MYC associated factor X (MAX) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2016)

This file was created to facilitate the description of sequence variants on transcript NM_002382.4 in the MAX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029830.1, covering MAX transcript NM_002382.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5176
                                    tgcgtgccgccgttgatccggtgct       c.-181

 .         .         .         .         .         .                g.5236
 gcagtgaggaggtggttcttgcccgtgttgtgtgtgtgtgtgagtgagagagcgagtgag       c.-121

 .         .         .         .         .         .                g.5296
 tgagtgagtgagtgtgtgtgtgggggggactcggcttgttgttgtcggtgacttccccct       c.-61

 .         .         .         .         .         .                g.5356
 ccccttcaccccttcccctccccgccgccgctgcagtggccgctccctgggccgtaggaa       c.-1

          .         .         .       | 02 .         .         .    g.6147
 ATGAGCGATAACGATGACATCGAGGTGGAGAGCGAC | GAAGAGCAACCGAGGTTTCAATCT    c.60
 M  S  D  N  D  D  I  E  V  E  S  D   | E  E  Q  P  R  F  Q  S      p.20

     | 03    .         .         .         .         .         .    g.13937
 GCG | GCTGACAAACGGGCTCATCATAATGCACTGGAACGAAAACGTAGGGACCACATCAAA    c.120
 A   | A  D  K  R  A  H  H  N  A  L  E  R  K  R  R  D  H  I  K      p.40

          .         .         .         .         .  | 04      .    g.29668
 GACAGCTTTCACAGTTTGCGGGACTCAGTCCCATCACTCCAAGGAGAGAAG | GCATCCCGG    c.180
 D  S  F  H  S  L  R  D  S  V  P  S  L  Q  G  E  K   | A  S  R      p.60

          .         .         .         .         .         .       g.29728
 GCCCAAATCCTAGACAAAGCCACAGAATATATCCAGTATATGCGAAGGAAAAACCACACA       c.240
 A  Q  I  L  D  K  A  T  E  Y  I  Q  Y  M  R  R  K  N  H  T         p.80

          .         .         .         .         .      | 05  .    g.31037
 CACCAGCAAGATATTGACGACCTCAAGCGGCAGAATGCTCTTCTGGAGCAGCAAG | TCCGT    c.300
 H  Q  Q  D  I  D  D  L  K  R  Q  N  A  L  L  E  Q  Q  V |   R      p.100

          .         .         .         .         .         .       g.31097
 GCACTGGAGAAGGCGAGGTCAAGTGCCCAACTGCAGACCAACTACCCCTCCTCAGACAAC       c.360
 A  L  E  K  A  R  S  S  A  Q  L  Q  T  N  Y  P  S  S  D  N         p.120

          .         .         .         .         .         .       g.31157
 AGCCTCTACACCAACGCCAAGGGCAGCACCATCTCTGCCTTCGATGGGGGCTCGGACTCC       c.420
 S  L  Y  T  N  A  K  G  S  T  I  S  A  F  D  G  G  S  D  S         p.140

          .         .         .         .         .         .       g.31217
 AGCTCGGAGTCTGAGCCTGAAGAGCCCCAAAGCAGGAAGAAGCTCCGGATGGAGGCCAGC       c.480
 S  S  E  S  E  P  E  E  P  Q  S  R  K  K  L  R  M  E  A  S         p.160

                                                                    g.31220
 TAA                                                                c.483
 X                                                                  p.160

          .         .         .         .         .         .       g.31280
 gccactcggggcaggccagcaataaaaactgtctgtctccatcgtctcatcctcctttca       c.*60

          .         .         .         .         .         .       g.31340
 gttcgttggtagagccctcagaaccatttaagagactctttatttttctctttctccctt       c.*120

          .         .         .         .         .         .       g.31400
 ttttttttaaatttttatttttacgtagaagctcttggacaacagctctcgttctccttc       c.*180

          .         .         .         .         .         .       g.31460
 cccatttccactgtatattttttaatgtattcccttcagggattccctgtccccaacagg       c.*240

          .         .         .         .         .         .       g.31520
 aatttttaaaccaaaacaccccaacttggcagctttttctgtggaggacagacggccggc       c.*300

          .         .         .         .         .         .       g.31580
 cggacctctgagcacatagtgtcctgcccaccctaccagctcctccagccctgccgggca       c.*360

          .         .         .         .         .         .       g.31640
 catgcccgggggacgcctgccctgcccaggtggcctcctggcccgccctcacctctgata       c.*420

          .         .         .         .         .         .       g.31700
 gactttgtgaatctgaactgctctactttgagaagatgaccggtttggagtaatcagaat       c.*480

          .         .         .         .         .         .       g.31760
 gaaccctcctcctttttaagggttttttttttttcctttttctaaaaagctatgtatcgc       c.*540

          .         .         .         .         .         .       g.31820
 tcctattgaaagaccagatccttagagaagtttgtggtataaaaaggaagtggggacaga       c.*600

          .         .         .         .         .         .       g.31880
 ttcgcagcacagagtcgctggcatgtttcactcctgcttctctcagccagctgtttaagc       c.*660

          .         .         .         .         .         .       g.31940
 ctgcggcgccagcctcacggagggccgtgtgacactctcgtggtatgtatgggagatggc       c.*720

          .         .         .         .         .         .       g.32000
 agcagtgaagcagcagccaccagggagtggccatttggggttgggacagggagggtgttt       c.*780

          .         .         .         .         .         .       g.32060
 tgggtggcatagaggttttgtattgagggccagtgatgatgttttgatatttatttcctg       c.*840

          .         .         .         .         .         .       g.32120
 ctacttaaatttgaatctgagtgaattgtacctatttctgatgatgtcggtcttgcaaag       c.*900

          .         .         .         .         .         .       g.32180
 cgacagattcataaagtaatgatgaaatctttctttcttcccgtgtgtatttctaagaaa       c.*960

          .         .         .         .         .         .       g.32240
 tagagccaactgattttgtatgtaaataccaagagcaatttacctggtactaaacccgca       c.*1020

          .         .         .         .         .         .       g.32300
 ccccagtgcggacccttcccagccctcatcccacttcctttcctactgtcctggaacctg       c.*1080

          .         .         .         .         .         .       g.32360
 tctccattgtgtgatccagccctggttctggctgtggtcagcagatgccagtgaagggtt       c.*1140

          .         .         .         .         .         .       g.32420
 ttgtgtgtttaggcctcatttctttgtctttttcctactccgttcctggcatttgctgat       c.*1200

          .         .         .         .         .         .       g.32480
 ttctagtgtatactctgtagtctcagttcgtgtttgattccattccatggaaataaaaag       c.*1260

          .         .         .         .         .         .       g.32540
 tatgttgtacatactgccgaagaattgtcttgcaagttaaggcttccccctttactataa       c.*1320

          .         .         .                                     g.32572
 gactataaataaaaacttattttatccttctt                                   c.*1352

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The MYC associated factor X protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.