minichromosome maintenance complex component 6 (MCM6) - coding DNA reference sequence

(used for variant description)

(last modified September 17, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_005915.5 in the MCM6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008958.1, covering MCM6 transcript NM_005915.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5016
         aagagggggcggggcggaagcggcggcggcgcgcgcaaagctgcagcgtctg       c.-61

 .         .         .         .         .         .                g.5076
 gaaaaaagcgacttgtggcggtcgagcgtggcgcaggcgaatcctcggcactaagcaaat       c.-1

          .         .         .         .         .         .       g.5136
 ATGGACCTCGCGGCGGCAGCGGAGCCGGGCGCCGGCAGCCAGCACCTGGAGGTCCGCGAC       c.60
 M  D  L  A  A  A  A  E  P  G  A  G  S  Q  H  L  E  V  R  D         p.20

          .         .         .         .        | 02.         .    g.8611
 GAGGTGGCCGAGAAGTGCCAGAAACTGTTCCTGGACTTCTTGGAGGA | GTTTCAGAGCAGC    c.120
 E  V  A  E  K  C  Q  K  L  F  L  D  F  L  E  E  |  F  Q  S  S      p.40

          .         .         .         .         .         .       g.8671
 GATGGAGAAATTAAATACTTGCAATTAGCAGAGGAACTGATTCGTCCTGAGAGAAACACA       c.180
 D  G  E  I  K  Y  L  Q  L  A  E  E  L  I  R  P  E  R  N  T         p.60

          .         .         .         .         .         .       g.8731
 TTGGTTGTGAGTTTTGTGGACCTGGAACAATTTAACCAGCAACTTTCCACCACCATTCAA       c.240
 L  V  V  S  F  V  D  L  E  Q  F  N  Q  Q  L  S  T  T  I  Q         p.80

          .     | 03   .         .         .         .         .    g.11126
 GAGGAGTTCTATAG | AGTTTACCCTTACCTGTGTCGGGCCTTGAAAACATTCGTCAAAGAC    c.300
 E  E  F  Y  R  |  V  Y  P  Y  L  C  R  A  L  K  T  F  V  K  D      p.100

          .         .         .         .         .         .       g.11186
 CGTAAAGAGATCCCTCTTGCCAAGGATTTTTATGTTGCATTCCAAGACCTGCCTACCAGA       c.360
 R  K  E  I  P  L  A  K  D  F  Y  V  A  F  Q  D  L  P  T  R         p.120

       | 04  .         .         .         .         .         .    g.12636
 CACAA | GATTCGAGAGCTCACCTCATCCAGAATTGGTTTGCTCACTCGCATCAGTGGGCAG    c.420
 H  K  |  I  R  E  L  T  S  S  R  I  G  L  L  T  R  I  S  G  Q      p.140

          .         .         .         .         .         .       g.12696
 GTGGTGCGGACTCACCCAGTTCACCCAGAGCTTGTGAGCGGAACTTTTCTGTGCTTGGAC       c.480
 V  V  R  T  H  P  V  H  P  E  L  V  S  G  T  F  L  C  L  D         p.160

          .         .         .         .         .         .       g.12756
 TGTCAGACAGTGATCAGGGATGTAGAACAGCAGTTCAAATACACACAGCCAAACATCTGC       c.540
 C  Q  T  V  I  R  D  V  E  Q  Q  F  K  Y  T  Q  P  N  I  C         p.180

          .         .         .         .         .         .       g.12816
 CGAAATCCAGTTTGTGCCAACAGGAGGAGATTCTTACTGGATACAAATAAATCAAGATTT       c.600
 R  N  P  V  C  A  N  R  R  R  F  L  L  D  T  N  K  S  R  F         p.200

          .      | 05  .         .         .         .         .    g.14758
 GTTGATTTTCAAAAG | GTTCGTATTCAAGAGACCCAAGCTGAGCTTCCTCGAGGGAGTATC    c.660
 V  D  F  Q  K   | V  R  I  Q  E  T  Q  A  E  L  P  R  G  S  I      p.220

          .         .         .         .         .         .       g.14818
 CCCCGCAGTTTAGAAGTAATTTTAAGGGCTGAAGCTGTGGAATCAGCTCAAGCTGGTGAC       c.720
 P  R  S  L  E  V  I  L  R  A  E  A  V  E  S  A  Q  A  G  D         p.240

          .         .         .         .         .         .       g.14878
 AAGTGTGACTTTACAGGGACACTGATTGTTGTGCCTGACGTCTCCAAGCTTAGCACACCA       c.780
 K  C  D  F  T  G  T  L  I  V  V  P  D  V  S  K  L  S  T  P         p.260

   | 06      .         .         .         .         .         .    g.15223
 G | GAGCACGTGCAGAAACTAATTCCCGTGTCAGTGGTGTTGATGGATATGAGACAGAAGGC    c.840
 G |   A  R  A  E  T  N  S  R  V  S  G  V  D  G  Y  E  T  E  G      p.280

          .         .         .         .         .         .       g.15283
 ATTCGAGGACTCCGGGCCCTTGGTGTTAGGGACCTTTCTTATAGGCTGGTCTTTCTTGCC       c.900
 I  R  G  L  R  A  L  G  V  R  D  L  S  Y  R  L  V  F  L  A         p.300

          .         .        | 07.         .         .         .    g.16311
 TGCTGTGTTGCGCCAACCAACCCAAGG | TTTGGGGGGAAAGAGCTCAGAGATGAGGAACAG    c.960
 C  C  V  A  P  T  N  P  R   | F  G  G  K  E  L  R  D  E  E  Q      p.320

          .         .         .         .         .         .       g.16371
 ACAGCTGAGAGCATTAAGAACCAAATGACTGTGAAAGAATGGGAGAAAGTGTTTGAGATG       c.1020
 T  A  E  S  I  K  N  Q  M  T  V  K  E  W  E  K  V  F  E  M         p.340

          .         .         .         .         .         | 08    g.18695
 AGTCAAGATAAAAATCTATACCACAATCTTTGTACCAGCCTGTTCCCTACTATACATG | GC    c.1080
 S  Q  D  K  N  L  Y  H  N  L  C  T  S  L  F  P  T  I  H  G |       p.360

          .         .         .         .         .         .       g.18755
 AATGATGAAGTAAAACGGGGTGTCCTGCTGATGCTCTTTGGTGGCGTTCCAAAGACAACA       c.1140
 N  D  E  V  K  R  G  V  L  L  M  L  F  G  G  V  P  K  T  T         p.380

          .         .         .         .         .         .       g.18815
 GGAGAAGGGACCTCTCTTCGAGGGGACATAAATGTTTGCATTGTTGGTGACCCAAGTACA       c.1200
 G  E  G  T  S  L  R  G  D  I  N  V  C  I  V  G  D  P  S  T         p.400

          .         . | 09       .         .         .         .    g.22039
 GCTAAGAGCCAATTTCTCAA | GCACGTGGAGGAGTTCAGCCCCAGAGCTGTCTACACCAGT    c.1260
 A  K  S  Q  F  L  K  |  H  V  E  E  F  S  P  R  A  V  Y  T  S      p.420

          .         .         .         .         .         .       g.22099
 GGTAAAGCGTCCAGTGCTGCTGGCTTAACAGCAGCTGTTGTGAGAGATGAAGAATCTCAT       c.1320
 G  K  A  S  S  A  A  G  L  T  A  A  V  V  R  D  E  E  S  H         p.440

          .         .         .         .   | 10     .         .    g.23455
 GAGTTTGTCATTGAGGCTGGAGCTTTGATGTTGGCTGATAAT | GGTGTGTGTTGTATTGAT    c.1380
 E  F  V  I  E  A  G  A  L  M  L  A  D  N   | G  V  C  C  I  D      p.460

          .         .         .         .         .         .       g.23515
 GAATTTGATAAGATGGACGTGCGGGATCAAGTTGCTATTCATGAAGCTATGGAACAGCAG       c.1440
 E  F  D  K  M  D  V  R  D  Q  V  A  I  H  E  A  M  E  Q  Q         p.480

          .         .         . | 11       .         .         .    g.24588
 ACCATATCCATCACTAAAGCAGGAGTGAAG | GCTACTCTGAACGCCCGGACGTCCATTTTG    c.1500
 T  I  S  I  T  K  A  G  V  K   | A  T  L  N  A  R  T  S  I  L      p.500

          .         .         .         .         .         .       g.24648
 GCAGCAGCAAACCCAATCAGTGGACACTATGACAGATCAAAATCATTGAAACAGAATATA       c.1560
 A  A  A  N  P  I  S  G  H  Y  D  R  S  K  S  L  K  Q  N  I         p.520

          .         .         .         .         .         .       g.24708
 AATTTGTCAGCTCCCATCATGTCCCGATTCGATCTCTTCTTTATCCTTGTGGATGAATGT       c.1620
 N  L  S  A  P  I  M  S  R  F  D  L  F  F  I  L  V  D  E  C         p.540

        | 12 .         .         .         .         .         .    g.28580
 AATGAG | GTTACAGATTATGCCATTGCCAGGCGCATAGTAGATTTGCATTCAAGAATTGAG    c.1680
 N  E   | V  T  D  Y  A  I  A  R  R  I  V  D  L  H  S  R  I  E      p.560

          .         .         .         .         .         .       g.28640
 GAATCAATTGATCGTGTCTATTCCCTCGATGATATCAGAAGATATCTTCTCTTTGCAAGA       c.1740
 E  S  I  D  R  V  Y  S  L  D  D  I  R  R  Y  L  L  F  A  R         p.580

          .      | 13  .         .         .         .         .    g.29923
 CAGTTTAAACCCAAG | ATTTCCAAAGAGTCAGAGGACTTCATTGTGGAGCAATATAAACAT    c.1800
 Q  F  K  P  K   | I  S  K  E  S  E  D  F  I  V  E  Q  Y  K  H      p.600

          .         .         .         .         .         .       g.29983
 CTCCGCCAGAGAGATGGTTCTGGAGTGACCAAGTCTTCATGGAGGATTACAGTGCGACAG       c.1860
 L  R  Q  R  D  G  S  G  V  T  K  S  S  W  R  I  T  V  R  Q         p.620

          .         .         .         .         .        | 14.    g.33256
 CTTGAGAGCATGATTCGTCTCTCTGAAGCTATGGCTCGGATGCACTGCTGTGATGAG | GTC    c.1920
 L  E  S  M  I  R  L  S  E  A  M  A  R  M  H  C  C  D  E   | V      p.640

          .         .         .         .         .         .       g.33316
 CAACCTAAACATGTGAAGGAAGCTTTCCGGTTACTGAATAAATCAATCATCCGTGTGGAA       c.1980
 Q  P  K  H  V  K  E  A  F  R  L  L  N  K  S  I  I  R  V  E         p.660

          .         .         .         .         .         .       g.33376
 ACACCTGATGTCAATCTAGATCAAGAGGAAGAGATCCAGATGGAGGTAGATGAGGGTGCT       c.2040
 T  P  D  V  N  L  D  Q  E  E  E  I  Q  M  E  V  D  E  G  A         p.680

          .    | 15    .         .         .         .         .    g.35096
 GGTGGCATCAATG | GTCATGCTGACAGCCCTGCTCCTGTGAACGGGATCAATGGCTACAAT    c.2100
 G  G  I  N  G |   H  A  D  S  P  A  P  V  N  G  I  N  G  Y  N      p.700

          .         .         .         .         .         .       g.35156
 GAAGACATAAATCAAGAGTCTGCTCCCAAAGCCTCCTTAAGGCTGGGCTTCTCTGAGTAC       c.2160
 E  D  I  N  Q  E  S  A  P  K  A  S  L  R  L  G  F  S  E  Y         p.720

          .         .         .         .          | 16        .    g.36768
 TGCCGAATCTCTAACCTTATTGTGCTTCACCTCAGAAAGGTGGAAGAAG | AAGAGGACGAG    c.2220
 C  R  I  S  N  L  I  V  L  H  L  R  K  V  E  E  E |   E  D  E      p.740

          .         .         .         .         .         .       g.36828
 TCAGCATTAAAGAGGAGCGAGCTTGTTAACTGGTACTTGAAGGAAATCGAATCAGAGATA       c.2280
 S  A  L  K  R  S  E  L  V  N  W  Y  L  K  E  I  E  S  E  I         p.760

          .         .         .         .         .         .       g.36888
 GACTCTGAAGAAGAACTTATAAATAAAAAAAGAATCATAGAGAAAGTTATTCATCGACTC       c.2340
 D  S  E  E  E  L  I  N  K  K  R  I  I  E  K  V  I  H  R  L         p.780

           | 17        .         .         .         .         .    g.40541
 ACACACTAT | GATCATGTTCTAATTGAGCTCACCCAGGCTGGATTGAAAGGCTCCACAGAG    c.2400
 T  H  Y   | D  H  V  L  I  E  L  T  Q  A  G  L  K  G  S  T  E      p.800

          .         .         .         .         .         .       g.40601
 GGAAGTGAGAGCTATGAAGAAGATCCCTACTTGGTAGTTAACCCTAACTACTTGCTCGAA       c.2460
 G  S  E  S  Y  E  E  D  P  Y  L  V  V  N  P  N  Y  L  L  E         p.820

                                                                    g.40607
 GATTGA                                                             c.2466
 D  X                                                               p.821

          .         .         .         .         .         .       g.40667
 gatagtgaaagtaactgaccagagctgaggaactgtggcacagcacctcgtggcctggag       c.*60

          .         .         .         .         .         .       g.40727
 cctggctggagctctgctagggacagaagtgtttctggaagtgatgcttccaggatttgt       c.*120

          .         .         .         .         .         .       g.40787
 tttcagaaacaagaattgagttgatggtcctatgtgtcacattcatcacaggtttcatac       c.*180

          .         .         .         .         .         .       g.40847
 caacacaggcttcagcacttcctttggtgtgtttcctgtcccagtgaagttggaaccaaa       c.*240

          .         .         .         .         .         .       g.40907
 taatgtgtagtctctataaccaatacctttgttttcatgtgtaagaaaaggcccattact       c.*300

          .         .         .         .         .         .       g.40967
 tttaaggtatgtgctgtcctattgagcaaataactttttttcaattgccagctactgctt       c.*360

          .         .         .         .         .         .       g.41027
 ttattcatcaaaataaaataacttgttctgaagttgtctattggatttctttctactgta       c.*420

          .         .         .         .         .         .       g.41087
 ccctgattattacttccatctacttctgaatgtgagactttccctttttgcttaacctgg       c.*480

          .         .         .         .         .         .       g.41147
 agtgaagaggtagaactgtggtattatggatgaggtttctatgagaaggagtcattagag       c.*540

          .         .         .         .         .         .       g.41207
 aactcatatgaaagctagaggccttagagatgactttccaaggttaattccagttgtttt       c.*600

          .         .         .         .         .         .       g.41267
 tttttttttttaagtttataaaagtttattatacttttttaaaattactctttagtaatt       c.*660

          .         .         .         .         .         .       g.41327
 tattttacttctgtgtcctaagggtaatttctcaggattgttttcaaattgcttttttag       c.*720

          .         .         .         .         .         .       g.41387
 gggaaataggtcatttgctatattacaagcaatccccaaattttatggtcttccaggaaa       c.*780

          .         .         .         .         .         .       g.41447
 agttattaccgtttatgatactaacagttcctgagacttagctatgatcagtatgttcat       c.*840

          .         .         .         .         .         .       g.41507
 gaggtggagcagttcctgtgttgcagcttttaacaacagatggcattcattaaatcacaa       c.*900

          .         .         .         .         .         .       g.41567
 agtatgttaaaggtcacaaaagcaaaataactgtctgaggctaaggcccacgtgggacag       c.*960

          .         .         .         .         .         .       g.41627
 tctaatacccatgagtactcaacttgccttgatgtctgagctttccagtgcaatgtgaat       c.*1020

          .         .         .         .         .         .       g.41687
 ttgagcagccagaaatctattagtagaaagcaagacagattaatataggttaaaacaatg       c.*1080

          .         .         .         .         .         .       g.41747
 atttaaatatgtttctcccaataattatctctttccctggaatcaacttgtatgaaacct       c.*1140

          .         .         .         .         .         .       g.41807
 tgtcaaaatgtactccacaagtatgtacaattaagtattttaaaaataaatggcaaacat       c.*1200

                                                                    g.41816
 taaaaacaa                                                          c.*1209

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Minichromosome maintenance complex component 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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