c-mer proto-oncogene tyrosine kinase (MERTK) - coding DNA reference sequence

(used for variant description)

(last modified June 20, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_006343.2 in the MERTK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011607.1, covering MERTK transcript NM_006343.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5002
                                                           ac       c.-121

 .         .         .         .         .         .                g.5062
 tcactgcccgggccgcccggacagggagcttcgctggcgcgcttggccggcgacaggaca       c.-61

 .         .         .         .         .         .                g.5122
 ggttcgggacgtccatctgtccatccgtccggagagaaattacagatccgcagccccggg       c.-1

          .         .         .         .         .         .       g.5182
 ATGGGGCCGGCCCCGCTGCCGCTGCTGCTGGGCCTCTTCCTCCCCGCGCTCTGGCGTAGA       c.60
 M  G  P  A  P  L  P  L  L  L  G  L  F  L  P  A  L  W  R  R         p.20

   | 02      .         .         .         .         .         .    g.35565
 G | CTATCACTGAGGCAAGGGAAGAAGCCAAGCCTTACCCGCTATTCCCGGGACCTTTTCCA    c.120
 A |   I  T  E  A  R  E  E  A  K  P  Y  P  L  F  P  G  P  F  P      p.40

          .         .         .         .         .         .       g.35625
 GGGAGCCTGCAAACTGACCACACACCGCTGTTATCCCTTCCTCACGCCAGTGGGTACCAG       c.180
 G  S  L  Q  T  D  H  T  P  L  L  S  L  P  H  A  S  G  Y  Q         p.60

          .         .         .         .         .         .       g.35685
 CCTGCCTTGATGTTTTCACCAACCCAGCCTGGAAGACCACATACAGGAAACGTAGCCATT       c.240
 P  A  L  M  F  S  P  T  Q  P  G  R  P  H  T  G  N  V  A  I         p.80

          .         .         .         .         .         .       g.35745
 CCCCAGGTGACCTCTGTCGAATCAAAGCCCCTACCGCCTCTTGCCTTCAAACACACAGTT       c.300
 P  Q  V  T  S  V  E  S  K  P  L  P  P  L  A  F  K  H  T  V         p.100

          .         .         .         .         .         .       g.35805
 GGACACATAATACTTTCTGAACATAAAGGTGTCAAATTTAATTGCTCAATCAGTGTACCT       c.360
 G  H  I  I  L  S  E  H  K  G  V  K  F  N  C  S  I  S  V  P         p.120

          .         .         .         .         .         .       g.35865
 AATATATACCAGGACACCACAATTTCTTGGTGGAAAGATGGGAAGGAATTGCTTGGGGCA       c.420
 N  I  Y  Q  D  T  T  I  S  W  W  K  D  G  K  E  L  L  G  A         p.140

          .         .         .         .         .         .       g.35925
 CATCATGCAATTACACAGTTTTATCCAGATGATGAAGTTACAGCAATAATCGCTTCCTTC       c.480
 H  H  A  I  T  Q  F  Y  P  D  D  E  V  T  A  I  I  A  S  F         p.160

    | 03     .         .         .         .         .         .    g.51404
 AG | CATAACCAGTGTGCAGCGTTCAGACAATGGGTCGTATATCTGTAAGATGAAAATAAAC    c.540
 S  |  I  T  S  V  Q  R  S  D  N  G  S  Y  I  C  K  M  K  I  N      p.180

          .         .         .         .    | 04    .         .    g.53797
 AATGAAGAGATCGTGTCTGATCCCATCTACATCGAAGTACAAG | GACTTCCTCACTTTACT    c.600
 N  E  E  I  V  S  D  P  I  Y  I  E  V  Q  G |   L  P  H  F  T      p.200

          .         .         .         .         .         .       g.53857
 AAGCAGCCTGAGAGCATGAATGTCACCAGAAACACAGCCTTCAACCTCACCTGTCAGGCT       c.660
 K  Q  P  E  S  M  N  V  T  R  N  T  A  F  N  L  T  C  Q  A         p.220

          .         .         .         .         .         .       g.53917
 GTGGGCCCGCCTGAGCCCGTCAACATTTTCTGGGTTCAAAACAGTAGCCGTGTTAACGAA       c.720
 V  G  P  P  E  P  V  N  I  F  W  V  Q  N  S  S  R  V  N  E         p.240

          .         .         .        | 05.         .         .    g.71600
 CAGCCTGAAAAATCCCCCTCCGTGCTAACTGTTCCAG | GCCTGACGGAGATGGCGGTCTTC    c.780
 Q  P  E  K  S  P  S  V  L  T  V  P  G |   L  T  E  M  A  V  F      p.260

          .         .         .         .         .         .       g.71660
 AGTTGTGAGGCCCACAATGACAAAGGGCTGACCGTGTCCAAGGGAGTGCAGATCAACATC       c.840
 S  C  E  A  H  N  D  K  G  L  T  V  S  K  G  V  Q  I  N  I         p.280

      | 06   .         .         .         .         .         .    g.74579
 AAAG | CAATTCCCTCCCCACCAACTGAAGTCAGCATCCGTAACAGCACTGCACACAGCATT    c.900
 K  A |   I  P  S  P  P  T  E  V  S  I  R  N  S  T  A  H  S  I      p.300

          .         .         .         .         .         .       g.74639
 CTGATCTCCTGGGTTCCTGGTTTTGATGGATACTCCCCGTTCAGGAATTGCAGCATTCAG       c.960
 L  I  S  W  V  P  G  F  D  G  Y  S  P  F  R  N  C  S  I  Q         p.320

  | 07       .         .         .         .         .         .    g.81735
  | GTCAAGGAAGCTGATCCGCTGAGTAATGGCTCAGTCATGATTTTTAACACCTCTGCCTTA    c.1020
  | V  K  E  A  D  P  L  S  N  G  S  V  M  I  F  N  T  S  A  L      p.340

          .         .         .         .         .         .       g.81795
 CCACATCTGTACCAAATCAAGCAGCTGCAAGCCCTGGCTAATTACAGCATTGGTGTTTCC       c.1080
 P  H  L  Y  Q  I  K  Q  L  Q  A  L  A  N  Y  S  I  G  V  S         p.360

          .         .         .         .         .         .       g.81855
 TGCATGAATGAAATAGGCTGGTCTGCAGTGAGCCCTTGGATTCTAGCCAGCACGACTGAA       c.1140
 C  M  N  E  I  G  W  S  A  V  S  P  W  I  L  A  S  T  T  E         p.380

      | 08   .         .         .         .         .         .    g.89284
 GGAG | CCCCATCAGTAGCACCTTTAAATGTCACTGTGTTTCTGAATGAATCTAGTGATAAT    c.1200
 G  A |   P  S  V  A  P  L  N  V  T  V  F  L  N  E  S  S  D  N      p.400

          .         .         .         .         .         .       g.89344
 GTGGACATCAGATGGATGAAGCCTCCGACTAAGCAGCAGGATGGAGAACTGGTGGGCTAC       c.1260
 V  D  I  R  W  M  K  P  P  T  K  Q  Q  D  G  E  L  V  G  Y         p.420

          .         .         .       | 09 .         .         .    g.100661
 CGGATATCCCACGTGTGGCAGAGTGCAGGGATTTCC | AAAGAGCTCTTGGAGGAAGTTGGC    c.1320
 R  I  S  H  V  W  Q  S  A  G  I  S   | K  E  L  L  E  E  V  G      p.440

          .         .         .         .         .         .       g.100721
 CAGAATGGCAGCCGAGCTCGGATCTCTGTTCAAGTCCACAATGCTACGTGCACAGTGAGG       c.1380
 Q  N  G  S  R  A  R  I  S  V  Q  V  H  N  A  T  C  T  V  R         p.460

          .         .         .         .         .         .       g.100781
 ATTGCAGCCGTCACCAGAGGGGGAGTTGGGCCCTTCAGTGATCCAGTGAAAATATTTATC       c.1440
 I  A  A  V  T  R  G  G  V  G  P  F  S  D  P  V  K  I  F  I         p.480

          . | 10       .         .         .         .         .    g.103759
 CCTGCACACG | GTTGGGTAGATTATGCCCCCTCTTCAACTCCGGCGCCTGGCAACGCAGAT    c.1500
 P  A  H  G |   W  V  D  Y  A  P  S  S  T  P  A  P  G  N  A  D      p.500

          .         .         .         .         .         .       g.103819
 CCTGTGCTCATCATCTTTGGCTGCTTTTGTGGATTTATTTTGATTGGGTTGATTTTATAC       c.1560
 P  V  L  I  I  F  G  C  F  C  G  F  I  L  I  G  L  I  L  Y         p.520

          .         .         .         .     | 11   .         .    g.107603
 ATCTCCTTGGCCATCAGAAAAAGAGTCCAGGAGACAAAGTTTGG | GAATGCATTCACAGAG    c.1620
 I  S  L  A  I  R  K  R  V  Q  E  T  K  F  G  |  N  A  F  T  E      p.540

          .         .         .         .         .         .       g.107663
 GAGGATTCTGAATTAGTGGTGAATTATATAGCAAAGAAATCCTTCTGTCGGCGAGCCATT       c.1680
 E  D  S  E  L  V  V  N  Y  I  A  K  K  S  F  C  R  R  A  I         p.560

          . | 12       .         .         .         .         .    g.109528
 GAACTTACCT | TACATAGCTTGGGAGTCAGTGAGGAACTACAAAATAAACTAGAAGATGTT    c.1740
 E  L  T  L |   H  S  L  G  V  S  E  E  L  Q  N  K  L  E  D  V      p.580

          .         .         .         .       | 13 .         .    g.110304
 GTGATTGACAGGAATCTTCTAATTCTTGGAAAAATTCTGGGTGAAG | GAGAGTTTGGGTCT    c.1800
 V  I  D  R  N  L  L  I  L  G  K  I  L  G  E  G |   E  F  G  S      p.600

          .         .         .         .         .         .       g.110364
 GTAATGGAAGGAAATCTTAAGCAGGAAGATGGGACCTCTCTGAAAGTGGCAGTGAAGACC       c.1860
 V  M  E  G  N  L  K  Q  E  D  G  T  S  L  K  V  A  V  K  T         p.620

         | 14.         .         .         .         .         .    g.114822
 ATGAAGT | TGGACAACTCTTCACAGCGGGAGATCGAGGAGTTTCTCAGTGAGGCAGCGTGC    c.1920
 M  K  L |   D  N  S  S  Q  R  E  I  E  E  F  L  S  E  A  A  C      p.640

          .         .         .         . | 15       .         .    g.116354
 ATGAAAGACTTCAGCCACCCAAATGTCATTCGACTTCTAG | GTGTGTGTATAGAAATGAGC    c.1980
 M  K  D  F  S  H  P  N  V  I  R  L  L  G |   V  C  I  E  M  S      p.660

          .         .         .         .         .         .       g.116414
 TCTCAAGGCATCCCAAAGCCCATGGTAATTTTACCCTTCATGAAATACGGGGACCTGCAT       c.2040
 S  Q  G  I  P  K  P  M  V  I  L  P  F  M  K  Y  G  D  L  H         p.680

          .         .         .          | 16        .         .    g.125820
 ACTTACTTACTTTATTCCCGATTGGAGACAGGACCAAAG | CATATTCCTCTGCAGACACTA    c.2100
 T  Y  L  L  Y  S  R  L  E  T  G  P  K   | H  I  P  L  Q  T  L      p.700

          .         .         .         .         .         .       g.125880
 TTGAAGTTCATGGTGGATATTGCCCTGGGAATGGAGTATCTGAGCAACAGGAATTTTCTT       c.2160
 L  K  F  M  V  D  I  A  L  G  M  E  Y  L  S  N  R  N  F  L         p.720

          .         .          | 17        .         .         .    g.127839
 CATCGAGATTTAGCTGCTCGAAACTGCAT | GTTGCGAGATGACATGACTGTCTGTGTTGCG    c.2220
 H  R  D  L  A  A  R  N  C  M  |  L  R  D  D  M  T  V  C  V  A      p.740

          .         .         .         .         .         .       g.127899
 GACTTCGGCCTCTCTAAGAAGATTTACAGTGGCGATTATTACCGCCAAGGCCGCATTGCT       c.2280
 D  F  G  L  S  K  K  I  Y  S  G  D  Y  Y  R  Q  G  R  I  A         p.760

          .         .         .         .         .         .       g.127959
 AAGATGCCTGTTAAATGGATCGCCATAGAAAGTCTTGCAGACCGAGTCTACACAAGTAAA       c.2340
 K  M  P  V  K  W  I  A  I  E  S  L  A  D  R  V  Y  T  S  K         p.780

           | 18        .         .         .         .         .    g.128695
 AGTGATGTG | TGGGCATTTGGCGTGACCATGTGGGAAATAGCTACGCGGGGAATGACTCCC    c.2400
 S  D  V   | W  A  F  G  V  T  M  W  E  I  A  T  R  G  M  T  P      p.800

          .         .         .         .         .         .       g.128755
 TATCCTGGGGTCCAGAACCATGAGATGTATGACTATCTTCTCCATGGCCACAGGTTGAAG       c.2460
 Y  P  G  V  Q  N  H  E  M  Y  D  Y  L  L  H  G  H  R  L  K         p.820

          .         .       | 19 .         .         .         .    g.134771
 CAGCCCGAAGACTGCCTGGATGAACT | GTATGAAATAATGTACTCTTGCTGGAGAACCGAT    c.2520
 Q  P  E  D  C  L  D  E  L  |  Y  E  I  M  Y  S  C  W  R  T  D      p.840

          .         .         .         .         .         .       g.134831
 CCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGT       c.2580
 P  L  D  R  P  T  F  S  V  L  R  L  Q  L  E  K  L  L  E  S         p.860

          .         .         .         .         .         .       g.134891
 TTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGC       c.2640
 L  P  D  V  R  N  Q  A  D  V  I  Y  V  N  T  Q  L  L  E  S         p.880

          .         .         .         .         .         .       g.134951
 TCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGAC       c.2700
 S  E  G  L  A  Q  G  S  T  L  A  P  L  D  L  N  I  D  P  D         p.900

          .         .         .         .         .         .       g.135011
 TCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCAT       c.2760
 S  I  I  A  S  C  T  P  R  A  A  I  S  V  V  T  A  E  V  H         p.920

          .         .         .         .         .         .       g.135071
 GACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGAT       c.2820
 D  S  K  P  H  E  G  R  Y  I  L  N  G  G  S  E  E  W  E  D         p.940

          .         .         .         .         .         .       g.135131
 CTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAG       c.2880
 L  T  S  A  P  S  A  A  V  T  A  E  K  N  S  V  L  P  G  E         p.960

          .         .         .         .         .         .       g.135191
 AGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCA       c.2940
 R  L  V  R  N  G  V  S  W  S  H  S  S  M  L  P  L  G  S  S         p.980

          .         .         .         .         .         .       g.135251
 TTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGA       c.3000
 L  P  D  E  L  L  F  A  D  D  S  S  E  G  S  E  V  L  M  X         p.999

          .         .         .         .         .         .       g.135311
 ggagaggtgcggggagacattccaaaaatcaagccaattcttctgctgtaggagaatcca       c.*60

          .         .         .         .         .         .       g.135371
 attgtacctgatgtttttggtatttgtcttccttaccaagtgaactccatggccccaaag       c.*120

          .         .         .         .         .         .       g.135431
 caccagatgaatgttgttaagtaagctgtcattaaaaatacataatatatatttatttaa       c.*180

          .         .         .         .         .         .       g.135491
 agagaaaaaatatgtgtatatcatggaaaaagacaaggatattttaataaaacattactt       c.*240

          .         .         .         .         .         .       g.135551
 atttcatttcacttatcttgcatatcttaaaattaagcttcagctgctccttgatattaa       c.*300

          .         .         .         .         .         .       g.135611
 catttgtacagagttgaagttgttttttcaagttcttttctttttcatgactattaaatg       c.*360

          .         .         .         .         .         .       g.135671
 taaaaatatttgtaaaatgaaatgccatatttgacttggcttctggtcttgatgtatttg       c.*420

          .         .         .         .         .         .       g.135731
 ataagaatgattcattcaatgtttaaagttgtataactgattaattttctgatatggctt       c.*480

          .         .                                               g.135755
 cctaataaaatatgaataaggaag                                           c.*504

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The C-mer proto-oncogene tyrosine kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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