mesoderm specific transcript (MEST) - coding DNA reference sequence

(used for variant description)

(last modified November 21, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_177524.2 in the MEST gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009226.1, covering MEST transcript NM_177524.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5012
                   ggcgctgacgcctggcagggagaaggcggcagcacatgctgg       c.-181

 .         .         .         .         .         .                g.5072
 gctcgggggcgatgggcttgtgcgcggacctggcgacgctctagccccgagccgcgtatt       c.-121

 .         .         .         .         .         .                g.5132
 cgtggccgggtcctccctgggaacagggtgaaggccgagaacctctggcctcaggaagcg       c.-61

 .         .         .         .         .         .         | 02    g.14164
 catgcgcaaccggttctccgaaacatggagtcctgtaggcaaggtcttacctgaatcag | g    c.-1

          .         .         .         .         .         .       g.14224
 ATGAGGGAGTGGTGGGTCCAGGTGGGGCTGCTGGCCGTGCCCCTGCTTGCTGCGTACCTG       c.60
 M  R  E  W  W  V  Q  V  G  L  L  A  V  P  L  L  A  A  Y  L         p.20

          .         .         .         .         .         .       g.14284
 CACATCCCACCCCCTCAGCTCTCCCCTGCCCTTCACTCATGGAAGTCTTCAGGCAAGTTT       c.120
 H  I  P  P  P  Q  L  S  P  A  L  H  S  W  K  S  S  G  K  F         p.40

          .         .         .     | 03   .         .         .    g.15977
 TTCACTTACAAGGGACTGCGTATCTTCTACCAAG | ACTCTGTGGGTGTGGTTGGAAGTCCA    c.180
 F  T  Y  K  G  L  R  I  F  Y  Q  D |   S  V  G  V  V  G  S  P      p.60

          .         .         .         .         .     | 04   .    g.16737
 GAGATAGTTGTGCTTTTACACGGTTTTCCAACATCCAGCTACGACTGGTACAAG | ATTTGG    c.240
 E  I  V  V  L  L  H  G  F  P  T  S  S  Y  D  W  Y  K   | I  W      p.80

          .         .         .         .         .         .       g.16797
 GAAGGTCTGACCTTGAGGTTTCATCGGGTGATTGCCCTTGATTTCTTAGGCTTTGGCTTC       c.300
 E  G  L  T  L  R  F  H  R  V  I  A  L  D  F  L  G  F  G  F         p.100

          .   | 05     .         .         .         .         .    g.16982
 AGTGACAAACCG | AGACCACATCACTATTCCATATTTGAGCAGGCCAGCATCGTGGAAGCG    c.360
 S  D  K  P   | R  P  H  H  Y  S  I  F  E  Q  A  S  I  V  E  A      p.120

          .         .         .         .         .         .       g.17042
 CTTTTGCGGCATCTGGGGCTCCAGAACCGCAGGATCAACCTTCTTTCTCATGACTATGGA       c.420
 L  L  R  H  L  G  L  Q  N  R  R  I  N  L  L  S  H  D  Y  G         p.140

          .         .          | 06        .         .         .    g.17245
 GATATTGTTGCTCAGGAGCTTCTCTACAG | GTACAAGCAGAATCGATCTGGTCGGCTTACC    c.480
 D  I  V  A  Q  E  L  L  Y  R  |  Y  K  Q  N  R  S  G  R  L  T      p.160

          .         .         | 07         .         .         .    g.18702
 ATAAAGAGTCTCTGTCTGTCAAATGGAG | GTATCTTTCCTGAGACTCACCGTCCACTCCTT    c.540
 I  K  S  L  C  L  S  N  G  G |   I  F  P  E  T  H  R  P  L  L      p.180

           | 08        .         .         .         .         .    g.19308
 CTCCAAAAG | CTACTCAAAGATGGAGGTGTGCTGTCACCCATCCTCACACGACTGATGAAC    c.600
 L  Q  K   | L  L  K  D  G  G  V  L  S  P  I  L  T  R  L  M  N      p.200

          .         . | 09       .         .         .         .    g.19624
 TTCTTTGTATTCTCTCGAGG | TCTCACCCCAGTCTTTGGGCCGTATACTCGGCCCTCTGAG    c.660
 F  F  V  F  S  R  G  |  L  T  P  V  F  G  P  Y  T  R  P  S  E      p.220

          .         .         .         .         .         .       g.19684
 AGTGAGCTGTGGGACATGTGGGCAGGGATCCGCAACAATGACGGGAACTTAGTCATTGAC       c.720
 S  E  L  W  D  M  W  A  G  I  R  N  N  D  G  N  L  V  I  D         p.240

    | 10     .         .         .         .         .         .    g.21497
 AG | TCTCTTACAGTACATCAATCAGAGGAAGAAGTTCAGAAGGCGCTGGGTGGGAGCTCTT    c.780
 S  |  L  L  Q  Y  I  N  Q  R  K  K  F  R  R  R  W  V  G  A  L      p.260

          .          | 11        .         .         .         .    g.22769
 GCCTCTGTAACTATCCCCA | TTCATTTTATCTATGGGCCATTGGATCCTGTAAATCCCTAT    c.840
 A  S  V  T  I  P  I |   H  F  I  Y  G  P  L  D  P  V  N  P  Y      p.280

          .         .    | 12    .         .         .         .    g.23771
 CCAGAGTTTTTGGAGCTGTACAG | GAAAACGCTGCCGCGGTCCACAGTGTCGATTCTGGAT    c.900
 P  E  F  L  E  L  Y  R  |  K  T  L  P  R  S  T  V  S  I  L  D      p.300

          .         .         .         .         .         .       g.23831
 GACCACATTAGCCACTATCCACAGCTAGAGGATCCCATGGGCTTCTTGAATGCATATATG       c.960
 D  H  I  S  H  Y  P  Q  L  E  D  P  M  G  F  L  N  A  Y  M         p.320

          .         .                                               g.23852
 GGCTTCATCAACTCCTTCTGA                                              c.981
 G  F  I  N  S  F  X                                                p.326

          .         .         .         .         .         .       g.23912
 gctggaaagagtagcttccctgtattacctcccctactcccttatgtgttgtgtattcca       c.*60

          .         .         .         .         .         .       g.23972
 cttaggaagaaatgcccaaaagaggtcctggccatcaaacataattctctcacaaagtcc       c.*120

          .         .         .         .         .         .       g.24032
 actttactcaaattggtgaacagtgtataggaagaagccagcaggagctctgactaaggt       c.*180

          .         .         .         .         .         .       g.24092
 tgacataatagtccacctcccattactttgatatctgatcaaatgtatagacttggcttt       c.*240

          .         .         .         .         .         .       g.24152
 gttttttgtgctattaggaaattctgatgagcattactattcactgatgcagaaagacgt       c.*300

          .         .         .         .         .         .       g.24212
 tcttttgcataaaagacttttttttaacactttggacttctctgaaatatttagaagtgc       c.*360

          .         .         .         .         .         .       g.24272
 taatttctggcccacccccaacaggaattctatagtaaggaggaggagaaggggggctcc       c.*420

          .         .         .         .         .         .       g.24332
 ttccctctcctcgaatgacgttatgggcacatgccttttaaaagttctttaagcaacaca       c.*480

          .         .         .         .         .         .       g.24392
 gagctgagtcctctttgtcatacctttggatttagtgtttcatcagctgtttttagttat       c.*540

          .         .         .         .         .         .       g.24452
 aaacattttgttaaaatagatattggtttaaatgatacagtattttaggtatgatttaag       c.*600

          .         .         .         .         .         .       g.24512
 actatgatttacctatacattatatatattttataaagatactaaaccagcataccctta       c.*660

          .         .         .         .         .         .       g.24572
 ctctgccagagtagtgaagctaattaaacacatttggtttctgaataaattgaactaaat       c.*720

          .         .         .         .         .         .       g.24632
 ccaaactatttcctaaaatcacaggacattaaggaccaatagcatctgtgccagagatgt       c.*780

          .         .         .         .         .         .       g.24692
 actgttattagctgggaagaccaattctaacagcaaataacagtctgagactcctcatac       c.*840

          .         .         .         .         .         .       g.24752
 ctcagtggttagaagcatgtctctcttgagctacagtagaggggaagggattgttgtgta       c.*900

          .         .         .         .         .         .       g.24812
 gtcaagtcaccatgctgaatgtacactgattcctttatgatgactgcttaactccccact       c.*960

          .         .         .         .         .         .       g.24872
 gcctgtcccagagaggctttccaatgtagctcagtaattcctgttactttacagacagga       c.*1020

          .         .         .         .         .         .       g.24932
 aagttccagaaactttaagaacaaactctgaaagacctatgagcaaatggtgctgaatac       c.*1080

          .         .         .         .         .         .       g.24992
 tttttttttaaagccacatttcattgtcttagtcaaagcaggattattaagtgattattt       c.*1140

          .         .         .         .         .         .       g.25052
 aaaattcgtttttttaaattagcaacttcaagtataacaactttgaaactggaataagtg       c.*1200

          .         .         .         .                           g.25093
 tttattttctattaataaaaatgaattgtgacaaaagtgga                          c.*1241

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mesoderm specific transcript protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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