mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001879.5 in the MASP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029440.1, covering MASP1 transcript NM_001879.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5030
                               acacacagagtgatacaaatacctgcttga       c.-361

 .         .         .         .         .         .                g.5090
 gcccctcagttattttctctcaagggctgaagtcagccacacaggataaaggagggaagg       c.-301

 .         .         .         .         .         .                g.5150
 gaaggagcagatcttttcggtaggaagacagattttgttgtcaggttcctgggagtgcaa       c.-241

 .         .         .         .         .         .                g.5210
 gagcaagtcaaaggagagagagaggagagaggaaaagccagagggagagagggggagagg       c.-181

 .         .         .         .         .         .                g.5270
 ggatctgttgcaggcaggggaaggcgtgacctgaatggagaatgccagccaattccagag       c.-121

 .         .         .         .         .         .                g.5330
 acacacagggacctcagaacaaagataaggcatcacggacaccacaccgggcacgagctc       c.-61

 .         .         .         .         .         .                g.5390
 acaggcaagtcaagctgggaggaccaaggccgggcagccgggagcacccaaggcaggaaa       c.-1

       | 02  .         .         .         .         .         .    g.11021
 ATGAG | GTGGCTGCTTCTCTATTATGCTCTGTGCTTCTCCCTGTCAAAGGCTTCAGCCCAC    c.60
 M  R  |  W  L  L  L  Y  Y  A  L  C  F  S  L  S  K  A  S  A  H      p.20

          .         .         .         .         .         .       g.11081
 ACCGTGGAGCTAAACAATATGTTTGGCCAGATCCAGTCGCCTGGTTATCCAGACTCCTAT       c.120
 T  V  E  L  N  N  M  F  G  Q  I  Q  S  P  G  Y  P  D  S  Y         p.40

          .         .         .         .         .         .       g.11141
 CCCAGTGATTCAGAGGTGACTTGGAATATCACTGTCCCAGATGGGTTTCGGATCAAGCTT       c.180
 P  S  D  S  E  V  T  W  N  I  T  V  P  D  G  F  R  I  K  L         p.60

          .         .         .         .         .        | 03.    g.34305
 TACTTCATGCACTTCAACTTGGAATCCTCCTACCTTTGTGAATATGACTATGTGAAG | GTA    c.240
 Y  F  M  H  F  N  L  E  S  S  Y  L  C  E  Y  D  Y  V  K   | V      p.80

          .         .         .         .         .         .       g.34365
 GAAACTGAGGACCAGGTGCTGGCAACCTTCTGTGGCAGGGAGACCACAGACACAGAGCAG       c.300
 E  T  E  D  Q  V  L  A  T  F  C  G  R  E  T  T  D  T  E  Q         p.100

          .         .         .         .         .         .       g.34425
 ACTCCCGGCCAGGAGGTGGTCCTCTCCCCTGGCTCCTTCATGTCCATCACTTTCCGGTCA       c.360
 T  P  G  Q  E  V  V  L  S  P  G  S  F  M  S  I  T  F  R  S         p.120

          .         .         .         .         .      | 04  .    g.36155
 GATTTCTCCAATGAGGAGCGTTTCACAGGCTTTGATGCCCACTACATGGCTGTGG | ATGTG    c.420
 D  F  S  N  E  E  R  F  T  G  F  D  A  H  Y  M  A  V  D |   V      p.140

          .         .         .         .         .         .       g.36215
 GACGAGTGCAAGGAGAGGGAGGACGAGGAGCTGTCCTGTGACCACTACTGCCACAACTAC       c.480
 D  E  C  K  E  R  E  D  E  E  L  S  C  D  H  Y  C  H  N  Y         p.160

          .         .         .         .         .         .       g.36275
 ATTGGCGGCTACTACTGCTCCTGCCGCTTCGGCTACATCCTCCACACAGACAACAGGACC       c.540
 I  G  G  Y  Y  C  S  C  R  F  G  Y  I  L  H  T  D  N  R  T         p.180

         | 05.         .         .         .         .         .    g.40215
 TGCCGAG | TGGAGTGCAGTGACAACCTCTTCACTCAAAGGACTGGGGTGATCACCAGCCCT    c.600
 C  R  V |   E  C  S  D  N  L  F  T  Q  R  T  G  V  I  T  S  P      p.200

          .         .         .         .         .         .       g.40275
 GACTTCCCAAACCCTTACCCCAAGAGCTCTGAATGCCTGTATACCATCGAGCTGGAGGAG       c.660
 D  F  P  N  P  Y  P  K  S  S  E  C  L  Y  T  I  E  L  E  E         p.220

          .         .         .         .         .         .       g.40335
 GGTTTCATGGTCAACCTGCAGTTTGAGGACATATTTGACATTGAGGACCATCCTGAGGTG       c.720
 G  F  M  V  N  L  Q  F  E  D  I  F  D  I  E  D  H  P  E  V         p.240

          .         .     | 06   .         .         .         .    g.43743
 CCCTGCCCCTATGACTACATCAAG | ATCAAAGTTGGTCCAAAAGTTTTGGGGCCTTTCTGT    c.780
 P  C  P  Y  D  Y  I  K   | I  K  V  G  P  K  V  L  G  P  F  C      p.260

          .         .         .         .         .         .       g.43803
 GGAGAGAAAGCCCCAGAACCCATCAGCACCCAGAGCCACAGTGTCCTGATCCTGTTCCAT       c.840
 G  E  K  A  P  E  P  I  S  T  Q  S  H  S  V  L  I  L  F  H         p.280

          .         .         .         .         .   | 07     .    g.45278
 AGTGACAACTCGGGAGAGAACCGGGGCTGGAGGCTCTCATACAGGGCTGCAG | GAAATGAG    c.900
 S  D  N  S  G  E  N  R  G  W  R  L  S  Y  R  A  A  G |   N  E      p.300

          .         .         .         .         .         .       g.45338
 TGCCCAGAGCTACAGCCTCCTGTCCATGGGAAAATCGAGCCCTCCCAAGCCAAGTATTTC       c.960
 C  P  E  L  Q  P  P  V  H  G  K  I  E  P  S  Q  A  K  Y  F         p.320

          .         .         .         .         .  | 08      .    g.46702
 TTCAAAGACCAAGTGCTCGTCAGCTGTGACACAGGCTACAAAGTGCTGAAG | GATAATGTG    c.1020
 F  K  D  Q  V  L  V  S  C  D  T  G  Y  K  V  L  K   | D  N  V      p.340

          .         .         .         .         .         .       g.46762
 GAGATGGACACATTCCAGATTGAGTGTCTGAAGGATGGGACGTGGAGTAACAAGATTCCC       c.1080
 E  M  D  T  F  Q  I  E  C  L  K  D  G  T  W  S  N  K  I  P         p.360

          . | 09       .         .         .         .         .    g.53451
 ACCTGTAAAA | TTGTAGACTGTAGAGCCCCAGGAGAGCTGGAACACGGGCTGATCACCTTC    c.1140
 T  C  K  I |   V  D  C  R  A  P  G  E  L  E  H  G  L  I  T  F      p.380

          .         .         .         .         .         .       g.53511
 TCTACAAGGAACAACCTCACCACATACAAGTCTGAGATCAAATACTCCTGTCAGGAGCCC       c.1200
 S  T  R  N  N  L  T  T  Y  K  S  E  I  K  Y  S  C  Q  E  P         p.400

          .         .         | 10         .         .         .    g.55499
 TATTACAAGATGCTCAACAATAACACAG | GTATATATACCTGTTCTGCCCAAGGAGTCTGG    c.1260
 Y  Y  K  M  L  N  N  N  T  G |   I  Y  T  C  S  A  Q  G  V  W      p.420

          .         .         .         .    | 11    .         .    g.67142
 ATGAATAAAGTATTGGGGAGAAGCCTACCCACCTGCCTTCCAG | TGTGTGGGCTCCCCAAG    c.1320
 M  N  K  V  L  G  R  S  L  P  T  C  L  P  V |   C  G  L  P  K      p.440

          .         .         .         .         .         .       g.67202
 TTCTCCCGGAAGCTGATGGCCAGGATCTTCAATGGACGCCCAGCCCAGAAAGGCACCACT       c.1380
 F  S  R  K  L  M  A  R  I  F  N  G  R  P  A  Q  K  G  T  T         p.460

          .         .         .         .         .         .       g.67262
 CCCTGGATTGCCATGCTGTCACACCTGAATGGGCAGCCCTTCTGCGGAGGCTCCCTTCTA       c.1440
 P  W  I  A  M  L  S  H  L  N  G  Q  P  F  C  G  G  S  L  L         p.480

   | 12      .         .         .         .         .         .    g.70561
 G | GCTCCAGCTGGATCGTGACCGCCGCACACTGCCTCCACCAGTCACTCGATCCGGAAGAT    c.1500
 G |   S  S  W  I  V  T  A  A  H  C  L  H  Q  S  L  D  P  E  D      p.500

          .         .         .         .         .      | 13  .    g.71518
 CCGACCCTACGTGATTCAGACTTGCTCAGCCCTTCTGACTTCAAAATCATCCTGG | GCAAG    c.1560
 P  T  L  R  D  S  D  L  L  S  P  S  D  F  K  I  I  L  G |   K      p.520

          .         .         .         .         .         .       g.71578
 CATTGGAGGCTCCGGTCAGATGAAAATGAACAGCATCTCGGCGTCAAACACACCACTCTC       c.1620
 H  W  R  L  R  S  D  E  N  E  Q  H  L  G  V  K  H  T  T  L         p.540

          .         .         .         .         .         .       g.71638
 CACCCCCAGTATGATCCCAACACATTCGAGAATGACGTGGCTCTGGTGGAGCTGTTGGAG       c.1680
 H  P  Q  Y  D  P  N  T  F  E  N  D  V  A  L  V  E  L  L  E         p.560

          .         .         .         .         .         .       g.71698
 AGCCCAGTGCTGAATGCCTTCGTGATGCCCATCTGTCTGCCTGAGGGACCCCAGCAGGAA       c.1740
 S  P  V  L  N  A  F  V  M  P  I  C  L  P  E  G  P  Q  Q  E         p.580

   | 14      .         .         .         .         .         .    g.73887
 G | GAGCCATGGTCATCGTCAGCGGCTGGGGGAAGCAGTTCTTGCAAAGGTTCCCAGAGACC    c.1800
 G |   A  M  V  I  V  S  G  W  G  K  Q  F  L  Q  R  F  P  E  T      p.600

           | 15        .         .         .         .         .    g.75939
 CTGATGGAG | ATTGAAATCCCGATTGTTGACCACAGCACCTGCCAGAAGGCTTATGCCCCG    c.1860
 L  M  E   | I  E  I  P  I  V  D  H  S  T  C  Q  K  A  Y  A  P      p.620

          .         .         .         .          | 16        .    g.76772
 CTGAAGAAGAAAGTGACCAGGGACATGATCTGTGCTGGGGAGAAGGAAG | GGGGAAAGGAC    c.1920
 L  K  K  K  V  T  R  D  M  I  C  A  G  E  K  E  G |   G  K  D      p.640

          .         .         .         .         .         .       g.76832
 GCCTGTGCGGGTGACTCTGGAGGCCCCATGGTGACCCTGAATAGAGAAAGAGGCCAGTGG       c.1980
 A  C  A  G  D  S  G  G  P  M  V  T  L  N  R  E  R  G  Q  W         p.660

          .         .         .         .         .         .       g.76892
 TACCTGGTGGGCACTGTGTCCTGGGGTGATGACTGTGGGAAGAAGGACCGCTACGGAGTA       c.2040
 Y  L  V  G  T  V  S  W  G  D  D  C  G  K  K  D  R  Y  G  V         p.680

          .         .         .         .         .         .       g.76952
 TACTCTTACATCCACCACAACAAGGACTGGATCCAGAGGGTCACCGGAGTGAGGAACTGA       c.2100
 Y  S  Y  I  H  H  N  K  D  W  I  Q  R  V  T  G  V  R  N  X         p.699

          .         .         .         .         .         .       g.77012
 atttggctcctcagccccagcaccaccagctgtgggcagtcagtagcagaggacgatcct       c.*60

          .         .         .         .         .         .       g.77072
 ccgatgaaagcagccatttctcctttccttcctcccatcccccctccttcggcctatcca       c.*120

          .         .         .         .         .         .       g.77132
 ttactgggcaatagagcaggtatcttcacccccttttcactctctttaaagagatggagc       c.*180

          .         .         .         .         .         .       g.77192
 aagagagtggtcagaacacaggccgaatccaggctctatcacttactagtttgcagtgct       c.*240

          .         .         .         .         .         .       g.77252
 gggcaggtgacttcatctcttcgaacttcagtttcttcataagatggaaatgctatacct       c.*300

          .         .         .         .         .         .       g.77312
 tacctacctcgtaaaagtctgatgaggaaaagattaactaatagatgcatagcacttaac       c.*360

          .         .         .         .         .         .       g.77372
 agagtgcatagcatacactgttttcaataaatgcaccttagcagaaggtcgatgtgtcta       c.*420

          .         .         .         .         .         .       g.77432
 ccaggcagacgaagctctcttacaaacccctgcctgggtcttagcattgatcagtgacac       c.*480

          .         .         .         .         .         .       g.77492
 acctctcccctcaaccttgaccatctccatctgcccttaaatgctgtatgcttttttgcc       c.*540

          .         .         .         .         .         .       g.77552
 accgtgcaacttgcccaacatcaatcttcaccctcatccctaaaaaagtaaaacagacaa       c.*600

          .         .         .         .         .         .       g.77612
 ggttctgagtcctgtggtatgtcccctagcaaatgtaactaggaacatgcactagatgac       c.*660

          .         .         .         .         .         .       g.77672
 agattgcgggagggcctgagagaagcagggacaggagggagcctggggattgtggtttgg       c.*720

          .         .         .         .         .         .       g.77732
 gaaggcagacacctggttctagaactagctctgcccttagccccctgtatgaccctatgc       c.*780

          .         .         .         .         .         .       g.77792
 aagtcctcctccctcatctcaaagggtcctcaaagctctgacgatctaagatacaatgaa       c.*840

          .         .         .         .         .         .       g.77852
 gccattttccccctgataagatgaggtaaagccaatgtaaccaaaaggcaaaaattacaa       c.*900

          .         .         .         .         .         .       g.77912
 tcggttcaaaggaactttgatgcagacaaaatgctgctgctgctgctcctgaaataccca       c.*960

          .         .         .         .         .         .       g.77972
 cccctttccactacgggtgggttcccaaggacatgggacaggcaaagtgtgagccaaagg       c.*1020

          .         .         .         .         .         .       g.78032
 atccttccttattcctaagcagagcatctgctctgggccctggcctccttcccttcttgg       c.*1080

          .         .         .         .         .         .       g.78092
 gaaactgggctgcatgaggtgggccctggtagtttgtaccccaggcccctatactcttcc       c.*1140

          .         .         .         .         .         .       g.78152
 ttcctatgtccacagctgaccccaagcagccgttccccgactcctcacccctgagcctca       c.*1200

          .         .         .         .         .         .       g.78212
 ccctgaactccctcatcttgcaaggccataagtgttttccaagcaaaatgcctctcccat       c.*1260

          .         .         .         .         .         .       g.78272
 cctctctcaggaagcttctagagactttatgccctccagagctccaagatataagccctc       c.*1320

          .         .         .         .         .         .       g.78332
 caagggatcagaagctccaagttcctgtcttctgttttatagaaattgatcttccctggg       c.*1380

          .         .         .         .         .         .       g.78392
 ggactttaactcttgacctgtatgcagctgttggagtaattccaggtctcttgaaaaaaa       c.*1440

          .         .         .         .         .         .       g.78452
 agaggaagataatggagaatgagaacatatatatatatatattaagccccaggctgaata       c.*1500

          .         .         .         .         .         .       g.78512
 ctcagggacagcaattcacagcctgcctctggttctataaacaagtcattctacctcttt       c.*1560

          .         .         .         .         .         .       g.78572
 gtgccctgctgtttattctgtaaggggaaggtggcaatgggacccagctccatcagacac       c.*1620

          .         .         .         .         .         .       g.78632
 ttgtcaagctagcagaaactccattttcaatgccaaagaagaactgtaatgctgttttgg       c.*1680

          .         .         .         .         .         .       g.78692
 aatcatcccaaggcatcccaagacaccatatcttcccatttcaagcactgcctgggcaca       c.*1740

          .         .         .         .         .         .       g.78752
 ccccaacatcccaggctgtggtggctcctgtgggaactacctagatgaagagagtatcat       c.*1800

          .         .         .         .         .         .       g.78812
 ttataccttctaggagctcctattgggagacatgaaacatatgtaattgactaccatgta       c.*1860

          .         .         .         .         .         .       g.78872
 atagaacaaaccctgccaagtgctgctttggaaagtcatggaggtaaaagaaagaccatt       c.*1920

          .         .         .         .         .         .       g.78932
 ctggtatgaaggttttgggggaggagatatcaatcaagaaggcttcccagaagaggtgac       c.*1980

          .         .         .         .         .         .       g.78992
 tggaccagagccttgtccacaggtaagacggaggaggccttccacatggagggagaacaa       c.*2040

          .         .         .         .         .         .       g.79052
 tagtaaatgtccactcaagatgtcctttattataccagctcctcccacaaaaacacatgt       c.*2100

          .         .         .         .         .         .       g.79112
 ccagtggactctttttctgggatcagaaccaacaccaaaaagagcttttctccttaaagt       c.*2160

          .         .         .         .         .         .       g.79172
 tagaattctaaacaggacttgaaatggcctcaaggtttgtgcacaaatactgacttctgg       c.*2220

          .         .         .         .         .         .       g.79232
 ctggacccagcttattctgtttatttctccaattgcaatttcatccttatcctgagaaaa       c.*2280

          .         .         .         .         .         .       g.79292
 tgtctaaataggccatggaacccaggcttccccgtgacctacaagcacttattagctgtg       c.*2340

          .         .         .         .         .         .       g.79352
 ccagctcctgcactgctgctaaggtccaagaaacccagatctctcacagagccatagaag       c.*2400

          .         .         .         .         .         .       g.79412
 cagagggctggagtatctgtgaggacaacaaccttgtctaacttcgcgacctcattcttg       c.*2460

          .         .         .         .         .         .       g.79472
 agcatttctactgatgagaaactcactacccccaattgcagctcattcaactttaaaatt       c.*2520

          .         .         .         .         .         .       g.79532
 gctgctttttgaatcactgattgtgaatattaatttaaaaaaataagtaagaaaatgttt       c.*2580

          .         .         .         .         .         .       g.79592
 taaatgtgctgcctctttaaaaggtctcctctttgtgcaaccaaaacccacctctctaga       c.*2640

          .         .         .         .         .         .       g.79652
 atacagtttgtataactgaagctataatttcataccatgagtgctgctgttagcaataat       c.*2700

          .         .         .         .         .         .       g.79712
 aatcatgcccggattttattaacaacagaagctgttgctcgtatgaaaaaacaaacatta       c.*2760

          .         .         .         .         .         .       g.79772
 gttctaataaacatctgcattgagtcaaagctccctgtttgtttgtatgtcttttatgca       c.*2820

          .         .         .         .         .         .       g.79832
 ctgatgattatagtgagttgctttcatttaccaacattttgttgtattcgtgtaggatca       c.*2880

          .         .         .         .         .         .       g.79892
 ctgtaccatgaagggagagagactatgatgggaagattgttgtagatacaaaagcatgtc       c.*2940

          .         .         .         .         .         .       g.79952
 ttaggtttttgggtcagttctgtttaaatacctgtcctattattcctgtaaattatcaaa       c.*3000

          .         .         .         .         .         .       g.80012
 atatcccagaatgtcaatgtttctgcatccacattacaattattaaatgccactcattta       c.*3060

          .         .         .         .         .         .       g.80072
 ttaaatttactattatcagtggcatttaataaatttgaatcatatgttcagtgtttggtt       c.*3120

          .         .         .         .         .         .       g.80132
 tagaaaatatggtgccatgtctatgagtggcctgttctggattggagtacatgccttctt       c.*3180

          .         .         .         .         .         .       g.80192
 tctgccttgagttaatcttactcaatggagaacaagaatcaaagaaacaccaccaccaag       c.*3240

          .         .         .         .         .         .       g.80252
 aagcccttcaagctagagttgggcaagagtcagggaggggaatgtagaccactcatatga       c.*3300

          .         .         .         .         .         .       g.80312
 cagaggtggaaaccaatcttggtctagaataagtctcaaaatcaaaagacttgaattcta       c.*3360

          .         .         .         .         .         .       g.80372
 gtgcagcgtaggttgactcccttatttatttaattttcccatctctacaccgctagaata       c.*3420

          .         .         .         .         .         .       g.80432
 acctctctcctgaggctgttgaatctgatgaattagcagataggaaagaacttagaaaat       c.*3480

          .         .         .         .         .         .       g.80492
 tataagttcactcaaatgtaaaaggttatatgggaaataatcaccactaacatttttgag       c.*3540

          .         .         .         .         .         .       g.80552
 tacttactatctgcttgttatacacattctctaatttaattttcacaagaaaattcatga       c.*3600

          .         .         .         .         .         .       g.80612
 aaggactatacttatcccccttttacaggtgagcaacctggagtgcagtgaagtgtaaaa       c.*3660

          .         .         .         .         .         .       g.80672
 tgtgggccgacttaggagcacaaataccccagcaacaatgagcactcttagtacacaggt       c.*3720

          .         .         .         .         .         .       g.80732
 cttggtttctaaaatatcatcatccgataaaaggaacacaggctctttgaagaaatgact       c.*3780

          .         .         .         .         .         .       g.80792
 gattccgggattggggcaagaaacacacaagctgagactggagcatcttgcagtcccaga       c.*3840

          .         .         .         .         .         .       g.80852
 aagtgaagaaacgctgaggatatgtcaaagggacacaggagccaaatgaaagagcttcca       c.*3900

          .         .         .         .         .         .       g.80912
 ctggccaaagctggaatgttgagcaacaaagcaacatagcattggataataacccaaagt       c.*3960

          .         .                                               g.80938
 ataaaataaatattcatgagtacata                                         c.*3986

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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