mediator complex subunit 25 (MED25) - coding DNA reference sequence

(used for variant description)

(last modified January 27, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_030973.3 in the MED25 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_017091.1, covering MED25 transcript NM_030973.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          att       c.-61

 .         .         .         .         .         .                g.5063
 tctgctcattccgcggcgtcggctgcggctgcagtggtggtggcgggtaccgcacggggt       c.-1

          .         .         .         .         .         .       g.5123
 ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTT       c.60
 M  V  P  G  S  E  G  P  A  R  A  G  S  V  V  A  D  V  V  F         p.20

          .         .         .         .         .         .       g.5183
 GTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTG       c.120
 V  I  E  G  T  A  N  L  G  P  Y  F  E  G  L  R  K  H  Y  L         p.40

          .     | 02   .         .         .         .         .    g.5338
 CTCCCGGCCATCGA | GTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC    c.180
 L  P  A  I  E  |  Y  F  N  G  G  P  P  A  E  T  D  F  G  G  D      p.60

  | 03       .         .         .         .         .         .    g.5953
  | TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCC    c.240
  | Y  G  G  T  Q  Y  S  L  V  V  F  N  T  V  D  C  A  P  E  S      p.80

          .         .         .         .         .         .       g.6013
 TACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGC       c.300
 Y  V  Q  C  H  A  P  T  S  S  A  Y  E  F  V  T  W  L  D  G         p.100

       | 04  .         .         .         .         .         .    g.15225
 ATTAA | GTTCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACA    c.360
 I  K  |  F  M  G  G  G  G  E  S  C  S  L  I  A  E  G  L  S  T      p.120

          .         .         .         .     | 05   .         .    g.15707
 GCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCGAGCAGAT | TGGCCAGACGCACCGG    c.420
 A  L  Q  L  F  D  D  F  K  K  M  R  E  Q  I  |  G  Q  T  H  R      p.140

          .         .         .         .         .         .       g.15767
 GTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACG       c.480
 V  C  L  L  I  C  N  S  P  P  Y  L  L  P  A  V  E  S  T  T         p.160

          .         .         .         .      | 06  .         .    g.16522
 TACTCTGGATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAG | CGGGGGATCCACTTC    c.540
 Y  S  G  C  T  T  E  N  L  V  Q  Q  I  G  E   | R  G  I  H  F      p.180

          .         .         .         .         .         .       g.16582
 TCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGCTTCTGTTTGAGAAGGCAGCCCCC       c.600
 S  I  V  S  P  R  K  L  P  A  L  R  L  L  F  E  K  A  A  P         p.200

          .         .         .         .         .         .       g.16642
 CCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATG       c.660
 P  A  L  L  E  P  L  Q  P  P  T  D  V  S  Q  D  P  R  H  M         p.220

          .         .         | 07         .         .         .    g.16841
 GTGCTGGTTCGGGGACTCGTGCTGCCTG | TTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAG    c.720
 V  L  V  R  G  L  V  L  P  V |   G  G  G  S  A  P  G  P  L  Q      p.240

          .         .         .         .         .         .       g.16901
 TCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCTCAGGTGCCACTCTCTCAGCAGCC       c.780
 S  K  Q  P  V  P  L  P  P  A  A  P  S  G  A  T  L  S  A  A         p.260

          .         .         .          | 08        .         .    g.17253
 CCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAG | GTTCCCGGGAACCTGAGTGCA    c.840
 P  Q  Q  P  L  P  P  V  P  P  Q  Y  Q   | V  P  G  N  L  S  A      p.280

          .         .         .         .         .         .       g.17313
 GCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGC       c.900
 A  Q  V  A  A  Q  N  A  V  E  A  A  K  N  Q  K  A  G  L  G         p.300

         | 09.         .         .         .         .         .    g.17468
 CCTCGCT | TCTCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTC    c.960
 P  R  F |   S  P  I  T  P  L  Q  Q  A  A  P  G  V  G  P  P  F      p.320

          .         .         .         .         .         .       g.17528
 AGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCT       c.1020
 S  Q  A  P  A  P  Q  L  P  P  G  P  P  G  A  P  K  P  P  P         p.340

          .         .         .         .         .         .       g.17588
 GCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCA       c.1080
 A  S  Q  P  S  L  V  S  T  V  A  P  G  S  G  L  A  P  T  A         p.360

          .         .  | 10      .         .         .         .    g.18093
 CAGCCCGGGGCACCGTCCATG | GCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCC    c.1140
 Q  P  G  A  P  S  M   | A  G  T  V  A  P  G  G  V  S  G  P  S      p.380

          .         .         .         .         .         .       g.18153
 CCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTG       c.1200
 P  A  Q  L  G  A  P  A  L  G  G  Q  Q  S  V  S  N  K  L  L         p.400

          .         .         . | 11       .         .         .    g.18687
 GCCTGGAGCGGGGTCCTGGAGTGGCAAGAG | AAACCCAAACCTGCCTCAGTGGATGCCAAC    c.1260
 A  W  S  G  V  L  E  W  Q  E   | K  P  K  P  A  S  V  D  A  N      p.420

          .         .         .         .         .       | 12 .    g.18825
 ACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCT | GAAG    c.1320
 T  K  L  T  R  S  L  P  C  Q  V  Y  V  N  H  G  E  N  L  |  K      p.440

          .         .         .         .         .     | 13   .    g.19035
 ACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTG | ACCACC    c.1380
 T  E  Q  W  P  Q  K  L  I  M  Q  L  I  P  Q  Q  L  L   | T  T      p.460

          .         .         .         .         .         .       g.19095
 CTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTG       c.1440
 L  G  P  L  F  R  N  S  R  M  V  Q  F  H  F  T  N  K  D  L         p.480

          .         .         .         .   | 14     .         .    g.21725
 GAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACGGCTTC | GCGGGCTGCGTGCACTTC    c.1500
 E  S  L  K  G  L  Y  R  I  M  G  N  G  F   | A  G  C  V  H  F      p.500

          .         .         .         .         .         .       g.21785
 CCCCACACGGCGCCCTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAG       c.1560
 P  H  T  A  P  C  E  V  R  V  L  M  L  L  Y  S  S  K  K  K         p.520

          .         .         .         .         .         .       g.21845
 ATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAACGGCATCCGGCAGGTC       c.1620
 I  F  M  G  L  I  P  Y  D  Q  S  G  F  V  N  G  I  R  Q  V         p.540

          .         .         .         .         .     | 15   .    g.22261
 ATCACCAACCACAAGCAGGTCCAGCAGCAGAAGCTGGAGCAGCAGCAGCGAGGA | ATGGGG    c.1680
 I  T  N  H  K  Q  V  Q  Q  Q  K  L  E  Q  Q  Q  R  G   | M  G      p.560

          .         .         .         .         .         .       g.22321
 GGACAGCAGGCACCCCCAGGGCTGGGGCCCATTCTGGAGGACCAAGCCAGGCCCTCACAG       c.1740
 G  Q  Q  A  P  P  G  L  G  P  I  L  E  D  Q  A  R  P  S  Q         p.580

        | 16 .         .         .         .         .         .    g.22502
 AATCTG | CTCCAGCTCCGCCCACCGCAGCCCCAGCCTCAGGGTACCGTAGGGGCCTCTGGG    c.1800
 N  L   | L  Q  L  R  P  P  Q  P  Q  P  Q  G  T  V  G  A  S  G      p.600

          .         .         .         .         .         .       g.22562
 GCCACGGGGCAGCCCCAGCCCCAAGGTACTGCCCAGCCCCCGCCAGGTGCCCCTCAAGGC       c.1860
 A  T  G  Q  P  Q  P  Q  G  T  A  Q  P  P  P  G  A  P  Q  G         p.620

          .         .         .         .         .         .       g.22622
 CCTCCTGGAGCAGCTTCTGGCCCACCCCCTCCTGGACCCATCCTTCGGCCCCAGAACCCT       c.1920
 P  P  G  A  A  S  G  P  P  P  P  G  P  I  L  R  P  Q  N  P         p.640

          .         .         .         .      | 17  .         .    g.22962
 GGGGCCAACCCTCAGCTGCGAAGCCTCCTCCTCAACCCACCACCG | CCGCAGACTGGGGTG    c.1980
 G  A  N  P  Q  L  R  S  L  L  L  N  P  P  P   | P  Q  T  G  V      p.660

          .         .         .         .         .         .       g.23022
 CCCCCACCCCAGGCCTCCCTCCACCACCTCCAGCCACCAGGGGCTCCTGCGCTGCTGCCT       c.2040
 P  P  P  Q  A  S  L  H  H  L  Q  P  P  G  A  P  A  L  L  P         p.680

          .         .         .         .         .         .       g.23082
 CCGCCGCACCAGGGCCTGGGGCAGCCCCAGTTGGGGCCCCCACTCCTGCATCCACCACCT       c.2100
 P  P  H  Q  G  L  G  Q  P  Q  L  G  P  P  L  L  H  P  P  P         p.700

          .         .         .         .       | 18 .         .    g.23582
 GCCCAGTCCTGGCCCGCACAACTTCCCCCTCGGGCTCCACTGCCAG | GTCAGATGCTGCTG    c.2160
 A  Q  S  W  P  A  Q  L  P  P  R  A  P  L  P  G |   Q  M  L  L      p.720

          .         .         .         .         .         .       g.23642
 AGCGGGGGTCCCCGGGGCCCGGTCCCCCAGCCGGGCCTGCAGCCCAGCGTCATGGAGGAC       c.2220
 S  G  G  P  R  G  P  V  P  Q  P  G  L  Q  P  S  V  M  E  D         p.740

          .         .                                               g.23666
 GACATCCTCATGGATCTCATCTGA                                           c.2244
 D  I  L  M  D  L  I  X                                             p.747

          .         .         .                                     g.23702
 atccccaacacccaataaagttcctttttaacacac                               c.*36

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mediator complex subunit 25 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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