minichromosome maintenance complex component 5 (MCM5) - coding DNA reference sequence

(used for variant description)

(last modified October 26, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_006739.3 in the MCM5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering MCM5 transcript NM_006739.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           accgcctcttgtttttcccgcgaaactcggcggc       c.-61

 .         .         .         .         .         .  | 02          g.5316
 tgagcgtggaggttcttgtctcccctggtttgtgaagtgcggaaaaccagag | gcgcagtc    c.-1

          .         .         .         .         .         .       g.5376
 ATGTCGGGATTCGACGATCCTGGCATTTTCTACAGCGACAGCTTCGGGGGCGACGCCCAG       c.60
 M  S  G  F  D  D  P  G  I  F  Y  S  D  S  F  G  G  D  A  Q         p.20

          .         .         .         .         .         .       g.5436
 GCCGACGAGGGGCAGGCCCGCAAATCGCAGCTGCAGAGGCGCTTCAAGGAGTTCCTGCGG       c.120
 A  D  E  G  Q  A  R  K  S  Q  L  Q  R  R  F  K  E  F  L  R         p.40

          .         .         .         .        | 03.         .    g.8097
 CAGTACCGAGTGGGCACCGACCGCACGGGCTTCACCTTCAAATACAG | GGATGAACTCAAG    c.180
 Q  Y  R  V  G  T  D  R  T  G  F  T  F  K  Y  R  |  D  E  L  K      p.60

          .         .         .         .         .         .       g.8157
 CGGCATTACAACCTGGGGGAGTACTGGATTGAGGTGGAGATGGAGGATCTGGCCAGCTTT       c.240
 R  H  Y  N  L  G  E  Y  W  I  E  V  E  M  E  D  L  A  S  F         p.80

          .         .         .         .         .     | 04   .    g.8297
 GATGAGGACCTGGCCGACTACTTGTACAAGCAGCCAGCCGAGCACCTGCAGCTG | CTGGAG    c.300
 D  E  D  L  A  D  Y  L  Y  K  Q  P  A  E  H  L  Q  L   | L  E      p.100

          .         .         .         .         .         .       g.8357
 GAAGCTGCCAAGGAGGTAGCTGATGAGGTGACCCGGCCCCGGCCTTCTGGGGAGGAGGTG       c.360
 E  A  A  K  E  V  A  D  E  V  T  R  P  R  P  S  G  E  E  V         p.120

          .         .         .         .         .         .       g.8417
 CTCCAGGACATCCAGGTCATGCTCAAGTCGGACGCCAGCCCTTCCAGCATTCGTAGCCTG       c.420
 L  Q  D  I  Q  V  M  L  K  S  D  A  S  P  S  S  I  R  S  L         p.140

     | 05    .         .         .         .         .         .    g.11487
 AAG | TCGGACATGATGTCACACCTGGTGAAGATCCCTGGCATCATCATCGCGGCCTCTGCG    c.480
 K   | S  D  M  M  S  H  L  V  K  I  P  G  I  I  I  A  A  S  A      p.160

          .         .         .         .         .         .       g.11547
 GTCCGTGCCAAGGCCACCCGCATCTCTATCCAGTGCCGCAGCTGCCGCAACACCCTCACC       c.540
 V  R  A  K  A  T  R  I  S  I  Q  C  R  S  C  R  N  T  L  T         p.180

          .         .         .         .         .       | 06 .    g.13289
 AACATTGCCATGCGCCCTGGCCTCGAGGGCTATGCCCTGCCCAGGAAGTGCAACAC | AGAT    c.600
 N  I  A  M  R  P  G  L  E  G  Y  A  L  P  R  K  C  N  T  |  D      p.200

          .         .         .         .         .         .       g.13349
 CAGGCTGGGCGCCCCAAATGCCCATTGGACCCGTACTTCATCATGCCCGACAAATGCAAA       c.660
 Q  A  G  R  P  K  C  P  L  D  P  Y  F  I  M  P  D  K  C  K         p.220

          .         .         .         .         .         .       g.13409
 TGCGTGGACTTCCAGACCCTGAAGCTGCAGGAGCTGCCTGATGCAGTCCCCCACGGGGAG       c.720
 C  V  D  F  Q  T  L  K  L  Q  E  L  P  D  A  V  P  H  G  E         p.240

          .         .         .   | 07     .         .         .    g.15649
 ATGCCCAGACACATGCAGCTCTACTGCGACAG | GTACCTGTGTGACAAGGTCGTCCCTGGG    c.780
 M  P  R  H  M  Q  L  Y  C  D  R  |  Y  L  C  D  K  V  V  P  G      p.260

          .         .         .         .         .         .       g.15709
 AACAGGGTTACCATCATGGGCATCTACTCCATCAAGAAGTTTGGCCTGACTACCAGCAGG       c.840
 N  R  V  T  I  M  G  I  Y  S  I  K  K  F  G  L  T  T  S  R         p.280

          .         .         .         .         .         .       g.15769
 GGCCGTGACAGGGTGGGCGTGGGCATCCGAAGCTCCTACATCCGTGTCCTGGGCATCCAG       c.900
 G  R  D  R  V  G  V  G  I  R  S  S  Y  I  R  V  L  G  I  Q         p.300

          .          | 08        .         .         .         .    g.17428
 GTGGACACAGATGGCTCTG | GCCGCAGCTTTGCTGGGGCCGTGAGCCCCCAGGAGGAGGAG    c.960
 V  D  T  D  G  S  G |   R  S  F  A  G  A  V  S  P  Q  E  E  E      p.320

          .         .         .         .         .         .       g.17488
 GAGTTCCGTCGCCTGGCTGCCCTCCCAAATGTCTATGAGGTCATCTCCAAGAGCATCGCC       c.1020
 E  F  R  R  L  A  A  L  P  N  V  Y  E  V  I  S  K  S  I  A         p.340

          .         .         .         .         .         .       g.17548
 CCCTCCATCTTTGGGGGCACAGACATGAAGAAGGCCATTGCCTGCCTGCTCTTTGGGGGC       c.1080
 P  S  I  F  G  G  T  D  M  K  K  A  I  A  C  L  L  F  G  G         p.360

          .  | 09      .         .         .         .         .    g.18801
 TCCCGAAAGAG | GCTCCCTGATGGACTTACTCGCCGAGGAGACATCAACCTGCTGATGCTA    c.1140
 S  R  K  R  |  L  P  D  G  L  T  R  R  G  D  I  N  L  L  M  L      p.380

          .         .         .         .         .         .       g.18861
 GGGGACCCTGGGACAGCCAAGTCCCAGCTTCTGAAGTTTGTGGAGAAGTGTTCTCCCATT       c.1200
 G  D  P  G  T  A  K  S  Q  L  L  K  F  V  E  K  C  S  P  I         p.400

     | 10    .         .         .         .         .         .    g.20763
 GGG | GTATACACGTCTGGGAAAGGCAGCAGCGCAGCTGGACTGACAGCCTCGGTGATGAGG    c.1260
 G   | V  Y  T  S  G  K  G  S  S  A  A  G  L  T  A  S  V  M  R      p.420

          .         .         .         .         .         .       g.20823
 GACCCTTCGTCCCGGAATTTCATCATGGAGGGCGGAGCCATGGTCCTGGCCGATGGTGGG       c.1320
 D  P  S  S  R  N  F  I  M  E  G  G  A  M  V  L  A  D  G  G         p.440

          .         .        | 11.         .         .         .    g.21249
 GTCGTCTGTATTGACGAGTTTGACAAG | ATGCGAGAAGATGACCGTGTGGCAATCCACGAA    c.1380
 V  V  C  I  D  E  F  D  K   | M  R  E  D  D  R  V  A  I  H  E      p.460

          .         .         .    | 12    .         .         .    g.21542
 GCCATGGAGCAGCAGACCATCTCTATCGCCAAG | GCTGGGATCACCACCACCCTGAACTCC    c.1440
 A  M  E  Q  Q  T  I  S  I  A  K   | A  G  I  T  T  T  L  N  S      p.480

          .         .         .         .         .         .       g.21602
 CGCTGCTCCGTCCTGGCTGCTGCCAACTCAGTGTTCGGCCGCTGGGATGAGACGAAGGGG       c.1500
 R  C  S  V  L  A  A  A  N  S  V  F  G  R  W  D  E  T  K  G         p.500

          .         .         .         .         .         .       g.21662
 GAGGACAACATTGACTTCATGCCCACCATCTTGTCGCGCTTCGACATGATCTTCATCGTC       c.1560
 E  D  N  I  D  F  M  P  T  I  L  S  R  F  D  M  I  F  I  V         p.520

          .         .         . | 13       .         .         .    g.22651
 AAGGATGAGCACAATGAGGAGAGGGATGTG | ATGCTGGCCAAGCATGTCATCACTCTGCAC    c.1620
 K  D  E  H  N  E  E  R  D  V   | M  L  A  K  H  V  I  T  L  H      p.540

          .         .         .         .         .         .       g.22711
 GTGAGCGCACTGACACAGACACAGGCTGTGGAGGGCGAGATTGACCTGGCCAAGCTGAAG       c.1680
 V  S  A  L  T  Q  T  Q  A  V  E  G  E  I  D  L  A  K  L  K         p.560

          .         .    | 14    .         .         .         .    g.24798
 AAGTTTATTGCCTACTGCCGAGT | GAAGTGTGGCCCCCGGCTGTCAGCAGAGGCTGCAGAG    c.1740
 K  F  I  A  Y  C  R  V  |  K  C  G  P  R  L  S  A  E  A  A  E      p.580

          .         .         .         .         .         .       g.24858
 AAACTGAAGAACCGCTACATCATCATGCGGAGCGGGGCCCGTCAGCACGAGAGGGACAGT       c.1800
 K  L  K  N  R  Y  I  I  M  R  S  G  A  R  Q  H  E  R  D  S         p.600

          .         .         .   | 15     .         .         .    g.26223
 GACCGCCGCTCCAGCATCCCCATCACTGTGCG | GCAGCTGGAGGCCATTGTGCGCATCGCG    c.1860
 D  R  R  S  S  I  P  I  T  V  R  |  Q  L  E  A  I  V  R  I  A      p.620

          .         .         .         .         .         .       g.26283
 GAAGCCCTCAGCAAGATGAAGCTGCAGCCCTTCGCCACAGAGGCAGATGTGGAGGAGGCC       c.1920
 E  A  L  S  K  M  K  L  Q  P  F  A  T  E  A  D  V  E  E  A         p.640

          .         .         .         .         .      | 16  .    g.28096
 CTGCGGCTCTTCCAAGTGTCCACGTTGGATGCTGCCTTGTCCGGTACCCTGTCAG | GGGTG    c.1980
 L  R  L  F  Q  V  S  T  L  D  A  A  L  S  G  T  L  S  G |   V      p.660

          .         .         .         .         .         .       g.28156
 GAGGGCTTCACCAGCCAGGAGGACCAGGAGATGCTGAGCCGCATCGAGAAGCAGCTCAAG       c.2040
 E  G  F  T  S  Q  E  D  Q  E  M  L  S  R  I  E  K  Q  L  K         p.680

          .         .         .         .         .         .       g.28216
 CGCCGCTTTGCCATTGGCTCCCAGGTGTCTGAGCACAGCATCATCAAGGACTTCACCAAG       c.2100
 R  R  F  A  I  G  S  Q  V  S  E  H  S  I  I  K  D  F  T  K         p.700

     | 17    .         .         .         .         .         .    g.29088
 CAG | AAATACCCGGAGCACGCCATCCACAAGGTGCTGCAGCTCATGCTGCGGCGCGGCGAG    c.2160
 Q   | K  Y  P  E  H  A  I  H  K  V  L  Q  L  M  L  R  R  G  E      p.720

          .         .         .         .                           g.29133
 ATCCAGCATCGCATGCAGCGCAAGGTTCTCTACCGCCTCAAGTGA                      c.2205
 I  Q  H  R  M  Q  R  K  V  L  Y  R  L  K  X                        p.734

          .         .         .         .         .         .       g.29193
 gtcgcgccgcctcactggactcatggactcgcccacgcctcgcccctcctgccgctgcct       c.*60

          .         .         .         .         .         .       g.29253
 gccattgacaatgttgctgggacctctgcctccccactgcagccctcgaacttcccaggc       c.*120

          .         .         .         .         .         .       g.29313
 accctcctttctgccccagaggaaggagctgtagtgtcctgctgcctctgggcgcccgcc       c.*180

          .         .         .         .         .         .       g.29373
 tctagcgcggttctgggaagtgtgcttttggcatccgttaataataaagccacggtgtgt       c.*240

                                                                    g.29380
 tcaggta                                                            c.*247

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Minichromosome maintenance complex component 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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