methionine adenosyltransferase II, alpha (MAT2A) - coding DNA reference sequence

(used for variant description)

(last modified February 14, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_005911.5 in the MAT2A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029183.1, covering MAT2A transcript NM_005911.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   ggccggattg       c.-301

 .         .         .         .         .         .                g.5070
 ccacggcacctcccgcggccgcgcagtgtggttcagcccggactccgcggggcgagctgc       c.-241

 .         .         .         .         .         .                g.5130
 ccttcctcccccgacccccgcgcaagtggtgcattggcgcgcggcgccgaggggcggggc       c.-181

 .         .         .         .         .         .                g.5190
 ccgagccgggcgcgcgcgggcgctgctctataaataccgggccgcaccgcccgctgcttc       c.-121

 .         .         .         .         .         .                g.5250
 gttcgctccgcgccgcccgcctgctacgagtagaacgctgtccgcagcttgcgcatttcg       c.-61

 .         .         .         .         .         .                g.5310
 cagccgctgccgcctcgccgctgctccttcgtaaggccacttccgcacaccgacaccaac       c.-1

          .         .         .         .         .         .       g.5370
 ATGAACGGACAGCTCAACGGCTTCCACGAGGCGTTCATCGAGGAGGGCACATTCCTTTTC       c.60
 M  N  G  Q  L  N  G  F  H  E  A  F  I  E  E  G  T  F  L  F         p.20

          .         .         .  | 02      .         .         .    g.7134
 ACCTCAGAGTCGGTCGGGGAAGGCCACCCAG | ATAAGATTTGTGACCAAATCAGTGATGCT    c.120
 T  S  E  S  V  G  E  G  H  P  D |   K  I  C  D  Q  I  S  D  A      p.40

          .         .         .         .          | 03        .    g.7288
 GTCCTTGATGCCCACCTTCAGCAGGATCCTGATGCCAAAGTAGCTTGTG | AAACTGTTGCT    c.180
 V  L  D  A  H  L  Q  Q  D  P  D  A  K  V  A  C  E |   T  V  A      p.60

          .         .         .         .         .         .       g.7348
 AAAACTGGAATGATCCTTCTTGCTGGGGAAATTACATCCAGAGCTGCTGTTGACTACCAG       c.240
 K  T  G  M  I  L  L  A  G  E  I  T  S  R  A  A  V  D  Y  Q         p.80

          .         .         .         .         .   | 04     .    g.7663
 AAAGTGGTTCGTGAAGCTGTTAAACACATTGGATATGATGATTCTTCCAAAG | GTTTTGAC    c.300
 K  V  V  R  E  A  V  K  H  I  G  Y  D  D  S  S  K  G |   F  D      p.100

          .         .         .         .         .         .       g.7723
 TACAAGACTTGTAACGTGCTGGTAGCCTTGGAGCAACAGTCACCAGATATTGCTCAAGGT       c.360
 Y  K  T  C  N  V  L  V  A  L  E  Q  Q  S  P  D  I  A  Q  G         p.120

          .         .         .         .      | 05  .         .    g.7866
 GTTCATCTTGACAGAAATGAAGAAGACATTGGTGCTGGAGACCAG | GGCTTAATGTTTGGC    c.420
 V  H  L  D  R  N  E  E  D  I  G  A  G  D  Q   | G  L  M  F  G      p.140

          .         .         .         .         .         .       g.7926
 TATGCCACTGATGAAACTGAGGAGTGTATGCCTTTAACCATTGTCTTGGCACACAAGCTA       c.480
 Y  A  T  D  E  T  E  E  C  M  P  L  T  I  V  L  A  H  K  L         p.160

          .         .         .         .         .         .       g.7986
 AATGCCAAACTGGCAGAACTACGCCGTAATGGCACTTTGCCTTGGTTACGCCCTGATTCT       c.540
 N  A  K  L  A  E  L  R  R  N  G  T  L  P  W  L  R  P  D  S         p.180

           | 06        .         .         .         .         .    g.8228
 AAAACTCAA | GTTACTGTGCAGTATATGCAGGATCGAGGTGCTGTGCTTCCCATCAGAGTC    c.600
 K  T  Q   | V  T  V  Q  Y  M  Q  D  R  G  A  V  L  P  I  R  V      p.200

          .         .         .         .         .         .       g.8288
 CACACAATTGTTATATCTGTTCAGCATGATGAAGAGGTTTGTCTTGATGAAATGAGGGAT       c.660
 H  T  I  V  I  S  V  Q  H  D  E  E  V  C  L  D  E  M  R  D         p.220

          .         .         .         .         .         .       g.8348
 GCCCTAAAGGAGAAAGTCATCAAAGCAGTTGTGCCTGCGAAATACCTTGATGAGGATACA       c.720
 A  L  K  E  K  V  I  K  A  V  V  P  A  K  Y  L  D  E  D  T         p.240

          .         .         .         .         | 07         .    g.8599
 ATCTACCACCTACAGCCAAGTGGCAGATTTGTTATTGGTGGGCCTCAG | GGTGATGCTGGT    c.780
 I  Y  H  L  Q  P  S  G  R  F  V  I  G  G  P  Q   | G  D  A  G      p.260

          .         .         .         .         .         .       g.8659
 TTGACTGGACGCAAAATCATTGTGGACACTTATGGCGGTTGGGGTGCTCATGGAGGAGGT       c.840
 L  T  G  R  K  I  I  V  D  T  Y  G  G  W  G  A  H  G  G  G         p.280

          .         .         .         .         .         .       g.8719
 GCCTTTTCAGGAAAGGATTATACCAAGGTCGACCGTTCAGCTGCTTATGCTGCTCGTTGG       c.900
 A  F  S  G  K  D  Y  T  K  V  D  R  S  A  A  Y  A  A  R  W         p.300

          .         .         .         .         .  | 08      .    g.8932
 GTGGCAAAATCCCTTGTTAAAGGAGGTCTGTGCCGGAGGGTTCTTGTTCAG | GTCTCTTAT    c.960
 V  A  K  S  L  V  K  G  G  L  C  R  R  V  L  V  Q   | V  S  Y      p.320

          .         .         .         .         .         .       g.8992
 GCTATTGGAGTTTCTCATCCATTATCTATCTCCATTTTCCATTATGGTACCTCTCAGAAG       c.1020
 A  I  G  V  S  H  P  L  S  I  S  I  F  H  Y  G  T  S  Q  K         p.340

          .         .         .         .         .         .       g.9052
 AGTGAGAGAGAGCTATTAGAGATTGTGAAGAAGAATTTCGATCTCCGCCCTGGGGTCATT       c.1080
 S  E  R  E  L  L  E  I  V  K  K  N  F  D  L  R  P  G  V  I         p.360

       | 09  .         .         .         .         .         .    g.9747
 GTCAG | GGATCTGGATCTGAAGAAGCCAATTTATCAGAGGACTGCAGCCTATGGCCACTTT    c.1140
 V  R  |  D  L  D  L  K  K  P  I  Y  Q  R  T  A  A  Y  G  H  F      p.380

          .         .         .         .                           g.9795
 GGTAGGGACAGCTTCCCATGGGAAGTGCCCAAAAAGCTTAAATATTGA                   c.1188
 G  R  D  S  F  P  W  E  V  P  K  K  L  K  Y  X                     p.395

          .         .         .         .         .         .       g.9855
 aagtgttagccttttttccccagacttgttggcgtaggctacagagaagccttcaagctc       c.*60

          .         .         .         .         .         .       g.9915
 tgagggaaagggccctccttcctaaattttcctgtcctctttcagctcctgaccagttgc       c.*120

          .         .         .         .         .         .       g.9975
 agtcactctagtcaatgacatgaattttagcttttgtgggggactgtaagttgggcttgc       c.*180

          .         .         .         .         .         .       g.10035
 tattctgtccctaggtgttttgttcaccattataatgaatttagtgagcataggtgatcc       c.*240

          .         .         .         .         .         .       g.10095
 atgtaactgcctagaaacaacactgtagtaaataatgctttgaaattgaacctttgtgcc       c.*300

          .         .         .         .         .         .       g.10155
 ctatcacccaacgctccaaagtcataattgcattgactttccccaccagatgctgaaaat       c.*360

          .         .         .         .         .         .       g.10215
 gtccttgtgatgtgcacgtaaagtacttgtagttccacttatagcctctgtctggcaatg       c.*420

          .         .         .         .         .         .       g.10275
 ccacagccctgtcagcatgaatttgtaatgtcttgagctctattatgaatgtgaagcctt       c.*480

          .         .         .         .         .         .       g.10335
 ccccttatcctccctgtaacttgatccatttctaattatgtagctctttgtcagggagtg       c.*540

          .         .         .         .         .         .       g.10395
 ttccctatccaatcaatcttgcatgtaacgcaagttcccagttggagctccagcctgaca       c.*600

          .         .         .         .         .         .       g.10455
 tcaaaaaaggcagttaccattaaaccatctccctggtgcttatgctcttaattgccacct       c.*660

          .         .         .         .         .         .       g.10515
 ctaacagcaccaaatcaaaatctctccactttcagctgtcttttggaggacgtacgtaat       c.*720

          .         .         .         .         .         .       g.10575
 aaggttttaatttagtaaaccaatcctatgcatggtttcagcactagccaaacctcacca       c.*780

          .         .         .         .         .         .       g.10635
 actcctagttctagaaaaacaggcacttggcagccttgtgatgtcatacagagaagtcac       c.*840

          .         .         .         .         .         .       g.10695
 agggcagtacctgagggtctgtaggttgcacactttggtaccagataacttttttttttc       c.*900

          .         .         .         .         .         .       g.10755
 tttataagaaagcctgagtactccacactgcacaataactcctcccagggttttaacttt       c.*960

          .         .         .         .         .         .       g.10815
 gttttattttcaaaaccaggtccaatgagctttctgaacagctggtgtagctacagagaa       c.*1020

          .         .         .         .         .         .       g.10875
 accagcttccttcagagagcagtgcttttggcggggaggaggaaatcccttcatacttga       c.*1080

          .         .         .         .         .         .       g.10935
 acgttttctaattgcttatttattgtattctggggtatggcgtaagtacagagaagccat       c.*1140

          .         .         .         .         .         .       g.10995
 cacctcagatggcagcttttaaaagattttttttttttctctcaacaccatgattccttt       c.*1200

          .         .         .         .         .         .       g.11055
 aacaacatgtttccagcattcccaggtaggccaaggtgtcctacagaaaaaccttgggtt       c.*1260

          .         .         .         .         .         .       g.11115
 agacctacagggggtctggctggtgttaacagaagggagggcagagctggtgcggctggc       c.*1320

          .         .         .         .         .         .       g.11175
 catggagaaagctgacttggctggtgtggtacagagaagccagcttgtttacatgcttat       c.*1380

          .         .         .         .         .         .       g.11235
 tccatgactgcttgccctaagcagaaagtgcctttcaggatctatttttggaggtttatt       c.*1440

          .         .         .         .         .         .       g.11295
 acgtatgtctggttctcaattccaacagtttaatgaagatctaaataaaatgctaggttc       c.*1500

                                                                    g.11303
 taccttaa                                                           c.*1508

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Methionine adenosyltransferase II, alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 12
©2004-2015 Leiden University Medical Center