccccctcctctcaggagacactgccgagggccacctggcagaagg       c.*1140

          .         .         .         .         .         .       g.76510
 ctgagttaggcagcagggccgggagcgtctgccctccacagggtgggggacagataggct       c.*1200

          .         .         .         .         .         .       g.76570
 aagcgactcccagcttgctaccctcagtggccagtgtgggcgtgggcggtttggggcgct       c.*1260

          .         .         .         .         .         .       g.76630
 tggctggtggtggccactgcatcccttaatttatttctctgctgtttctgttcttgagaa       c.*1320

          .         .         .         .         .         .       g.76690
 attgggggtgggagtcctacacagaggctgcccctaccctcacctgagttgtacattttt       c.*1380

          .         .         .         .         .         .       g.76750
 ttgtgatgggttttattttttattattttattttattttttttttttttgatttatgatg       c.*1440

          .         .         .         .         .         .       g.76810
 actccacccctcttcatcacccccgctcccaggccaggctcagcgattaagccgagccct       c.*1500

          .         .         .         .         .         .       g.76870
 tgcgtcctaggaaggggccttgccaacctcagccctcctgccccacactcctactgcggc       c.*1560

          .         .         .         .         .         .       g.76930
 tcagaccaagggctccccctccctcccttcccccctcctgccctatggaacagcccgggt       c.*1620

          .         .         .         .         .         .       g.76990
 gctctgagggggctgggagggcatggcttggctcccaaagggggtaggggcccggggcac       c.*1680

          .         .         .         .         .         .       g.77050
 ccaggcaaggtggcccctccccgtctagccccctcctccccaaccctgcacttagtttct       c.*1740

          .         .         .         .                           g.77093
 cctctggatcaaacacgtaataaagagaatgtttggaatctga                        c.*1783

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The MAP/microtubule affinity-regulating kinase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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