methionyl-tRNA synthetase 2, mitochondrial (MARS2) - coding DNA reference sequence

(used for variant description)

(last modified February 20, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_138395.3 in the MARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering MARS2 transcript NM_138395.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   attggctttccggccggaagctgcggcgcgacccggctgcgc       c.-61

 .         .         .         .         .         .                g.5102
 atgcgcctctcacacgtgctgtcagaacgccgcctcctccgcttgcggccggtctgcacc       c.-1

          .         .         .         .         .         .       g.5162
 ATGCTGCGAACGTCCGTCCTCCGCCTGCTAGGACGCACGGGGGCTAGTAGGCTGTCTCTC       c.60
 M  L  R  T  S  V  L  R  L  L  G  R  T  G  A  S  R  L  S  L         p.20

          .         .         .         .         .         .       g.5222
 CTGGAGGACTTCGGCCCACGCTACTACAGTTCGGGCTCCCTCAGTGCCGGCGATGATGCT       c.120
 L  E  D  F  G  P  R  Y  Y  S  S  G  S  L  S  A  G  D  D  A         p.40

          .         .         .         .         .         .       g.5282
 TGTGATGTGCGCGCCTACTTCACTACACCCATTTTCTACGTGAACGCGGCGCCGCACATC       c.180
 C  D  V  R  A  Y  F  T  T  P  I  F  Y  V  N  A  A  P  H  I         p.60

          .         .         .         .         .         .       g.5342
 GGGCACCTGTACTCGGCACTACTGGCGGACGCCCTATGCCGCCACCGTCGCCTCCGAGGT       c.240
 G  H  L  Y  S  A  L  L  A  D  A  L  C  R  H  R  R  L  R  G         p.80

          .         .         .         .         .         .       g.5402
 CCCAGCACGGCCGCCACGCGATTCTCCACTGGTACCGACGAGCACGGGCTGAAGATTCAG       c.300
 P  S  T  A  A  T  R  F  S  T  G  T  D  E  H  G  L  K  I  Q         p.100

          .         .         .         .         .         .       g.5462
 CAGGCAGCAGCTACCGCGGGCCTGGCCCCGACCGAGCTGTGCGACCGAGTCTCTGAGCAG       c.360
 Q  A  A  A  T  A  G  L  A  P  T  E  L  C  D  R  V  S  E  Q         p.120

          .         .         .         .         .         .       g.5522
 TTCCAGCAGCTTTTCCAGGAGGCCGGTATCTCCTGCACAGATTTCATCCGCACCACGGAG       c.420
 F  Q  Q  L  F  Q  E  A  G  I  S  C  T  D  F  I  R  T  T  E         p.140

          .         .         .         .         .         .       g.5582
 GCCCGGCACCGGGTGGCTGTGCAGCACTTCTGGGGGGTGCTTAAGTCCCGCGGTCTGCTC       c.480
 A  R  H  R  V  A  V  Q  H  F  W  G  V  L  K  S  R  G  L  L         p.160

          .         .         .         .         .         .       g.5642
 TACAAGGGCGTCTATGAAGGTTGGTATTGCGCTTCCGACGAGTGCTTCCTGCCTGAGGCC       c.540
 Y  K  G  V  Y  E  G  W  Y  C  A  S  D  E  C  F  L  P  E  A         p.180

          .         .         .         .         .         .       g.5702
 AAGGTCACCCAGCAGCCGGGCCCATCGGGGGATTCGTTTCCTGTATCTCTCGAGAGCGGG       c.600
 K  V  T  Q  Q  P  G  P  S  G  D  S  F  P  V  S  L  E  S  G         p.200

          .         .         .         .         .         .       g.5762
 CATCCAGTCTCCTGGACCAAGGAAGAAAACTACATTTTCAGGCTTTCCCAGTTCCGGAAG       c.660
 H  P  V  S  W  T  K  E  E  N  Y  I  F  R  L  S  Q  F  R  K         p.220

          .         .         .         .         .         .       g.5822
 CCACTCCAGCGGTGGCTGCGGGGCAACCCTCAGGCGATCACCCCCGAACCATTTCATCAC       c.720
 P  L  Q  R  W  L  R  G  N  P  Q  A  I  T  P  E  P  F  H  H         p.240

          .         .         .         .         .         .       g.5882
 GTAGTTCTTCAGTGGCTGGACGAGGAGCTGCCCGACCTGTCCGTGTCTCGCAGAAGTAGC       c.780
 V  V  L  Q  W  L  D  E  E  L  P  D  L  S  V  S  R  R  S  S         p.260

          .         .         .         .         .         .       g.5942
 CACTTGCACTGGGGCATTCCGGTGCCCGGGGATGATTCGCAGACCATCTATGTATGGCTG       c.840
 H  L  H  W  G  I  P  V  P  G  D  D  S  Q  T  I  Y  V  W  L         p.280

          .         .         .         .         .         .       g.6002
 GATGCCCTGGTCAACTACCTCACTGTAATTGGCTACCCAAATGCTGAGTTCAAATCTTGG       c.900
 D  A  L  V  N  Y  L  T  V  I  G  Y  P  N  A  E  F  K  S  W         p.300

          .         .         .         .         .         .       g.6062
 TGGCCGGCCACCTCTCATATCATAGGTAAGGACATTCTCAAATTCCATGCCATCTATTGG       c.960
 W  P  A  T  S  H  I  I  G  K  D  I  L  K  F  H  A  I  Y  W         p.320

          .         .         .         .         .         .       g.6122
 CCTGCCTTCCTGTTAGGGGCCGGCATGAGCCCGCCACAGCGCATCTGTGTCCATTCCCAC       c.1020
 P  A  F  L  L  G  A  G  M  S  P  P  Q  R  I  C  V  H  S  H         p.340

          .         .         .         .         .         .       g.6182
 TGGACAGTCTGTGGCCAAAAGATGTCCAAGAGCTTGGGCAACGTGGTGGATCCTAGGACT       c.1080
 W  T  V  C  G  Q  K  M  S  K  S  L  G  N  V  V  D  P  R  T         p.360

          .         .         .         .         .         .       g.6242
 TGCCTTAACCGCTATACCGTGGATGGCTTCCGCTACTTTCTCCTTCGGCAGGGCGTCCCC       c.1140
 C  L  N  R  Y  T  V  D  G  F  R  Y  F  L  L  R  Q  G  V  P         p.380

          .         .         .         .         .         .       g.6302
 AACTGGGACTGTGACTACTATGATGAAAAGGTGGTTAAGTTGCTGAACTCCGAGCTGGCA       c.1200
 N  W  D  C  D  Y  Y  D  E  K  V  V  K  L  L  N  S  E  L  A         p.400

          .         .         .         .         .         .       g.6362
 GATGCCTTGGGAGGTCTCTTGAACCGATGCACTGCCAAAAGAATAAATCCTTCTGAGACC       c.1260
 D  A  L  G  G  L  L  N  R  C  T  A  K  R  I  N  P  S  E  T         p.420

          .         .         .         .         .         .       g.6422
 TACCCAGCCTTCTGCACTACCTGCTTCCCTAGTGAGCCAGGGTTGGTGGGGCCGTCAGTT       c.1320
 Y  P  A  F  C  T  T  C  F  P  S  E  P  G  L  V  G  P  S  V         p.440

          .         .         .         .         .         .       g.6482
 CGTGCTCAGGCAGAGGATTATGCTCTGGTGAGCGCAGTGGCCACTTTGCCAAAGCAGGTA       c.1380
 R  A  Q  A  E  D  Y  A  L  V  S  A  V  A  T  L  P  K  Q  V         p.460

          .         .         .         .         .         .       g.6542
 GCAGACCACTATGATAACTTTCGGATATATAAGGCTCTGGAGGCCGTGTCCAGCTGTGTC       c.1440
 A  D  H  Y  D  N  F  R  I  Y  K  A  L  E  A  V  S  S  C  V         p.480

          .         .         .         .         .         .       g.6602
 CGGCAAACTAATGGTTTTGTCCAAAGGCATGCACCATGGAAGCTGAACTGGGAGAGCCCA       c.1500
 R  Q  T  N  G  F  V  Q  R  H  A  P  W  K  L  N  W  E  S  P         p.500

          .         .         .         .         .         .       g.6662
 GTGGATGCTCCCTGGCTGGGTACTGTGCTTCATGTGGCCTTGGAATGTTTGCGAGTCTTT       c.1560
 V  D  A  P  W  L  G  T  V  L  H  V  A  L  E  C  L  R  V  F         p.520

          .         .         .         .         .         .       g.6722
 GGGACTTTGCTGCAGCCTGTCACCCCAAGCCTAGCTGACAAGCTGCTGTCTAGGCTGGGG       c.1620
 G  T  L  L  Q  P  V  T  P  S  L  A  D  K  L  L  S  R  L  G         p.540

          .         .         .         .         .         .       g.6782
 GTCTCTGCCTCAGAGAGGAGTCTTGGAGAGCTCTATTTCTTGCCTCGATTCTATGGACAT       c.1680
 V  S  A  S  E  R  S  L  G  E  L  Y  F  L  P  R  F  Y  G  H         p.560

          .         .         .         .         .         .       g.6842
 CCATGCCCTTTTGAAGGGAGGAGGCTGGGACCTGAAACTGGGCTTTTGTTTCCAAGACTA       c.1740
 P  C  P  F  E  G  R  R  L  G  P  E  T  G  L  L  F  P  R  L         p.580

          .         .         .         .                           g.6884
 GACCAGTCCAGGACTTGGCTGGTGAAAGCCCACCGGACCTAG                         c.1782
 D  Q  S  R  T  W  L  V  K  A  H  R  T  X                           p.593

          .         .         .         .         .         .       g.6944
 aaactcagttcttaccggcttgtggtaaaaaagcaaatgtgttatctttttattttttat       c.*60

          .         .         .         .         .         .       g.7004
 tttcaggaaagttatactagtattttcttaagtgtggaatcaaatgagcacataagctgt       c.*120

          .         .         .         .         .         .       g.7064
 gtccctgtgaaaagaggtttgtagcctttcaggtgcctgctcctattcatttctctgtga       c.*180

          .         .         .         .         .         .       g.7124
 ccattgatcactgtcctttgtgcattgtgtgtctaagatgtcttcaggggaaagatgggt       c.*240

          .         .         .         .         .         .       g.7184
 aagagacagtgttgctaatgctgttccttctttgtgcctccttccaaaccacagttattt       c.*300

          .         .         .         .         .         .       g.7244
 gcccaaactacctctcgtggctggtttttcattggcctggcctctgcttctcaggctaat       c.*360

          .         .         .         .         .         .       g.7304
 tagtgactcctttctttgagggtcagggttggaggccccttactggtggttttacagggg       c.*420

          .         .         .         .         .         .       g.7364
 gatcctactttgttacacatgttgggtttcctgataaaaagagagtattttattaaaccc       c.*480

          .         .         .         .         .         .       g.7424
 ttgaaccagtgtcctagaccagatgatttttgcccatgtgtatccccatttaaattccta       c.*540

          .         .         .         .         .         .       g.7484
 caactaagtctccctgctttgttaatagtccaacagttgggttgtgtaacatcacacttc       c.*600

          .         .         .         .         .         .       g.7544
 aaccggtagatggctctaatctcacacatttacttactaaagattgaggattcggaatat       c.*660

          .         .         .         .         .         .       g.7604
 ttagaataaattagttttctgctttctaattttgcagatctttacatttttattgctttt       c.*720

          .         .         .         .         .         .       g.7664
 cttaaaataagggatagctttgcaaccactattgttttaatggaaagcaaaaaacccccc       c.*780

          .         .         .         .         .         .       g.7724
 caaacttatcagaatcctcgttctttttcagactactgaaaaatgacatttactctgtta       c.*840

          .         .         .         .         .         .       g.7784
 aatgtttaataagtgaataagtaaatgtatcaagttgtttatataataaattataaaact       c.*900

          .         .         .         .         .         .       g.7844
 cttgaggcacttggtatgttaaaaattttaaactttagtaacattaggttacaggtatga       c.*960

          .         .         .         .         .         .       g.7904
 tttaaaaatttgtaaatagttcaaaagggcaatgttttctttatatttcttatagtctta       c.*1020

          .         .         .         .         .         .       g.7964
 attttgttatccatgtgcataatttacctcatgatttcttttggtcaatcaggatcttta       c.*1080

          .         .         .         .         .         .       g.8024
 atacaatatagaaattgtgtaatagttattataaatgttaatacacaactttcaggtaat       c.*1140

          .         .         .         .         .         .       g.8084
 tttaactgattatttcttttgctcttttaacttaagttattaaagtttaaaagttcgtaa       c.*1200

                                                                    g.8087
 gta                                                                c.*1203

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Methionyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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