methyltransferase like 9 (METTL9) - coding DNA reference sequence

(used for variant description)

(last modified April 26, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_016025.3 in the METTL9 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering METTL9 transcript NM_016025.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          ggaagggaagggggaggtg       c.-181

 .         .         .         .         .         .                g.5079
 ccgaggctgcgcgccggctgctcctccccacccccagcctttgccctgaagggggctgga       c.-121

 .         .         .         .         .         .                g.5139
 tgggcaaggcggccgcgatggctcgagctcgggcggtggcggcggtggccggaggcggcg       c.-61

 .         .         .         .         .         .                g.5199
 gtgcctcctcctcctcgccccggcgccggcggtgatccgagcgagcggccgcggcccccg       c.-1

          .         .         .         .         .         .       g.5259
 ATGAGACTGCTGGCGGGCTGGCTGTGCCTGAGCCTGGCGTCCGTGTGGCTGGCGCGGAGG       c.60
 M  R  L  L  A  G  W  L  C  L  S  L  A  S  V  W  L  A  R  R         p.20

          .         .         .         .         .         .       g.5319
 ATGTGGACGCTGCGGAGCCCGCTCACCCGCTCCCTGTACGTGAACATGACTAGCGGCCCG       c.120
 M  W  T  L  R  S  P  L  T  R  S  L  Y  V  N  M  T  S  G  P         p.40

          .         .         .         .      | 02  .         .    g.18125
 GGTGGGCCGGCGGCGGCCGCGGGCGGCAGGAAGGAGAACCACCAG | TGGTATGTGTGCAAC    c.180
 G  G  P  A  A  A  A  G  G  R  K  E  N  H  Q   | W  Y  V  C  N      p.60

          .         .         .         .         .         .       g.18185
 AGAGAGAAATTATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGA       c.240
 R  E  K  L  C  E  S  L  Q  A  V  F  V  Q  S  Y  L  D  Q  G         p.80

          .         .         .         .         .         .       g.18245
 ACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGGCTATTTATCCAATTATAT       c.300
 T  Q  I  F  L  N  N  S  I  E  K  S  G  W  L  F  I  Q  L  Y         p.100

          .         .         .         .         .       | 03 .    g.23334
 CATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGG | GTTG    c.360
 H  S  F  V  S  S  V  F  S  L  F  M  S  R  T  S  I  N  G  |  L      p.120

          .         .         .         .         .         .       g.23394
 CTAGGAAGAGGCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATT       c.420
 L  G  R  G  S  M  F  V  F  S  P  D  Q  F  Q  R  L  L  K  I         p.140

          .         .         .         .         .         .       g.23454
 AATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCTGGAGATGGAGAAGTCACA       c.480
 N  P  D  W  K  T  H  R  L  L  D  L  G  A  G  D  G  E  V  T         p.160

          .         .         .         .         .         .       g.23514
 AAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATA       c.540
 K  I  M  S  P  H  F  E  E  I  Y  A  T  E  L  S  E  T  M  I         p.180

          .         .       | 04 .         .         .         .    g.30430
 TGGCAGCTTCAGAAAAAGAAATACAG | AGTCCTTGGTATAAATGAATGGCAGAATACGGGG    c.600
 W  Q  L  Q  K  K  K  Y  R  |  V  L  G  I  N  E  W  Q  N  T  G      p.200

          .         .         .         .         .         .       g.30490
 TTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGCTGTGATCAGCCCCTGACT       c.660
 F  Q  Y  D  V  I  S  C  L  N  L  L  D  R  C  D  Q  P  L  T         p.220

          .         .         .         .         .         .       g.30550
 TTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTT       c.720
 L  L  K  D  I  R  S  V  L  E  P  T  R  G  R  V  I  L  A  L         p.240

          .         .         .  | 05      .         .         .    g.60721
 GTCCTCCCCTTTCATCCCTATGTGGAAAACG | TAGGTGGCAAGTGGGAGAAACCATCAGAA    c.780
 V  L  P  F  H  P  Y  V  E  N  V |   G  G  K  W  E  K  P  S  E      p.260

          .         .         .         .         .         .       g.60781
 ATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTC       c.840
 I  L  E  I  K  G  Q  N  W  E  E  Q  V  N  S  L  P  E  V  F         p.280

          .         .         .         .         .         .       g.60841
 AGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGAC       c.900
 R  K  A  G  F  V  I  E  A  F  T  R  L  P  Y  L  C  E  G  D         p.300

          .         .         .         .         .                 g.60898
 ATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAA          c.957
 M  Y  N  D  Y  Y  V  L  D  D  A  V  F  V  L  K  P  V  X            p.318

          .         .         .         .         .         .       g.60958
 acacgtggaggtcgaagtcttcagagtccgcaccctccgggatgtgcccttggaagaggg       c.*60

          .         .         .         .         .         .       g.61018
 tctgtgttcacaattacgtgaagggaggacccttggggaccgccattctaaatatcatgt       c.*120

          .         .         .         .         .         .       g.61078
 aggaatttaaaaagccaaaatactaattatttctttgtagtgtgtaaaggaatgttttta       c.*180

          .         .         .         .         .         .       g.61138
 aaagacaaaaacccaactctttgtggatttttatcaactctttactcagagccactctcc       c.*240

          .         .         .         .         .         .       g.61198
 aatgcaggtcacactccaattatgatggaagatattttttatacttaattgcagtaggga       c.*300

          .         .         .         .         .         .       g.61258
 ctcattcccagacaaagcaatagtcacgacttcatggaaccaatcaatggattgtttttt       c.*360

          .         .         .         .         .         .       g.61318
 gaagactggcaataaagctgtccattcaattccaaatactggttttaaggtatagccact       c.*420

          .         .         .         .         .         .       g.61378
 gatattctttcatgtttagaaattctttctgttattattcaagaaaatgtttttaatcat       c.*480

          .         .         .         .         .         .       g.61438
 gctaataaacttttttggagatgactttggcatcatgtttgaattcatataaagctcccc       c.*540

          .         .         .         .         .         .       g.61498
 tagcattttttattggtttggcttcaggagtacccaaatagtagcattatgagaatgacg       c.*600

          .         .         .         .         .         .       g.61558
 cagacaatttgaataggggggaaggaaggcttcagacttgggggaaggggagattattgc       c.*660

          .         .         .         .         .         .       g.61618
 aaattgcagtgaacactgagtcagtaaaaaaaaaaaacagaaacaaaaacccagcctcat       c.*720

          .         .         .         .         .         .       g.61678
 tcagatacagaacttcagggacccctccccccacccccccagttaatgctgctgtgaaaa       c.*780

          .         .         .         .         .         .       g.61738
 atgcaaaataacctggttctgactttgtgatcactcatgtcccatacactgaactttgtt       c.*840

          .         .         .         .         .         .       g.61798
 tttttctggacaatctcaggttctcagaattgaaacattcagttttgtctactgacaaaa       c.*900

          .         .         .         .         .         .       g.61858
 tgcaactaaaaatgttttaattcaacttcttactctacacttatatacctctctcccaga       c.*960

          .         .         .         .         .         .       g.61918
 gcttggctcttccctgaaatccttaaaggagtttattatttgccaagaatatggtttgat       c.*1020

          .         .         .         .         .         .       g.61978
 gaagaccgtgtcagactcatgcattctggaatccgtgagtgcctccaaccataaacccag       c.*1080

          .         .         .         .         .         .       g.62038
 aaatgctgccatagaggaacccattagcaagatcaataaccatcgtggatattccaaaga       c.*1140

          .         .         .         .         .         .       g.62098
 gcagagcatttaacccagaatctgaaatctcagtaataacagaaatgtcaatatgagatt       c.*1200

          .         .         .         .         .         .       g.62158
 gtggttattaacaatatgttatcctcactactttatttcttttttcatccaggtgtttca       c.*1260

          .         .         .         .         .         .       g.62218
 ttaagtattctcatttatatgctcatagaagtcatcagatcaacacattcactccaacac       c.*1320

          .         .         .         .         .         .       g.62278
 ctgggtataaaggcgaattaaaacctgaagaattactttattattcattaagaactgcat       c.*1380

          .         .         .         .         .         .       g.62338
 tcccacatcctcacaccaatatcttccactgttactgtgcagtcataataagagttgggt       c.*1440

          .         .         .         .         .         .       g.62398
 tatgtgatttatgcaaaattgttattggtgtgttctaatgatttttttccaggaattcaa       c.*1500

          .         .         .         .         .         .       g.62458
 gtaagtgaagtacaaatacttagcaccatagattgtaaaaatagaaagaggaaatgagaa       c.*1560

          .         .         .         .         .         .       g.62518
 aacttaatgtcgttcttgtacagttgagttttgcttctttataaactgtctgttaaaatc       c.*1620

          .         .         .         .         .         .       g.62578
 aggggttgctgttagactgtcaagcagaagtgatggatgttcaaggaggcaggttgcccc       c.*1680

          .         .         .         .         .         .       g.62638
 aaagtgttttctaactttcaagtagagaactttatgctctaataagaaaaatacaactca       c.*1740

          .         .         .         .         .         .       g.62698
 ttcttaaccacccccccaaaacagagaaaacacatacatttatgcattttaaagataaaa       c.*1800

          .         .         .         .         .         .       g.62758
 agtagtttctcaaaaaaatctgaagttctctgaaaaccagcttattaaaagtgctgtttt       c.*1860

          .         .         .         .         .         .       g.62818
 gtggtgaaaattgaaaccaaatccactcacatttcctatcgggtcttgaaattcttggtg       c.*1920

          .         .         .         .         .         .       g.62878
 gtgtgtcaccattccactagatggcagtgttgcttactgagtgtcaatggcttttttccc       c.*1980

          .         .         .         .         .                 g.62937
 cgtaaatggaatcatgtttttctcccccaaagtacaataaagctgccttgtctgcacca        c.*2039

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Methyltransferase like 9 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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