minichromosome maintenance complex component 7 (MCM7) - coding DNA reference sequence

(used for variant description)

(last modified April 25, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_005916.4 in the MCM7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering MCM7 transcript NM_005916.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.4910
               agtcccgtcagcttccggtagaagagctcggccacatcccggccgc       c.-601

 .         .         .         .         .         .                g.4970
 cactgtccccgcggactggcgggtggaaggactcagtgaaggatcctgcgacacaggctg       c.-541

 .         .         .         .         .         .                g.5030
 gccctgggcgcccctcccgcccggcccctccgccccttcccagccccaagggtctaggat       c.-481

 .         .         .         .         .         .                g.5090
 acagtctttgtagatgagcgggtcccccttggaggacagaatgaagaattgggaaatcat       c.-421

 .         .         .         .         .         .                g.5150
 ggccgttctggagagtagacaagaagacggcgaaagtcgggcctgccccgccctgcggcc       c.-361

 .         .         .         .         .         .                g.5210
 ccggaacaaaagaacgcgtgtgcgctggccctttaagagcgattctcctccgcccgcgcc       c.-301

 .         .         .         .         .         .                g.5270
 agctcggaccgcgggaaacccggcgcctgcactaccccgcccggagattcccttccgacg       c.-241

 .         .         .         .         .         .                g.5330
 cccgcaccgcctccccgtcactcattctaggcccgcacggtgattggcttgcggctagcg       c.-181

 .         .         .         .         .         .                g.5390
 ggaggtgaagaaggccgccttgtccgattggcccgcacgcagtggcgccggtcacgtggg       c.-121

 .         .         .         .         .         .                g.5450
 gggcgacgtttcgcgccaatttcggttggccggccacagtccaccgcgcggagattctca       c.-61

 .         .         .         .         .         .                g.5510
 gcttccccaggagcaagacctctgagcccgccaagcgcggccgcacggccctcggcagcg       c.-1

          .         .         .  | 02      .         .         .    g.6740
 ATGGCACTGAAGGACTACGCGCTAGAGAAGG | AAAAGGTTAAGAAGTTCTTACAAGAGTTC    c.60
 M  A  L  K  D  Y  A  L  E  K  E |   K  V  K  K  F  L  Q  E  F      p.20

          .         .         .         .         .  | 03      .    g.7060
 TACCAGGATGATGAACTCGGGAAGAAGCAGTTCAAGTATGGGAACCAGTTG | GTTCGGCTG    c.120
 Y  Q  D  D  E  L  G  K  K  Q  F  K  Y  G  N  Q  L   | V  R  L      p.40

          .         .         .         .         .         .       g.7120
 GCTCATCGGGAACAGGTGGCTCTGTATGTGGACCTGGACGACGTAGCCGAGGATGACCCC       c.180
 A  H  R  E  Q  V  A  L  Y  V  D  L  D  D  V  A  E  D  D  P         p.60

          .         .         .         .         .         .       g.7180
 GAGTTGGTGGACTCAATTTGTGAGAATGCCAGGCGCTACGCGAAGCTCTTTGCTGATGCC       c.240
 E  L  V  D  S  I  C  E  N  A  R  R  Y  A  K  L  F  A  D  A         p.80

          .         .         .       | 04 .         .         .    g.7425
 GTACAAGAGCTGCTGCCTCAGTACAAGGAGAGGGAA | GTGGTAAATAAAGATGTCCTGGAC    c.300
 V  Q  E  L  L  P  Q  Y  K  E  R  E   | V  V  N  K  D  V  L  D      p.100

          .         .         .         .         .         .       g.7485
 GTTTACATTGAGCATCGGCTAATGATGGAGCAGCGGAGTCGGGACCCTGGGATGGTCCGA       c.360
 V  Y  I  E  H  R  L  M  M  E  Q  R  S  R  D  P  G  M  V  R         p.120

          .         .         .         .  | 05      .         .    g.7620
 AGCCCCCAGAACCAGTACCCTGCTGAACTCATGCGCAGATT | TGAGCTGTATTTTCAAGGC    c.420
 S  P  Q  N  Q  Y  P  A  E  L  M  R  R  F  |  E  L  Y  F  Q  G      p.140

          .         .         .         .         .         .       g.7680
 CCTAGCAGCAACAAGCCTCGTGTGATCCGGGAAGTGCGGGCTGACTCTGTGGGGAAGTTG       c.480
 P  S  S  N  K  P  R  V  I  R  E  V  R  A  D  S  V  G  K  L         p.160

          .         .         .         .         .         .       g.7740
 GTAACTGTGCGTGGAATCGTCACTCGTGTCTCTGAAGTCAAACCCAAGATGGTGGTGGCC       c.540
 V  T  V  R  G  I  V  T  R  V  S  E  V  K  P  K  M  V  V  A         p.180

          .         .         .         .   | 06     .         .    g.8107
 ACTTACACTTGTGACCAGTGTGGGGCAGAGACCTACCAGCCG | ATCCAGTCTCCCACTTTC    c.600
 T  Y  T  C  D  Q  C  G  A  E  T  Y  Q  P   | I  Q  S  P  T  F      p.200

          .         .         .         .         .         .       g.8167
 ATGCCTCTGATCATGTGCCCAAGCCAGGAGTGCCAAACCAACCGCTCAGGAGGGCGGCTG       c.660
 M  P  L  I  M  C  P  S  Q  E  C  Q  T  N  R  S  G  G  R  L         p.220

          .         .         .         .         .         .       g.8227
 TATCTGCAGACACGGGGCTCCAGATTCATCAAATTCCAGGAGATGAAGATGCAAGAACAT       c.720
 Y  L  Q  T  R  G  S  R  F  I  K  F  Q  E  M  K  M  Q  E  H         p.240

  | 07       .         .         .         .         .         .    g.8574
  | AGTGATCAGGTGCCTGTGGGAAATATCCCTCGTAGTATCACGGTGCTGGTAGAAGGAGAG    c.780
  | S  D  Q  V  P  V  G  N  I  P  R  S  I  T  V  L  V  E  G  E      p.260

          .         .         .         .         .         .       g.8634
 AACACAAGGATTGCCCAGCCTGGAGACCACGTCAGCGTCACTGGTATTTTCTTGCCAATC       c.840
 N  T  R  I  A  Q  P  G  D  H  V  S  V  T  G  I  F  L  P  I         p.280

          .         .         . | 08       .         .         .    g.8886
 CTGCGCACTGGGTTCCGACAGGTGGTACAG | GGTTTACTCTCAGAAACCTACCTGGAAGCC    c.900
 L  R  T  G  F  R  Q  V  V  Q   | G  L  L  S  E  T  Y  L  E  A      p.300

          .         .         .         .         .         .       g.8946
 CATCGGATTGTGAAGATGAACAAGAGTGAGGATGATGAGTCTGGGGCTGGAGAGCTCACC       c.960
 H  R  I  V  K  M  N  K  S  E  D  D  E  S  G  A  G  E  L  T         p.320

          .         .      | 09  .         .         .         .    g.9094
 AGGGAGGAGCTGAGGCAAATTGCAG | AGGAGGATTTCTACGAAAAGCTGGCAGCTTCAATC    c.1020
 R  E  E  L  R  Q  I  A  E |   E  D  F  Y  E  K  L  A  A  S  I      p.340

          .         .         .         .         .         .       g.9154
 GCCCCAGAAATATACGGGCATGAAGATGTGAAGAAGGCACTGCTGCTCCTGCTAGTCGGG       c.1080
 A  P  E  I  Y  G  H  E  D  V  K  K  A  L  L  L  L  L  V  G         p.360

          .         .         .        | 10.         .         .    g.9443
 GGTGTGGACCAGTCTCCTCGAGGCATGAAAATCCGGG | GCAACATCAACATCTGTCTGATG    c.1140
 G  V  D  Q  S  P  R  G  M  K  I  R  G |   N  I  N  I  C  L  M      p.380

          .         .         .         .         .         .       g.9503
 GGGGATCCTGGTGTGGCCAAGTCTCAGCTCCTGTCATACATTGATCGACTGGCGCCTCGC       c.1200
 G  D  P  G  V  A  K  S  Q  L  L  S  Y  I  D  R  L  A  P  R         p.400

   | 11      .         .         .         .         .         .    g.10696
 A | GCCAGTACACAACAGGCCGGGGCTCCTCAGGAGTGGGGCTTACGGCAGCTGTGCTGAGA    c.1260
 S |   Q  Y  T  T  G  R  G  S  S  G  V  G  L  T  A  A  V  L  R      p.420

          .         .         .         .         .         .       g.10756
 GACTCCGTGAGTGGAGAACTGACCTTAGAGGGTGGGGCCCTGGTGCTGGCTGACCAGGGT       c.1320
 D  S  V  S  G  E  L  T  L  E  G  G  A  L  V  L  A  D  Q  G         p.440

          .         .         .         .         .         .       g.10816
 GTGTGCTGCATTGATGAGTTCGACAAGATGGCTGAGGCCGACCGCACAGCCATCCACGAG       c.1380
 V  C  C  I  D  E  F  D  K  M  A  E  A  D  R  T  A  I  H  E         p.460

          .         .         .         .         .         .       g.10876
 GTCATGGAGCAGCAGACCATCTCCATTGCCAAGGCCGGCATTCTCACCACACTCAATGCC       c.1440
 V  M  E  Q  Q  T  I  S  I  A  K  A  G  I  L  T  T  L  N  A         p.480

          .         .         .         .         .         .       g.10936
 CGCTGCTCCATCCTGGCTGCCGCCAACCCTGCCTACGGGCGCTACAACCCTCGCCGCAGC       c.1500
 R  C  S  I  L  A  A  A  N  P  A  Y  G  R  Y  N  P  R  R  S         p.500

          .         .         .         .         .         .       g.10996
 CTGGAGCAGAACATACAGCTACCTGCTGCACTGCTCTCCCGGTTTGACCTCCTCTGGCTG       c.1560
 L  E  Q  N  I  Q  L  P  A  A  L  L  S  R  F  D  L  L  W  L         p.520

          .         .         .      | 12  .         .         .    g.11359
 ATTCAGGACCGGCCCGACCGAGACAATGACCTACG | GTTGGCCCAGCACATCACCTATGTG    c.1620
 I  Q  D  R  P  D  R  D  N  D  L  R  |  L  A  Q  H  I  T  Y  V      p.540

          .         .         .         .         .          | 13    g.12464
 CACCAGCACAGCCGGCAGCCCCCCTCCCAGTTTGAACCTCTGGACATGAAGCTCATGAG | G    c.1680
 H  Q  H  S  R  Q  P  P  S  Q  F  E  P  L  D  M  K  L  M  R  |      p.560

          .         .         .         .         .         .       g.12524
 CGTTACATAGCCATGTGCCGCGAGAAGCAGCCCATGGTGCCAGAGTCTCTGGCTGACTAC       c.1740
 R  Y  I  A  M  C  R  E  K  Q  P  M  V  P  E  S  L  A  D  Y         p.580

          .         .         .         .         .         .       g.12584
 ATCACAGCAGCATACGTGGAGATGAGGCGAGAGGCTTGGGCTAGTAAGGATGCCACCTAT       c.1800
 I  T  A  A  Y  V  E  M  R  R  E  A  W  A  S  K  D  A  T  Y         p.600

          .         .         .         .         | 14         .    g.13415
 ACTTCTGCCCGGACCCTGCTGGCTATCCTGCGCCTTTCCACTGCTCTG | GCACGTCTGAGA    c.1860
 T  S  A  R  T  L  L  A  I  L  R  L  S  T  A  L   | A  R  L  R      p.620

          .         .         .         .         .         .       g.13475
 ATGGTGGATGTGGTGGAGAAAGAAGATGTGAATGAAGCCATCAGGCTAATGGAGATGTCA       c.1920
 M  V  D  V  V  E  K  E  D  V  N  E  A  I  R  L  M  E  M  S         p.640

          .         .         .         | 15         .         .    g.13693
 AAGGACTCTCTTCTAGGAGACAAGGGGCAGACAGCTAG | GACTCAGAGACCAGCAGATGTG    c.1980
 K  D  S  L  L  G  D  K  G  Q  T  A  R  |  T  Q  R  P  A  D  V      p.660

          .         .         .         .         .         .       g.13753
 ATATTTGCCACCGTCCGTGAACTGGTCTCAGGGGGCCGAAGTGTCCGGTTCTCTGAGGCA       c.2040
 I  F  A  T  V  R  E  L  V  S  G  G  R  S  V  R  F  S  E  A         p.680

          .         .         .         .         .         .       g.13813
 GAGCAGCGCTGTGTATCTCGTGGCTTCACACCCGCCCAGTTCCAGGCGGCTCTGGATGAA       c.2100
 E  Q  R  C  V  S  R  G  F  T  P  A  Q  F  Q  A  A  L  D  E         p.700

          .         .         .         .         .         .       g.13873
 TATGAGGAGCTCAATGTCTGGCAGGTCAATGCTTCCCGGACACGGATCACTTTTGTCTGA       c.2160
 Y  E  E  L  N  V  W  Q  V  N  A  S  R  T  R  I  T  F  V  X         p.719

          .         .         .         .         .         .       g.13933
 ttccagcctgcttgcaaccctggggtcctcttgttccctgctggcctgccccttgggaag       c.*60

          .         .         .         .         .         .       g.13993
 gggcagtgatgcctttgaggggaaggaggagcccctctttctcccatgctgcacttactc       c.*120

          .         .         .         .         .         .       g.14053
 cttttgctaataaaagtgtttgtagattgtcatcttctagcctgggcctgacttccatta       c.*180

          .         .                                               g.14077
 aaacagggttttgtgcgtttttta                                           c.*204

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Minichromosome maintenance complex component 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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