multiple endocrine neoplasia I (MEN1) - coding DNA reference sequence

(used for variant description)

(last modified June 30, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000244.3 in the MEN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008929.1, covering MEN1 transcript NM_000244.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5628
           ggtgtccggagccgcggacctagagatcccagaagccacagcgcagcggc       c.-61

 .         .         .         .       | 02 .         .             g.6185
 ccggcccgccactatttccaggctcagcggggcaggg | gccgccgcccaccgcccgccgcc    c.-1

          .         .         .         .         .         .       g.6245
 ATGGGGCTGAAGGCCGCCCAGAAGACGCTGTTCCCGCTGCGCTCCATCGACGACGTGGTG       c.60
 M  G  L  K  A  A  Q  K  T  L  F  P  L  R  S  I  D  D  V  V         p.20

          .         .         .         .         .         .       g.6305
 CGCCTGTTTGCTGCCGAGCTGGGCCGAGAGGAGCCGGACCTGGTGCTCCTTTCCTTGGTG       c.120
 R  L  F  A  A  E  L  G  R  E  E  P  D  L  V  L  L  S  L  V         p.40

          .         .         .         .         .         .       g.6365
 CTGGGCTTCGTGGAGCATTTTCTGGCTGTCAACCGCGTCATCCCTACCAACGTTCCCGAG       c.180
 L  G  F  V  E  H  F  L  A  V  N  R  V  I  P  T  N  V  P  E         p.60

          .         .         .         .         .         .       g.6425
 CTCACCTTCCAGCCCAGCCCCGCCCCCGACCCGCCTGGCGGCCTCACCTACTTTCCCGTG       c.240
 L  T  F  Q  P  S  P  A  P  D  P  P  G  G  L  T  Y  F  P  V         p.80

          .         .         .         .         .         .       g.6485
 GCCGACCTGTCTATCATCGCCGCCCTCTATGCCCGCTTCACCGCCCAGATCCGAGGCGCC       c.300
 A  D  L  S  I  I  A  A  L  Y  A  R  F  T  A  Q  I  R  G  A         p.100

          .         .         .         .         .         .       g.6545
 GTCGACCTGTCCCTCTATCCTCGAGAAGGGGGTGTCTCCAGCCGTGAGCTGGTGAAGAAG       c.360
 V  D  L  S  L  Y  P  R  E  G  G  V  S  S  R  E  L  V  K  K         p.120

          .         .         .         .         .         .       g.6605
 GTCTCCGATGTCATATGGAACAGCCTCAGCCGCTCCTACTTCAAGGATCGGGCCCACATC       c.420
 V  S  D  V  I  W  N  S  L  S  R  S  Y  F  K  D  R  A  H  I         p.140

          .         .         .         . | 03       .         .    g.8215
 CAGTCCCTCTTCAGCTTCATCACAGGTTGGAGCCCAGTAG | GCACCAAATTGGACAGCTCC    c.480
 Q  S  L  F  S  F  I  T  G  W  S  P  V  G |   T  K  L  D  S  S      p.160

          .         .         .         .         .         .       g.8275
 GGTGTGGCCTTTGCTGTGGTTGGGGCCTGCCAGGCCCTGGGTCTCCGGGATGTCCACCTC       c.540
 G  V  A  F  A  V  V  G  A  C  Q  A  L  G  L  R  D  V  H  L         p.180

          .         .         .         .         .         .       g.8335
 GCCCTGTCTGAGGATCATGCCTGGGTAGTGTTTGGGCCCAATGGGGAGCAGACAGCTGAG       c.600
 A  L  S  E  D  H  A  W  V  V  F  G  P  N  G  E  Q  T  A  E         p.200

          .         .         .         .         .         .       g.8395
 GTCACCTGGCACGGCAAGGGCAACGAGGACCGCAGGGGCCAGACAGTCAATGCCGGTGTG       c.660
 V  T  W  H  G  K  G  N  E  D  R  R  G  Q  T  V  N  A  G  V         p.220

           | 04        .         .         .         .         .    g.8665
 GCTGAGCGG | AGCTGGCTGTACCTGAAAGGATCATACATGCGCTGTGACCGCAAGATGGAG    c.720
 A  E  R   | S  W  L  Y  L  K  G  S  Y  M  R  C  D  R  K  M  E      p.240

          .         .         .         .         .         .       g.8725
 GTGGCGTTCATGGTGTGTGCCATCAACCCTTCCATTGACCTGCACACCGACTCGCTGGAG       c.780
 V  A  F  M  V  C  A  I  N  P  S  I  D  L  H  T  D  S  L  E         p.260

          .         | 05         .         .         .          | 06 g.9197
 CTTCTGCAGCTGCAGCAG | AAGCTGCTCTGGCTGCTCTATGACCTGGGACATCTGGAAAG | G c.840
 L  L  Q  L  Q  Q   | K  L  L  W  L  L  Y  D  L  G  H  L  E  R  |   p.280

          .         .         .         .         .         .       g.9257
 TACCCCATGGCCTTAGGGAACCTGGCAGATCTAGAGGAGCTGGAGCCCACCCCTGGCCGG       c.900
 Y  P  M  A  L  G  N  L  A  D  L  E  E  L  E  P  T  P  G  R         p.300

          .         .        | 07.         .         .         .    g.9959
 CCAGACCCACTCACCCTCTACCACAAG | GGCATTGCCTCAGCCAAGACCTACTATCGGGAT    c.960
 P  D  P  L  T  L  Y  H  K   | G  I  A  S  A  K  T  Y  Y  R  D      p.320

          .         .         .         .         .         .       g.10019
 GAACACATCTACCCCTACATGTACCTGGCTGGCTACCACTGTCGCAACCGCAATGTGCGG       c.1020
 E  H  I  Y  P  Y  M  Y  L  A  G  Y  H  C  R  N  R  N  V  R         p.340

          .         .         .         .     | 08   .         .    g.10540
 GAAGCCCTGCAGGCCTGGGCGGACACGGCCACTGTCATCCAGGA | CTACAACTACTGCCGG    c.1080
 E  A  L  Q  A  W  A  D  T  A  T  V  I  Q  D  |  Y  N  Y  C  R      p.360

          .         .         .         .         .         .       g.10600
 GAAGACGAGGAGATCTACAAGGAGTTCTTTGAAGTAGCCAATGATGTCATCCCCAACCTG       c.1140
 E  D  E  E  I  Y  K  E  F  F  E  V  A  N  D  V  I  P  N  L         p.380

          .         .         .         .         .         .       g.10660
 CTGAAGGAGGCAGCCAGCTTGCTGGAGGCGGGCGAGGAGCGGCCGGGGGAGCAAAGCCAG       c.1200
 L  K  E  A  A  S  L  L  E  A  G  E  E  R  P  G  E  Q  S  Q         p.400

  | 09       .         .         .         .         .         .    g.11156
  | GGCACCCAGAGCCAAGGTTCCGCCCTCCAGGACCCTGAGTGCTTCGCCCACCTGCTGCGA    c.1260
  | G  T  Q  S  Q  G  S  A  L  Q  D  P  E  C  F  A  H  L  L  R      p.420

          .         .         .         .         .         .       g.11216
 TTCTACGACGGCATCTGCAAATGGGAGGAGGGCAGTCCCACGCCTGTGCTGCACGTGGGC       c.1320
 F  Y  D  G  I  C  K  W  E  E  G  S  P  T  P  V  L  H  V  G         p.440

          .         .         .         .      | 10  .         .    g.11493
 TGGGCCACCTTTCTTGTGCAGTCCCTAGGCCGTTTTGAGGGACAG | GTGCGGCAGAAGGTG    c.1380
 W  A  T  F  L  V  Q  S  L  G  R  F  E  G  Q   | V  R  Q  K  V      p.460

          .         .         .         .         .         .       g.11553
 CGCATAGTGAGCCGAGAGGCCGAGGCGGCCGAGGCCGAGGAGCCGTGGGGCGAGGAAGCC       c.1440
 R  I  V  S  R  E  A  E  A  A  E  A  E  E  P  W  G  E  E  A         p.480

          .         .         .         .         .         .       g.11613
 CGGGAAGGCCGGCGGCGGGGCCCACGGCGGGAGTCCAAGCCAGAGGAGCCCCCGCCGCCC       c.1500
 R  E  G  R  R  R  G  P  R  R  E  S  K  P  E  E  P  P  P  P         p.500

          .         .         .         .         .         .       g.11673
 AAGAAGCCAGCACTGGACAAGGGCCTGGGCACCGGCCAGGGTGCAGTGTCAGGACCCCCC       c.1560
 K  K  P  A  L  D  K  G  L  G  T  G  Q  G  A  V  S  G  P  P         p.520

          .         .         .         .         .         .       g.11733
 CGGAAGCCTCCTGGGACTGTCGCTGGCACAGCCCGAGGCCCTGAAGGTGGCAGCACGGCT       c.1620
 R  K  P  P  G  T  V  A  G  T  A  R  G  P  E  G  G  S  T  A         p.540

          .         .         .         .         .         .       g.11793
 CAGGTGCCAGCACCCGCAGCATCACCACCGCCGGAGGGTCCAGTGCTCACTTTCCAGAGT       c.1680
 Q  V  P  A  P  A  A  S  P  P  P  E  G  P  V  L  T  F  Q  S         p.560

          .         .         .         .         .         .       g.11853
 GAGAAGATGAAGGGCATGAAGGAGCTGCTGGTGGCCACCAAGATCAACTCGAGCGCCATC       c.1740
 E  K  M  K  G  M  K  E  L  L  V  A  T  K  I  N  S  S  A  I         p.580

          .         .         .         .         .         .       g.11913
 AAGCTGCAACTCACGGCACAGTCGCAAGTGCAGATGAAGAAGCAGAAAGTGTCCACCCCT       c.1800
 K  L  Q  L  T  A  Q  S  Q  V  Q  M  K  K  Q  K  V  S  T  P         p.600

          .         .         .         .                           g.11961
 AGTGACTACACTCTGTCTTTCCTCAAGCGGCAGCGCAAAGGCCTCTGA                   c.1848
 S  D  Y  T  L  S  F  L  K  R  Q  R  K  G  L  X                     p.615

          .         .         .         .         .         .       g.12021
 actactggggacttcggaccgcttgtggggacccaggctccgcccttagtcccccaactc       c.*60

          .         .         .         .         .         .       g.12081
 tgagcccatgttctgcccccagcccaaaggggacaggcctcacctctacccaaaccctag       c.*120

          .         .         .         .         .         .       g.12141
 gttcccggtcccgagtacagtctgtatcaaacccacgattttctccagctcagaacccag       c.*180

          .         .         .         .         .         .       g.12201
 ggctctgccccagtcgttagaatataggtctcttctcccagaatcccagccggccaatgg       c.*240

          .         .         .         .         .         .       g.12261
 aaacctcacgctgggtcctaattaccagtctttaaaggcccagcccctagaaacccaagc       c.*300

          .         .         .         .         .         .       g.12321
 tcctcctcggaaccgctcacctagagccagaccaacgttactcagggctcctcccagctt       c.*360

          .         .         .         .         .         .       g.12381
 gtaggagctgaggtttcacccttaacccaaggagcacaggtcccacctccagcccgggag       c.*420

          .         .         .         .         .         .       g.12441
 cctaggaccactcagcccctaggagtatatttccgcacttcagaattccatatcttgcga       c.*480

          .         .         .         .         .         .       g.12501
 atccaagctccctgccccaaataacttcagtcctgctccagaatttggaaatcctagttt       c.*540

          .         .         .         .         .         .       g.12561
 cctctccttcgtatcccgagtctgggacacaaaactccgcccccagcctatgagcatcct       c.*600

          .         .         .         .         .         .       g.12621
 gagccccgccctcttcctgacgaaactggccccggatcagagcaggacctcccttccgac       c.*660

          .         .         .         .         .         .       g.12681
 cctctgggaacctcccagaggtccagcccatctcggagcatcccggaggaaatctgcaga       c.*720

          .         .         .         .         .         .       g.12741
 gggttaggagtgggtgacaagagcctgatctcttcctgttttgtacatagatttattttt       c.*780

          .         .         .         .                           g.12781
 cagttccaagaaagatgaatacattttgttaaaaaaaata                           c.*820

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Multiple endocrine neoplasia I protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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