membrane frizzled-related protein (MFRP) - coding DNA reference sequence

(used for variant description)

(last modified December 27, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_031433.3 in the MFRP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering MFRP transcript NM_031433.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     actctaccaaggacagcccaagaactggtctagcctggca       c.-121

 .         .         .         .         .         .                g.5100
 gccttttccctcgggtagtagaggctgcccctctgacagggagtttgtggtcagcgagtg       c.-61

 .         .         .         .         .         .                g.5160
 ggcccttgggggtcttgggctgtcacagggactccagaaagccatgcagagccttgtgcc       c.-1

          .         .         .         .         .     | 02   .    g.5305
 ATGAAGGACTTCTCAGATGTCATCCTCTGCATGGAGGCAACAGAATCGAGCAAG | ACCGAG    c.60
 M  K  D  F  S  D  V  I  L  C  M  E  A  T  E  S  S  K   | T  E      p.20

          .         .         .         .         .         .       g.5365
 TTCTGCAATCCTGCCTTCGAGCCTGAGTCTGGGCCACCCTGCCCTCCCCCAGTTTTCCCA       c.120
 F  C  N  P  A  F  E  P  E  S  G  P  P  C  P  P  P  V  F  P         p.40

          .         .         .        | 03.         .         .    g.5537
 GAGGATGCCAGCTACAGCGTCCCAGCTCCCTGGCATG | GTCGGCGTCCTCGAGGGCTACGG    c.180
 E  D  A  S  Y  S  V  P  A  P  W  H  G |   R  R  P  R  G  L  R      p.60

          .         .         .         .         .         .       g.5597
 CCAGACTGCCGCTTCTCCTGGCTCTGTGTCCTCCTGCTCTCCAGCCTGCTCCTCCTGCTG       c.240
 P  D  C  R  F  S  W  L  C  V  L  L  L  S  S  L  L  L  L  L         p.80

          .         .         .  | 04      .         .         .    g.5774
 CTTGGGCTGCTGGTGGCCATCATCCTGGCCC | AGCTGCAGGCTGCACCCCCATCTGGGGCG    c.300
 L  G  L  L  V  A  I  I  L  A  Q |   L  Q  A  A  P  P  S  G  A      p.100

          .         .         .         .         .         .       g.5834
 TCCCATAGCCCACTGCCTGCCGGAGGCCTTACCACGACCACCACCACCCCCACCATCACC       c.360
 S  H  S  P  L  P  A  G  G  L  T  T  T  T  T  T  P  T  I  T         p.120

          .         .         .         .         .         .       g.5894
 ACCTCTCAGGCAGCTGGGACCCCTAAAGGGCAGCAGGAGTCAGGCGTGAGCCCCTCCCCA       c.420
 T  S  Q  A  A  G  T  P  K  G  Q  Q  E  S  G  V  S  P  S  P         p.140

         | 05.         .         .         .         .         .    g.6093
 CAGTCCA | CCTGTGGAGGCCTCCTCTCTGGCCCAAGGGGCTTCTTCAGCAGCCCTAACTAC    c.480
 Q  S  T |   C  G  G  L  L  S  G  P  R  G  F  F  S  S  P  N  Y      p.160

          .         .         .         .         .         .       g.6153
 CCAGACCCTTACCCCCCCAACACCCACTGCGTGTGGCATATCCAGGTGGCCACAGACCAT       c.540
 P  D  P  Y  P  P  N  T  H  C  V  W  H  I  Q  V  A  T  D  H         p.180

          .         .         .         .         .         .       g.6213
 GCAATACAGCTCAAGATCGAAGCCCTCAGCATAGAGAGTGTGGCCTCTTGCCTTTTTGAT       c.600
 A  I  Q  L  K  I  E  A  L  S  I  E  S  V  A  S  C  L  F  D         p.200

          .         .         .         .  | 06      .         .    g.6688
 CGCTTGGAACTCTCCCCTGAGCCTGAAGGCCCCCTCCTCAG | GGTTTGTGGAAGGGTGCCT    c.660
 R  L  E  L  S  P  E  P  E  G  P  L  L  R  |  V  C  G  R  V  P      p.220

          .         .         .         .         .         .       g.6748
 CCCCCCACGCTCAACACCAATGCCAGCCACCTCCTGGTGGTCTTCGTCTCTGACAGCAGT       c.720
 P  P  T  L  N  T  N  A  S  H  L  L  V  V  F  V  S  D  S  S         p.240

          .         .         .         .         .   | 07     .    g.6924
 GTGGAAGGATTTGGTTTCCATGCCTGGTACCAGGCTATGGCCCCTGGGCGCG | GGAGCTGT    c.780
 V  E  G  F  G  F  H  A  W  Y  Q  A  M  A  P  G  R  G |   S  C      p.260

          .         .         .         .         .         .       g.6984
 GCCCATGATGAGTTCCGCTGTGACCAGCTCATCTGCCTGCTACCTGACTCAGTGTGTGAT       c.840
 A  H  D  E  F  R  C  D  Q  L  I  C  L  L  P  D  S  V  C  D         p.280

          .         .         .         .         .         | 08    g.7284
 GGTTTTGCCAACTGTGCTGACGGCAGTGATGAGACCAATTGCAGTGCCAAGTTCTCGG | GG    c.900
 G  F  A  N  C  A  D  G  S  D  E  T  N  C  S  A  K  F  S  G |       p.300

          .         .         .         .         .         .       g.7344
 TGTGGGGGGAATCTGACTGGCCTCCAGGGCACTTTCTCTACTCCCAGCTACCTGCAGCAG       c.960
 C  G  G  N  L  T  G  L  Q  G  T  F  S  T  P  S  Y  L  Q  Q         p.320

          .      | 09  .         .         .         .         .    g.7754
 TACCCTCACCAACTG | CTCTGCACCTGGCATATCTCGGTGCCTGCCGGACACAGCATAGAA    c.1020
 Y  P  H  Q  L   | L  C  T  W  H  I  S  V  P  A  G  H  S  I  E      p.340

          .         .         .         .         .         .       g.7814
 CTACAGTTCCACAACTTCAGCCTGGAGGCTCAGGACGAGTGCAAGTTTGACTACGTGGAG       c.1080
 L  Q  F  H  N  F  S  L  E  A  Q  D  E  C  K  F  D  Y  V  E         p.360

          .         .         .         .     | 10   .         .    g.8686
 GTGTATGAGACCAGCAGCTCAGGGGCCTTCAGCCTCCTGGGCAG | GTTCTGTGGAGCAGAG    c.1140
 V  Y  E  T  S  S  S  G  A  F  S  L  L  G  R  |  F  C  G  A  E      p.380

          .         .         .         .         .         .       g.8746
 CCACCCCCCCACCTCGTCTCCTCGCACCATGAGCTGGCTGTGCTGTTTAGGACAGATCAT       c.1200
 P  P  P  H  L  V  S  S  H  H  E  L  A  V  L  F  R  T  D  H         p.400

          .         .         .         .         .      | 11  .    g.8951
 GGCATCAGCAGTGGAGGCTTCTCAGCCACCTACCTGGCCTTCAATGCCACGGAGA | ACCCC    c.1260
 G  I  S  S  G  G  F  S  A  T  Y  L  A  F  N  A  T  E  N |   P      p.420

          .         .         .         .         .         .       g.9011
 TGTGGGCCCAGTGAGCTCTCCTGCCAGGCAGGAGGGTGTAAGGGTGTGCAGTGGATGTGT       c.1320
 C  G  P  S  E  L  S  C  Q  A  G  G  C  K  G  V  Q  W  M  C         p.440

          .         .         .         .         .         .       g.9071
 GACATGTGGAGAGACTGCACCGATGGCAGCGATGACAACTGCAGCGGCCCCTTGTTCCCA       c.1380
 D  M  W  R  D  C  T  D  G  S  D  D  N  C  S  G  P  L  F  P         p.460

         | 12.         .         .         .         .         .    g.9742
 CCCCCAG | AGCTGGCCTGTGAGCCTGTCCAGGTGGAGATGTGCCTCGGTCTGAGCTACAAC    c.1440
 P  P  E |   L  A  C  E  P  V  Q  V  E  M  C  L  G  L  S  Y  N      p.480

          .         .         .         .         .         .       g.9802
 ACCACAGCCTTCCCTAACATCTGGGTGGGCATGATCACCCAGGAGGAGGTGGTAGAGGTC       c.1500
 T  T  A  F  P  N  I  W  V  G  M  I  T  Q  E  E  V  V  E  V         p.500

          .      | 13  .         .         .         .         .    g.9946
 CTCAGCGGTTACAAG | AGCCTGACAAGCCTGCCCTGCTACCAGCATTTCCGGAGGCTCCTG    c.1560
 L  S  G  Y  K   | S  L  T  S  L  P  C  Y  Q  H  F  R  R  L  L      p.520

          .         .         .         .         .         .       g.10006
 TGTGGGCTGCTTGTGCCCCGTTGCACCCCACTAGGCAGTGTTCTGCCCCCTTGCCGCTCT       c.1620
 C  G  L  L  V  P  R  C  T  P  L  G  S  V  L  P  P  C  R  S         p.540

          .         .         .         .         .         .       g.10066
 GTCTGCCAGGAAGCGGAGCACCAGTGCCAGTCTGGCCTGGCACTACTGGGCACCCCCTGG       c.1680
 V  C  Q  E  A  E  H  Q  C  Q  S  G  L  A  L  L  G  T  P  W         p.560

          .         .         .         .         .         .       g.10126
 CCCTTCAACTGCAACAGGCTGCCAGAGGCAGCTGACCTGGAAGCTTGTGCCCAGCCCTGA       c.1740
 P  F  N  C  N  R  L  P  E  A  A  D  L  E  A  C  A  Q  P  X         p.579

          .         .         .         .         .         .       g.10186
 ccctgaagccggcccctgccctcttcctgcccgtcctcttttgccggtcagggctggcac       c.*60

          .         .         .         .         .         .       g.10246
 gcaggggaacaaaggaaggagcatcagcagggtctctacccatccttctctggggctccc       c.*120

          .         .         .         .         .         .       g.10306
 agggagggggaagagaagtcctcagctggggctcatgggaccctaccaccctccctgctc       c.*180

          .         .         .         .         .         .       g.10366
 cttcctgtccctttaccggtcccaggctgctgactggccccacactgtgccaccggacaa       c.*240

          .         .         .         .         .         .       g.10426
 tcgagaccacttcccatccaggcctcttcccctttccatctgctttttcagcttctccat       c.*300

          .         .         .         .         .         .       g.10486
 cgcctgccttctgaccttttccttgattcaacaaaaatgtactgagcatctattcatgtg       c.*360

          .         .         .         .         .         .       g.10546
 gcaggcccctgtcctaggccctagggatccaactggctgtctgcctctagaactctccac       c.*420

          .         .         .         .         .         .       g.10606
 cctcatctctctgcgtatttctccctgaaatggggtctggtccttggtctctgccactgc       c.*480

          .         .         .         .         .         .       g.10666
 cctgcctctcctctggccctgggaacaggaggtgccctgtgtgtccgtctctcgaagttc       c.*540

          .         .         .         .         .         .       g.10726
 tgcctctctgtgcccagctcaagtctctctccccctcctttctccccctaaactttggcc       c.*600

          .         .         .         .         .         .       g.10786
 ggccgccgggcgacaccacgagttatttcccagctatttcccggtccgggagctcttggc       c.*660

          .         .         .         .         .         .       g.10846
 ccctgaacaactggtttcctcttggagtctgggaggaggaaagcggagccggcagggagc       c.*720

          .         .         .         .         .         .       g.10906
 gaaccaggactggggtgacggcagggcagggggcgcctggccggggagaagcgcgggggc       c.*780

          .         .         .         .         .         .       g.10966
 tggagcaccaccaactggagggtccggagtagcgagcgccccgaaggaggccatcgggga       c.*840

          .    | 14    .         .         .         .         .    g.11280
 gccgggagggggg | actgcgagaggaccccggcgtccgggctcccggtgccagcgctatga    c.*900

          .         .         .         .         .         .       g.11340
 ggccactcctcgtcctgctgctcctgggcctggcggccggctcgcccccactggacgaca       c.*960

          .         .         .         .         .         .       g.11400
 acaagatccccagcctctgcccggggcaccccggccttccaggcacgccgggccaccatg       c.*1020

          .         .         .         .         .         .       g.11460
 gcagccagggcttgccgggccgcgatggccgcgacggccgcgacggcgcgcccggggctc       c.*1080

          .         .         . | 15       .         .         .    g.11855
 cgggagagaaaggcgagggcgggaggccgg | gactgccgggacctcgaggggaccccgggc    c.*1140

          .         .         .         .         .         .       g.11915
 cgcgaggagaggcgggacccgcggggcccaccgggcctgccggggagtgctcggtgcctc       c.*1200

          .         .         .         .         .         .       g.11975
 cgcgatccgccttcagcgccaagcgctccgagagccgggtgcctccgccgtctgacgcac       c.*1260

          .         .         .         .         .         .       g.12035
 ccttgcccttcgaccgcgtgctggtgaacgagcagggacattacgacgccgtcaccggca       c.*1320

          .         .         .         .         .         .       g.12095
 agttcacctgccaggtgcctggggtctactacttcgccgtccatgccaccgtctaccggg       c.*1380

          .         .         .         .         .         .       g.12155
 ccagcctgcagtttgatctggtgaagaatggcgaatccattgcctctttcttccagtttt       c.*1440

          .         .         .         .         .         .       g.12215
 tcggggggtggcccaagccagcctcgctctcggggggggccatggtgaggctggagcctg       c.*1500

          .         .         .         .         .         .       g.12275
 aggaccaagtgtgggtgcaggtgggtgtgggtgactacattggcatctatgccagcatca       c.*1560

          .         .         .         .         .         .       g.12335
 agacagacagcaccttctccggatttctggtgtactccgactggcacagctccccagtct       c.*1620

          .         .         .         .         .         .       g.12395
 ttgcttagtgcccactgcaaagtgagctcatgctctcactcctagaaggagggtgtgagg       c.*1680

          .         .         .         .         .         .       g.12455
 ctgacaaccaggtcatccaggagggctggcccccctggaatattgtgaatgactagggag       c.*1740

          .         .         .         .         .         .       g.12515
 gtggggtagagcactctccgtcctgctgctggcaaggaatgggaacagtggctgtctgcg       c.*1800

          .         .         .         .         .         .       g.12575
 atcaggtctggcagcatggggcagtggctggatttctgcccaagaccagaggagtgtgct       c.*1860

          .         .         .         .         .         .       g.12635
 gtgctggcaagtgtaagtcccccagttgctctggtccaggagcccacggtggggtgctct       c.*1920

          .         .         .         .         .         .       g.12695
 cttcctggtcctctgcttctctggatcctccccaccccctcctgctcctggggccggccc       c.*1980

          .         .         .         .                           g.12740
 ttttctcagagatcactcaataaacctaagaaccctcctaccggc                      c.*2025

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Membrane frizzled-related protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 30b
©2004-2025 Leiden University Medical Center