methylcrotonoyl-CoA carboxylase 2 (beta) (MCCC2) - coding DNA reference sequence

(used for variant description)

(last modified August 29, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_022132.4 in the MCCC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008882.1, covering MCCC2 transcript NM_022132.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           acaggcctgagaatcaga       c.-121

 .         .         .         .         .         .                g.5078
 gaaaccttctctggggctgcaaggacctgagctcagcttccgccccagccagggaagcgg       c.-61

 .         .         .         .         .         .                g.5138
 caggggaaagcaccggctccaggccagcgtgggccgctctctcgctcggtgcccgccgcc       c.-1

          .         .         .         .         .         .       g.5198
 ATGTGGGCCGTCCTGAGGTTAGCCCTGCGGCCGTGTGCCCGCGCCTCTCCCGCCGGGCCG       c.60
 M  W  A  V  L  R  L  A  L  R  P  C  A  R  A  S  P  A  G  P         p.20

          .         .         .         .         .         .       g.5258
 CGCGCCTATCACGGGGACTCGGTGGCCTCGCTGGGCACCCAGCCGGACTTGGGCTCTGCC       c.120
 R  A  Y  H  G  D  S  V  A  S  L  G  T  Q  P  D  L  G  S  A         p.40

           | 02        .         .         .         .         .    g.10689
 CTCTACCAG | GAGAACTACAAGCAGATGAAAGCACTAGTAAATCAGCTCCATGAACGAGTG    c.180
 L  Y  Q   | E  N  Y  K  Q  M  K  A  L  V  N  Q  L  H  E  R  V      p.60

          .       | 03 .         .         .         .         .    g.14036
 GAGCATATAAAACTAG | GAGGTGGTGAGAAAGCCCGAGCACTTCACATATCAAGAGGAAAA    c.240
 E  H  I  K  L  G |   G  G  E  K  A  R  A  L  H  I  S  R  G  K      p.80

          .         .         .         .  | 04      .         .    g.17390
 CTATTGCCCAGAGAAAGAATTGACAATCTCATAGACCCAGG | GTCTCCATTTCTGGAATTA    c.300
 L  L  P  R  E  R  I  D  N  L  I  D  P  G  |  S  P  F  L  E  L      p.100

          .         .         .         .         .         .       g.17450
 TCCCAGTTTGCAGGTTACCAGTTATATGACAATGAGGAGGTGCCAGGAGGTGGCATTATT       c.360
 S  Q  F  A  G  Y  Q  L  Y  D  N  E  E  V  P  G  G  G  I  I         p.120

          .         .    | 05    .         .         .         .    g.20255
 ACAGGCATTGGAAGAGTATCAGG | AGTAGAATGCATGATTATTGCCAATGATGCCACCGTC    c.420
 T  G  I  G  R  V  S  G  |  V  E  C  M  I  I  A  N  D  A  T  V      p.140

          .         .         .         .         .         .       g.20315
 AAAGGAGGTGCCTACTACCCAGTGACTGTGAAAAAACAATTACGGGCCCAAGAAATTGCC       c.480
 K  G  G  A  Y  Y  P  V  T  V  K  K  Q  L  R  A  Q  E  I  A         p.160

          .         .         .  | 06      .         .         .    g.22097
 ATGCAAAACAGGCTCCCCTGCATCTACTTAG | TTGATTCGGGAGGAGCATACTTACCTCGA    c.540
 M  Q  N  R  L  P  C  I  Y  L  V |   D  S  G  G  A  Y  L  P  R      p.180

          .         .         .         .         .         .       g.22157
 CAAGCAGATGTGTTTCCAGATCGAGACCACTTTGGCCGTACATTCTATAATCAGGCAATT       c.600
 Q  A  D  V  F  P  D  R  D  H  F  G  R  T  F  Y  N  Q  A  I         p.200

          .         .     | 07   .         .         .         .    g.44388
 ATGTCTTCTAAAAATATTGCACAG | ATCGCAGTGGTCATGGGCTCCTGCACCGCAGGAGGA    c.660
 M  S  S  K  N  I  A  Q   | I  A  V  V  M  G  S  C  T  A  G  G      p.220

          .         .         .         .         .         .       g.44448
 GCCTATGTGCCTGCCATGGCTGATGAAAACATCATTGTACGCAAGCAGGGTACCATTTTC       c.720
 A  Y  V  P  A  M  A  D  E  N  I  I  V  R  K  Q  G  T  I  F         p.240

          .         | 08         .         .         .         .    g.49875
 TTGGCAGGACCCCCCTTG | GTTAAAGCGGCAACTGGGGAAGAAGTATCTGCTGAGGATCTT    c.780
 L  A  G  P  P  L   | V  K  A  A  T  G  E  E  V  S  A  E  D  L      p.260

          .         .    | 09    .         .         .         .    g.52692
 GGAGGTGCTGATCTTCATTGCAG | AAAGTCTGGAGTAAGTGACCACTGGGCTTTGGATGAT    c.840
 G  G  A  D  L  H  C  R  |  K  S  G  V  S  D  H  W  A  L  D  D      p.280

          .         .         .         .         .         .       g.52752
 CATCATGCCCTTCACTTAACTAGGAAGGTTGTGAGGAATCTAAATTATCAGAAGAAATTG       c.900
 H  H  A  L  H  L  T  R  K  V  V  R  N  L  N  Y  Q  K  K  L         p.300

     | 10    .         .         .         .         .         .    g.52920
 GAT | GTCACCATTGAACCTTCTGAAGAGCCTTTATTTCCTGCTGATGAATTGTATGGAATA    c.960
 D   | V  T  I  E  P  S  E  E  P  L  F  P  A  D  E  L  Y  G  I      p.320

          .         .         .          | 11        .         .    g.58736
 GTTGGTGCTAACCTTAAGAGGAGCTTTGATGTCCGAGAG | GTCATTGCTAGAATCGTGGAT    c.1020
 V  G  A  N  L  K  R  S  F  D  V  R  E   | V  I  A  R  I  V  D      p.340

          .         .         .         .         .   | 12     .    g.61539
 GGAAGCAGATTCACTGAGTTCAAAGCCTTTTATGGAGACACATTAGTTACAG | GATTTGCT    c.1080
 G  S  R  F  T  E  F  K  A  F  Y  G  D  T  L  V  T  G |   F  A      p.360

          .         .         .         .         .         .       g.61599
 CGAATATTTGGGTACCCAGTAGGTATCGTTGGAAACAACGGAGTTCTCTTTTCTGAATCT       c.1140
 R  I  F  G  Y  P  V  G  I  V  G  N  N  G  V  L  F  S  E  S         p.380

           | 13        .         .         .         .         .    g.63974
 GCAAAAAAG | GGTACTCACTTTGTCCAGTTATGCTGCCAAAGAAATATTCCTCTGCTGTTC    c.1200
 A  K  K   | G  T  H  F  V  Q  L  C  C  Q  R  N  I  P  L  L  F      p.400

          .       | 14 .         .         .         .         .    g.66853
 CTTCAAAACATTACTG | GATTTATGGTTGGTAGAGAGTATGAAGCTGAAGGAATTGCCAAG    c.1260
 L  Q  N  I  T  G |   F  M  V  G  R  E  Y  E  A  E  G  I  A  K      p.420

          .         .         .         .         .         .       g.66913
 GATGGTGCCAAGATGGTGGCCGCTGTGGCCTGTGCCCAAGTGCCTAAGATAACCCTCATC       c.1320
 D  G  A  K  M  V  A  A  V  A  C  A  Q  V  P  K  I  T  L  I         p.440

          .         .         .         .         .    | 15    .    g.67788
 ATTGGGGGCTCCTATGGAGCCGGAAACTATGGGATGTGTGGCAGAGCATATAG | CCCAAGA    c.1380
 I  G  G  S  Y  G  A  G  N  Y  G  M  C  G  R  A  Y  S  |  P  R      p.460

          .         .         .         .         .         .       g.67848
 TTTCTCTACATTTGGCCAAATGCTCGTATCTCAGTGATGGGAGGAGAGCAGGCAGCCAAT       c.1440
 F  L  Y  I  W  P  N  A  R  I  S  V  M  G  G  E  Q  A  A  N         p.480

          .         .         .         .         | 16         .    g.70393
 GTGTTGGCCACGATAACAAAGGACCAAAGAGCCCGGGAAGGAAAGCAG | TTCTCCAGTGCT    c.1500
 V  L  A  T  I  T  K  D  Q  R  A  R  E  G  K  Q   | F  S  S  A      p.500

          .         .         .         .         .         .       g.70453
 GATGAAGCGGCTTTAAAAGAGCCCATCATTAAGAAGTTTGAAGAGGAAGGAAACCCTTAC       c.1560
 D  E  A  A  L  K  E  P  I  I  K  K  F  E  E  E  G  N  P  Y         p.520

          .     | 17   .         .         .         .         .    g.74501
 TATTCCAGCGCAAG | GGTATGGGATGATGGGATCATTGATCCAGCAGACACCAGACTGGTC    c.1620
 Y  S  S  A  R  |  V  W  D  D  G  I  I  D  P  A  D  T  R  L  V      p.540

          .         .         .         .         .         .       g.74561
 TTGGGTCTCAGTTTTAGTGCAGCCCTCAACGCACCAATAGAGAAGACTGACTTCGGTATC       c.1680
 L  G  L  S  F  S  A  A  L  N  A  P  I  E  K  T  D  F  G  I         p.560

          .                                                         g.74573
 TTCAGGATGTAA                                                       c.1692
 F  R  M  X                                                         p.563

          .         .         .         .         .         .       g.74633
 ctggaataaaggatgttttctgttggacatgtactgaaaattaacacatgtagtagcctt       c.*60

          .         .         .         .         .         .       g.74693
 aaaattttagacttctcgaacatgaggctgttacagtaatttttttaacactgtgcattg       c.*120

          .         .         .         .         .         .       g.74753
 tacttttctaccttaaaaaaatcagtgaggatatttatttaatgaacatcaattcctttt       c.*180

          .         .         .         .         .         .       g.74813
 aaattttcttagagaaatttctctgtggctcagttttaccacccataaagcggagacagt       c.*240

          .         .         .         .         .         .       g.74873
 aatttacggttatcctttctgacccacaaagtatgaaaagttctgtaatctgtaaactca       c.*300

          .         .         .         .         .         .       g.74933
 gttctgtaatctgtattattgagatgattaatataaagttgtattttcactgaaatgatt       c.*360

          .         .         .         .         .         .       g.74993
 gttttgctggttatgcttggtgatattttagcgggcttatttttgaaaggcatctgttac       c.*420

          .         .         .         .         .         .       g.75053
 ttcagtggcataaagtgccctcacactgctgtgcagccatcaccaccattcatctccaga       c.*480

          .         .         .         .         .         .       g.75113
 atttgttctcagtcccaaactgaaactataccattcaaacaacagcgctccccatttccc       c.*540

          .         .         .         .         .         .       g.75173
 cctcccccgagcccatgacatctccttattattattttttttttgagacagggtgtttct       c.*600

          .         .         .         .         .         .       g.75233
 ctgttgcccaggctggagtgcggtggtgtgatctcggctcactgcagcttccacctcccg       c.*660

          .         .         .         .         .         .       g.75293
 ggttcaagcgattcttgtgcctcagcctcccaagcagctgggactataggcacgcaccac       c.*720

          .         .         .         .         .         .       g.75353
 cacacccagctaagttctgtatttttagcagagacgggatttcactaggttgcccaggct       c.*780

          .         .         .         .         .         .       g.75413
 ggtctcaaactactgacctcaagtgatccacccgcctcggcctcccaaagtgctgggatt       c.*840

          .         .         .         .         .         .       g.75473
 acaggtgtgagccaccgcgcctgaccacatctccttattcttaaatgtatgtgtttctca       c.*900

          .         .         .         .         .         .       g.75533
 tggtttgatttattcttgctgggccatttcagcccctgtcatggcttcactcgccatcta       c.*960

          .         .         .         .         .         .       g.75593
 aatgcagatgattactgccttgacggttcttaacccagctctcccctgagctgcaggcct       c.*1020

          .         .         .         .         .         .       g.75653
 gcatatccagtaggtctactggacatctgtactggttgttgtggaggaacctctggcttg       c.*1080

          .         .         .         .         .         .       g.75713
 ctcattaagtcctactgattttcactatcccctgaatttccccacttatttttgtctttc       c.*1140

          .         .         .         .         .         .       g.75773
 actatcgcaggccttagaagaggtctacctgcctccagtcttacctagtccagtctaccc       c.*1200

          .         .         .         .         .         .       g.75833
 cctggagttagaatggccatcctgaagtgaaaagtaatgtcagattactcccttcagtga       c.*1260

          .         .         .         .         .         .       g.75893
 tttcttgtagaagtgccaatccctgaatgccaccaagatcttaatcttcacatctttaat       c.*1320

          .         .         .         .         .         .       g.75953
 cttatctctttgactcctctttacaccggagaacggctccagctgttctagctctctttc       c.*1380

          .         .         .         .         .         .       g.76013
 agttctttgaaccttcccaccttagggtctataaggttccctctgcccaaattgttctac       c.*1440

          .         .         .         .         .         .       g.76073
 tctcccttcttcttcaacacatccttcagtttaagcacttgcttctctcagtttaaactc       c.*1500

          .         .         .         .         .         .       g.76133
 cacttccttagggatgtctctgtgacctccctgtgctggattagcttccctactctatgc       c.*1560

          .         .         .         .         .         .       g.76193
 tcttgtaaaacactatctacttcctttgtcataaactcatcattttcctataaacattaa       c.*1620

          .         .         .         .         .         .       g.76253
 tattgtcctcctgctagaatgtaagctccgtgagagcaaggatcctcctgtttaccctgt       c.*1680

          .         .         .         .         .         .       g.76313
 acctccaatgtctggcacttgtaggtgctcaaatattcgttgaatgaatgaaaaatccat       c.*1740

          .         .         .         .         .         .       g.76373
 attgtaattgatgtcctctggccacatagttttaaaattaggtgattgattatatgaccg       c.*1800

          .         .         .         .                           g.76417
 aatagaactatcaaatgttttcctaataaagtcaatatttcaaa                       c.*1844

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Methylcrotonoyl-CoA carboxylase 2 (beta) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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