mediator complex subunit 12 (MED12) - coding DNA reference sequence

(used for variant description)

(last modified June 8, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_005120.2 in the MED12 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering MED12 transcript NM_005120.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          attgtccgatggttcccgg       c.-181

 .         .         .         .         .         .                g.5079
 cgtacctcggcttccctcggtagtttccggcaatggtcgagagtttctaacgtgccccct       c.-121

 .         .         .         .         .         .                g.5139
 tgttgtctctcggccgccgtcctctcaaccaccgccccccttttcggctccctctccccc       c.-61

 .         .         .         .         .         .                g.5199
 ttcccgttcccccagtcagcctggccctgctggtgcctccggcgctacgggctgggcaag       c.-1

          .         .         .         .         .         .       g.5259
 ATGGCGGCCTTCGGGATCTTGAGCTACGAACACCGGCCCCTGAAGCGGCCGCGGCTGGGG       c.60
 M  A  A  F  G  I  L  S  Y  E  H  R  P  L  K  R  P  R  L  G         p.20

          .         .         .          | 02        .         .    g.5838
 CCTCCCGATGTTTACCCTCAGGACCCCAAACAGAAGGAG | GATGAACTGACGGCCTTGAAT    c.120
 P  P  D  V  Y  P  Q  D  P  K  Q  K  E   | D  E  L  T  A  L  N      p.40

          .         .         .         .         .         .       g.5898
 GTAAAACAAGGTTTCAATAACCAGCCTGCTGTCTCTGGGGATGAGCATGGCAGTGCCAAG       c.180
 V  K  Q  G  F  N  N  Q  P  A  V  S  G  D  E  H  G  S  A  K         p.60

          .         .     | 03   .         .         .         .    g.6166
 AACGTCAGCTTCAATCCTGCCAAG | ATCAGTTCCAACTTCAGCAGCATTATTGCAGAGAAA    c.240
 N  V  S  F  N  P  A  K   | I  S  S  N  F  S  S  I  I  A  E  K      p.80

          .         .         .         .         .         .       g.6226
 TTACGTTGTAATACCCTTCCTGACACTGGTCGCAGGAAGCCCCAAGTGAACCAGAAGGAT       c.300
 L  R  C  N  T  L  P  D  T  G  R  R  K  P  Q  V  N  Q  K  D         p.100

          .         .         .         .         .         .       g.6286
 AACTTCTGGCTGGTGACTGCACGATCCCAGAGTGCCATTAACACTTGGTTCACTGACTTG       c.360
 N  F  W  L  V  T  A  R  S  Q  S  A  I  N  T  W  F  T  D  L         p.120

          .         .         .       | 04 .         .         .    g.6482
 GCTGGCACCAAGCCACTCACGCAACTAGCCAAAAAG | GTCCCCATTTTCAGTAAGAAGGAA    c.420
 A  G  T  K  P  L  T  Q  L  A  K  K   | V  P  I  F  S  K  K  E      p.140

          .         .         .         .         .         .       g.6542
 GAGGTGTTTGGGTACTTAGCCAAATACACAGTGCCTGTGATGCGGGCTGCCTGGCTCATT       c.480
 E  V  F  G  Y  L  A  K  Y  T  V  P  V  M  R  A  A  W  L  I         p.160

          .         .         .         .         .         .       g.6602
 AAGATGACCTGTGCCTACTATGCAGCAATCTCTGAGACCAAGGTTAAGAAGAGACATGTT       c.540
 K  M  T  C  A  Y  Y  A  A  I  S  E  T  K  V  K  K  R  H  V         p.180

          .    | 05    .         .         .         .         .    g.7462
 GACCCTTTCATGG | AATGGACTCAGATCATCACCAAGTACTTATGGGAGCAGTTACAGAAG    c.600
 D  P  F  M  E |   W  T  Q  I  I  T  K  Y  L  W  E  Q  L  Q  K      p.200

          .         .         .         .         .         .       g.7522
 ATGGCTGAATACTACCGGCCAGGGCCTGCAGGAAGTGGGGGCTGTGGTTCCACGATAGGG       c.660
 M  A  E  Y  Y  R  P  G  P  A  G  S  G  G  C  G  S  T  I  G         p.220

          .         .         .         .         .         .       g.7582
 CCCTTGCCCCATGATGTAGAGGTGGCAATCCGGCAGTGGGATTACACCGAGAAGCTGGCC       c.720
 P  L  P  H  D  V  E  V  A  I  R  Q  W  D  Y  T  E  K  L  A         p.240

          .      | 06  .         .         .         .         .    g.7816
 ATGTTCATGTTTCAG | GATGGAATGCTGGACAGACATGAGTTCCTGACCTGGGTGCTTGAG    c.780
 M  F  M  F  Q   | D  G  M  L  D  R  H  E  F  L  T  W  V  L  E      p.260

          .         .         .         .         .         .       g.7876
 TGTTTTGAGAAGATCCGCCCTGGAGAGGATGAATTGCTTAAACTGCTGCTGCCTCTGCTT       c.840
 C  F  E  K  I  R  P  G  E  D  E  L  L  K  L  L  L  P  L  L         p.280

        | 07 .         .         .         .         .         .    g.8060
 CTCCGA | TACTCTGGGGAATTTGTTCAGTCTGCATACCTGTCCCGCCGGCTTGCCTACTTC    c.900
 L  R   | Y  S  G  E  F  V  Q  S  A  Y  L  S  R  R  L  A  Y  F      p.300

          .         .         .         .         .         .       g.8120
 TGTACACGGAGACTGGCCCTGCAGCTGGATGGTGTGAGCAGTCACTCATCTCATGTTATA       c.960
 C  T  R  R  L  A  L  Q  L  D  G  V  S  S  H  S  S  H  V  I         p.320

          .         .         .         .         .         .       g.8180
 TCTGCTCAGTCAACAAGCACGCTACCCACCACCCCTGCTCCTCAGCCCCCAACTAGCAGC       c.1020
 S  A  Q  S  T  S  T  L  P  T  T  P  A  P  Q  P  P  T  S  S         p.340

          .         .         .         .         .         .       g.8240
 ACACCCTCGACTCCCTTTAGTGACCTGCTTATGTGCCCTCAGCACCGGCCCCTGGTTTTT       c.1080
 T  P  S  T  P  F  S  D  L  L  M  C  P  Q  H  R  P  L  V  F         p.360

          .         .  | 08      .         .         .         .    g.8683
 GGCCTCAGCTGTATCCTACAG | ACCATCCTCCTGTGCTGTCCTAGTGCCTTGGTTTGGCAC    c.1140
 G  L  S  C  I  L  Q   | T  I  L  L  C  C  P  S  A  L  V  W  H      p.380

          .         .         .         .         .         .       g.8743
 TACTCACTGACTGATAGCAGAATTAAGACCGGCTCACCACTTGACCACTTGCCTATTGCC       c.1200
 Y  S  L  T  D  S  R  I  K  T  G  S  P  L  D  H  L  P  I  A         p.400

          .         .         .         .         | 09         .    g.8964
 CCGTCCAACCTGCCCATGCCAGAGGGTAACAGTGCCTTCACTCAGCAG | GTCCGTGCAAAG    c.1260
 P  S  N  L  P  M  P  E  G  N  S  A  F  T  Q  Q   | V  R  A  K      p.420

          .         .         .         .         .         .       g.9024
 TTGCGGGAGATCGAGCAGCAGATCAAGGAGCGGGGACAGGCAGTTGAAGTTCGCTGGTCT       c.1320
 L  R  E  I  E  Q  Q  I  K  E  R  G  Q  A  V  E  V  R  W  S         p.440

          .         .         | 10         .         .         .    g.9214
 TTCGATAAATGCCAGGAAGCTACTGCAG | GCTTCACCATTGGACGGGTACTTCATACTTTG    c.1380
 F  D  K  C  Q  E  A  T  A  G |   F  T  I  G  R  V  L  H  T  L      p.460

          .         .         .         .         .         .       g.9274
 GAAGTGCTGGACAGCCATAGTTTTGAACGCTCTGACTTCAGCAACTCTCTTGACTCCCTT       c.1440
 E  V  L  D  S  H  S  F  E  R  S  D  F  S  N  S  L  D  S  L         p.480

          .         .         .         .      | 11  .         .    g.9554
 TGTAACCGAATCTTTGGATTGGGACCTAGCAAGGATGGGCATGAG | ATCTCCTCAGATGAT    c.1500
 C  N  R  I  F  G  L  G  P  S  K  D  G  H  E   | I  S  S  D  D      p.500

          .         .         .         .         .         .       g.9614
 GATGCTGTGGTGTCATTGCTATGTGAATGGGCTGTCAGCTGCAAGCGTTCTGGTCGGCAT       c.1560
 D  A  V  V  S  L  L  C  E  W  A  V  S  C  K  R  S  G  R  H         p.520

          .         .         .         .         .        | 12.    g.10041
 CGTGCTATGGTGGTAGCCAAGCTCCTGGAGAAGAGACAGGCGGAGATTGAGGCTGAG | CGT    c.1620
 R  A  M  V  V  A  K  L  L  E  K  R  Q  A  E  I  E  A  E   | R      p.540

          .         .         .         .         .         .       g.10101
 TGTGGAGAATCAGAAGCCGCAGATGAGAAGGGTTCCATCGCCTCTGGCTCCCTTTCTGCT       c.1680
 C  G  E  S  E  A  A  D  E  K  G  S  I  A  S  G  S  L  S  A         p.560

          .         .         .         .         .         .       g.10161
 CCCAGTGCTCCCATTTTCCAGGATGTCCTCCTGCAGTTTCTGGATACACAGGCTCCCATG       c.1740
 P  S  A  P  I  F  Q  D  V  L  L  Q  F  L  D  T  Q  A  P  M         p.580

      | 13   .         .         .         .         .         .    g.10659
 CTGA | CGGACCCTCGAAGTGAGAGTGAGCGGGTGGAATTCTTTAACTTAGTACTGCTGTTC    c.1800
 L  T |   D  P  R  S  E  S  E  R  V  E  F  F  N  L  V  L  L  F      p.600

          .         .         .         .         .         .       g.10719
 TGTGAACTGATTCGACATGATGTTTTCTCCCACAACATGTATACTTGCACTCTCATCTCC       c.1860
 C  E  L  I  R  H  D  V  F  S  H  N  M  Y  T  C  T  L  I  S         p.620

          .         .         .         .         .         .       g.10779
 CGAGGGGACCTTGCCTTTGGAGCCCCTGGTCCCCGGCCTCCCTCTCCCTTTGATGATCCT       c.1920
 R  G  D  L  A  F  G  A  P  G  P  R  P  P  S  P  F  D  D  P         p.640

          .         .         .         .         .     | 14   .    g.11214
 GCCGATGACCCAGAGCACAAGGAGGCTGAAGGCAGCAGCAGCAGCAAGCTGGAA | GATCCA    c.1980
 A  D  D  P  E  H  K  E  A  E  G  S  S  S  S  K  L  E   | D  P      p.660

          .         .         .         .         .         .       g.11274
 GGGCTCTCAGAATCTATGGACATTGACCCTAGTTCCAGTGTTCTCTTTGAGGACATGGAG       c.2040
 G  L  S  E  S  M  D  I  D  P  S  S  S  V  L  F  E  D  M  E         p.680

          .      | 15  .         .         .         .         .    g.11465
 AAGCCTGATTTCTCA | TTGTTCTCCCCTACTATGCCCTGTGAGGGGAAGGGCAGTCCATCC    c.2100
 K  P  D  F  S   | L  F  S  P  T  M  P  C  E  G  K  G  S  P  S      p.700

          .         .         .         .         .         .       g.11525
 CCTGAGAAGCCAGATGTCGAGAAGGAGGTGAAGCCCCCACCCAAGGAGAAGATTGAAGGG       c.2160
 P  E  K  P  D  V  E  K  E  V  K  P  P  P  K  E  K  I  E  G         p.720

          .         .         .         .         .         .       g.11585
 ACCCTTGGGGTTCTTTACGACCAGCCACGACACGTGCAGTACGCCACCCATTTTCCCATC       c.2220
 T  L  G  V  L  Y  D  Q  P  R  H  V  Q  Y  A  T  H  F  P  I         p.740

        | 16 .         .         .         .         .         .    g.11849
 CCCCAG | GAGGAGTCATGCAGCCATGAGTGCAACCAGCGGTTGGTCGTACTGTTTGGGGTG    c.2280
 P  Q   | E  E  S  C  S  H  E  C  N  Q  R  L  V  V  L  F  G  V      p.760

          .         .         .         .         .         .       g.11909
 GGAAAGCAGCGAGATGATGCCCGCCATGCCATCAAGAAAATCACCAAGGATATCTTGAAG       c.2340
 G  K  Q  R  D  D  A  R  H  A  I  K  K  I  T  K  D  I  L  K         p.780

          .         .         .  | 17      .         .         .    g.12136
 GTTCTGAACCGCAAAGGGACAGCAGAAACTG | ACCAGCTTGCTCCTATTGTGCCTCTGAAT    c.2400
 V  L  N  R  K  G  T  A  E  T  D |   Q  L  A  P  I  V  P  L  N      p.800

          .         .   | 18     .         .         .         .    g.12518
 CCTGGAGACCTGACATTCTTAG | GTGGGGAGGATGGGCAGAAGCGGCGACGCAACCGGCCT    c.2460
 P  G  D  L  T  F  L  G |   G  E  D  G  Q  K  R  R  R  N  R  P      p.820

          .         .         .         .         .         .       g.12578
 GAAGCCTTCCCCACTGCTGAAGATATCTTTGCTAAGTTCCAGCACCTTTCACATTATGAC       c.2520
 E  A  F  P  T  A  E  D  I  F  A  K  F  Q  H  L  S  H  Y  D         p.840

          .         .  | 19      .         .         .         .    g.12824
 CAACACCAGGTCACGGCTCAG | GTCTCCCGGAATGTTCTGGAGCAGATCACGAGCTTTGCC    c.2580
 Q  H  Q  V  T  A  Q   | V  S  R  N  V  L  E  Q  I  T  S  F  A      p.860

          .         .         .         .         .         .       g.12884
 CTTGGCATGTCATACCACTTGCCTCTGGTGCAGCATGTGCAGTTCATCTTCGACCTCATG       c.2640
 L  G  M  S  Y  H  L  P  L  V  Q  H  V  Q  F  I  F  D  L  M         p.880

          .         .         .         .      | 20  .         .    g.13428
 GAATATTCACTCAGCATCAGTGGCCTCATCGACTTTGCCATTCAG | CTGCTGAATGAACTG    c.2700
 E  Y  S  L  S  I  S  G  L  I  D  F  A  I  Q   | L  L  N  E  L      p.900

          .         .         .         .         .         .       g.13488
 AGTGTAGTTGAGGCTGAGCTGCTTCTCAAATCCTCGGATCTGGTGGGCAGCTACACTACT       c.2760
 S  V  V  E  A  E  L  L  L  K  S  S  D  L  V  G  S  Y  T  T         p.920

          .         .         .         .         .         .       g.13548
 AGCCTGTGCCTGTGCATCGTGGCTGTCCTGCGGCACTATCATGCCTGCCTCATCCTCAAC       c.2820
 S  L  C  L  C  I  V  A  V  L  R  H  Y  H  A  C  L  I  L  N         p.940

          .         .          | 21        .         .         .    g.13811
 CAGGACCAGATGGCACAGGTCTTTGAGGG | GCTGTGTGGCGTCGTGAAGCATGGGATGAAC    c.2880
 Q  D  Q  M  A  Q  V  F  E  G  |  L  C  G  V  V  K  H  G  M  N      p.960

          .         .         .         .         .         .       g.13871
 CGGTCCGATGGCTCCTCTGCAGAGCGCTGTATCCTTGCTTATCTCTATGATCTGTACACC       c.2940
 R  S  D  G  S  S  A  E  R  C  I  L  A  Y  L  Y  D  L  Y  T         p.980

          .         .         .         .  | 22      .         .    g.14356
 TCCTGTAGCCATTTAAAGAACAAATTTGGGGAGCTCTTCAG | CGACTTTTGCTCAAAGGTG    c.3000
 S  C  S  H  L  K  N  K  F  G  E  L  F  S  |  D  F  C  S  K  V      p.1000

          .         .         .         .         .         .       g.14416
 AAGAACACCATCTACTGCAACGTGGAGCCATCGGAATCAAATATGCGCTGGGCACCTGAG       c.3060
 K  N  T  I  Y  C  N  V  E  P  S  E  S  N  M  R  W  A  P  E         p.1020

          .         .         .         .         .         .       g.14476
 TTCATGATCGACACTCTAGAGAACCCTGCAGCTCACACCTTCACCTACACGGGGCTAGGC       c.3120
 F  M  I  D  T  L  E  N  P  A  A  H  T  F  T  Y  T  G  L  G         p.1040

          .         .         .         .         .         .       g.14536
 AAGAGTCTTAGTGAGAACCCTGCTAACCGCTACAGCTTTGTCTGCAATGCCCTTATGCAC       c.3180
 K  S  L  S  E  N  P  A  N  R  Y  S  F  V  C  N  A  L  M  H         p.1060

          .         .          | 23        .         .         .    g.14771
 GTCTGTGTGGGGCACCATGATCCCGATAG | GGTGAATGACATCGCAATCCTGTGTGCAGAG    c.3240
 V  C  V  G  H  H  D  P  D  R  |  V  N  D  I  A  I  L  C  A  E      p.1080

          .         .         .         .         .         .       g.14831
 CTGACCGGCTATTGCAAGTCACTGAGTGCAGAATGGCTAGGAGTGCTTAAGGCCTTGTGC       c.3300
 L  T  G  Y  C  K  S  L  S  A  E  W  L  G  V  L  K  A  L  C         p.1100

          .         .         .         .         .     | 24   .    g.15048
 TGCTCCTCTAACAATGGCACTTGTGGTTTCAACGATCTCCTCTGCAATGTTGAT | GTCAGT    c.3360
 C  S  S  N  N  G  T  C  G  F  N  D  L  L  C  N  V  D   | V  S      p.1120

          .         .         .         .         .         .       g.15108
 GACCTATCTTTTCATGACTCGCTGGCTACTTTTGTTGCCATCCTCATCGCTCGGCAGTGT       c.3420
 D  L  S  F  H  D  S  L  A  T  F  V  A  I  L  I  A  R  Q  C         p.1140

          .         .         .         .         .      | 25  .    g.15563
 TTGCTCCTGGAAGATCTGATTCGCTGTGCTGCCATCCCTTCACTCCTTAATGCTG | CTTGT    c.3480
 L  L  L  E  D  L  I  R  C  A  A  I  P  S  L  L  N  A  A |   C      p.1160

          .         .         .         .         .         .       g.15623
 AGTGAACAGGACTCTGAGCCAGGGGCCCGGCTTACCTGCCGCATCCTCCTTCACCTTTTC       c.3540
 S  E  Q  D  S  E  P  G  A  R  L  T  C  R  I  L  L  H  L  F         p.1180

          .         .         .        | 26.         .         .    g.15783
 AAGACACCGCAGCTCAATCCTTGCCAGTCTGATGGAA | ACAAGCCTACAGTAGGAATCCGC    c.3600
 K  T  P  Q  L  N  P  C  Q  S  D  G  N |   K  P  T  V  G  I  R      p.1200

          .         .         .         .         .         .       g.15843
 TCCTCCTGCGACCGCCACCTGCTGGCTGCCTCCCAGAACCGCATCGTGGATGGAGCCGTG       c.3660
 S  S  C  D  R  H  L  L  A  A  S  Q  N  R  I  V  D  G  A  V         p.1220

          .         .         .  | 27      .         .         .    g.16153
 TTTGCTGTTCTCAAGGCTGTGTTTGTACTTG | GGGATGCGGAACTGAAAGGTTCAGGCTTC    c.3720
 F  A  V  L  K  A  V  F  V  L  G |   D  A  E  L  K  G  S  G  F      p.1240

          .         .         .         .         .         .       g.16213
 ACTGTGACAGGAGGAACAGAAGAACTTCCAGAGGAGGAGGGAGGAGGTGGCAGTGGTGGT       c.3780
 T  V  T  G  G  T  E  E  L  P  E  E  E  G  G  G  G  S  G  G         p.1260

          .         .         .         .         .         .       g.16273
 CGGAGGCAGGGTGGCCGCAACATCTCTGTGGAGACAGCCAGTCTGGATGTCTATGCCAAG       c.3840
 R  R  Q  G  G  R  N  I  S  V  E  T  A  S  L  D  V  Y  A  K         p.1280

          .         .        | 28.         .         .         .    g.16512
 TACGTGCTGCGCAGCATCTGCCAACAG | GAATGGGTAGGAGAACGTTGCCTTAAGTCTCTG    c.3900
 Y  V  L  R  S  I  C  Q  Q   | E  W  V  G  E  R  C  L  K  S  L      p.1300

          .         .         .         .         .         .       g.16572
 TGTGAGGACAGCAATGACCTGCAAGACCCAGTGTTGAGTAGTGCCCAGGCGCAGCGCCTC       c.3960
 C  E  D  S  N  D  L  Q  D  P  V  L  S  S  A  Q  A  Q  R  L         p.1320

          .         .         .         .         .         .       g.16632
 ATGCAGCTCATTTGCTATCCACATCGACTGCTGGACAATGAGGATGGGGAAAACCCCCAG       c.4020
 M  Q  L  I  C  Y  P  H  R  L  L  D  N  E  D  G  E  N  P  Q         p.1340

          .         .        | 29.         .         .         .    g.18027
 CGGCAGCGCATAAAGCGCATTCTCCAG | AACTTGGACCAGTGGACCATGCGCCAGTCTTCC    c.4080
 R  Q  R  I  K  R  I  L  Q   | N  L  D  Q  W  T  M  R  Q  S  S      p.1360

          .         .         .          | 30        .         .    g.18538
 TTGGAGCTGCAGCTCATGATCAAGCAGACCCCTAACAAT | GAGATGAACTCCCTCTTGGAG    c.4140
 L  E  L  Q  L  M  I  K  Q  T  P  N  N   | E  M  N  S  L  L  E      p.1380

          .         .         .         .         .         .       g.18598
 AACATCGCCAAGGCCACAATCGAGGTTTTCCAACAGTCAGCAGAGACAGGGTCATCTTCT       c.4200
 N  I  A  K  A  T  I  E  V  F  Q  Q  S  A  E  T  G  S  S  S         p.1400

          .         .         .         .         .    | 31    .    g.18828
 GGAAGTACTGCAAGCAACATGCCCAGCAGCAGCAAGACCAAGCCTGTGCTCAG | CTCTCTA    c.4260
 G  S  T  A  S  N  M  P  S  S  S  K  T  K  P  V  L  S  |  S  L      p.1420

          .         .         .         .         .         .       g.18888
 GAGCGCTCTGGTGTATGGCTGGTGGCCCCCCTCATTGCTAAACTGCCCACCTCAGTCCAG       c.4320
 E  R  S  G  V  W  L  V  A  P  L  I  A  K  L  P  T  S  V  Q         p.1440

          .         .         .         .         .         .       g.18948
 GGACATGTGTTAAAGGCTGCTGGGGAAGAATTGGAGAAGGGTCAGCACCTGGGTTCCTCT       c.4380
 G  H  V  L  K  A  A  G  E  E  L  E  K  G  Q  H  L  G  S  S         p.1460

          .         .         .      | 32  .         .         .    g.19314
 TCACGCAAAGAACGTGATCGACAAAAGCAGAAGAG | CATGTCCCTATTGAGCCAGCAGCCC    c.4440
 S  R  K  E  R  D  R  Q  K  Q  K  S  |  M  S  L  L  S  Q  Q  P      p.1480

          .         .         .         .         .         .       g.19374
 TTCTTATCGCTGGTGCTAACATGTCTGAAAGGGCAGGATGAACAACGCGAGGGACTCCTT       c.4500
 F  L  S  L  V  L  T  C  L  K  G  Q  D  E  Q  R  E  G  L  L         p.1500

          .         .        | 33.         .         .         .    g.19600
 ACCTCCCTCTACAGCCAGGTGCACCAG | ATTGTGAATAATTGGCGAGATGACCAGTACTTA    c.4560
 T  S  L  Y  S  Q  V  H  Q   | I  V  N  N  W  R  D  D  Q  Y  L      p.1520

          .         .         .         .         .        | 34.    g.20804
 GATGATTGCAAACCAAAGCAGCTTATGCATGAGGCACTCAAACTGCGGCTCAACCTG | GTG    c.4620
 D  D  C  K  P  K  Q  L  M  H  E  A  L  K  L  R  L  N  L   | V      p.1540

          .         .         .         .         .         .       g.20864
 GGGGGCATGTTTGACACGGTGCAGCGCAGCACCCAGCAGACCACGGAGTGGGCCATGCTC       c.4680
 G  G  M  F  D  T  V  Q  R  S  T  Q  Q  T  T  E  W  A  M  L         p.1560

          .         .         .         .        | 35.         .    g.21170
 CTCCTGGAGATCATCATCAGCGGCACTGTCGACATGCAGTCCAACAA | TGAGCTCTTCACT    c.4740
 L  L  E  I  I  I  S  G  T  V  D  M  Q  S  N  N  |  E  L  F  T      p.1580

          .         .         .         .         .         .       g.21230
 ACTGTGTTGGACATGCTGAGCGTGCTCATCAATGGGACATTGGCTGCAGACATGTCTAGC       c.4800
 T  V  L  D  M  L  S  V  L  I  N  G  T  L  A  A  D  M  S  S         p.1600

          .         .         .         .         .         .       g.21290
 ATCTCGCAAGGTAGCATGGAGGAAAACAAGCGTGCATACATGAACCTGGCGAAGAAGTTG       c.4860
 I  S  Q  G  S  M  E  E  N  K  R  A  Y  M  N  L  A  K  K  L         p.1620

     | 36    .         .         .         .         .         .    g.21593
 CAG | AAGGAGTTGGGGGAGCGCCAGTCAGACAGTCTGGAAAAGGTTCGCCAGCTGCTGCCA    c.4920
 Q   | K  E  L  G  E  R  Q  S  D  S  L  E  K  V  R  Q  L  L  P      p.1640

          .         .         .         .         .         .       g.21653
 CTGCCCAAGCAGACCCGAGATGTCATCACGTGTGAGCCACAGGGCTCCCTTATCGATACC       c.4980
 L  P  K  Q  T  R  D  V  I  T  C  E  P  Q  G  S  L  I  D  T         p.1660

          .         .         .         .      | 37  .         .    g.22740
 AAGGGCAACAAGATTGCTGGCTTCGATTCCATCTTCAAGAAGGAG | GGTCTACAGGTTTCC    c.5040
 K  G  N  K  I  A  G  F  D  S  I  F  K  K  E   | G  L  Q  V  S      p.1680

          .         .         .         .         .         .       g.22800
 ACCAAACAGAAGATCTCGCCCTGGGATCTTTTTGAGGGGTTGAAGCCGTCAGCACCACTC       c.5100
 T  K  Q  K  I  S  P  W  D  L  F  E  G  L  K  P  S  A  P  L         p.1700

          .         .         .         .         .         .       g.22860
 TCTTGGGGCTGGTTTGGAACAGTCCGAGTGGACCGGCGAGTGGCTCGAGGAGAGGAGCAG       c.5160
 S  W  G  W  F  G  T  V  R  V  D  R  R  V  A  R  G  E  E  Q         p.1720

          .         .         .         .         .         .       g.22920
 CAGCGGTTGCTGCTCTACCACACACACCTGAGGCCCCGGCCCCGCGCCTATTACCTGGAG       c.5220
 Q  R  L  L  L  Y  H  T  H  L  R  P  R  P  R  A  Y  Y  L  E         p.1740

          .         .         .         .         .         .       g.22980
 CCACTGCCACTGCCCCCAGAAGATGAGGAGCCGCCTGCTCCTACCCTGCTAGAGCCTGAG       c.5280
 P  L  P  L  P  P  E  D  E  E  P  P  A  P  T  L  L  E  P  E         p.1760

          .         .         .         .         .         .       g.23040
 AAAAAGGCTCCAGAGCCCCCCAAAACTGACAAACCGGGGGCTGCTCCACCCAGTACTGAG       c.5340
 K  K  A  P  E  P  P  K  T  D  K  P  G  A  A  P  P  S  T  E         p.1780

          .         .         .         .         .         .       g.23100
 GAACGCAAGAAGAAGTCCACCAAGGGCAAGAAACGCAGCCAGCCAGCTACCAAGACAGAG       c.5400
 E  R  K  K  K  S  T  K  G  K  K  R  S  Q  P  A  T  K  T  E         p.1800

  | 38       .         .         .         .         .         .    g.23383
  | GACTATGGAATGGGCCCGGGTCGGAGCGGCCCTTATGGTGTGACAGTGCCTCCGGACCTC    c.5460
  | D  Y  G  M  G  P  G  R  S  G  P  Y  G  V  T  V  P  P  D  L      p.1820

          .         .         .         .         .         .       g.23443
 CTGCACCACCCAAACCCTGGTTCTATAACACACCTTAACTACAGGCAAGGCTCCATAGGC       c.5520
 L  H  H  P  N  P  G  S  I  T  H  L  N  Y  R  Q  G  S  I  G         p.1840

          .         .         .  | 39      .         .         .    g.23660
 CTGTACACCCAGAACCAGCCACTACCTGCAG | GTGGCCCTCGTGTGGACCCATACCGTCCT    c.5580
 L  Y  T  Q  N  Q  P  L  P  A  G |   G  P  R  V  D  P  Y  R  P      p.1860

          .         .         .         .         .         .       g.23720
 GTGCGCTTACCAATGCAGAAGCTGCCCACCCGACCAACTTACCCTGGAGTGCTGCCCACA       c.5640
 V  R  L  P  M  Q  K  L  P  T  R  P  T  Y  P  G  V  L  P  T         p.1880

          .         .         .         .         .         .       g.23780
 ACCATGACTGGCGTCATGGGTTTAGAACCCTCCTCTTATAAGACCTCTGTGTACCGGCAG       c.5700
 T  M  T  G  V  M  G  L  E  P  S  S  Y  K  T  S  V  Y  R  Q         p.1900

          .         .         .         .         | 40         .    g.24014
 CAGCAACCTGCGGTGCCCCAAGGACAGCGCCTTCGCCAACAGCTCCAG | CAGAGTCAGGGC    c.5760
 Q  Q  P  A  V  P  Q  G  Q  R  L  R  Q  Q  L  Q   | Q  S  Q  G      p.1920

          .         .         .         .         .         .       g.24074
 ATGTTGGGACAGTCATCTGTCCATCAGATGACTCCCAGCTCTTCCTACGGTTTGCAGACT       c.5820
 M  L  G  Q  S  S  V  H  Q  M  T  P  S  S  S  Y  G  L  Q  T         p.1940

        | 41 .         .         .         .         .         .    g.24224
 TCCCAG | GGCTATACTCCTTATGTTTCTCATGTGGGATTGCAGCAACACACAGGCCCTGCA    c.5880
 S  Q   | G  Y  T  P  Y  V  S  H  V  G  L  Q  Q  H  T  G  P  A      p.1960

          .         .         .         .         .         .       g.24284
 GGTACCATGGTGCCCCCCAGCTACTCCAGCCAGCCTTACCAGAGCACCCACCCTTCTACC       c.5940
 G  T  M  V  P  P  S  Y  S  S  Q  P  Y  Q  S  T  H  P  S  T         p.1980

          .         .         .         .         .         .       g.24344
 AATCCTACTCTTGTAGATCCTACCCGCCACCTGCAACAGCGGCCCAGTGGCTATGTGCAC       c.6000
 N  P  T  L  V  D  P  T  R  H  L  Q  Q  R  P  S  G  Y  V  H         p.2000

          .         .         .         .     | 42   .         .    g.27095
 CAGCAGGCCCCCACCTATGGACATGGACTGACCTCCACTCAAAG | GTTTTCACACCAGACA    c.6060
 Q  Q  A  P  T  Y  G  H  G  L  T  S  T  Q  R  |  F  S  H  Q  T      p.2020

          .         .         .         .         .         .       g.27155
 CTGCAGCAGACACCCATGATAAGTACCATGACTCCAATGAGTGCCCAGGGCGTCCAGGCA       c.6120
 L  Q  Q  T  P  M  I  S  T  M  T  P  M  S  A  Q  G  V  Q  A         p.2040

          .         .         .         .         .         .       g.27215
 GGCGTCCGTTCAACAGCCATCCTACCTGAGCAGCAGCAGCAGCAGCAACAGCAGCAACAG       c.6180
 G  V  R  S  T  A  I  L  P  E  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q         p.2060

          .         .         .         .         .         .       g.27275
 CAACAGCAGCAGCAGCAGCAACAGCAACAGCAGCAGCAGCAGCAGCAGTACCACATCCGG       c.6240
 Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Y  H  I  R         p.2080

          .         .        | 43.         .         .         .    g.27707
 CAGCAGCAGCAGCAGCAGATCCTGCGG | CAGCAGCAGCAACAGCAACAGCAGCAGCAGCAG    c.6300
 Q  Q  Q  Q  Q  Q  I  L  R   | Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q      p.2100

          .         .         .         .         .         .       g.27767
 CAGCAGCAACAGCAACAGCAGCAGCAGCAACAGCAACAACAGCAACACCAGCAGCAACAG       c.6360
 Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  H  Q  Q  Q  Q         p.2120

          .         .         .         .         | 44         .    g.28339
 CAGCAACAGGCGGCTCCTCCCCAACCCCAGCCCCAGTCCCAGCCCCAG | TTCCAGCGCCAG    c.6420
 Q  Q  Q  A  A  P  P  Q  P  Q  P  Q  S  Q  P  Q   | F  Q  R  Q      p.2140

          .         .         .         .         .         .       g.28399
 GGGCTTCAGCAGACCCAGCAGCAGCAACAGACAGCAGCTTTGGTCCGGCAACTTCAACAA       c.6480
 G  L  Q  Q  T  Q  Q  Q  Q  Q  T  A  A  L  V  R  Q  L  Q  Q         p.2160

          . | 45       .         .         .         .              g.28669
 CAGCTCTCTA | ATACCCAGCCACAGCCCAGTACCAACATATTTGGACGCTACTGA          c.6534
 Q  L  S  N |   T  Q  P  Q  P  S  T  N  I  F  G  R  Y  X            p.2177

          .         .         .         .         .         .       g.28729
 gccacctggaggaactgcttgtgcactggatgtggccccaccctttcctcttaattccca       c.*60

          .         .         .         .         .         .       g.28789
 atcccattcctgggctagcaccagtagtggttggggccctcccctcaggctccattttta       c.*120

          .         .         .         .         .         .       g.28849
 ataagtttttagtatttttgttaatgtgaggcattgagctgttgggttttgtatattatt       c.*180

          .         .         .         .         .                 g.28905
 tatatagagaccccagagctgttgcacccaatacacagagcttctttgcaaaggga           c.*236

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mediator complex subunit 12 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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