mediator complex subunit 23 (MED23) - coding DNA reference sequence

(used for variant description)

(last modified December 22, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_015979.3 in the MED23 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031860.1, covering MED23 transcript NM_015979.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4994
                                                   ttccgtacag       c.-181

 .         .         .         .         .         .                g.5054
 gttcctgctgttggctgggctcgggagggaacgctccaggtaaagcgctgggggaggaag       c.-121

 .         .         .         .         .         .                g.5114
 cgacgccgaggagctacggtttcctccagaggtctccgcccctctgcccctatattccca       c.-61

 .         .         .         .         .         .                g.5174
 gagctcgagtctgatccgggccttgccgggcaccctggaaaggcgggggtgatagtacag       c.-1

          .         .         .          | 02        .         .    g.5572
 ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTG | AAAACGGAAGTTATAGAAGAG    c.60
 M  E  T  Q  L  Q  S  I  F  E  E  V  V   | K  T  E  V  I  E  E      p.20

          .  | 03      .         .         .         .         .    g.5789
 GCTTTTCCTGG | CATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATTAGCTGT    c.120
 A  F  P  G  |  M  F  M  D  T  P  E  D  E  K  T  K  L  I  S  C      p.40

          .         .         .          | 04        .         .    g.8255
 TTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAG | GAGTCTCATGAACAGTGTATC    c.180
 L  G  A  F  R  Q  F  W  G  G  L  S  Q   | E  S  H  E  Q  C  I      p.60

          .         .         .         .         .         .       g.8315
 CAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTAT       c.240
 Q  W  I  V  K  F  I  H  G  Q  H  S  P  K  R  I  S  F  L  Y         p.80

          .         .         .         .     | 05   .         .    g.9777
 GACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTTCCACCCAG | GCTGGTTTGTGAATCC    c.300
 D  C  L  A  M  A  V  E  T  G  L  L  P  P  R  |  L  V  C  E  S      p.100

          .         .         .         .         .         .       g.9837
 CTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAA       c.360
 L  I  N  S  D  T  L  E  W  E  R  T  Q  L  W  A  L  T  F  K         p.120

          .         .         .       | 06 .         .         .    g.11268
 CTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAG | GGTGTTCGAGATCTCTTAAAAGTG    c.420
 L  V  R  K  I  I  G  G  V  D  Y  K   | G  V  R  D  L  L  K  V      p.140

          .         .         .         .         .         .       g.11328
 ATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAGCAGCTT       c.480
 I  L  E  K  I  L  T  I  P  N  T  V  S  S  A  V  V  Q  Q  L         p.160

          .      | 07  .         .         .         .         .    g.12539
 CTGGCAGCAAGAGAG | GTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCC    c.540
 L  A  A  R  E   | V  I  A  Y  I  L  E  R  N  A  C  L  L  P  A      p.180

          .         .         .         .         .        | 08.    g.13330
 TATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGG | TTA    c.600
 Y  F  A  V  T  E  I  R  K  L  Y  P  E  G  K  L  P  H  W   | L      p.200

          .         .         .         .         .         .       g.13390
 CTTGGAAACCTAGTATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATAAACTCC       c.660
 L  G  N  L  V  S  D  F  V  D  T  F  R  P  T  A  R  I  N  S         p.220

         | 09.         .         .         .         .         .    g.14757
 ATTTGTG | GTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCA    c.720
 I  C  G |   R  C  S  L  L  P  V  V  N  N  S  G  A  I  C  N  S      p.240

          .         .         .         .         .         .       g.14817
 TGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAG       c.780
 W  K  L  D  P  A  T  L  R  F  P  L  K  G  L  L  P  Y  D  K         p.260

  | 10       .         .         .         .         .         .    g.17281
  | GATCTGTTTGAACCACAGACTGCTTTGTTGAGATATGTATTGGAGCAGCCTTATTCCAGG    c.840
  | D  L  F  E  P  Q  T  A  L  L  R  Y  V  L  E  Q  P  Y  S  R      p.280

          .         .         .       | 11 .         .     | 12   . g.22983
 GATATGGTCTGCAATATGCTAGGTTTAAATAAGCAG | ACCTTGAACATTGCTCAG | CACAAG c.900
 D  M  V  C  N  M  L  G  L  N  K  Q   | T  L  N  I  A  Q   | H  K   p.300

          .         .         .         .         .         .       g.23043
 CAGCGCTGCCCTGTGCTGGAGGACCAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGA       c.960
 Q  R  C  P  V  L  E  D  Q  L  V  D  L  V  V  Y  A  M  E  R         p.320

          .         .         .         .         .         .       g.23103
 TCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTGTGGCAGCATCTC       c.1020
 S  E  T  E  E  K  F  D  D  G  G  T  S  Q  L  L  W  Q  H  L         p.340

          .         .         .         .         .         .       g.23163
 TCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTT       c.1080
 S  S  Q  L  I  F  F  V  L  F  Q  F  A  S  F  P  H  M  V  L         p.360

          .      | 13  .         .         .         .         .    g.25197
 TCTCTTCATCAGAAG | TTAGCAGGGCGAGGACTGATTAAAGGCAGAGATCATCTTATGTGG    c.1140
 S  L  H  Q  K   | L  A  G  R  G  L  I  K  G  R  D  H  L  M  W      p.380

          .         .         .         .         .         .       g.25257
 GTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCTGATTTTCTCCCT       c.1200
 V  L  L  Q  F  I  S  G  S  I  Q  K  N  A  L  A  D  F  L  P         p.400

          .         .         .          | 14        .         .    g.26620
 GTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAA | TATATCCCAGTTCCTGATATT    c.1260
 V  M  K  L  F  D  L  L  Y  P  E  K  E   | Y  I  P  V  P  D  I      p.420

          .         .         .         .         .         .       g.26680
 AACAAACCCCAGTCAACCCATGCCTTTGCAATGACCTGTATTTGGATTCATCTCAATAGA       c.1320
 N  K  P  Q  S  T  H  A  F  A  M  T  C  I  W  I  H  L  N  R         p.440

          .         .         .         .         .         .       g.26740
 AAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCCCTAAGACTTCAC       c.1380
 K  A  Q  N  D  N  S  K  L  Q  I  P  I  P  H  S  L  R  L  H         p.460

       | 15  .         .         .         .         .         .    g.27793
 CATGA | GTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATT    c.1440
 H  E  |  F  L  Q  Q  S  L  R  N  K  S  L  Q  M  N  D  Y  K  I      p.480

          .         .         .         .         .         .       g.27853
 GCTCTATTGTGTAATGCATACTCTACAAATTCAGAATGTTTTACATTACCCATGGGAGCT       c.1500
 A  L  L  C  N  A  Y  S  T  N  S  E  C  F  T  L  P  M  G  A         p.500

          .         .         .         .         .         .       g.27913
 CTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCTGGAACAAACTGT       c.1560
 L  V  E  T  I  Y  G  N  G  I  M  R  I  P  L  P  G  T  N  C         p.520

          .         .         .         .         .         .       g.27973
 ATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCAT       c.1620
 M  A  S  G  S  I  T  P  L  P  M  N  L  L  D  S  L  T  V  H         p.540

          .  | 16      .         .         .         .         .    g.28952
 GCCAAAATGAG | CCTTATTCACAGCATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAG    c.1680
 A  K  M  S  |  L  I  H  S  I  A  T  R  V  I  K  L  A  H  A  K      p.560

          .         .         .         .         .         .       g.29012
 TCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTATTGGTCTATATG       c.1740
 S  S  V  A  L  A  P  A  L  V  E  T  Y  S  R  L  L  V  Y  M         p.580

          .         .         .     | 17   .         .         .    g.30045
 GAAATAGAGTCTTTGGGCATCAAAGGATTTATCA | GTCAGCTTTTGCCAACTGTTTTCAAA    c.1800
 E  I  E  S  L  G  I  K  G  F  I  S |   Q  L  L  P  T  V  F  K      p.600

          .         .         .         .         .         .       g.30105
 TCACATGCATGGGGGATCTTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCAT       c.1860
 S  H  A  W  G  I  L  H  T  L  L  E  M  F  S  Y  R  M  H  H         p.620

          .         .         .         .         .         .       g.30165
 ATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCAGTTGCA       c.1920
 I  Q  P  H  Y  R  V  Q  L  L  S  H  L  H  T  L  A  A  V  A         p.640

          .         .          | 18        .         .         .    g.30873
 CAAACAAACCAGAACCAGCTCCATCTTTG | TGTCGAGAGCACTGCTCTCAGGCTTATAACA    c.1980
 Q  T  N  Q  N  Q  L  H  L  C  |  V  E  S  T  A  L  R  L  I  T      p.660

          .         .         .         .         .         .       g.30933
 GCATTAGGTAGCTCAGAGGTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACA       c.2040
 A  L  G  S  S  E  V  Q  P  Q  F  T  R  F  L  S  D  P  K  T         p.680

          .         .         .         .         .         .       g.30993
 GTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCTAGAGCA       c.2100
 V  L  S  A  E  S  E  E  L  N  R  A  L  I  L  T  L  A  R  A         p.700

          .    | 19    .         .         .         .         .    g.33108
 ACTCATGTAACAG | ATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGAC    c.2160
 T  H  V  T  D |   F  F  T  G  S  D  S  I  Q  G  T  W  C  K  D      p.720

          .         .         .         .         .         .       g.33168
 ATACTTCAGACCATCATGAGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGT       c.2220
 I  L  Q  T  I  M  S  F  T  P  H  N  W  A  S  H  T  L  S  C         p.740

          .         | 20         .         .         .         .    g.34504
 TTTCCAGGCCCACTACAG | GCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGCCGTTTT    c.2280
 F  P  G  P  L  Q   | A  F  F  K  Q  N  N  V  P  Q  E  S  R  F      p.760

          .         .         .         .         .         .       g.34564
 AATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAAC       c.2340
 N  L  K  K  N  V  E  E  E  Y  R  K  W  K  S  M  S  N  E  N         p.780

          .         .         .         .         .         .       g.34624
 GACATTATTACCCACTTCTCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGG       c.2400
 D  I  I  T  H  F  S  M  Q  G  S  P  P  L  F  L  C  L  L  W         p.800

          .         .         .         .     | 21   .         .    g.34772
 AAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAG | AGTATTAGAGAGAATT    c.2460
 K  M  L  L  E  T  D  H  I  N  Q  I  G  Y  R  |  V  L  E  R  I      p.820

          .         .         .         .         .         .       g.34832
 GGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTT       c.2520
 G  A  R  A  L  V  A  H  V  R  T  F  A  D  F  L  V  Y  E  F         p.840

          .         .         .         .         .         .       g.34892
 TCTACATCAGCAGGGGGTCAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTA       c.2580
 S  T  S  A  G  G  Q  Q  L  N  K  C  I  E  I  L  N  D  M  V         p.860

          .         .         .         .      | 22  .         .    g.36550
 TGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTG | GCCATGCGTAGTCAC    c.2640
 W  K  Y  N  I  V  T  L  D  R  L  I  L  C  L   | A  M  R  S  H      p.880

          .         .         .         .         .         .       g.36610
 GAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAAC       c.2700
 E  G  N  E  A  Q  V  C  Y  F  I  I  Q  L  L  L  L  K  P  N         p.900

          .         .         .         .         .         .       g.36670
 GATTTTAGAAATCGAGTAAGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAG       c.2760
 D  F  R  N  R  V  S  D  F  V  K  E  N  S  P  E  H  W  L  Q         p.920

          .         .         .       | 23 .         .         .    g.37084
 AATGACTGGCACACCAAGCACATGAATTATCACAAG | AAATATCCAGAGAAGTTGTATTTT    c.2820
 N  D  W  H  T  K  H  M  N  Y  H  K   | K  Y  P  E  K  L  Y  F      p.940

          .         .         .         .         .         .       g.37144
 GAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATC       c.2880
 E  G  L  A  E  Q  V  D  P  P  V  Q  I  Q  S  P  Y  L  P  I         p.960

          .         .         .         .         .         .       g.37204
 TATTTTGGGAATGTGTGTCTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTT       c.2940
 Y  F  G  N  V  C  L  R  F  L  P  V  F  D  I  V  I  H  R  F         p.980

          .         .         .         .         .         .       g.37264
 TTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGAGGCTTA       c.3000
 L  E  L  L  P  V  S  K  S  L  E  T  L  L  D  H  L  G  G  L         p.1000

          .    | 24    .         .         .         .         .    g.38935
 TATAAATTTCATG | ATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATG    c.3060
 Y  K  F  H  D |   R  P  V  T  Y  L  Y  N  T  L  H  Y  Y  E  M      p.1020

          .         .         .         .         .         .       g.38995
 CACCTGAGAGACCGCGCATTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTG       c.3120
 H  L  R  D  R  A  F  L  K  R  K  L  V  H  A  I  I  G  S  L         p.1040

          .         .         .         .         .         .       g.39055
 AAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCTATGAAT       c.3180
 K  D  N  R  P  Q  G  W  C  L  S  D  T  Y  L  K  C  A  M  N         p.1060

          .         .         .         .         .         .       g.39115
 GCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGA       c.3240
 A  R  E  E  N  P  W  V  P  D  D  T  Y  Y  C  R  L  I  G  R         p.1080

          . | 25       .         .         .         .         .    g.40102
 CTAGTCGATA | CGATGGCTGGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTC    c.3300
 L  V  D  T |   M  A  G  K  S  P  G  P  F  P  N  C  D  W  R  F      p.1100

          .         .         .         .         .         .       g.40162
 AATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTCATGGCC       c.3360
 N  E  F  P  N  P  A  A  H  A  L  H  V  T  C  V  E  L  M  A         p.1120

          .         .         .         .         .       | 26 .    g.40767
 TTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAG | TCAG    c.3420
 L  A  V  S  G  K  E  V  G  N  A  L  L  N  V  V  L  K  S  |  Q      p.1140

          .         .         .         .         .         .       g.40827
 CCTTTAGTGCCAAGAGAGAACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACT       c.3480
 P  L  V  P  R  E  N  I  T  A  W  M  N  A  I  G  L  I  I  T         p.1160

           | 27        .         .         .         .         .    g.41747
 GCCCTACCA | GAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATCAGCAGC    c.3540
 A  L  P   | E  P  Y  W  I  V  L  H  D  R  I  V  S  V  I  S  S      p.1180

          .         .         .         .         .         .       g.41807
 CCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACT       c.3600
 P  S  L  T  S  E  T  E  W  V  G  Y  P  F  R  L  F  D  F  T         p.1200

          .         .         .         .         .         .       g.41867
 GCCTGTCATCAGTCCTACTCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCT       c.3660
 A  C  H  Q  S  Y  S  E  M  S  C  S  Y  T  L  A  L  A  H  A         p.1220

          .         .         .         .     | 28   .         .    g.42797
 GTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAA | GTTTCTTACTGAAGTA    c.3720
 V  W  H  H  S  S  I  G  Q  L  S  L  I  P  K  |  F  L  T  E  V      p.1240

          .         .         .         .         .         .       g.42857
 CTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCA       c.3780
 L  L  P  I  V  K  T  E  F  Q  L  L  Y  V  Y  H  L  V  G  P         p.1260

          .         .         .         .      | 29  .         .    g.43642
 TTTTTACAAAGATTTCAGCAAGAGAGAACTCGTTGTATGATAGAG | ATTGGTGTGGCGTTT    c.3840
 F  L  Q  R  F  Q  Q  E  R  T  R  C  M  I  E   | I  G  V  A  F      p.1280

          .         .         .         .         .         .       g.43702
 TATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGATCCCATC       c.3900
 Y  D  M  L  L  N  V  D  Q  C  S  T  H  L  N  Y  M  D  P  I         p.1300

          .         .         .         .         .        | 30.    g.45380
 TGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAA | GTA    c.3960
 C  D  F  L  Y  H  M  K  Y  M  F  T  G  D  S  V  K  E  Q   | V      p.1320

          .         .         .         .         .         .       g.45440
 GAGAAGATTATCTGTAACTTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACAC       c.4020
 E  K  I  I  C  N  L  K  P  A  L  K  L  R  L  R  F  I  T  H         p.1340

          .         .         .         .         .         .       g.45500
 ATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCTCCAGCA       c.4080
 I  S  K  M  E  P  A  A  V  P  P  Q  A  M  N  S  G  S  P  A         p.1360

          .      | 31                                               g.58973
 CCTCAGTCTAATCAG | TAA                                              c.4098
 P  Q  S  N  Q   | X                                                p.1365

          .         .         .         .         .         .       g.59033
 aaagtcagagtacacagcaagggttccaaattaagaggaagcaaaacgctgcccagatcc       c.*60

          .         .         .         .         .         .       g.59093
 tgagaaacctggagaaaatcaaccttagtagtttcaactcatacattgtcttgtttgatt       c.*120

          .         .         .         .         .         .       g.59153
 ttgttctttgttttttatcctctttaagcacagatgcgtgttgaagtctaaggtgttctg       c.*180

          .         .         .         .         .         .       g.59213
 tcatcacactctctttactagaataagtgtgcccaggcagaaaaaaaagtgtattcaatg       c.*240

          .         .         .         .         .         .       g.59273
 ttgctggcatgtgtggattcacagctcgtggctgtaaggaaatctgggggtttcataaat       c.*300

          .         .                                               g.59300
 ccattaaaatccttttagagttgccaa                                        c.*327

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mediator complex subunit 23 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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